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Abrams Lab

We use genetic systems to deconstruct functions associated with the most commonly mutated genes found in human cancers.

  • John M. Abrams
Transposons Cancer and Cell Death
Cancer Biology Genetics, Development and Disease

Acute Liver Failure Study Group

The Acute Liver Failure Study Group (ALFSG) is a clinical research network funded by the National Institutes of Health since 1997, to gather important prospective data and biosamples on this rare condition. 

  • William M. Lee, M.D.
  • Shannan Tujios, M.D.

Advanced Imaging and Informatics for Radiation Therapy (AIRT) Lab

The Advanced Imaging and Informatics for Radiation Therapy (AIRT) Lab's research is focused on the development of novel imaging and beam delivery techniques and new machine learning algorithms to improve the efficacy of radiation therapy

  • Jing Wang, Ph.D., DABR
  • You Zhang, Ph.D., DABR
Clinical Decision Making treatment outcome prediction medical imaging processing medical imaging analysis
Biomedical Engineering Biomedical Engineering

Agarwal Lab

The focus of Dr. Agarwal's research has been on mechanisms of steroid action with emphases on: 1) structure-activity relationships of ligand-steroid receptor interactions, and 2) steroid metabolism.

  • Anil Agarwal, Ph.D.

Agathocleous Lab

We are interested in the relationship between metabolism and cell type. We focus on the metabolism of hematopoietic stem cells (HSCs) and their progeny including cells of the myeloid and T cell lineages.

  • Dr. Michalis Agathocleous

Aguilera Lab

Our lab is using various approaches to explore this biology and develop new treatments with a focus on targeting tumor intrinsic factors such as genetic programs like the epithelial to mesenchymal transition that coordinate with infiltrating immune cells in enhance therapeutic resistance and assist distant spread.

  • Todd Aguilera, M.D., Ph.D.
Cancer Biology Immunology

Akbay Lab

Akbay Lab studies genetic and molecular events that lead to lung-tumor initiation and immune evasion. 

  • Esra Akbay, Ph.D.
Tumor immune escape
Cancer Biology Immunology

Alluri Lab

Our mission is to improve the care of breast cancer patients through cutting-edge translational research at the interface of clinical oncology, cancer biology, molecular genetics, and translational genomics.

  • Prasanna Alluri, M.D., Ph.D.
Cancer Biology

Alto Lab

Our goal is to track the signaling dynamics of individual effectors and toxins in living cells, using a combination of fluorescent genetic reporters, microinjection of labeled bacterial proteins, and live cell imaging techniques. 

  • Neal M. Alto, Ph.D.
Cell and Molecular Biology Molecular Microbiology

ANSIR Lab

The ANSIR lab is devoted to the application of novel image analysis methods (e.g. diffeomorphic registration, machine learning, graph theory, ASL) to research studies, as well as to robust clinical translation of these techniques.

  • Joseph A. Maldjian, M.D.
Biomedical Engineering

Aroumougame Lab

Our group studies the effect of cancer therapeutics and aging on the growth and renewal of heart muscle.

  • Asaithamby Aroumougame, Ph.D.
Biomedical Engineering Cancer Biology

Arteaga Lab

The Arteaga laboratory has a longstanding interest in understanding the molecular pathways that drive breast cancer progression and influence response to therapies.

  • Carlos L. Arteaga, M.D.
Cancer Biology

Bagrodia Lab

Our research is focused on (1) identifying low-risk patients that would benefit from minimal treatment or surveillance, and (2) devising methods of sensitization to current therapies.

  • Aditya Bagrodia, M.D.

Bai Lab

Our goal is to employ cryo-EM to determine high resolution structures of important membrane protein complexes involved in cellular signaling, including cellular receptors and ion channels. We also combine structural approaches with functional studies to reveal the structure-function relationships of these membrane proteins.

  • Xiaochen Bai

Bailey Lab

The Bailey lab focuses on developing gene therapies for neurological disorders. We work on monogenetic pediatric disorders, including SLC13A5 epileptic encephalopathy, multiple sulfatase deficiency, Charcot Marie Tooth disease type 4J, giant axonal neuropathy and ECHS1 deficiency.

  • Rachel Bailey, Ph.D.
Gene therapy for neurological disorders
Neuroscience

Ball Lab

The primary role of our lab is to provide services to the research community in the areas of organic and analytical chemistry via the Protein Chemistry Technology Core. 

  • Haydn Ball, Ph.D.

Banaszynski Lab

We study the role of chromatin regulation in cell fate decisions.

  • Laura Banaszynski, Ph.D.

Baum Lab

Our laboratory has characterized many of the transporters responsible for proximal tubule acidification and solute transport

  • Michel Baum, M.D.

Bedimo Lab

Dr. Bedimo studies strategies for optimally managing drug-resistant HIV patients, analyzing metabolic abnormalities in HIV patients, and studying the effects of HCV co-infection. 

  • Roger Bedimo, M.D.
Highly Active Anti-retroviral Therapy HAART

Berglund Lab

We are interested in how CNS signals are transmitted via hormonal or neural mechanisms to modulate specific organs, with a special interest diabetes and obesity.

  • Eric Berglund, Ph.D.

Beutler Lab

We combine classical genetics with modern technology to understand human physiology and search for breakthrough treatments for diseases.

  • Bruce Beutler, M.D.

