We use genetic systems to deconstruct functions associated with the most commonly mutated genes found in human cancers.
- John M. Abrams
We use genetic systems to deconstruct functions associated with the most commonly mutated genes found in human cancers.
The Acute Liver Failure Study Group (ALFSG) is a clinical research network funded by the National Institutes of Health since 1997, to gather important prospective data and biosamples on this rare condition.
The Advanced Imaging and Informatics for Radiation Therapy (AIRT) Lab's research is focused on the development of novel imaging and beam delivery techniques and new machine learning algorithms to improve the efficacy of radiation therapy
The focus of Dr. Agarwal's research has been on mechanisms of steroid action with emphases on: 1) structure-activity relationships of ligand-steroid receptor interactions, and 2) steroid metabolism.
We are interested in the relationship between metabolism and cell type. We focus on the metabolism of hematopoietic stem cells (HSCs) and their progeny including cells of the myeloid and T cell lineages.
Our lab is using various approaches to explore this biology and develop new treatments with a focus on targeting tumor intrinsic factors such as genetic programs like the epithelial to mesenchymal transition that coordinate with infiltrating immune cells in enhance therapeutic resistance and assist distant spread.
Akbay Lab studies genetic and molecular events that lead to lung-tumor initiation and immune evasion.
Our mission is to improve the care of breast cancer patients through cutting-edge translational research at the interface of clinical oncology, cancer biology, molecular genetics, and translational genomics.
Our goal is to track the signaling dynamics of individual effectors and toxins in living cells, using a combination of fluorescent genetic reporters, microinjection of labeled bacterial proteins, and live cell imaging techniques.
The ANSIR lab is devoted to the application of novel image analysis methods (e.g. diffeomorphic registration, machine learning, graph theory, ASL) to research studies, as well as to robust clinical translation of these techniques.
Our group studies the effect of cancer therapeutics and aging on the growth and renewal of heart muscle.
The Arteaga laboratory has a longstanding interest in understanding the molecular pathways that drive breast cancer progression and influence response to therapies.
Our research is focused on (1) identifying low-risk patients that would benefit from minimal treatment or surveillance, and (2) devising methods of sensitization to current therapies.
Our goal is to employ cryo-EM to determine high resolution structures of important membrane protein complexes involved in cellular signaling, including cellular receptors and ion channels. We also combine structural approaches with functional studies to reveal the structure-function relationships of these membrane proteins.
The Bailey lab focuses on developing gene therapies for neurological disorders. We work on monogenetic pediatric disorders, including SLC13A5 epileptic encephalopathy, multiple sulfatase deficiency, Charcot Marie Tooth disease type 4J, giant axonal neuropathy and ECHS1 deficiency.
The Baker Laboratory focuses on the causes of birth defects or diseases of the urogenital tract.
The primary role of our lab is to provide services to the research community in the areas of organic and analytical chemistry via the Protein Chemistry Technology Core.
We study the role of chromatin regulation in cell fate decisions.
Our laboratory has characterized many of the transporters responsible for proximal tubule acidification and solute transport
Dr. Bedimo studies strategies for optimally managing drug-resistant HIV patients, analyzing metabolic abnormalities in HIV patients, and studying the effects of HCV co-infection.
We are interested in how CNS signals are transmitted via hormonal or neural mechanisms to modulate specific organs, with a special interest diabetes and obesity.
We combine classical genetics with modern technology to understand human physiology and search for breakthrough treatments for diseases.
The Bioinformatics Lab provides services to manage and analyze next-generation sequencing data.
Our mission is to innovate, develop, and apply biomedical technology to empower cancer research.
This facility is the home to five high field solution NMR spectrometers ranging from 500 MHz to 800 MHz and a Solid State 600 MHz DNP system, primarily in support of studies of macromolecular structure, function and dynamics.
Our research is largely aimed at understanding how an organism detects mechanical force.
The Bowen Lab focuses on the development of hybrid positron emission tomography (PET) (e.g. PET-CT and PET-MR) tools to enable precision imaging for the care and study of oncology, neurology, and cardiology patients.
The BRAIN lab, short for Brain Aging, Injury, and Modulation Lab, has two lines of research in the area of aging and neurodegenerative diseases. The lab investigates the later-in-life effects of traumatic brain injury, which involves understanding the potential risk associated with developing dementia and the underlying biological pathways. The lab also studies the effects of noninvasive brain stimulation in Alzheimer’s disease and related disorders with the goal of informing the development of new treatments.
The Brekken laboratory, located in the Hamon Center for Therapeutic Oncology Research, studies tumor-host interactions with a particular emphasis on extracellular matrix (ECM) and angiogenesis.
Our laboratory discovered a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control cholesterol and fatty acid synthesis.
The Burgess lab uses Nuclear Magnetic Resonance spectroscopy and Mass Spectrometry in conjunction with stable isotope (non-radioactive) tracers to study how metabolic flux is altered by disease, pharmacology, or targeted genetic interventions.
Burstein Laboratory focuses on understanding the regulation of the inflammatory response at a molecular level, and elucidating how these events may participate in human disease.
The Busch Lab develops optical technologies for minimally and non-invasive bedside assessment of microvascular blood flow and oxygen saturation, allowing continuous assessment of aerobic metabolism.
Buszczak laboratory seeks to gain new insights into mRNA translation, ribosome biogenesis and germ cell biology
Our lab is working with to develop a gene therapy that would allow increased Ube3a expression in the paternal copy of the gene that causes Angelman syndrome.
My research interests include lipidomics, enzymology, drug discovery, and bioanalytical chemistry in the relation to ocular biochemistry, biophysics, and physiology.
The Collaborative for Advanced Clinical Techniques in UltraSound (CACTUS) constitutes a group of like-minded physicians, scientists, and technical experts dedicated to the advancement of clinical imaging, technical and translational research, and image-guided intervention in ultrasound.
We are broadly interested in how cancer cells sense and use extracellular nutrient for growth and proliferation. Specifically, we seek to understand how extracellular nutrients and small molecules regulate cellular growth and proliferation.
The Camacho Lab focuses on understanding key genetic events that lead to cancer in an effort to identify novel targets that will help improve existing therapies
Please contact our team if planning neoadjuvant Adriamycin (doxorubicin), for enrollment in the HP Cardiotox Study.
We conduct state-of-the-art clinical trials in the field of cardiovascular diseases, offering patients access to advanced clinical therapies that would otherwise not be available.
The work of Deborah Carlson, Ph.D., focuses on characterizing the inflammasome mediating the inflammatory response in the heart following thermal injury and thermal injury complicated with sepsis.
Kidney disease has reached epidemic proportions in the U.S. The Carroll Lab performs basic and translational research focused on kidney development, maintenance and regeneration.
Castrillion Lab's work is aimed at understanding why endometrial or uterine cancers arise and spread, with an eye on prevention, earlier and more accurate diagnosis, improved treatments, and better overall patient outcomes.
Our research team conducts clinical studies of neurodevelopmental conditions including Autism Spectrum Disorder, Fragile X Syndrome, and Phelan-McDermid Syndrome.
Interrogating the genome to better understand the mechanisms causing autism spectrum disorder and other neurodevelopmental disorders and inform innovative therapies
Our lab is creating better experimental models that reveal how cancer cells metastasize and evade our immune system. We use these models to develop new drugs that engage our immune system to kill cancer cells.
We work to understand the role of DNA-PKcs in DNA repair and maintenance, with the ultimate goal of improving radiation therapy as cancer treatment.
We are interested in building small organic molecules and studying their functions in biological systems. Our lab started in 2004 using state-of-the-art tools to address challenging issues in the field of natural product synthesis.
Deficiencies in DNA-damage signaling and repair pathways are fundamental to the etiology of most human cancers. Of the many types of DNA damage that occur within the cell, DNA double-strand breaks (DSBs) are particularly dangerous.
Elizabeth Chen Lab focuses research on cell-cell fusion, drosophila myoblast fusion, invasive membrane protrusions, actin binding and bundling proteins, and mechanoresponsive proteins.
Welcome to the Reproductive Genomics Laboratory (RGL) at UT Southwestern Medical Center where we innovate at the intersection of genomics, bioengineering, and data science to answer fundamental questions in reproductive biology.
Our primary research interest is to understand the emerging roles of the “unannotated genome,” which encodes a whole new class of uncharacterized microproteins. We focus on the relevance and function of this “dark proteome” in regulating development and disease.
