The Acute Liver Failure Study Group (ALFSG) is a clinical research network funded by the National Institutes of Health since 1997, to gather important prospective data and biosamples on this rare condition.
The Advanced Imaging and Informatics for Radiation Therapy (AIRT) Lab's research is focused on the development of novel imaging and beam delivery techniques and new machine learning algorithms to improve the efficacy of radiation therapy
We are interested in the relationship between metabolism and cell type. We focus on the metabolism of hematopoietic stem cells (HSCs) and their progeny including cells of the myeloid and T cell lineages.
Our lab is using various approaches to explore this biology and develop new treatments with a focus on targeting tumor intrinsic factors such as genetic programs like the epithelial to mesenchymal transition that coordinate with infiltrating immune cells in enhance therapeutic resistance and assist distant spread.
Our mission is to improve the care of breast cancer patients through cutting-edge translational research at the interface of clinical oncology, cancer biology, molecular genetics, and translational genomics.
Our goal is to track the signaling dynamics of individual effectors and toxins in living cells, using a combination of fluorescent genetic reporters, microinjection of labeled bacterial proteins, and live cell imaging techniques.
The ANSIR lab is devoted to the application of novel image analysis methods (e.g. diffeomorphic registration, machine learning, graph theory, ASL) to research studies, as well as to robust clinical translation of these techniques.
Our goal is to employ cryo-EM to determine high resolution structures of important membrane protein complexes involved in cellular signaling, including cellular receptors and ion channels. We also combine structural approaches with functional studies to reveal the structure-function relationships of these membrane proteins.
The Bailey lab focuses on developing gene therapies for neurological disorders. We work on monogenetic pediatric disorders, including SLC13A5 epileptic encephalopathy, multiple sulfatase deficiency, Charcot Marie Tooth disease type 4J, giant axonal neuropathy and ECHS1 deficiency.
This facility is the home to five high field solution NMR spectrometers ranging from 500 MHz to 800 MHz and a Solid State 600 MHz DNP system, primarily in support of studies of macromolecular structure, function and dynamics.
The Bowen Lab focuses on the development of hybrid positron emission tomography (PET) (e.g. PET-CT and PET-MR) tools to enable precision imaging for the care and study of oncology, neurology, and cardiology patients.
The Burgess lab uses Nuclear Magnetic Resonance spectroscopy and Mass Spectrometry in conjunction with stable isotope (non-radioactive) tracers to study how metabolic flux is altered by disease, pharmacology, or targeted genetic interventions.
The Collaborative for Advanced Clinical Techniques in UltraSound (CACTUS) constitutes a group of like-minded physicians, scientists, and technical experts dedicated to the advancement of clinical imaging, technical and translational research, and image-guided intervention in ultrasound.
Castrillion Lab's work is aimed at understanding why endometrial or uterine cancers arise and spread, with an eye on prevention, earlier and more accurate diagnosis, improved treatments, and better overall patient outcomes.
Our lab is creating better experimental models that reveal how cancer cells metastasize and evade our immune system. We use these models to develop new drugs that engage our immune system to kill cancer cells.
We are interested in building small organic molecules and studying their functions in biological systems. Our lab started in 2004 using state-of-the-art tools to address challenging issues in the field of natural product synthesis.
Deficiencies in DNA-damage signaling and repair pathways are fundamental to the etiology of most human cancers. Of the many types of DNA damage that occur within the cell, DNA double-strand breaks (DSBs) are particularly dangerous.
Welcome to the Reproductive Genomics Laboratory (RGL) at UT Southwestern Medical Center where we innovate at the intersection of genomics, bioengineering, and data science to answer fundamental questions in reproductive biology.
Our primary research interest is to understand the emerging roles of the “unannotated genome,” which encodes a whole new class of uncharacterized microproteins. We focus on the relevance and function of this “dark proteome” in regulating development and disease.