Bioinformatics Lab

The Bioinformatics Lab provides services to manage and analyze next-generation sequencing data.

  • Dr. Chao Xing, Director
bioinformatics statistical genomics statistical genetics genetics biostatistics Human Disease Mapping GWAS sequencing
Biomedical Engineering Genetics, Development and Disease

Biomedical Imaging and Radiation Technology (BIRT) Lab

Our mission is to innovate, develop, and apply biomedical technology to empower cancer research.

  • Ken Kang-Hsin Wang
Biomedical imaging radiation therapy
Biomedical Engineering

Biomolecular NMR Facility

This facility is the home to five high field solution NMR spectrometers ranging from 500 MHz to 800 MHz and a Solid State 600 MHz DNP system, primarily in support of studies of macromolecular structure, function and dynamics.

  • Jose Rizo-Rey
  • Michael Rosen
  • Kendra Frederick
  • Xuelian Luo
  • Hongtao Yu
Molecular Biophysics Neuroscience Molecular Biophysics Molecular Biophysics Molecular Biophysics

Blount Lab

Our research is largely aimed at understanding how an organism detects mechanical force.

Molecular Biophysics Molecular Microbiology

Bowen Lab

The Bowen Lab focuses on the development of hybrid positron emission tomography (PET) (e.g. PET-CT and PET-MR) tools to enable precision imaging for the care and study of oncology, neurology, and cardiology patients.

  • Spencer Bowen, Ph.D.
Biomedical Engineering

Brekken Lab

The Brekken laboratory, located in the Hamon Center for Therapeutic Oncology Research, studies tumor-host interactions with a particular emphasis on extracellular matrix (ECM) and angiogenesis.

  • Rolf A. Brekken, Ph.D.
Tumor microenvironment
Cancer Biology

Brown & Goldstein Lab

Our laboratory discovered a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control cholesterol and fatty acid synthesis. 

  • Michael S. Brown, M.D., Joseph L. Goldstein, M.D.

Brugarolas Lab

  • To understand how kidney cancer develops at the molecular level.
  • To translate our findings into new treatments for kidney cancer patients.
  • To train the next generation of physicians and scientists.
  • James Brugarolas, M.D., Ph.D.

Burgess Lab

The Burgess lab uses Nuclear Magnetic Resonance spectroscopy and Mass Spectrometry in conjunction with stable isotope (non-radioactive) tracers to study how metabolic flux is altered by disease, pharmacology, or targeted genetic interventions.

  • Shawn Burgess, Ph.D.
Biomedical Engineering

Burstein Lab

Burstein Laboratory focuses on understanding the regulation of the inflammatory response at a molecular level, and elucidating how these events may participate in human disease.

  • Ezra Burstein, M.D., Ph.D.
Inflammation Endosomal biology
Genetics, Development and Disease Immunology

Busch Lab

The Busch Lab develops optical technologies for non- and minimally-invasive bedside assessment of microvascular blood flow and oxygen saturation, allowing continuous assessment of oxygen metabolism. 

  • Dr. David Busch
translational neuromonitoring
Biomedical Engineering Neuroscience

Buszczak Lab

Buszczak laboratory seeks to gain new insights into the unique biology of germ cells.

  • Michael Buszczak, Ph.D.
Germ cells
Genetics, Development and Disease

Butler Lab

Our lab is working with to develop a gene therapy that would allow increased Ube3a expression in the paternal copy of the gene that causes Angelman syndrome.

  • Ryan Butler, Ph.D.
Neuroscience

Butovich Lab

My research interests include lipidomics, enzymology, drug discovery, and bioanalytical chemistry in the relation to ocular biochemistry, biophysics, and physiology. 

  • Igor A. Butovich, Ph.D.
Biological Chemistry

CACTUS Lab

The Collaborative for Advanced Clinical Techniques in UltraSound (CACTUS) constitutes a group of like-minded physicians, scientists, and technical experts dedicated to the advancement of clinical imaging, technical and translational research, and image-guided intervention in ultrasound.

  • David Fetzer, M.D.​
Ultrasound Translational Research

Cardio-Oncology Research Lab

Please contact our team if planning neoadjuvant Adriamycin (doxorubicin), for enrollment in the HP Cardiotox Study.

  • Vlad G. Zaha, MD, PhD
Cardio-oncology Cardiac Metabolism immuno-cardiovascular interactions Advanced Cardiovascular Imaging myocardial regeneration
Biomedical Engineering

Cardiovascular Clinical Research Center (CCRC)

We conduct state-of-the-art clinical trials in the field of cardiovascular diseases, offering patients access to advanced clinical therapies that would otherwise not be available.

  • Jose Joglar, M.D. FACC, FAHA, FHRS,
  • Darren K. McGuire, M.D., M.H.Sc., FACC, FAHA,

Carlson Lab

The work of Deborah Carlson, Ph.D., focuses on characterizing the inflammasome mediating the inflammatory response in the heart following thermal injury and thermal injury complicated with sepsis. 

  • Deborah Carlson, Ph.D.

Carroll Lab

The Carroll lab is interested in how groups of cells organize themselves into properly sized, polarized tubules and then maintain these structures throughout their life. 

  • Thomas Carroll, Ph.D.

Castrillon Lab

Castrillion Lab's work is aimed at understanding why endometrial or uterine cancers arise and spread, with an eye on prevention, earlier and more accurate diagnosis, improved treatments, and better overall patient outcomes.