Chen lab studies how dysregulation of RNA synthesis and degradation drives childhood cancers with the ultimate goal of identifying new therapeutic vulnerabilities to exploit in treating them.
Chen Lab is broadly interested in mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself.
Jonathan Cheng's Lab performs a comprehensive suite of outcome measures to assess peripheral nerve recovery and chronic neural interfacing in the research setting.
My lab has a long-time interest in understanding the mechanisms of transcription and gene regulation in mammalian cells using initially cell-free systems reconstituted with purified gene-specific transcription factors, general cofactors, and components of the general transcription machinery to recapitulate transcriptional events in vitro.
Magnetic resonance spectroscopy (MRS) provides an effective tool for detecting bio-chemicals in living systems noninvasively. Dr. Choi’s lab focuses on technical and clinical development of MR spectroscopy (MRS) in the brain in vivo.
Ascending somatosensory circuitry that shapes the perception of touch and pain. We study the development, function and dysfunction of ascending somatosensory pathways.
The Chong Research group has been conducting clinical and translational research on cutaneous lupus including outcome measure development for clinical trials, biomarkers for diagnosis and prognosis, and disease outcomes.
The Chook Lab studies physical and cellular mechanisms of Kaps. Our long-term goals are to understand how the macromolecular nuclear traffic patterns coordinated by the 20 human Kaps contribute to overall cellular organization.
We use in vivo models of ischemic acute kidney injury in mice, and in vitro model systems to perform detailed studies of proinflammatory genes activated by renal ischemia/reperfusion.
Chung Lab uses primary human specimens, patient-derived xenograft models, and genetically engineered mouse models to study the molecular mechanisms underlying disease stem cell function in hematologic malignancies.
Our lab focuses on the molecular and cellular mechanisms underlying cell fate specification during blood vessel development and organogenesis.
The discovery of ANP many years ago sparked interest in the use of natriuretic peptides to diagnose and treat heart failure and other salt-retaining disorders. Since then, there have been successes and failures. A more comprehensive understanding of the natriuretic peptide system, including the role of noncardiac factors such as race/ethnicity, may encourage more targeted approaches. One of the original insights of de Bold et al, was that the heart is an endocrine organ. Endocrine therapies are administered to individuals with specific evidence of endocrine dysfunction, not to capture short-term beneficial effects. For instance, thyroid hormone is given only to patients in whom hypothyroidism is demonstrated, not based on its metabolic actions. Studies are warranted to determine whether a similar strategy for the heart’s endocrine system can advance the prevention and treatment of cardiometabolic disease. CMRU is strategically positioned to advance research toward this important strategic goal.
Both we (Cobanoglu et al., 2013) and others (Murphy, 2011) have reported that active machine learning driven experimentation can increase efficiency in the drug discovery process in the preclinical stage. We have a view towards integrating our computational work with an experimental pipeline. That is exactly why we are housed in a biomedical powerhouse, the UT Southwestern Medical Center, to execute this vision.
The Cobb lab studies signal transduction mechanisms of protein kinases and how kinase structures lead to cell biological functions. We are particularly focused on the contributions of ERK MAP kinases to pancreatic beta-cell function and to lung cancers, and on the cell biological actions of WNK protein kinases.
We believe that understanding the basic biology of the schistosomes is key to developing the next generation of anti-schistosome drugs and vaccines. We also contend that by studying the basic biology of these fascinating organisms, we can better understand important basic biological processes common to all animals, including humans. For that reason, we study schistosomes from multiple angles using a variety of modern molecular approaches.of the lab.
We mine large-scale data for biological discoveries.
RNA Biology Meets Herpes Virology
In prior work, my laboratory focused on identifying novel mechanisms of therapy-resistance and progression in breast, prostate and ovarian cancer.
The research focus in the Corbin lab investigates strategies that exploits the deviant metabolism of cancer cells (namely the reprogramming of lipid metabolism and altered redox biology) for therapeutic purposes.
Corey Lab is using nucleic acids or nucleic acid mimics to explore important cellular processes, develop novel therapeutic tools and strategies.
Dr. Cowell has built a research program focused on the development of bioinformatics and computational biology methods for studying the immune system and infectious diseases.
D'Orso Lab studies gene regulatory networks in normal and disease states as well as in the context of host-pathogen interactions.
The Danuser lab develops computer vision methods and mathematical models in combination with live cell imaging approaches to unveil non-genetic mechanisms of cancer metastasis and drug resistance.
Specialty areas: Computer Vision, Computational Biology, Live Cell Imaging
We work with you on data management and process, database and web application, experimental design and grant support.
The central goal of the Dauer Lab is to unravel the molecular and cellular mechanisms of diseases that disrupt the motor system. In exploring these diseases, we also aim to understand a fundamental question relevant to CNS disease generally: what factors determine the selective vulnerability of particular cell types or circuits to insults? Our primary focus is on Parkinson’s disease and inherited forms of dystonia. We focus our efforts on disease genes that cause these disorders, employing a range of molecular, cellular, and whole animal studies to dissect the normal role of disease proteins, and how pathogenic mutations lead to disease.
The Davenport Lab is a branch of the ANSIR Lab at UTSW that focuses on quantitative methods for human brain imaging, primarily using MRI and Magnetoencephalography (MEG).
The Davis Lab is part of the Division of Molecular Radiation Oncology in the Department of Radiation Oncology
The De Brabander Lab focuses on the synthesis of complex molecular architectures, including both designed and naturally occurring substances with novel structural features and interesting biological function.
Check out the latest research efforts of de Gracia Lux's Lab!
The Dean Lab aims to develop and apply cutting-edge microscopy instrumentation and analyses to gain insight into otherwise intractable biological problems.
We are using a combination of genetics, biochemistry, electrophysiology, cell biology, and molecular biology to undertake a molecular dissection of the chemosensory behavior in Drosophila.
Proper control of metabolism is required for essentially every basic biological process. Altered metabolism at the cellular level contributes to several serious diseases including inborn errors of metabolism (the result of inherited genetic defects in metabolic enzymes that lead to chemical imbalances in children) and cancer. Our laboratory seeks to characterize these metabolic disorders, understand how they compromise tissue function, develop methods to monitor metabolism in vivo and design therapies to restore normal metabolism and improve health.
Our group is interested in analyzing three-dimensional structures of macromolecules using computational methods.
The Dellinger Laboratory studies the development of the lymphatic vasculature and diseases caused by errors in the development of lymphatic vessels.
DeMartino Lab studies the biochemical mechanisms and the physiologic regulation of intracellular protein degradation.
We focus on neurodegenerative diseases linked to amyloid protein accumulation with the goal of developing mechanism-based diagnosis and therapy.
We study the physical mechanisms that underlie animal development.
The Douglas lab seeks to understand how stress response pathways alter cell physiology, and ultimately influence the aging process and human disease.
Our group is interested in how cells process information, particularly through heterotrimeric G proteins.
The Elmquist laboratory uses mouse genetics to identify circuits in the nervous system that regulate energy balance and glucose homeostasis. We have developed unique mouse models allowing neuron-specific manipulation of genes regulating these processes.
Our laboratory is focused on the molecular control of lipid metabolism, particularly in the intestinal tract. We employ a variety of disciplines including molecular and cell biology, mouse models and organoid technologies.
Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery.
The long-term goal of Fiolka Lab's research is to develop and implement imaging technologies that provide unprecedented insight into cancer biology.
We study the impact of disease-related hypoxic stress with aging upon synaptic plasticity, white matter connectivity, and cognitive performance.
Our laboratory studies the cell biology of viral-host interactions.
Bacteria and phages are in everlasting conflict – constantly devising new genes, systems, and mechanisms to keep pace with their competitors. The Forsberg lab studies this “evolutionary arms race”, using high-powered selections to unearth new functions and careful experiments to reveal their mechanisms.
We investigate how the immune system and gut microbiota influence brain function and behavior. We use molecular, behavioral, anatomical, and immunological approaches in the lab. In parallel, we collaborate with clinical groups to examine the role of inflammatory and gut-brain mediators in psychiatric illness.
The Foster Lab research program represents a “best in class” translational research approach in an enriched, multidisciplinary environment. Foster's academic activities include a strong translational research program, a comprehensive teaching portfolio, science outreach, contribution to local, national, and international peer review and knowledge translation.
The Fragile X Syndrome Research Center is a team of investigators from UT Southwestern and the University of California at Riverside. The Center supports three projects representing a multilevel, integrated approach that tests mechanisms of sensory neocortical dysfunction in fragile X syndrome (FXS) and pharmacological approaches to reduce the deficits.
