Forward Genetics Screen

Pioneering the use of forward genetics and positional cloning in the mouse as a tool for discovery of genes underlying neurobiology and behavior, the discovery of the mouse and human clock genes led to a description of a conserved circadian clock mechanism in animals. The search for novel genes continues.

Actigrams Actigrams showing wheel running activity from wild-type, heterozygous, and homozygous Clock mutant mice.