  • Diego Castrillon, M.D., Ph.D.
Endometrial cancer
Cancer Biology

Chahrour Lab

Interrogating the genome to better understand the mechanisms causing autism spectrum disorder and other neurodevelopmental disorders and inform innovative therapies

  • Maria Chahrour, Ph.D.
Genetics, Development and Disease Neuroscience

Chan Lab

Our lab is creating better experimental models that reveal how cancer cells metastasize and evade our immune system. We use these models to develop new drugs that engage our immune system to kill cancer cells.

  • Isaac Chan, M.D., Ph.D.

Chen (Benjamin) Lab

We work to understand the role of DNA-PKcs in DNA repair and maintenance, with the ultimate goal of improving radiation therapy as cancer treatment.

  • Benjamin Chen, Ph.D.
Cancer Biology

Chen (Chuo) Lab

We are interested in building small organic molecules and studying their functions in biological systems. Our lab started in 2004 using state-of-the-art tools to address challenging issues in the field of natural product synthesis. 

  • Chuo Chen Ph.D.
Organic Chemistry Biological Chemistry

Chen (David) Lab

Deficiencies in DNA-damage signaling and repair pathways are fundamental to the etiology of most human cancers. Of the many types of DNA damage that occur within the cell, DNA double-strand breaks (DSBs) are particularly dangerous.

  • David Chen, Ph.D.

Chen (Elizabeth) Lab

Elizabeth Chen Lab focuses research on cell-cell fusion, drosophila myoblast fusion, invasive membrane protrusions, actin binding and bundling proteins, and mechanoresponsive proteins.

  • Elizabeth Chen, Ph.D.
Cell and Molecular Biology Genetics, Development and Disease

Chen (Haiqi) Lab

Welcome to the Reproductive Genomics Laboratory (RGL) at UT Southwestern Medical Center where we innovate at the intersection of genomics, bioengineering, and data science to answer fundamental questions in reproductive biology.

  • Haiqi Chen

Chen (Jin) Lab

Our primary research interest is to understand the emerging roles of the “unannotated genome,” which encodes a whole new class of uncharacterized microproteins. We focus on the relevance and function of this “dark proteome” in regulating development and disease.

  • Jin Chen

Chen (Kenneth) Lab

Chen lab studies how dysregulation of RNA synthesis and degradation drives childhood cancers with the ultimate goal of identifying new therapeutic vulnerabilities to exploit in treating them.

  • Kenneth Chen, MD
Childhood cancer
Cancer Biology

Chen (Zhijian "James") Lab

Chen Lab is broadly interested in mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself.

  • Zhijian "James" Chen, Ph.D.
Genetics, Development and Disease Immunology

Cheng (Jonathan) Lab

Jonathan Cheng's Lab performs a comprehensive suite of outcome measures to assess peripheral nerve recovery and chronic neural interfacing in the research setting.

  • Jonathan Cheng, M.D.
Peripheral nerve
Biomedical Engineering

Chiang Lab

My lab has a long-time interest in understanding the mechanisms of transcription and gene regulation in mammalian cells using initially cell-free systems reconstituted with purified gene-specific transcription factors, general cofactors, and components of the general transcription machinery to recapitulate transcriptional events in vitro. 

  • Cheng-Ming Chiang, Ph.D.
Cancer Biology Cell and Molecular Biology

Choi (Changho) Lab

Magnetic resonance spectroscopy (MRS) provides an effective tool for detecting bio-chemicals in living systems noninvasively. Dr. Choi’s lab focuses on technical and clinical development of MR spectroscopy (MRS) in the brain in vivo.

  • Changho Choi, Ph.D.

Chong Lab

The Chong Research group has been conducting clinical and translational research on cutaneous lupus including outcome measure development for clinical trials, biomarkers for diagnosis and prognosis, and disease outcomes.

  • Benjamin Chong, M.D.

Chook Lab

The Chook Lab studies physical and cellular mechanisms of Kaps. Our long-term goals are to understand how the macromolecular nuclear traffic patterns coordinated by the 20 human Kaps contribute to overall cellular organization.

  • Yuh Min Chook, Ph.D.

Chopra Lab

Chopra Lab's research is focused on High-Intensity Focused Ultrasound (HIFU) , which is a form of image-guided therapy capable of non-invasive tissue ablation and drug delivery.

  • Rajiv Chopra, Ph.D.

Chuang (David) Lab

The unifying theme of David Chuang Lab's research focuses on the biochemistry and structural biology of macromolecular machines.

  • David Chuang, Ph.D.
Biological Chemistry

Chung Lab

Chung Lab uses primary human specimens, patient-derived xenograft models, and genetically engineered mouse models to study the molecular mechanisms underlying disease stem cell function in hematologic malignancies.

  • Stephen Chung, M.D.
Cancer Biology

Cleaver Lab

Our lab focuses on the molecular and cellular mechanisms underlying cell fate specification during blood vessel development and organogenesis.

  • Ondine Cleaver, Ph.D.
Organogenesis
Genetics, Development and Disease

Cobanoglu Lab

Both we (Cobanoglu et al., 2013) and others (Murphy, 2011) have reported that active machine learning driven experimentation can increase efficiency in the drug discovery process in the preclinical stage. We have a view towards integrating our computational work with an experimental pipeline. That is exactly why we are housed in a biomedical powerhouse, the UT Southwestern Medical Center, to execute this vision.