Our lab is interested in addressing a fundamental question of cell biology: How are organelles spatially organized?
Obesity and metabolic diseases have been increasing at the alarming rate and threatening our health and economy over the world. However, we still don’t know much about how our metabolic homeostasis is regulated. Understanding the mechanism underlying the regulation of metabolism is a fundamental step towards designing new treatments for obesity and its associated diseases, and many other metabolic diseases
We are interested in the circuit mechanisms of how the cerebellum helps the brain to work better in health and disease.
My lab’s research efforts are based upon a fundamental interest in the genetic and molecular mechanisms involved in childhood cancer.
Our research is driven by a desire to understand how these microscopic machines both replicate themselves and, at the same time, manage to evade, manipulate, and counter a myriad of host defenses.
We are working at the interface of nanotechnology, drug delivery, and tumor immunology
Dr. Garg's research focuses on diabetes, insulin resistance, and disorders of adipose tissue.
The autonomic nervous system comprises a network of sensory and motor neurons that connect the brainstem and spinal cord to thoracic and abdominal organs. A better understanding of the anatomical and functional plasticity of the autonomic nervous system will likely move forward our understanding of numerous chronic diseases including, but not limited to, obesity, diabetes, visceral pain, neuropathy, and eating disorders.
We seek breakthroughs that change scientific fields and yield new strategies for treating disease. Our ultimate goal is to cure people who would not be cured otherwise.
The German Lab focuses its research on Neurodegenerative Diseases and Autism.
Dr. Gibson's current research focuses on the changes in neocortical circuitry in the mouse model of Fragile X Syndrome (the Fmr1 KO mouse), and the mechanisms underlying these changes.
The Glass lab focuses on how genes regulate skin development and function by studying how gene mutations or abnormal gene expression lead to skin disease.
Goldsmith Lab combines drug discovery and mechanistic analysis to understanding protein kinases.
The Goss lab collaborates with a multidisciplinary group of researchers to study the heart and lungs long after preterm birth. We are part of the Parkland Outcomes after Prematurity Study (POPS), which conducts collaborative research on outcomes of prematurity from birth through adulthood.
Dr. Gray is overseeing one of the nation’s few facilities that manufactures a special type of gene-delivering virus for patient use.
The general focus of the Green Lab is to understand the molecular mechanism of the mammalian circadian clock, how it controls rhythmic biochemistry, physiology and behavior and how loss of clock function can impact health, resulting in metabolic disease, cancer and other ailments.
The Greenberg Lab focuses on translational research relative to autoimmune disorders of the central nervous system.
The Greenberg lab is focused on the development of novel therapeutic approaches to combat infectious diseases. For specific projects, please click on the links to the left.
Our lab uses a combination of electrophysiological and molecular techniques to examine functions sub-served by these states at the cellular and circuit levels.
Working at the boundary between science and philosophy with the goal to inform public policy and advance science education and public understanding of science.
We use theoretical methods to study proteins, genomes and organisms.
The Grow lab takes genome-wide, single-cell, and computational approaches to deeply understand epigenome and transcriptome landscapes and how they are reprogrammed.
Our goal is to tackle difficult problems in human health and cancer biology. We work on the diseases of triple-negative breast cancer and other difficult-to-treat cancers.
Dr. Grundy's major research area is in cholesterol and lipoprotein metabolism.
The main focus of our laboratory is characterizing the contribution of non-adipocyte cells within adipose tissueto insulin resistance and systemic inflammation in both rodent and human models.
The Gupta Lab employs modern approaches in molecular genetics and molecular/cellular biology to explore various aspects of adipocyte development.
Our laboratory is interested in improving treatment for patients with glioblastoma (GBM) and other cancers. We work on understanding signal transduction pathways involved in the pathogenesis of cancer. Recent work has focused on investigating mechanisms of resistance to targeted treatment in GBM and lung cancer. We are also interested in mechanisms regulating invasion in GBM.
We employ a variety of methods including evolutionary analysis, genomics, and molecular biology to study the biology of infection.
Our goal is to understand and exploit the immunogenic properties of tumor irradiation in integrating it with immunotherapy to improve cancer patient outcome.
Dr. Harbour’s research focuses on the use of genetic and genomic technology, cell culture experiments and genetically modified experimental models to understand mechanisms of tumor progression in major forms of eye cancer, including uveal melanoma, retinoblastoma, intraocular lymphoma and others.
Our focus is on gaining a greater understanding of how bacteria on the skin surface affect skin health and diseases.
The Hattori lab studies how neural circuits integrate sensorimotor information, memory, and internal state to guide behavior.
The goal of our research lab is to identify the early steps in the pathogenesis of AMD, and to investigate the novel methods to treat and even to prevent its development.
The Hendrixson Lab is largely focused on exploring the biology of polarly-flagellated bacterial pathogens….and junk food, donuts, and cake.
The primary goal of Henkemeyer laboratory is to understand the biochemical signals that regulate cell-cell interactions during embryonic development.
Henne lab is interested in how cells spatially organize their metabolism to adapt to a constantly changing environment.
The goal of the Herz Lab is to identify the underlying biochemical principles of human diseases & disorders in order to design novel therapies to prevent, delay, or cure them.
The Hibbs lab is pursuing atomic-scale mechanisms of synaptic proteins, with a current focus on ligand-gated ion channel structure and function.
HIFU Lab's research is focused on High-Intensity Focused Ultrasound (HIFU) , which is a form of image-guided therapy capable of non-invasive tissue ablation and drug delivery.
The Core supports the early, pre-clinical discovery and development of new small molecule therapeutics, and assists in identifying and characterizing novel biological targets and pathways for therapeutic intervention.
We do difficult experiments at the frontier of cell physiology, often with our own methods and always with our own hands. Enter a description of the lab. This information will appear on the lab listing page.
We strive to decipher mechanisms of structural, functional, and electrical remodeling in heart disease with an eye toward therapeutic intervention.
Our lab focuses on investigating the brain circuits implicated in treatment resistant depression with the ultimate goal of developing novel therapies for this devastating disease.
Our research program focuses on understanding how dysregulation of lipid uptake and trafficking contributes to human diseases.
We explore questions on genomes using a systems biology approach: developing and employing integrative approaches at the interface of gene regulation, epigenetics, single-cell genomics, and bioinformatics.
We are broadly interested in understanding how resident intestinal bacteria influence the biology of humans and other mammalian hosts.
We are multidisciplinary team of clinicians and scientists, focusing on liver cancer risk-predictive molecular biomarkers specific to clinical contexts (ex. geographic region, liver disease etiology, and patient race/ethnicity) individual risk-stratified personalized cancer screening.
In diseases like cancer, signaling pathways can be corrupted by mutations that cause the cells to grow and spread uncontrollably. Our lab is interested in understanding how these defective pathways reprogram cellular metabolism to drive cancer growth.
Jer-Tsong Hsieh Lab research interests focus on key molecular mechanisms leading to urologic cancer progression, development of precision medicine of cancer therapy assisted with non-invasive molecular imaging.
Ming-Chang Hu Lab strives to offer novel insight into the cellular and molecular mechanisms of AKI progression to CKD and cardiovascular diseases (vascular calcification and uremic cardiomyopathy) development in CKD, and set up a solid basis for preclinical and clinical study in the future.
Publications for Dr. Emina Huang's Lab
The research of the Huang Laboratory focuses on understanding the function of fibroblast progenitor cells and fibroblasts in regulating the immune system.
Our laboratory is interested in the molecular mechanisms governing cytokine receptor signal transduction in hematopoietic stem and progenitor cells, and understanding how deregulation in these mechanisms results in hematological malignancies and cancer.
The Huber lab is focused on understanding how activity-regulated transcription and translation in neurons controls synapse and circuit plasticity and development.
Huen Lab studies how metabolic adaption promotes survival during sepsis and how the kidneys contribute to systemic metabolism during inflammation.
The Hulleman Laboratory is committed to understanding and rectifying the underlying causes of inherited and idiopathic eye disorders caused by protein misfolding.
Our goal is to provide state-of-the-art expertise for analysis of exome and genome sequencing.
Our laboratory actively studies disease processes that disrupt normal metabolism.