My lab has a long-time interest in understanding the mechanisms of transcription and gene regulation in mammalian cells using initially cell-free systems reconstituted with purified gene-specific transcription factors, general cofactors, and components of the general transcription machinery to recapitulate transcriptional events in vitro.
Magnetic resonance spectroscopy (MRS) provides an effective tool for detecting bio-chemicals in living systems noninvasively. Dr. Choi’s lab focuses on technical and clinical development of MR spectroscopy (MRS) in the brain in vivo.
The Chong Research group has been conducting clinical and translational research on cutaneous lupus including outcome measure development for clinical trials, biomarkers for diagnosis and prognosis, and disease outcomes.
The Chook Lab studies physical and cellular mechanisms of Kaps. Our long-term goals are to understand how the macromolecular nuclear traffic patterns coordinated by the 20 human Kaps contribute to overall cellular organization.
Chung Lab uses primary human specimens, patient-derived xenograft models, and genetically engineered mouse models to study the molecular mechanisms underlying disease stem cell function in hematologic malignancies.
Both we (Cobanoglu et al., 2013) and others (Murphy, 2011) have reported that active machine learning driven experimentation can increase efficiency in the drug discovery process in the preclinical stage. We have a view towards integrating our computational work with an experimental pipeline. That is exactly why we are housed in a biomedical powerhouse, the UT Southwestern Medical Center, to execute this vision.
The Cobb lab studies signal transduction mechanisms of protein kinases and how kinase structures lead to cell biological functions. We are particularly focused on the contributions of ERK MAP kinases to pancreatic beta-cell function and to lung cancers, and on the cell biological actions of WNK protein kinases.
We believe that understanding the basic biology of the schistosomes is key to developing the next generation of anti-schistosome drugs and vaccines. We also contend that by studying the basic biology of these fascinating organisms, we can better understand important basic biological processes common to all animals, including humans. For that reason, we study schistosomes from multiple angles using a variety of modern molecular approaches.of the lab.
James J. Collins III, Ph.D.
Cell and Molecular BiologyGenetics, Development and Disease
The research focus in the Corbin lab investigates strategies that exploits the deviant metabolism of cancer cells (namely the reprogramming of lipid metabolism and altered redox biology) for therapeutic purposes.
The central goal of the Dauer Lab is to unravel the molecular and cellular mechanisms of diseases that disrupt the motor system. In exploring these diseases, we also aim to understand a fundamental question relevant to CNS disease generally: what factors determine the selective vulnerability of particular cell types or circuits to insults? Our primary focus is on Parkinson’s disease and inherited forms of dystonia. We focus our efforts on disease genes that cause these disorders, employing a range of molecular, cellular, and whole animal studies to dissect the normal role of disease proteins, and how pathogenic mutations lead to disease.
William Dauer, M.D.
parkinson's diseasecentral nervous system diseaseDystonia
The De Brabander Lab focuses on the synthesis of complex molecular architectures, including both designed and naturally occurring substances with novel structural features and interesting biological function.
Proper control of metabolism is required for essentially every basic biological process. Altered metabolism at the cellular level contributes to several serious diseases including inborn errors of metabolism (the result of inherited genetic defects in metabolic enzymes that lead to chemical imbalances in children) and cancer. Our laboratory seeks to characterize these metabolic disorders, understand how they compromise tissue function, develop methods to monitor metabolism in vivo and design therapies to restore normal metabolism and improve health.
The Elmquist laboratory uses mouse genetics to identify circuits in the nervous system that regulate energy balance and glucose homeostasis. We have developed unique mouse models allowing neuron-specific manipulation of genes regulating these processes.
Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery.
Bacteria and phages are in everlasting conflict – constantly devising new genes, systems, and mechanisms to keep pace with their competitors. The Forsberg lab studies this “evolutionary arms race”, using high-powered selections to unearth new functions and careful experiments to reveal their mechanisms.