  • Murat Can Çobanoğlu, Ph.D.

Cobb Lab

The Cobb lab studies signal transduction mechanisms of protein kinases and how kinase structures lead to cell biological functions. We are particularly focused on the contributions of ERK MAP kinases to pancreatic beta-cell function and to lung cancers, and on the cell biological actions of WNK protein kinases.

  • Melanie Cobb, Ph.D.
Cancer Biology Cell and Molecular Biology

Collins Lab

We believe that understanding the basic biology of the schistosomes is key to developing the next generation of anti-schistosome drugs and vaccines. We also contend that by studying the basic biology of these fascinating organisms, we can better understand important basic biological processes common to all animals, including humans. For that reason, we study schistosomes from multiple angles using a variety of modern molecular approaches.of the lab. 

  • James J. Collins III, Ph.D.
Cell and Molecular Biology Genetics, Development and Disease

Conrad Lab

RNA Biology Meets Herpes Virology

  • Nicholas K. Conrad, Ph.D.
RNA
Biological Chemistry Molecular Microbiology

Conzen Lab

 In prior work, my laboratory focused on identifying novel mechanisms of therapy-resistance and progression in breast, prostate and ovarian cancer. 

  • Suzanne D. Conzen, M.D.
Cancer Biology

Corbin Lab

The research focus in the Corbin lab investigates strategies that exploits the deviant metabolism of cancer cells (namely the reprogramming of lipid metabolism and altered redox biology) for therapeutic purposes.

  • Ian Corbin, Ph.D.
Biomedical Engineering Cancer Biology

Corey Lab

Corey Lab is using nucleic acids or nucleic acid mimics to explore important cellular processes, develop novel therapeutic tools and strategies.

  • David R. Corey, Ph.D.
Nucleic Acids
Biological Chemistry Molecular Biophysics

Cowell Lab

Dr. Cowell has built a research program focused on the development of bioinformatics and computational biology methods for studying the immune system and infectious diseases.  

  • Lindsay Cowell, Ph.D.
Cancer Biology Immunology

D'Orso Lab

D'Orso Lab studies gene regulatory networks in normal and disease states as well as in the context of host-pathogen interactions.

  • Ivan D'Orso, Ph.D.
HIV-1 AIDS Host-Pathogen Cancer Gene regulation Transcription Chromatin Epigenetics
Biological Chemistry Molecular Microbiology

Danuser Lab

Danuser Lab tackles quantitative understanding of morphogenesis and how the processes are coordinated. 

  • Gaudenz Danuser, Ph.D.
Biomedical Engineering Cancer Biology

Data Science Shared Resource

We work with you on data management and process, database and web application, experimental design and grant support.

  • Yang Xie, Ph.D.
Biomedical Engineering Cancer Biology Molecular Biophysics

Dauer Lab

The central goal of the Dauer Lab is to unravel the molecular and cellular mechanisms of diseases that disrupt the motor system. In exploring these diseases, we also aim to understand a fundamental question relevant to CNS disease generally: what factors determine the selective vulnerability of particular cell types or circuits to insults? Our primary focus is on Parkinson’s disease and inherited forms of dystonia. We focus our efforts on disease genes that cause these disorders, employing a range of molecular, cellular, and whole animal studies to dissect the normal role of disease proteins, and how pathogenic mutations lead to disease.

  • William Dauer, M.D.
parkinson's disease central nervous system disease Dystonia

Davis (Anthony) Lab

The Davis Lab is part of the Division of Molecular Radiation Oncology in the Department of Radiation Oncology

  • Anthony Davis, Ph.D.
DNA damage response
Cancer Biology Cell and Molecular Biology

De Brabander Lab

The De Brabander Lab focuses on the synthesis of complex molecular architectures, including both designed and naturally occurring substances with novel structural features and interesting biological function. 

  • Jef De Brabander, Ph.D.
Organic Chemistry

de Gracia Lux Lab

Check out the latest research efforts of de Gracia Lux's Lab!

  • Caroline de Gracia Lux, Ph.D.
Biomedical Engineering

Dean Lab

The Dean Lab aims to develop and apply cutting-edge microscopy instrumentation and analyses to gain insight into otherwise intractable biological problems.

  • Kevin M. Dean, Ph.D.

Dean Smith Lab

We are using a combination of genetics, biochemistry, electrophysiology, cell biology, and molecular biology to undertake a molecular dissection of the chemosensory behavior in Drosophila.

  • Dean P. Smith, M.D., Ph.D.
Cell and Molecular Biology Neuroscience

DeBerardinis Lab

Proper control of metabolism is required for essentially every basic biological process. Altered metabolism at the cellular level contributes to several serious diseases including inborn errors of metabolism (the result of inherited genetic defects in metabolic enzymes that lead to chemical imbalances in children) and cancer. Our laboratory seeks to characterize these metabolic disorders, understand how they compromise tissue function, develop methods to monitor metabolism in vivo and design therapies to restore normal metabolism and improve health.

  • Ralph DeBerardinis

Deisenhofer Lab

Our group is interested in analyzing three-dimensional structures of macromolecules using computational methods.

  • Johann Deisenhofer, Ph.D.
Molecular Biophysics

Dellinger Lab

The Dellinger Laboratory studies the development of the lymphatic vasculature and diseases caused by errors in the development of lymphatic vessels.