The Institute for Exercise and Environmental Medicine is a 40,000 square-foot research facility with 12 UTSW faculty working in multiple departments and divisions (Internal Medicine/Cardiology/Pulmonary, Neurology, PM&R, Anesthesiology, Applied Physiology) with up to 20 postdocs, and 40 staff on 70 active protocols and 15 federal grants. It is a research enterprise devoted to the study of human physiology and the limits to human functional capacity in health and disease.
We focus on
The Jain Lab is broadly interested in sex disparities in research on women's health, as well as the impact of sex hormones on airway diseases and immune response.
The James Kim Lab examines the communication between epithelia and stroma through the lens of fundamental developmental pathways such as Hedgehog, Wnt, and Notch pathways.
The Jamieson Lab lab emphasizes AI/ML, software development, and image analysis.
We are a group of biophysicists, cell biologists and computational folks interested in the spatiotemporal organization of cell surface receptors, the mechanisms underlying it, and its consequences for cell signaling.
The Jewell Lab investigates how organisms sense environmental nutrient fluctuations and respond appropriately, fine tuning anabolic and catabolic processes to control cell growth, metabolism, and autophagy.
Huaqi Jiang Lab studies the regulation of adult tissue homeostasis and regeneration using a genetic model system, the adult Drosophila midgut.
The Jiang lab studies fundamental mechanisms governing how diverse cell types are generated from naive progenitor cells and how cells of different types are put together to form appropriate body structures such as limbs during embryonic development. The lab also studies how damaged cells are replenished by stem cells during tissue repair and organ regeneration in adult life. We are particularly interested in understanding how cells communicate with one another to influence their growth and fate determination and how miscommunication among different cells leads to developmental abnormality and cancer progression.
Enter a description of the lab. This information will appear on the lab listing page.
Our lab seeks to uncover the structure-function relationship of macromolecules involved in protein misfolding — a key element of Alzheimer’s and other neurodegenerative diseases.
The research in the Johnson lab is focused on vertebrate nervous system development during the transition from proliferating neural stem cells to differentiating neurons and glia.
We have two major areas of research: respiratory viruses and newly emerging pathogens.
The primary research focus of the Karner lab is to create and utilize novel mouse genetic models to study the role of cellular metabolism during skeletal development and disease.
The Khan Lab's research is focused on autoimmunity and cancer.
Research in the Kim lab is focused on developing computer algorithms and statistical methods that enable accurate and rapid analysis of biological data, in particular sequencing data.
Kim (Jaehyup) lab studies the mechanism of immune regulatory receptor regulation with a special focus on ligand identification and modulation.
Taekyung Kim Lab is interested in understanding how sensory experience can be accurately translated into neuronal and behavioral plasticity through genetic and epigenetic networks.
Kitamura Lab's research aims to provide a biophysically-based mechanistic understanding of the neural process for learning and memory in the mouse brain.
The ultimate goal of the Kittler Lab's research is to develop novel therapeutic approaches that target transcription factors, which play important roles in common solid tumors (brain, breast, lung and prostate cancer) and could therefore have translational potential.
We are investigating how protein degradation is controlled in cells and how protein degradation contributes to lipid homeostasis.
We are broadly interested in understanding how resident intestinal microorganisms (particularly bacteria and fungi and collectively referred to as the gut microbiome) influence the health of human cancer and stem cell transplant patients.
The Kohler research group is committed to developing and implementing new tools optimized for the study of glycosylated molecules.
Kong lab aims to harness the cutting-edge technologies in human genetics and genomics, immunology, and molecular biology to better understand the pathogenesis of gastrointestinal inflammation.
We are taking a comparative genomics approach to identify genes that have been modified in the human brain.
Our research focuses on two main areas: hyperpolarized 13C, 15N, 89Y and 107, 109Ag compounds, and conventional lanthanide-based T1 shortening and paraCEST imaging agents.
The goal of the Krämer laboratory is to understand the molecular mechanisms that regulate responses to diverse cellular stresses.
The Kraus Lab is interested in the basic mechanisms of nuclear signaling and gene regulation by small molecules and how these signaling pathways relate to human physiology and disease states.
We are interested in understanding how animals process both external and internal sensory information to interact appropriately with their environment.
Welcome to the Le Laboratory in the Department of Dermatology and Simmons Comprehensive Cancer Center. One aim of our lab is to help train the next generation of scientists and physicians.
Our research is aimed at innovating and translating computational technology to advance biomedical research and medical diagnoses/treatments.
The Lehrman lab uses biochemical approaches to study the functions of sugars and sugar-polymers coupled to proteins and lipids, and as free molecules. Our work involves broken-cell systems, living cultured cells, and animals. This area of research, known as Glycobiology, is an emerging field that encompasses most aspects of biology and medicine.
Our mission is to improve the lives of people living with skin and musculoskeletal diseases through rigorous science and compassion.
We are interested in understanding the process of co-evolution of tumor and immune cells during cancer development, which can be tracked from clonal expansion events, together with components of the tumor microenvironment and infiltrating immune repertoire.
We are broadly interested in cellular mechanisms maintaining genome stability and their impact on human diseases, including cancer and neurodegenerative disorders.
The N-LAB's mission is to develop novel neuroimaging and neuroengineering methods to integrate molecular and system neuroscience and solve brain science problems.
The overarching goal of Wen-hong Li Lab is to investigate mechanisms responsible for maintaining islet cell function and to devise new strategies for enhancing beta cell fitness and robustness to prevent or treat diabetes.
Our lab focuses on membrane proteins in cholesterol biogenesis, transport, and signaling using multiple approaches from protein engineering, to x-ray crystallography and cryo-EM.
Our mission is to understand the most fundamental questions in cancer biology, such as tumor initiation, progession, and response to therapy, through state-of-the-art experimentation, fruitful collaborations and, above all, out-of-the box thinking to develop novel, safe(r) and more effective therapies to win the fight against cancer!
The Lin lab develops theoretical models and uses computational tools to find the performance limits of complex biological systems.
The goal of Lin (Weichun) Lab's research is to understand how neurons establish synaptic connections during development, and how these connections are maintained throughout adulthood. Toward this goal, we are currently focusing on the following two areas of research.
The Liou Lab seeks to understand the principles underlying communication between organelles within mammalian cells.
Glen Liszczak laboratory is exploring cellular signaling mechanisms that regulate transcription and preserve genome stability.
The Liu lab investigates genetic and environmental factors leading towards obesity and metabolic syndrome in children and adolescents.
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Xin Liu Lab is interested in understanding the regulation of transcription and chromatin dynamics underlying many fundamental biological processes including differentiation, development, and oncogenesis.
The Liu Lab is interested in the functions and mechanism of codon usage biases, circadian clocks, and non-coding RNA
The major interest of my lab is to understand the transcriptional regulatory mechanisms involved in human diseases with a focus on cardiovascular diseases and cancer.
Our mission is to better unravel the causes and mechanisms underlying tremor disorders as well as understand the clinical features of these disorders.
For decades, the field of tuberculosis (TB) immunology has focused on T cell mediated protection, yet Mycobacterium tuberculosis (Mtb) still impacts one in four individuals worldwide today.
The lab of Lawrence Lum, Ph.D., studies cellular signaling processes important in adult stem cell renewal and cancer.
The Luo lab studies hypoxia stress in human cancers.
The Luo lab studies the molecular mechanisms of intracellular signal transduction, focusing on the spindle checkpoint and the Hippo tumor-suppressor pathway.
The research interests of the Lux Lab lie in the development of novel nanomedicine platforms to diagnose and treat disease in vivo noninvasively.
The Ly Laboratory studies how cell cycle defects and mitotic errors shape the complex mutational landscape of human cancer genomes.
Our research aims to obtain a comprehensive picture of how genomic stability and chromatin dynamics affect neuronal functions, including learning behaviors, and to apply this knowledge to combat neurological disorders.
Using novel multi-omics approaches and model systems to treat pancreatic cancer
Research in our laboratory is focused on the development and evaluation of various novel magnetic resonance imaging (MRI) techniques to improve diagnosis and therapy response assessment.
We study the molecular events that drive this process in a term pregnancy and how perturbation of these processes contribute to premature birth.
Medical Artificial Intelligence and Automation
We study how disseminated cancer cells survive and give rise to overt metastatic lesions.
Malloy Lab has all the tools necessary for students at all levels to lean about metabolic imaging of physiology and disease and I am excited to participate.
Malter Lab focuses on exploring and characterizing intracellular signaling pathways in the immune and nervous systems and identifying how defects/abnormalities can lead to disease.
The Mangelsdorf/Kliewer Lab studies two signal transduction pathways that offer new therapeutic potential for treating diseases such as diabetes, obesity, cancer, and parasitism.