The Fragile X Syndrome Research Center is a team of investigators from UT Southwestern and the University of California at Riverside. The Center supports three projects representing a multilevel, integrated approach that tests mechanisms of sensory neocortical dysfunction in fragile X syndrome (FXS) and pharmacological approaches to reduce the deficits.
Obesity and metabolic diseases have been increasing at the alarming rate and threatening our health and economy over the world. However, we still don’t know much about how our metabolic homeostasis is regulated. Understanding the mechanism underlying the regulation of metabolism is a fundamental step towards designing new treatments for obesity and its associated diseases, and many other metabolic diseases
The autonomic nervous system comprises a network of sensory and motor neurons that connect the brainstem and spinal cord to thoracic and abdominal organs. A better understanding of the anatomical and functional plasticity of the autonomic nervous system will likely move forward our understanding of numerous chronic diseases including, but not limited to, obesity, diabetes, visceral pain, neuropathy, and eating disorders.
The Goss lab collaborates with a multidisciplinary group of researchers to study the heart and lungs long after preterm birth. We are part of the Parkland Outcomes after Prematurity Study (POPS), which conducts collaborative research on outcomes of prematurity from birth through adulthood.
The general focus of the Green Lab is to understand the molecular mechanism of the mammalian circadian clock, how it controls rhythmic biochemistry, physiology and behavior and how loss of clock function can impact health, resulting in metabolic disease, cancer and other ailments.
Our laboratory is interested in improving treatment for patients with glioblastoma (GBM) and other cancers. We work on understanding signal transduction pathways involved in the pathogenesis of cancer. Recent work has focused on investigating mechanisms of resistance to targeted treatment in GBM and lung cancer. We are also interested in mechanisms regulating invasion in GBM.
Dr. Harbour’s research focuses on the use of genetic and genomic technology, cell culture experiments and genetically modified experimental models to understand mechanisms of tumor progression in major forms of eye cancer, including uveal melanoma, retinoblastoma, intraocular lymphoma and others.
The Core supports the early, pre-clinical discovery and development of new small molecule therapeutics, and assists in identifying and characterizing novel biological targets and pathways for therapeutic intervention.
We do difficult experiments at the frontier of cell physiology, often with our own methods and always with our own hands. Enter a description of the lab. This information will appear on the lab listing page.
We explore questions on genomes using a systems biology approach: developing and employing integrative approaches at the interface of gene regulation, epigenetics, single-cell genomics, and bioinformatics.
We are multidisciplinary team of clinicians and scientists, focusing on liver cancer risk-predictive molecular biomarkers specific to clinical contexts (ex. geographic region, liver disease etiology, and patient race/ethnicity) individual risk-stratified personalized cancer screening.
In diseases like cancer, signaling pathways can be corrupted by mutations that cause the cells to grow and spread uncontrollably. Our lab is interested in understanding how these defective pathways reprogram cellular metabolism to drive cancer growth.
Jer-Tsong Hsieh Lab research interests focus on key molecular mechanisms leading to urologic cancer progression, development of precision medicine of cancer therapy assisted with non-invasive molecular imaging.
Ming-Chang Hu Lab strives to offer novel insight into the cellular and molecular mechanisms of AKI progression to CKD and cardiovascular diseases (vascular calcification and uremic cardiomyopathy) development in CKD, and set up a solid basis for preclinical and clinical study in the future.
Our laboratory is interested in the molecular mechanisms governing cytokine receptor signal transduction in hematopoietic stem and progenitor cells, and understanding how deregulation in these mechanisms results in hematological malignancies and cancer.
The Institute for Exercise and Environmental Medicine is a 40,000 square-foot research facility with 12 UTSW faculty working in multiple departments and divisions (Internal Medicine/Cardiology/Pulmonary, Neurology, PM&R, Anesthesiology, Applied Physiology) with up to 20 postdocs, and 40 staff on 70 active protocols and 15 federal grants. It is a research enterprise devoted to the study of human physiology and the limits to human functional capacity in health and disease.
