Under the guidance of director Dr. Daolin Tang, the research group focuses on basic, translational and clinical application research on damage-associated molecular patterns (DAMPs) signaling pathways. Inflammation is a fundamental response to infection and injury in all multicellular organisms. The danger hypothesis states that endogenous molecules (protein and non-protein) released during cell death or tissue damage can trigger inflammation in the absence of infection, collectively referred to as DAMPs. We are particularly interested in elucidating the molecular mechanisms underlying stress-induced cellular defense and cell death signaling in normal and cancer cells, and how release of DAMPs modulates immune responses in disease.

The Sandstrom Lab works to identify the fundamental molecular mechanisms through which the immune system can recognize pathogens and stress. 

We use genetic systems to deconstruct functions associated with the most commonly mutated genes found in human cancers.

We employ a variety of methods including evolutionary analysis, genomics, and molecular biology to study the biology of infection.