The overall focus of the Ram Mani Lab is to study the molecular genetic and epigenetic events associated with cancer development.
The Marciano laboratory investigates fundamental aspects of kidney development and regeneration, in both health and disease.
We are interested in understanding the deregulation of epigenetic and transcriptional pathways in human disease and in finding small molecules with therapeutic potential to normalize these gene expression patterns.
The overarching goal of Mason Lab's research is the development of prognostic imaging signatures defining biomarkers of disease progression and response to therapy.
McAdams Lab at UT Southwestern focuses on functional neuro-imaging studies to examine the connection between biological, psychological, and social aspects of eating disorders.
Our goal is to identify the metabolic mechanisms that push cells to become cancerous and find new ways to inhibit them.
The McFadden lab uses genetically engineered mice and human cancer cells to identify new genes and small molecules that regulate cancer cell growth.
The McKnight Lab at UT Southwestern Medical Center studies a broad spectrum of biological phenomena by use of a combination of biochemical, genetic, biophysical, bioinformatic and molecular biological approaches.
The Meeks Lab studies olfactory neural circuits that are involved in establishing and modifying mammalian social behaviors.
The Mendell laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.
Research in the Mendelson lab focuses on molecular mechanisms involved in developmental and hormonal regulation of key genes and signaling pathways in perinatal biology and female reproduction.
The mission in the Meng Lab is to develop a better understanding of how fundamental alterations to cell polarity contribute towards development of invasive disease in kidney cancer.
Michaely Lab focuses on the function of the proteins that control plasma membrane function. We have on-going projects investigating ARH/LDLR endocytosis and caveolae signal transduction.
Minassian Lab has been involved in the identification and co-discovery of the causative gene mutations in over 20 different childhood neurological diseases.
The main focus of the Minna Lab is translational (“bench to bedside”) cancer research aimed at developing new ways to diagnose, prevent, and treat lung cancer based on a detailed understanding of the molecular pathogenesis of lung cancer.
Mirpuri Lab is focused on neonatal innate immunity and the role of maternal diet (mHFD), dietary metabolites and innate lymphoid cells in offspring outcomes.
Our research focuses on how mitochondria are embedded in normal cellular function.
Dr. Mizuno's laboratory studies autonomic control of the cardiovascular system, particularly the underlying alterations in circulatory control in type 1 or type 2 diabetes and Alzheimer’s disease.
The Moe Lab specializes in translational pathophysiology that spans from individual molecules, in vitro cell models, in vivo animal models, to metabolic human studies.
We develop the theory and application of deep learning to improve diagnoses, prognoses and therapy decision making.
Mootha Lab uses human genetics and genomics to understand the molecular basis of Fuchs' endothelial corneal dystrophy and develop novel therapeutic strategies.
The Moreland and Potera Labs utilize basic science approaches, in vivo models, and clinical studies to investigate cellular functions of the innate immune system.
Our goal is to better understand the mechanisms that maintain adult tissues and how cancer cells hijack these mechanisms to enable the formation of tumors.
Our laboratory seeks to understand the molecular mechanisms of targeted therapy resistance in various cancers, to identify novel biomarkers, and to develop therapeutic approaches to prevent or overcome resistance.
Mukhopadhyay Lab research aims to understand how the primary cilium regulates downstream pathways to ultimately drive morphogenesis in different tissues. We undertake a multi-pronged approach including proteomics, cell biology, biochemistry, reverse genetics, and generation of innovative mouse models to study regulation of signaling pathways by cilia in in cellular and organismal contexts.
The Munshi Lab is a dedicated group of scientists seeking to identify the molecular drivers of normal cardiac rhythm and disease-associated dysrhythmias.
The Nair-Gill Lab dissects the cellular infrastructure that dictates immune cell survival and fate decisions.
The mission of the Najafov Lab is to understand the role of cell death in physiology and disease. Our research is focused on necroptosis and how it can be targeted to develop novel strategies for treating cancer.
The Nam lab asks how the shape of an RNA regulates its function. We study the biochemical and structural mechanisms in RNA-mediated gene regulation pathways important for normal and disease states.
The mission of Napierala Lab is to contribute to the development of therapies and a cure for Friedreich’s ataxia (FRDA) by elucidating molecular mechanisms causing the disease, developing novel cellular and animal models of FRDA, identifying disease biomarkers and testing novel therapeutic approaches.
Shawna D. (Smith) Nesbitt, M.D., M.S., studies hypertension in African-Americans, insulin resistance, and hyperlipidemia.
The focus of the Neuromuscular Center is the diagnosis and treatment of muscle diseases known as metabolic myopathies, including inherited disorders of muscle fat, carbohydrate, and mitochondrial muscle metabolism.
The Neurorepair Lab focuses on the investigation of mechanisms of injury and recovery following damage to the central nervous system (CNS), primarily following stroke and perinatal hypoxia.
We study bacterial colonization of the intestinal tract, to understand how both benign and pathological bacteria affect their environment. Our long-term goal is to treat intestinal diseases by genetically engineering bacteria in vivo.
The Nicastro Lab studies 3D ultra-structures and cell biological functions of macro-molecular complexes inside cells.
The Ank Nijhawan research team is focused on improving outcomes for people living with or at risk for HIV, and ensuring their access to comprehensive healthcare and social support services. We also focus on individuals involved in the criminal legal system, and specifically the overlap of infectious diseases such as HIV, hepatitis, sexually transmitted infections and substance use.
The ultimate goal of the Nijhawan lab aims is to discover first in class drugs for the treatment of cancer.
Our lab works with murine disease models and employs Biochemistry, Molecular and Cell Biology to investigate brain glycogen metabolism and related neurodegenerative diseases.
Research conducted by the Nomellini Lab utilizes animal models as well as human samples to examine the interaction between the innate and adaptive immune responses that occur after injury or infection, and the heterogeneity of the immune responses that occur in each individual. Led by Vanessa Nomellini, M.D., Ph.D., our lab ultimately aims to develop personalized immune therapies to reverse the immunosuppression that can occur in ICU survivors.
The Norgard Laboratory is engaged in three areas of infectious disease research: syphilis, Lyme disease, and tularemia.
The long-term goals of the Nwariaku Laboratory are to understand the cellular mechanisms that regulate endothelial dysfunction during inflammatory and neoplastic conditions with a hope to use this knowledge in designing novel therapeutic agents.
O'Donnell Lab investigates mechanisms of tumor initiation, progression, and metastasis using molecular and biochemical studies and animal models.
The focus of the Obata Lab is to study how environmental signals (e.g., microbiota, diet, day/night cycles) shape intestinal neural circuits and immune cell networks. A variety of experimental techniques are used, including state-of-the-art imaging technologies, viral tracing of gut innervation, in vivo and ex vivo physiological assays, gnotobiotic systems and multi-omics technologies. The Obata lab is also interested in elucidating the molecular mechanisms of inter-organ communication, including the Gut-Brain axis.
The Oh lab is committed to elucidating how GPCRs work in regulating metabolism and identifying new avenues for developing therapeutics to treat metabolic syndromes such as type 2 diabetes, insulin resistance.
Olson Lab studies muscle cells as a model for understanding how stem cells adopt specific fates and how programs of cell differentiation and morphogenesis are controlled during development.
Orchard Lab at UT Southwestern Medical Center
The Orth lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems.
The Osborne Lab focuses on how regulation of miRNA and mRNA controls the branching of developing cells, and how disregulation of these pathways contributes to aggressive tumor behavior.
The main research focus of the Otwinowski lab is on developing computational and statistical
methods and protocols for macromolecular structure determination using X-ray crystallography.
Oz Lab combines imaging, interventional radiology, radiotracers (novel and known), and animal models to study physiology and disease pathophysiology.
The Pan laboratory uses Drosophila and mice as model systems to investigate size-control mechanisms in normal development and their pathological roles in cancer.
Our research is focused on mechanisms underlying acute kidney injury and sepsis. Our laboratory has implicated mitochondrial maintenance via PGC1alpha and NAD+ as a novel pathway for resilience against acute physiological stressors.
Welcome to the PARK Lab.
Our lab focuses on:
We study how cells duplicate their genomic material and how this process goes awry in disease.
The Parkland Outcomes after Prematurity Study research group focuses on the short- and long-term effects of preterm birth, to improve lifelong health outcomes for current and future patients.
In the Pascual Lab, we study the genetic and molecular basis of neurological and neuromuscular diseases of infancy and childhood.