Benjamin Levine, M.D., Tony Babb, Ph.D., Craig Crandall, Ph.D., Qi Fu, M.D., Ph.D., Rong Zhang, Ph.D., Tom Sarma, M.D., James MacNamara, M.D., Christopher M. Hearon, Jr., Ph.D., Renie Guilliod, M.D., James Berry, M.D., Andrew Tomlinson, M.D.
We are a group of biophysicists, cell biologists and computational folks interested in the spatiotemporal organization of cell surface receptors, the mechanisms underlying it, and its consequences for cell signaling.
The Jewell Lab investigates how organisms sense environmental nutrient fluctuations and respond appropriately, fine tuning anabolic and catabolic processes to control cell growth, metabolism, and autophagy.
The ultimate goal of the Kittler Lab's research is to develop novel therapeutic approaches that target transcription factors, which play important roles in common solid tumors (brain, breast, lung and prostate cancer) and could therefore have translational potential.
We are broadly interested in understanding how resident intestinal microorganisms (particularly bacteria and fungi and collectively referred to as the gut microbiome) influence the health of human cancer and stem cell transplant patients.
The Lehrman lab uses biochemical approaches to study the functions of sugars and sugar-polymers coupled to proteins and lipids, and as free molecules. Our work involves broken-cell systems, living cultured cells, and animals. This area of research, known as Glycobiology, is an emerging field that encompasses most aspects of biology and medicine.
We are interested in understanding the process of co-evolution of tumor and immune cells during cancer development, which can be tracked from clonal expansion events, together with components of the tumor microenvironment and infiltrating immune repertoire.
The overarching goal of Wen-hong Li Lab is to investigate mechanisms responsible for maintaining islet cell function and to devise new strategies for enhancing beta cell fitness and robustness to prevent or treat diabetes.
Our mission is to understand the most fundamental questions in cancer biology, such as tumor initiation, progession, and response to therapy, through state-of-the-art experimentation, fruitful collaborations and, above all, out-of-the box thinking to develop novel, safe(r) and more effective therapies to win the fight against cancer!
The goal of Lin (Weichun) Lab's research is to understand how neurons establish synaptic connections during development, and how these connections are maintained throughout adulthood. Toward this goal, we are currently focusing on the following two areas of research.
Xin Liu Lab is interested in understanding the regulation of transcription and chromatin dynamics underlying many fundamental biological processes including differentiation, development, and oncogenesis.
Our research aims to obtain a comprehensive picture of how genomic stability and chromatin dynamics affect neuronal functions, including learning behaviors, and to apply this knowledge to combat neurological disorders.
We are interested in understanding the deregulation of epigenetic and transcriptional pathways in human disease and in finding small molecules with therapeutic potential to normalize these gene expression patterns.
The McKnight Lab at UT Southwestern Medical Center studies a broad spectrum of biological phenomena by use of a combination of biochemical, genetic, biophysical, bioinformatic and molecular biological approaches.
The Mendell laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.
The main focus of the Minna Lab is translational (“bench to bedside”) cancer research aimed at developing new ways to diagnose, prevent, and treat lung cancer based on a detailed understanding of the molecular pathogenesis of lung cancer.
Mukhopadhyay Lab research aims to understand how the primary cilium regulates downstream pathways to ultimately drive morphogenesis in different tissues. We undertake a multi-pronged approach including proteomics, cell biology, biochemistry, reverse genetics, and generation of innovative mouse models to study regulation of signaling pathways by cilia in in cellular and organismal contexts.
The mission of the Najafov Lab is to understand the role of cell death in physiology and disease. Our research is focused on necroptosis and how it can be targeted to develop novel strategies for treating cancer.