  • Michael Dellinger, Ph.D.
Genetics, Development and Disease

DeMartino Lab

DeMartino Lab studies the biochemical mechanisms and the physiologic regulation of intracellular protein degradation.

  • George N. DeMartino, Ph.D.
Protein Degradation
Biological Chemistry

Diamond Lab

We focus on neurodegenerative diseases linked to amyloid protein accumulation with the goal of developing mechanism-based diagnosis and therapy.

  • Marc Diamond, M.D.
tau protein Neurodegeneration alzheimer's disease parkinson's disease
Molecular Biophysics Neuroscience

Doubrovinski Lab

We study the physical mechanisms that underlie animal development.

  • Konstantin Doubrovinski

Douglas Lab

The Douglas lab seeks to understand how stress response pathways alter cell physiology, and ultimately influence the aging process and human disease.

  • Peter Douglas, Ph.D.
stress age lipid sensing concussion
Genetics, Development and Disease Neuroscience

Elliott Ross Lab

Our group is interested in how cells process information, particularly through heterotrimeric G proteins. 

  • Elliott M. Ross, Ph.D.
G proteins
Cell and Molecular Biology Molecular Biophysics

Elmquist Lab

The Elmquist laboratory uses mouse genetics to identify circuits in the nervous system that regulate energy balance and glucose homeostasis. We have developed unique mouse models allowing neuron-specific manipulation of genes regulating these processes.

  • Joel Elmquist, D.V.M., Ph.D.

Erzberger Lab

Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery.

  • Jan Erzberger, Ph.D.
Ribosomes
Molecular Biophysics

Fiolka Lab

The long-term goal of Fiolka Lab's research is to develop and implement imaging technologies that provide unprecedented insight into cancer biology. 

  • Reto Fiolka, Ph.D.
Microscopy
Biomedical Engineering

Floyd Hypoxia, Cognition, and Aging Lab

We study the impact of disease-related hypoxic stress with aging upon synaptic plasticity, white matter connectivity, and cognitive performance.

    • Thomas F. Floyd, MD
    Biomedical Engineering Neuroscience

    Fontoura Lab

    Our laboratory studies the cell biology of viral-host interactions. 

    • Beatriz M.A. Fontoura, Ph.D.
    Cancer Biology Molecular Microbiology

    Forsberg Lab

    Bacteria and phages are in everlasting conflict – constantly devising new genes, systems, and mechanisms to keep pace with their competitors. The Forsberg lab studies this “evolutionary arms race”, using high-powered selections to unearth new functions and careful experiments to reveal their mechanisms.

    • Kevin Forsberg

    Fragile X Syndrome Research Center

    The Fragile X Syndrome Research Center is a team of investigators from UT Southwestern and the University of California at Riverside. The Center supports three projects representing a multilevel, integrated approach that tests mechanisms of sensory neocortical dysfunction in fragile X syndrome (FXS) and pharmacological approaches to reduce the deficits.

    • Kimberly Huber, Ph.D.
    Neuroscience

    Friedman Lab

    Our lab is interested in addressing a fundamental question of cell biology: How are organelles spatially organized?

    • Jonathan Friedman, Ph.D.
    Mitochondria
    Cell and Molecular Biology

    Fujikawa Lab

    Obesity and metabolic diseases have been increasing at the alarming rate and threatening our health and economy over the world. However, we still don’t know much about how our metabolic homeostasis is regulated. Understanding the mechanism underlying the regulation of metabolism is a fundamental step towards designing new treatments for obesity and its associated diseases, and many other metabolic diseases

    • Teppei Fujikawa, Ph.D.

    Galindo Lab

    My lab’s research efforts are based upon a fundamental interest in the genetic and molecular mechanisms involved in childhood cancer.

    • Rene L. Galindo, M.D., Ph.D

    Gammon Lab

    Our research is driven by a desire to understand how these microscopic machines both replicate themselves and, at the same time, manage to evade, manipulate, and counter a myriad of host defenses. 

    • Don Gammon, Ph.D.
    Viral Immunity
    Molecular Microbiology

    Gao Lab

    We are working at the interface of nanomedicine, cancer, metabolism, and immunotherapy

    • Jinming Gao, Ph.D.
    Nano-Immuno-Oncology
    Biomedical Engineering Cancer Biology

    Garg Lab

    Dr. Garg's research focuses on diabetes, insulin resistance, and disorders of adipose tissue.

    • Abhimanyu Garg, M.D.Dr. Garg's research has focused on the problems of diabetes, insulin resistance, and disorders of adipose tissue.

    Gautron Lab

    The autonomic nervous system comprises a network of sensory and motor neurons that connect the brainstem and spinal cord to thoracic and abdominal organs. A better understanding of the anatomical and functional plasticity of the autonomic nervous system will likely move forward our understanding of numerous chronic diseases including, but not limited to, obesity, diabetes, visceral pain, neuropathy, and eating disorders.

    • Laurent Gautron, Ph.D.

    Ge (Woo-Ping) Lab

    We seek breakthroughs that change scientific fields and yield new strategies for treating disease. Our ultimate goal is to cure people who would not be cured otherwise.

    • Woo-Ping Ge

    German Lab

    The German Lab focuses its research on Neurodegenerative Diseases and Autism.