Dr. Pawlowski's laboratory studies how mutant genes affect the structure of the Organ of Corti, and searches for treatments against otitis media and infection of cochlear implants.
Our lab focuses on the use of cardiac magnetic resonance imaging (CMR) in pediatric and congenital heart disease.
The mission of the Pedrosa Lab is to develop and implement new imaging methods that facilitate better morphologic and pathophysiologic characterization of diseases in the body for improved patient outcomes
Translational biophotonics for cutaneous manifestations of systemic disease.
Petroll Lab applies engineering approaches and design principles to the investigation of fundamental clinical and biological problems in ophthalmology, while providing training to graduate students, medical students, and post-docs.
The Pfeiffer Lab is interested in how the brain forms neural representations of experience, how those representations are consolidated into long-term memory, and how those representations can be later recalled to inform behavior.
Our lab uses tractable model viruses to learn about niche-specific factors that influence viral infection and evolution.
We are developing inhibitors of pyrimidine biosynthesis and polyamine biosynthesis to treat malaria and African sleeping sickness. We study polyamine and nucleotide metabolism in African trypanosomes to learn about novel metabolism and regulation.
Welcome to the Phlebotomy Services/CTSA Core in the Eugene McDermott Center for Human Growth and Development.
The goal of our research is to identify key immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.
The Pool Lab studies neural circuits that provide a sense of purpose and direction to animal behavior and develops targeted gene therapies to re-engineer their function.
Pouratian Lab's primary mission is to explore basic human neuroscientific principles as well as identify brain mapping biomarkers of disease that can drive innovative approaches to restore function to patients with neurological and psychiatric diseases.
Dr. Prinz's research is focused on the tiny organelles within cells that do the cell’s work, much like the organs in a human body. He is best known for studies into the exchange of fats (also called lipids) between organelles at so-called membrane contact sites where organelles come in close contact within a cell.
The METRICS PROSPR II Research Center studies the multilevel factors that hamper or facilitate the cervical cancer screening process and reduce disparities in vulnerable populations.
The Psychoneuroendocrine Research Program (PNE) at UT Southwestern Medical Center focuses on two different areas of research: substance abuse, particularly dual diagnoses (e.g., depression or bipolar disorder); and the effects of corticosteroids (e.g., prednisone) on mood and memory.
Dr. Robin Jarrett’s Psychosocial Research and Depression Clinic aims to understand how psychosocial factors influence health in mood and related disorders.
Qiao lab focuses on mechanisms of cancer immunotherapy and immune-related adverse events (irAEs)
Qin Lab focuses on the development of novel synthetic transformations and strategies that will allow access to bioactive, complex natural products and efficient synthesis of pharmaceuticals and their derivatives.
We are interested in how membrane cholesterol controls diverse cellular signaling pathways to ensure lipid homeostasis, enable cell growth, and protect against infections.
Our mission is to decrease suffering and death from metastatic cancers
We are driven by the belief that the spatial organization of tissue provides a powerful window into cell-cell interactions, a crucial component of disease progression and response.
The Ready Lab is engaged in the discovery and synthesis of biologically active small molecules
The Reddy Lab focuses on restoring effective antigen presentation to enhance anti-tumor immunity in breast cancers.
Our lab is broadly focused on the cellular signaling that drives the interactions between the intracellular parasite Toxoplasma gondii and its varied hosts.
In our lab, we investigate the interactions between these multiple pathogens and the immune system.
The Reinecker laboratory unravels and targets molecular mechanisms of key human genetic variants that cause chronic inflammatory diseases and cancer by creating novel genetic mouse and human organotypic model systems.
We are interested in the molecular mechanisms by which nuclear hormone receptors regulate lipid and carbohydrate metabolism in the liver, intestine, pancreatic islet, and central nervous system.
We use statistical analysis of genome sequences drawn from thousands of organisms to distill out general patterns describing the organization of cellular systems and individual proteins.
The Rice Lab uses structure, biochemistry, reconstitution, microscopy, computer modeling, and more to study the molecular mechanisms that generate and regulate microtubule dynamics.
We investigate the mechanism of neurotransmitter release using a variety of biophysical approaches, including NMR spectroscopy, X-ray crystallography, cryo-EM, molecular dynamics simulations and liposome fusion assays.
Roberts Lab focuses on understanding the cellular and circuit mechanisms for behavioral learning, learning from social experiences and from example.
The Rohatgi Lab focuses on the role of reverse cholesterol transport in atheroprotection.
The Rosen Lab seeks to understand the formation, regulation, functions and internal structures of membraneless cellular compartments termed biomolecular condensates.
The significance of our research is to show effective anti-Aβ42 antibody production in large animals and safety of DNA Aβ42 immunotherapy in these models to proceed with vaccination in patients at risk for Alzheimer’s disease.
Research in the Rothermel Laboratory focuses on deciphering the molecular mechanisms that control cardiac structure and function during normal development and in response to pathological stress.
We study how biomolecular condensates organize gene regulation.
A major focus of our lab is to identify mechanisms of cardiomyocyte cell cycle regulation, and discover ways to reawaken regenerative pathways in the adult mammalian heart. We are also developing several structural, molecular, and physiological tools to interrogate the mechanistic underpinnings of various forms of cardiomyopathy.
Saelices Lab employs crystallography and cryo-EM to study amyloid deposition and design anti-amyloid tools.
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We seek to understand the processes that control the immune system and how they malfunction in autoimmune diseases of the brain, including multiple sclerosis (MS).
The Sandstrom Lab works to identify the fundamental molecular mechanisms through which the immune system can recognize pathogens and stress.
Satterthwaite Lab studies the signals that control B lymphocyte development, activation, and differentiation into antibody-secreting plasma cells, both normally and in autoimmune diseases such as lupus. We hope that by defining these events, we can reveal new approaches to modulate antibody responses therapeutically.
The Saunders Lab aims to advance our understanding of the bacterial domain of life using high throughput genetics to map the molecular interactions that underly cellular physiology.
The Saxena lab's research interests include Icodextin in high peritoneal transporters; Kremezin study in patients with chronic kidney disease; SV40 in focal segmental glomerulosclerosis; molecular studies in lupus nephritis.
The main focus in our laboratory is the identification and physiological characterization of adipocyte-specific gene products and the elucidation of pathways that are an integral part of the complex set of reactions that drive adipogenesis.
The lab investigates the nature and treatment of cognitive deficits commonly seen in schizophrenia and related disorders.
We study clathrin-mediated endocytosis (CME), the major and best understood endocytic pathway.
The Schoggins Lab studies innate immunity at the virus-host interface. We are interested in mechanisms of cellular antiviral defense and the role these responses play during viral disease.
What are the causes and consequences of cytoskeletal diversification?
The Seemann Lab studies the molecular mechanisms governing the function and inheritance of the mammalian Golgi apparatus.
We aim to characterize the ways in which reward systems vary from individual to individual and understand how this variation determines propensity for depression and addiction-like behavior.
Nutrition and exercise intervention to reduce cardiovascular risk factors; weight loss and maintenance in bariatric surgery patients; role of nutrition and exercise in cardiovascular risk factors; influence of the eating environment on energy intake.
The Shahmoradian lab focuses on deciphering the structure and native cellular context of brain disease-causing proteins using cryo-electron microscopy and tomography.
Our lab researches Cerebellar Dysfunction, Brainstem Dysfunction, High-Throughput Screen, and Human Studies.
The Sharma lab is interested in investigating intermediary metabolism utilizing carbon-13 stable isotope tracers in conjunction with magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), and mass spectrometry (MS).
The overall goal of our laboratory is to discover the processes in endothelial cells that govern cardiovascular and metabolic health and disease.
Shay Lab is interested in the relationships between aging and cancer and have focused on the role of the telomeres and telomerase in these processes.
The ultimate aim of the Shiloh Lab is to contribute to the development of vaccines and treatments for Mycobacterium tuberculosis (Mtb).
Our primary goal in Sieber Lab is to understand the dynamic changes in metabolic programs that support developmental and disease progression.
We aim to globally understand how the physical and chemical properties of materials affect interactions with biological systems in the context of improving therapies.
The Sinnett Lab develops and assesses gene therapies for rare neurodevelopmental disorders.
Our work examines the interface between cancer and developmental biology
Smith Lab strives to develop enabling tools for organic synthesis, allowing bioactive molecules of great complexity to be prepared in a concise and sustainable fashion.