The mission of Napierala Lab is to contribute to the development of therapies and a cure for Friedreich’s ataxia (FRDA) by elucidating molecular mechanisms causing the disease, developing novel cellular and animal models of FRDA, identifying disease biomarkers and testing novel therapeutic approaches.
The focus of the Neuromuscular Center is the diagnosis and treatment of muscle diseases known as metabolic myopathies, including inherited disorders of muscle fat, carbohydrate, and mitochondrial muscle metabolism.
The long-term goals of the Nwariaku Laboratory are to understand the cellular mechanisms that regulate endothelial dysfunction during inflammatory and neoplastic conditions with a hope to use this knowledge in designing novel therapeutic agents.
The focus of the Obata Lab is to study how environmental signals (e.g., microbiota, diet, day/night cycles) shape intestinal neural circuits and immune cell networks. A variety of experimental techniques are used, including state-of-the-art imaging technologies, viral tracing of gut innervation, in vivo and ex vivo physiological assays, gnotobiotic systems and multi-omics technologies. The Obata lab is also interested in elucidating the molecular mechanisms of inter-organ communication, including the Gut-Brain axis.
The Oh lab is committed to elucidating how GPCRs work in regulating metabolism and identifying new avenues for developing therapeutics to treat metabolic syndromes such as type 2 diabetes, insulin resistance.
Dayoung Oh, Ph.D.
G protein-coupled receptortype 2 diabetesobesitymetabolic syndrome
The mission of the Pedrosa Lab is to develop and implement new imaging methods that facilitate better morphologic and pathophysiologic characterization of diseases in the body for improved patient outcomes
Petroll Lab applies engineering approaches and design principles to the investigation of fundamental clinical and biological problems in ophthalmology, while providing training to graduate students, medical students, and post-docs.
The Pfeiffer Lab is interested in how the brain forms neural representations of experience, how those representations are consolidated into long-term memory, and how those representations can be later recalled to inform behavior.
We are developing inhibitors of pyrimidine biosynthesis and polyamine biosynthesis to treat malaria and African sleeping sickness. We study polyamine and nucleotide metabolism in African trypanosomes to learn about novel metabolism and regulation.
Pouratian Lab's primary mission is to explore basic human neuroscientific principles as well as identify brain mapping biomarkers of disease that can drive innovative approaches to restore function to patients with neurological and psychiatric diseases.
The Psychoneuroendocrine Research Program (PNE) at UT Southwestern Medical Center focuses on two different areas of research: substance abuse, particularly dual diagnoses (e.g., depression or bipolar disorder); and the effects of corticosteroids (e.g., prednisone) on mood and memory.
Qin Lab focuses on the development of novel synthetic transformations and strategies that will allow access to bioactive, complex natural products and efficient synthesis of pharmaceuticals and their derivatives.
Tian Qin, Ph.D.
Chemical synthesisBioactive natural productsCross CouplingsBioisosteres
The Reinecker laboratory unravels and targets molecular mechanisms of key human genetic variants that cause chronic inflammatory diseases and cancer by creating novel genetic mouse and human organotypic model systems.
We investigate the mechanism of neurotransmitter release using a variety of biophysical approaches, including NMR spectroscopy, X-ray crystallography, cryo-EM, molecular dynamics simulations and liposome fusion assays.
The significance of our research is to show effective anti-Aβ42 antibody production in large animals and safety of DNA Aβ42 immunotherapy in these models to proceed with vaccination in patients at risk for Alzheimer’s disease.
A major focus of our lab is to identify mechanisms of cardiomyocyte cell cycle regulation, and discover ways to reawaken regenerative pathways in the adult mammalian heart. We are also developing several structural, molecular, and physiological tools to interrogate the mechanistic underpinnings of various forms of cardiomyopathy.
Satterthwaite Lab studies the signals that control B lymphocyte development, activation, and differentiation into antibody-secreting plasma cells, both normally and in autoimmune diseases such as lupus. We hope that by defining these events, we can reveal new approaches to modulate antibody responses therapeutically.