    • Dwight German, Ph.D.
    Neuroscience

    Gibson Lab

    Dr. Gibson's current research focuses on the changes in neocortical circuitry in the mouse model of Fragile X Syndrome (the Fmr1 KO mouse), and the mechanisms underlying these changes.

    • Jay Gibson, Ph.D.
    Neuroscience

    Glass Lab

    The Glass lab focuses on how genes regulate skin development and function by studying how gene mutations or abnormal gene expression lead to skin disease.

    • Donald Glass, M.D., Ph.D.

    Goldsmith Lab

    Goldsmith Lab combines drug discovery and mechanistic analysis to understanding protein kinases. 

    • Elizabeth J. Goldsmith, Ph.D.
    Molecular Biophysics

    Goss Lab

    The Goss lab collaborates with a multidisciplinary group of researchers to study the heart and lungs long after preterm birth. We are part of the Parkland Outcomes after Prematurity Study (POPS), which conducts collaborative research on outcomes of prematurity from birth through adulthood.

    • Kara Goss, M.D.

    Gray Lab

    Dr. Gray is overseeing one of the nation’s few facilities that manufactures a special type of gene-delivering virus for patient use.

    • Dr. Steven Gray
    gene therapy
    Genetics, Development and Disease

    Green Lab

    The general focus of the Green Lab is to understand the molecular mechanism of the mammalian circadian clock, how it controls rhythmic biochemistry, physiology and behavior and how loss of clock function can impact health, resulting in metabolic disease, cancer and other ailments.

    • Carla Green, Ph.D.
    Cell and Molecular Biology Neuroscience

    Greenberg Lab

    The Greenberg lab is focused on the development of novel therapeutic approaches to combat infectious diseases. For specific projects, please click on the links to the left.

    • David Greenberg, M.D.
    antibiotic resistance
    Molecular Microbiology

    Greene Lab

    Our lab uses a combination of electrophysiological and molecular techniques to examine functions sub-served by these states at the cellular and circuit levels.

    • Robert Greene, M.D., Ph.D.
    Neuroscience

    Grinnell Lab

    Working at the boundary between science and philosophy with the goal to inform public policy and advance science education and public understanding of science.

    • Frederick Grinnell, Ph.D.
    Science Education Bioethics Research Integrity
    Biomedical Engineering

    Grishin Lab

    We use theoretical methods to study proteins, genomes and organisms.

    • Nick V. Grishin

    Grow Lab

    The Grow lab takes genome-wide, single-cell, and computational approaches to deeply understand epigenome and transcriptome landscapes and how they are reprogrammed.

    • Dr. Edward Grow, Ph.D.

    Gruber Lab

    Our goal is to tackle difficult problems in human health and cancer biology. We work on the diseases of triple-negative breast cancer and other difficult-to-treat cancers.

    • Joshua Gruber, MD, PhD

    Grundy Lab

    Dr. Grundy's major research area is in cholesterol and lipoprotein metabolism.

    • Scott Grundy, M.D., Ph.D.
    Biological Chemistry

    Gupta (Olga) Lab

    The main focus of our laboratory is characterizing the contribution of non-adipocyte cells within adipose tissueto insulin resistance and systemic inflammation in both rodent and human models.

    • Olga Gupta M.D.

    Gupta (Rana) Lab

    The Gupta Lab employs modern approaches in molecular genetics and molecular/cellular biology to explore various aspects of adipocyte development.

    • Rana K. Gupta Ph.D.

    Habib Lab

    Our laboratory is interested in improving treatment for patients with glioblastoma (GBM) and other cancers. We work on understanding signal transduction pathways involved in the pathogenesis of cancer. Recent work has focused on investigating mechanisms of resistance to targeted treatment in GBM and lung cancer. We are also interested in mechanisms regulating invasion in GBM. 

    • Amyn Habib, M.D.
    glioblastoma
    Cancer Biology

    Haiyang Yu Lab

    The Yu lab focuses on anisosomes, TDP-43 aggregation, and molecular glue in studying the mechanisms behind age-related neurodegeneration.

    • Haiyang Yu, Ph.D.
    anisosomes  TDP-43 aggregation molecular glue
    Genetics, Development and Disease

    Hancks Lab

    We employ a variety of methods including evolutionary analysis, genomics, and molecular biology to study the biology of infection.

    • Dustin Hancks
    genetics of host-virus interfaces
    Genetics, Development and Disease Immunology

    Hannan Lab

    Our goal is to understand and exploit the immunogenic properties of tumor irradiation in integrating it with immunotherapy to improve cancer patient outcome.

    • Raquibul Hannan, M.D., Ph.D.
    RCC prostate cancer immunotherapy immunomodulation cancer immunology cancer vaccination SBRT stereotactic radiation
    Cancer Biology

    Harbour Lab

    Dr. Harbour’s research focuses on the use of genetic and genomic technology, cell culture experiments and genetically modified experimental models to understand mechanisms of tumor progression in major forms of eye cancer, including uveal melanoma, retinoblastoma, intraocular lymphoma and others.

    • J. William Harbour, M.D.

    Harris-Tryon Lab

    Our focus is on gaining a greater understanding of how bacteria on the skin surface affect skin health and diseases.

    • Tamia Harris-Tryon, M.D., Ph.D.
    Skin Microbiota
    Immunology

    Hattori Lab

    The Hattori lab studies how neural circuits integrate sensorimotor information, memory, and internal state to guide behavior.