Our lab aim is to discover and translate findings into diagnostic and therapeutic solutions for patients with allergy.
The Sorrell laboratory utilizes integrative approaches that include metabolomics, transcriptomics, organoid cultures, live microcopy, and animal models, to investigate fundamental pathways that control the uptake of nutrients and the biosynthesis of macromolecules in proliferative cells.
Our laboratory is interested in investigating the molecular mechanisms of selenoproteins in health and disease.
The Story Lab has a robust research portfolio that includes radiation-induced carcinogenesis associated with the unique environment of space, molecular markers of carcinogenic risk after radiation, intrinsic radiosensitivity, modulation of drug and radiation response by pentaazamacrocyclic ring compounds with dismutase activity, high-dose per fraction radiotherapy, charged particle radiotherapy, the mechanism(s) of action of Tumor Treating Fields, and the enhancement of cancer therapy through radiation and drug combination used concomitantly with Tumor Treating Fields.
The Stowe Lab conducts both bench and clinical research with the goal of deepening the understanding of the etiology of stroke as well as finding better therapies for those who have suffered a stroke.
The main goals of the Strand Lab are to create accurate cellular atlases of the human and mouse lower urinary tract, characterize the molecular and cellular alterations in human lower urinary tract disease, and design new mouse models.
We investigate epigenome regulation of nervous system development and homeostasis. We are particularly interested in understanding how disruption of these mechanisms lead to neurological disorders.
The UTSW Structural Biology Laboratory (SBL) was formed to add macromolecular crystallography to the scientific toolkit available to the general researcher.
The vision of the lab is to further understand the pathogenesis of autoimmunity of the central nervous system through basic science and translational research.
Sumber Lab conducts translational research that seeks to uncover the mysteries of cancer and develop powerful methods for its detection and cure.
The Sun Lab studies the most numerous cells in the brain, called “glial cells”.
The Sun Lab is focused on developing novel imaging probes for noninvasive assessment of specific biomarkers implicated in disease initiation, progression, or regression, and exploring the translational roles of imaging probes and/or methodologies in clinical medicine practice with the ultimate goal to improve the outcome of patient care.
Our lab's focus is to develop novel tools aimed at understanding ion channel physiology and molecular mechanism in an isolated membrane environment.
The Tagliabracci Lab studies the phosphorylation of extracellular proteins by a novel family of secreted kinases. This kinase family is so different from canonical kinases that it was not included as a branch on the human kinome tree.
The Takahashi Lab is interested in understanding the genetic and molecular basis of circadian rhythms as well as other complex behaviors.
The Tambar Group develops new strategies and concepts in synthetic chemistry to address challenging problems in chemistry and biology.
Under the guidance of director Dr. Daolin Tang, the research group focuses on basic, translational and clinical application research on damage-associated molecular patterns (DAMPs) signaling pathways. Inflammation is a fundamental response to infection and injury in all multicellular organisms. The danger hypothesis states that endogenous molecules (protein and non-protein) released during cell death or tissue damage can trigger inflammation in the absence of infection, collectively referred to as DAMPs. We are particularly interested in elucidating the molecular mechanisms underlying stress-induced cellular defense and cell death signaling in normal and cancer cells, and how release of DAMPs modulates immune responses in disease.
The Terada Lab is focused on several areas of cellular signaling which control basic mechanical and cell fate decision programs.
Research in my laboratory focuses on better understanding the molecules and mechanisms that assemble axonal connections with a goal of utilizing this knowledge to encourage axons to reestablish their connections after trauma or disease.
Texas Computational Memory Lab research focuses on analyzing the neural activity that gives rise to successful memories and facilitates memory retrieval.
This information will appear on the lab listing page.The Tong lab studies the cellular and molecular mechanisms of cardiovascular diseases associated with systemic metabolic disorders, particularly heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), with an eye toward translating these findings into innovative solutions to clinical problems.
We investigate genetic and molecular basis of phenotypic diversity observed in nature by using a range of methodologies such as whole genome sequencing, fluidics, long-term evolution experiments, and large-scale combinatorial mutagenesis.
My research interests include prevention of progression of renal diseases, diagnoses, and management of lipid disorders in renal disease, hypertensive nephrosclerosis, the role of angiotensin II converting enzyme inhibitors, and angiotensin II receptor blockers in renal disease.
The Tower lab integrates multi-omics-based approaches in the fields of musculoskeletal development, homeostasis, repair and regeneration.
The Center for Depression Research and Clinical Care (CDRC) is nationally recognized for its cutting-edge research in unipolar and bipolar depression. The research conducted within the center brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.
Translational Research in UltraSound Theranostics (TRUST) Lab at UT Southwestern
Tsai Lab studies the cellular and molecular mechanisms of synapse and neural circuit development.
The Tu Lab is investigating how a variety of cellular processes and decisions are coordinated with metabolic state, and how the dysregulation of these mechanisms might be linked to disease and aging.
The Turer Lab is interested in finding genes with novel functions in intestinal immune homeostasis. Our projects generally involve a mix of experimental approaches examining both the intestinal epithelium as well as hematopoietic causes of intestinal inflammation.
spinal cord injury, wound, pressure ulcer
The long-term goal of the Ufret-Vincenty Lab is to develop new therapeutic strategies for age-related macular degeneration (AMD).
In addition to glucagon and t1dm, the Unger lab studied the interrelationships between obesity and type 2 diabetes (t2dm) and metabolic syndrome.
Children with in-born errors of immunity are prone to life-threatening viral, bacterial, and fungal infections. We study the causes of their immune system problems, combining clinical insights and mouse models genocopying the various mutations. This work includes a profiling of immune responses to infections (e.g., COVID-19) in normal healthy individuals and patients.
Our team at UT Southwestern is conducting the study Improving Chronic Disease Management with Pieces (IDC-Pieces) in patients with coexistent chronic kidney disease, diabetes and hypertension.
Dr. Vega and co-workers have discovered three other causes of high LDL. First, she found that some patients have abnormal LDL particles that cannot be removed from circulation because the abnormal LDL does not recognize the receptors.
The Vernino Lab focuses on the mechanisms of autoimmune disorders of the nervous system, especially those associated with neurological autoantibodies. We use a variety of techniques including histology, and immunology. This research is complemented by clinical therapeutic trials studying novel treatments for autoimmune encephalitis and autonomic disorders.
The main focus of the Vinogradov Lab is developing MRI methods that are based on the intrinsic biochemical processes and physical properties of the tissue: chemical exchange rearrangements, molecular networks, and relaxation.
Our research efforts are currently focused in four areas of cancer research.
The Volk Lab's research focuses on the hippocampus as they research how the brain balances dynamic learning and persistent memory.
Dr. Vongpatanasin studies neural control of blood pressure and the influence of various hormones and antihypertensive agents on autonomic control of blood pressure in humans.
The research of Wai Lab focuses on female pelvic floor disorders and understanding the functional anatomy of the lower urinary tract and anal sphincter.
The Wakeland Lab utilizes state-of-the-art genomic strategies to investigate the diversity of the human and mouse immune systems.
The Wang Lab uses chemical biology tools to study the molecular mechanisms underlying interesting bacterial behaviors.
We apply advanced MRI technologies to study many different diseases.
Statistical methodology development
Dr. Wang's research interests primarily involve the development of statistical methodologies for the design and analysis of clinical trials, as well as the evaluation of correlated data and repeated measurements. Her specific focus has been on power analysis, experimental design, and sample size determination for longitudinal studies using Frequentist and Bayesian approaches. Dr. Wang has also developed the methodologies that are very flexible and can accommodate various pragmatic issues such as longitudinal and clustered outcomes, random variability in cluster size, unbalanced randomization, complicated correlation structures, missing data, and small sample sizes. Those methodologies have achieved great performances across a broad spectrum of design configurations and made innovative contributions to clinical studies.
Another area of Dr. Wang's research interest is the collaboration with clinicians, investigators, and multidisciplinary research teams on a wide range of biomedical and clinical studies. Through these collaborations, Dr. Wang has provided statistical expertise and guidance to support the design, implementation, and analysis of research studies. Her contributions have led to many peer-reviewed publications and have helped to ensure that research findings are sound and reliable. Dr. Wang is dedicated to advancing the use of rigorous statistical methods in clinical research to improve the quality of evidence and ultimately enhance patient health.
Our research focuses on how the conserved signaling pathways that underlie normal skin development are altered during the development of non-melanoma skin cancers and inflammatory skin disease.