The main focus in our laboratory is the identification and physiological characterization of adipocyte-specific gene products and the elucidation of pathways that are an integral part of the complex set of reactions that drive adipogenesis.
Nutrition and exercise intervention to reduce cardiovascular risk factors; weight loss and maintenance in bariatric surgery patients; role of nutrition and exercise in cardiovascular risk factors; influence of the eating environment on energy intake.
The Sorrell laboratory utilizes integrative approaches that include metabolomics, transcriptomics, organoid cultures, live microcopy, and animal models, to investigate fundamental pathways that control the uptake of nutrients and the biosynthesis of macromolecules in proliferative cells.
The Story Lab has a robust research portfolio that includes radiation-induced carcinogenesis associated with the unique environment of space, molecular markers of carcinogenic risk after radiation, intrinsic radiosensitivity, modulation of drug and radiation response by pentaazamacrocyclic ring compounds with dismutase activity, high-dose per fraction radiotherapy, charged particle radiotherapy, the mechanism(s) of action of Tumor Treating Fields, and the enhancement of cancer therapy through radiation and drug combination used concomitantly with Tumor Treating Fields.
The main goals of the Strand Lab are to create accurate cellular atlases of the human and mouse lower urinary tract, characterize the molecular and cellular alterations in human lower urinary tract disease, and build appropriate models of the human disease in novel mouse models.
The Sun Lab is focused on developing novel imaging probes for noninvasive assessment of specific biomarkers implicated in disease initiation, progression, or regression, and exploring the translational roles of imaging probes and/or methodologies in clinical medicine practice with the ultimate goal to improve the outcome of patient care.
The Tagliabracci Lab studies the phosphorylation of extracellular proteins by a novel family of secreted kinases. This kinase family is so different from canonical kinases that it was not included as a branch on the human kinome tree.
Vincent "Vinnie" Tagliabracci, Ph.D.
Cell and Molecular BiologyGenetics, Development and Disease
Research in my laboratory focuses on better understanding the molecules and mechanisms that assemble axonal connections with a goal of utilizing this knowledge to encourage axons to reestablish their connections after trauma or disease.
We investigate genetic and molecular basis of phenotypic diversity observed in nature by using a range of methodologies such as whole genome sequencing, fluidics, long-term evolution experiments, and large-scale combinatorial mutagenesis.
The Center for Depression Research and Clinical Care (CDRC) is nationally recognized for its cutting edge research in unipolar and bipolar depression. The research conducted within the center brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.
The Turer Lab is interested in finding genes with novel functions in intestinal immune homeostasis. Our projects generally involve a mix of experimental approaches examining both the intestinal epithelium as well as hematopoietic causes of intestinal inflammation.
Children with in-born errors of immunity are prone to life-threatening viral, bacterial, and fungal infections. We study the causes of their immune system problems, combining clinical insights and mouse models genocopying the various mutations. This work includes a profiling of immune responses to infections (e.g., COVID-19) in normal healthy individuals and patients.
Dr. Vega and co-workers have discovered three other causes of high LDL. First, she found that some patients have abnormal LDL particles that cannot be removed from circulation because the abnormal LDL does not recognize the receptors.
The main focus of the Vinogradov Lab is developing MRI methods that are based on the intrinsic biochemical processes and physical properties of the tissue: chemical exchange rearrangements, molecular networks, and relaxation.
Dr. Wang's primary research interest includes the statistical methodology development for the design and analysis of clinical trials, as well as the evaluation of repeated measurements and correlated data.
Our research revolves around using state-of-the-art bioinformatics and biostatistics approaches to study the implications of tumor immunology for tumorigenesis, metastasis, prognosis, and treatment response in a variety of cancers.
Dr. Waugh is a physician-scientist whose research focuses on the structural brain abnormalities that lead to dystonia, a movement disorder that leads muscles to twist and contort into painful positions.