    • Daisuke Hattori, Ph.D.
    Systems Neuroscience
    Neuroscience

    He Lab

    The goal of our research lab is to identify the early steps in the pathogenesis of AMD, and to investigate the novel methods to treat and even to prevent its development.

    • Yu-Guang He, M.D.

    Hendrixson Lab

    The Hendrixson Lab is largely focused on exploring the biology of polarly-flagellated bacterial pathogens….and junk food, donuts, and cake.

    • David Hendrixson, Ph.D.
    Campylobacter jejuni Flagellar Motility Short-Chain Fatty Acid
    Molecular Microbiology

    Henne Lab

    Henne lab is interested in how cells spatially organize their metabolism to adapt to a constantly changing environment.

    • W. Mike Henne, Ph.D. Associate Professor Department of Cell Biology & Department of Biophysics
    organelle biology
    Cell and Molecular Biology Molecular Biophysics

    Herz Lab

    The goal of the Herz Lab is to identify the underlying biochemical principles of human diseases & disorders in order to design novel therapies to prevent, delay, or cure them.

    • Joachim Herz, M.D.
    Neuroscience

    Hibbs Lab

    The Hibbs lab is pursuing atomic-scale mechanisms of synaptic proteins, with a current focus on ligand-gated ion channel structure and function.

    • Ryan Hibbs, Ph.D.
    Neuropharmacology
    Molecular Biophysics Neuroscience

    High-Throughput Screening

    The Core supports the early, pre-clinical discovery and development of new small molecule therapeutics, and assists in identifying and characterizing novel biological targets and pathways for therapeutic intervention.

    • Bruce Posner, Ph.D.
    Biological Chemistry

    Hilgemann Lab

    We do difficult experiments at the frontier of cell physiology, often with our own methods and always with our own hands. Enter a description of the lab. This information will appear on the lab listing page.

    • Donald W. Hilgemann, Ph.D.
    Neuroscience

    Hobbs-Cohen Lab

    The central focus of our research program is how dysregulation of lipid uptake and trafficking contributes to human diseases. 

    • Helen Hobbs, M.D.
    • Jonathan Cohen, Ph.D.
    Lipid Metabolism
    Genetics, Development and Disease Genetics, Development and Disease

    Hon Lab

    We explore questions on genomes using a systems biology approach: developing and employing integrative approaches at the interface of gene regulation, epigenetics, single-cell genomics, and bioinformatics.

    • Gary Hon

    Hooper Lab

    We are broadly interested in understanding how resident intestinal bacteria influence the biology of humans and other mammalian hosts.

    • Dr. Lora Hooper

    Hoshida Lab

    We are multidisciplinary team of clinicians and scientists, focusing on liver cancer risk-predictive molecular biomarkers specific to clinical contexts (ex. geographic region, liver disease etiology, and patient race/ethnicity) individual risk-stratified personalized cancer screening.

    • Yujin Hoshida, MD, PhD

    Hoxhaj Lab

     In diseases like cancer, signaling pathways can be corrupted by mutations that cause the cells to grow and spread uncontrollably. Our lab is interested in understanding how these defective pathways reprogram cellular metabolism to drive cancer growth.

    • Gerta Hoxhaj

    Hsieh (Jer-Tsong) Lab

    Jer-Tsong Hsieh Lab research interests focus on key molecular mechanisms leading to urologic cancer progression, development of precision medicine of cancer therapy assisted with non-invasive molecular imaging.

    • JT Hsieh, Ph.D.
    Cancer Biology Cell and Molecular Biology

    Hu (Ming-Chang) Lab

    Ming-Chang Hu Lab strives to offer novel insight into the cellular and molecular mechanisms of AKI progression to CKD and cardiovascular diseases (vascular calcification and uremic cardiomyopathy) development in CKD, and set up a solid basis for preclinical and clinical study in the future.

    • Ming-Chang Hu, M.D., Ph.D.

    Huang (Emina) Lab

    Publications for Dr. Emina Huang's Lab

    • Dr. Emina Huang
    Cancer Biology

    Huang (Huocong) Lab

    The research of the Huang Laboratory focuses on understanding the function of fibroblast progenitor cells and fibroblasts in regulating the immune system.

    • Huocong Huang, M.D., Ph.D
    Immunology Fibroblast

    Huang (Lily) Lab

    Our laboratory is interested in the molecular mechanisms governing cytokine receptor signal transduction in hematopoietic stem and progenitor cells, and understanding how deregulation in these mechanisms results in hematological malignancies and cancer.

    • Lily Huang, Ph.D.
    Cancer Biology Cell and Molecular Biology

    Huber Lab

    The Huber lab is focused on understanding how activity-regulated transcription and translation in neurons controls synapse and circuit plasticity and development.

    • Kimberly Huber, Ph.D
    Autism
    Neuroscience

    Huen Lab

    Huen Lab studies how metabolic adaption promotes survival during sepsis and how the kidneys contribute to systemic metabolism during inflammation.

    • Sarah Huen, M.D., Ph.D.
    metabolism
    Cell and Molecular Biology

    Hulleman Lab

    The Hulleman Laboratory is committed to understanding and rectifying the underlying causes of inherited and idiopathic eye disorders caused by protein misfolding.