Our research revolves around using state-of-the-art bioinformatics and biostatistics approaches to study the implications of tumor immunology for tumorigenesis, metastasis, prognosis, and treatment response in a variety of cancers.
We study ion channel clusters. To study such clusters without the complications arising from the complex cellular environment, components from cells are purified and studied in isolation.
The Wang Lab studies neurodegeneration and cell death induced by brain injury, mitochondrial dysfunction, and/or genome instability.
Dr. Waugh is a physician-scientist whose research focuses on the structural brain abnormalities that lead to dystonia, a movement disorder that leads muscles to twist and contort into painful positions.
The over-arching theme of the Weaver Lab is to deeply understand how proteolytic factors mediate diverse physiological functions.
The Welch Lab has a primary interest in developing materials and medical devices for use in treatment of congenital heart disease.
The Wert laboratory studies the post-mitotic neuronal cells of the retina, particularly the photoreceptor cells. Our goal is to discover and understand the mechanisms underlying retinal degenerative disease, and to provide novel therapeutics for these complex degenerative disorders using gene therapy and genome engineering technologies, human stem cell transplantations, and metabolic rescue.
We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.
The Wetzel Lab targets critical steps in the parasite’s life cycle in order to develop therapeutics for Leishmaniasis.
White, Perrin Lab - Labs - Research
The Whitehurst Lab uses RNAi-based functional genomics to identify gene products that support viability and/or modulate chemotherapeutic sensitivity in tumor cells.
We are interested in understanding at a cellular level the neural control of energy balance and glucose metabolism, and elucidating how these events may participate in human disease.
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Scientists in the Center for Pediatric Bone Biology and Translational Research work to discover the underlying causes of poorly understood musculoskeletal disorders in children, and to understand the fundamental steps that lead to disease.
Wolf Lab's research focuses on the roles of urinary proteins Uromodulin and Mucin-1 in health and disease.
We use live-cell microscopy, nano-rheology, and synthetic biology to understand oocyte ageing, embryogenesis, and cancer onset.
In our laboratory, we utilize molecular and cellular approaches to decipher mechanisms of extracellular matrix remodeling of the female reproductive tract in both physiologic states (e.g., during pregnancy, parturition, and the puerperium) and pathologic conditions (pelvic organ prolapse, urinary incontinence, and injury of the external anal sphincter).
The Wu Laboratory mainly focuses on using human primary nasal and oral epithelium culture to gain novel insights in virus-host interactions.
We are interested in the function of chromatin regulation of signaling pathways important for neural development, brain tumor growth and autism pathogenesis.
The Wu Laboratory mainly focuses on using stem cell models to gain novel insights in mammalian development and develop regenerative medical applications.
The long-term goal of our lab is to understand the functions of ecDNA and how ecDNA is maintained in cancer.
The Wu Lab focuses on understanding the molecular pathways that govern T cell differentiation and function during infection and cancer.
I am interested in developing computational models and algorithms for big data to predict patients' outcomes, which can help clinicians to tailor treatment plans for individual patients.
The focus of our current research is the biochemistry and molecular characterization of ABCG5/ABCG8 transporter, aiming at understanding the mechanism by which this transport system operates to translocate cholesterol cross membranes.
Our team is interested in developing computational models to predict patient outcomes, which will allow clinicians to tailor treatment plans for individual patients.
Welcome to the Xing Lab in the Eugene McDermott Center for Human Growth and Development!
Dr. Xu’s primary research interests include tissue engineering of the vocal fold, anatomy and physiology of voice production, and laryngeal biomechanics.
Our goal is to better understand the gene regulatory processes that control stem cell development and cancers.
The lab focuses on developing bioinformatics algorithms and deep learning models to identify new disease genes and therapeutic targets for human diseases, as well as development and maintenance of data management system for genomic and clinical databases.
Wei Xu Lab strives to achieve a mechanistic understanding of fundamental cognitive processes whose dysfunctions are implicated in neuropsychiatric disorders.
Our lab focuses on the neural dynamics for successful memory access and retrieval during episodic working memory tasks to elucidate the neural circuit mechanism in the hippocampal-cortical network.
Since I began studying the biological rhythms of insects during graduate school, I have been fascinated with the accuracy of the circadian timing system and the phenomenal influence of the circadian clock on almost all biological activities. This fascination has fueled my interest in learning about circadian rhythms for more than a quarter of a century.
The Yan Lab studies molecular mechanisms of innate immunity in infection, autoimmune diseases, cancer immunology and neurodegenative diseases.
The Yang Lab aims to overcome clinical unmet needs and help patients by developing and validating advanced radionuclide imaging technologies for positron emission tomography (PET) and single photon emission computed tomography (SPECT) imaging. Deep learning is an important engine for overcoming the current limitations (low spatial resolution, slow data acquisition, etc.) of PET and SPECT imaging. .
Yao Laboratory identifies molecular and cellular mechanisms that determine the efficacy of vaccines and immunotherapies against infectious diseases and cancers.
We study how the membrane lipid phosphatidylinositol 4,5 bisphosphate (PIP2) regulates the actin scaffold in proliferating and autophagic cells.
We are interested in how metabolism regulates various behaviors. We use two invertebrate model systems of C. elegans and D. melanogaster, ultimately aiming to unveil conserved neuro-molecular mechanisms throughout animals including mammals.
Yu Lab is interested in the molecular and cellular basis of Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and related neurodegenerative disorders.
The Yu lab focuses on anisosomes, TDP-43 aggregation, and molecular glue in studying the mechanisms behind age-related neurodegeneration.
Zaki Lab's research focuses on the the study of gastrointestinal inflammation and cancer.
Zang Lab investigates the molecular mechanisms underlying the pathogenesis of sepsis. We use the heart as a model, since cardiac dysfunction is a vital component of multi-organ failure during sepsis.
Zeng Lab is interested in understanding at the molecular level key questions lying at the interface between biochemistry, cell biology, metabolic and neural physiology, including the bidirectional communication between autonomic neurons and adipocytes, the molecular basis of the phenotypic plasticity, or the lack of, in brown, beige and white adipocytes, and roles of uncharacterized enzymatic pathways in adipose thermogenesis.
Zhan Lab's mission is to advance medical genetics research through cutting-edge statistic models and computationally efficient software tools
The lab's long-term goal is to illuminate the function of immune surface molecules and to open up a new research field at the interface of cancer, immunology, and stem cell research. Zhang Lab also actively develops novel therapies for cancer treatment.
Zhang (Chun-Li) Lab research focuses on cellular plasticity in the adult nervous system and modeling human neurodegenerative diseases. We use cell culture and genetically modified mice as model systems. Molecular, cellular, electrophysiological, and behavioral methods are employed.
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Our lab currently studies hypoxia, prolyl hydroxylase, and VHL signaling in cancer, especially breast and renal cell carcinomas.
The central theme of our research program in our laboratory is to explore the co-evolution between tumor cells and the tumor microenvironment (TME) during the development of therapeutic resistance and metastatic relapse.
Our lab combines normative theories and biologically plausible neural circuit models to study the principles of neural information processing, in order to answer how perception, cognition, and behavior emerge from neural circuits.
The Zhang lab studies intra- and inter-molecular interactions to understand how signaling proteins are regulated, using biochemistry, X-ray crystallography, cryo-EM and cell biology.
In the Zhang Lab, we seek to understand the molecular mechanisms of metabolic diseases, with the long-term goal of creating novel therapeutic strategies.
Zheng Lab is dedicated to women’s health care, specializing in gynecologic pathology, particularly in oncologic and hormone related pathology within the GYN Pathology field.
Zhong Lab studies studies inflammation, mitochondrial stress responses, tumor immunology and obesity-associated liver disorders.
Our aim is to develop computational methods to unveil the hidden biological circuitries behind the data, from understanding sequence-based regulations to the evolution of genomes and their impact to diseases.
Our lab is interested in understanding the relationship between injury, regeneration, and cancer. We are focused on identifying the genes and mechanisms that regulate regenerative capacity in the liver and understanding how these contribute to hepatocellular carcinoma development.
The Zia Research Group focuses on clinical and translational hematology research to improve the understanding of pediatric thrombotic and hemostatic disorders with the long-term goal of improving the lives of affected children and young adults with these disorders.
We investigate the neuro-hormonal basis for complex eating behaviors and blood glucose control, with the ultimate goal of designing new methods to prevent and treat extremes of body weight, blood glucose, and associated disorders of mood and metabolism.