The Wert laboratory studies the post-mitotic neuronal cells of the retina, particularly the photoreceptor cells. Our goal is to discover and understand the mechanisms underlying retinal degenerative disease, and to provide novel therapeutics for these complex degenerative disorders using gene therapy and genome engineering technologies, human stem cell transplantations, and metabolic rescue.
Our laboratory was established in 2012 in the Department of Biochemistry at UT Southwestern Medical Center. The Biochemistry Department features exceptional depth of expertise in both biology and chemistry.
Scientists in the Center for Pediatric Bone Biology and Translational Research work to discover the underlying causes of poorly understood musculoskeletal disorders in children, and to understand the fundamental steps that lead to disease.
In our laboratory, we utilize molecular and cellular approaches to decipher mechanisms of extracellular matrix remodeling of the female reproductive tract in both physiologic states (e.g., during pregnancy, parturition, and the puerperium) and pathologic conditions (pelvic organ prolapse, urinary incontinence, and injury of the external anal sphincter).
The focus of our current research is the biochemistry and molecular characterization of ABCG5/ABCG8 transporter, aiming at understanding the mechanism by which this transport system operates to translocate cholesterol cross membranes.
The lab focuses on developing bioinformatics algorithms and deep learning models to identify new disease genes and therapeutic targets for human diseases, as well as development and maintenance of data management system for genomic and clinical databases.
Since I began studying the biological rhythms of insects during graduate school, I have been fascinated with the accuracy of the circadian timing system and the phenomenal influence of the circadian clock on almost all biological activities. This fascination has fueled my interest in learning about circadian rhythms for more than a quarter of a century.
We are interested in how metabolism regulates various behaviors. We use two invertebrate model systems of C. elegans and D. melanogaster, ultimately aiming to unveil conserved neuro-molecular mechanisms throughout animals including mammals.
Zeng Lab is interested in understanding at the molecular level key questions lying at the interface between biochemistry, cell biology, metabolic and neural physiology, including the bidirectional communication between autonomic neurons and adipocytes, the molecular basis of the phenotypic plasticity, or the lack of, in brown, beige and white adipocytes, and roles of uncharacterized enzymatic pathways in adipose thermogenesis.
The lab's long-term goal is to illuminate the function of immune surface molecules and to open up a new research field at the interface of cancer, immunology, and stem cell research. Zhang Lab also actively develops novel therapies for cancer treatment.
Zhang (Chun-Li) Lab research focuses on cellular plasticity in the adult nervous system and modeling human neurodegenerative diseases. We use cell culture and genetically modified mice as model systems. Molecular, cellular, electrophysiological, and behavioral methods are employed.
Chun-Li Zhang, Ph.D.
in vivo reprogrammingneurogenesisglial cellsastrocytesNG2 gliachun-li zhangutswutsouthwestern
The central theme of our research program in our laboratory is to explore the co-evolution between tumor cells and the tumor microenvironment (TME) during the development of therapeutic resistance and metastatic relapse.
Our lab combines normative theories and biologically plausible neural circuit models to study the principles of neural information processing, in order to answer how perception, cognition, and behavior emerge from neural circuits.
Our aim is to develop computational methods to unveil the hidden biological circuitries behind the data, from understanding sequence-based regulations to the evolution of genomes and their impact to diseases.
Our lab is interested in understanding the relationship between injury, regeneration, and cancer. We are focused on identifying the genes and mechanisms that regulate regenerative capacity in the liver and understanding how these contribute to hepatocellular carcinoma development.
The Zia Research Group focuses on clinical and translational hematology research to improve the understanding of pediatric thrombotic and hemostatic disorders with the long-term goal of improving the lives of affected children and young adults with these disorders.
We investigate the neuro-hormonal basis for complex eating behaviors and blood glucose control, with the ultimate goal of designing new methods to prevent and treat extremes of body weight, blood glucose, and associated disorders of mood and metabolism.