    • John Hulleman, Ph.D.
    ocular proteostasis
    Biological Chemistry Cell and Molecular Biology

    Human Gene Discovery Laboratory

    Our goal is to provide state-of-the-art expertise for analysis of exome and genome sequencing.

    • Jonathan Rios, Ph.D.

    Infante Lab

    Our laboratory actively studies disease processes that disrupt normal metabolism.

    • Rodney Infante, M.D., Ph.D
    Cell and Molecular Biology

    Institute for Exercise and Environmental Medicine (IEEM)

    The Institute for Exercise and Environmental Medicine is a 40,000 square-foot research facility with 12 UTSW faculty working in multiple departments and divisions (Internal Medicine/Cardiology/Pulmonary, Neurology, PM&R, Anesthesiology, Applied Physiology) with up to 20 postdocs, and 40 staff on 70 active protocols and 15 federal grants. It is a research enterprise devoted to the study of human physiology and the limits to human functional capacity in health and disease. 

    • Benjamin Levine, M.D., Tony Babb, Ph.D., Craig Crandall, Ph.D., Qi Fu, M.D., Ph.D., Rong Zhang, Ph.D., Tom Sarma, M.D., James MacNamara, M.D., Christopher M. Hearon, Jr., Ph.D., Renie Guilliod, M.D., James Berry, M.D., Andrew Tomlinson, M.D.

    Jain (Mamta) Lab

    We focus on

    •  Therapeutic clinical trials in infectious diseases
    •  Improving outcomes through the improvement of the delivery of health services
    •  Analysis of outcomes among those with infections
    • Mamta K. Jain, M.D. MPH
    AIDS co-morbidities Hepatitis C HVC influenza COVID-19

    Jain (Raksha) Lab

    The Jain Lab is broadly interested in sex disparities in research on women's health, as well as the impact of sex hormones on airway diseases and immune response.

    Innate Immunity Adult Cystic Fibrosis Biology of sex differences gender disparities in health Pseudomonas aeruginosa
    Molecular Microbiology

    James Kim Lab

    The James Kim Lab examines the communication between epithelia and stroma through the lens of fundamental developmental pathways such as Hedgehog, Wnt, and Notch pathways.

    • James Kim

    Jamieson Lab

    The Jamieson Lab lab emphasizes AI/ML, software development, and image analysis.

    • Andrew R. Jamieson, Ph.D.

    Jaqaman Lab

    We are a group of biophysicists, cell biologists and computational folks interested in the spatiotemporal organization of cell surface receptors, the mechanisms underlying it, and its consequences for cell signaling. 

    • Khuloud Jaqaman, Ph.D.
    Cell Signaling
    Biomedical Engineering Molecular Biophysics

    Jewell Lab

    The Jewell Lab investigates how organisms sense environmental nutrient fluctuations and respond appropriately, fine tuning anabolic and catabolic processes to control cell growth, metabolism, and autophagy.

    • Jenna L. Jewell, Ph.D.

    Jiang (Huaqi) Lab

    Huaqi Jiang Lab studies the regulation of adult tissue homeostasis and regeneration using a genetic model system, the adult Drosophila midgut. 

    • Huaqi Jiang, Ph.D.

    Jiang (Jin) Lab

    The Jiang lab carries out systematic genetic screens to identify genes controlling pattern formation and growth of Drosophila adult organs.

    • Jin Jiang
    Cell Signaling development regeneration stem cell cell growth tumor suppressor organ size pattern formation Cancer
    Cancer Biology Genetics, Development and Disease

    Jiang (Youxing) Lab

    Enter a description of the lab. This information will appear on the lab listing page.

    • Youxing Jiang
    Molecular Biophysics Neuroscience

    Johnson Lab

    The research in the Johnson lab is focused on vertebrate nervous system development during the transition from proliferating neural stem cells to differentiating neurons and glia. 

    • Jane E. Johnson, Ph.D.
    transcriptional control of neural development
    Genetics, Development and Disease Neuroscience

    Joseph Hill Lab

    We strive to decipher mechanisms of structural, functional, and electrical remodeling in heart disease with an eye toward therapeutic intervention. 

    • Joseph Hill, M.D., Ph.D.

    Kahn Lab

    We have two major areas of research: respiratory viruses and newly emerging pathogens. 

    • Jeffrey Kahn
    Molecular Microbiology

    Karner Lab

    The primary research focus of the Karner lab is to create and utilize novel mouse genetic models to study the role of cellular metabolism during skeletal development and disease. 

    • Courtney Karner, Ph.D.
    Bone Development
    Genetics, Development and Disease

    Khan Lab

    The Khan Lab's research is focused on autoimmunity and cancer.

    • Shaheen Khan, Ph.D.

    Kim (Daehwan) Lab

    Research in the Kim lab is focused on developing computer algorithms and statistical methods that enable accurate and rapid analysis of biological data, in particular sequencing data.

    • Daehwan Kim, Ph.D.

    Kim (Taekyung) Lab

    Taekyung Kim Lab is interested in understanding how sensory experience can be accurately translated into neuronal and behavioral plasticity through genetic and epigenetic networks. 

    • Taekyung Kim, Ph.D.

    Kitamura Lab

    Kitamura Lab's research aims to provide a biophysically-based mechanistic understanding of the neural process for learning and memory in the mouse brain.

    • Takashi Kitamura, Ph.D.
    Learning and memory neural circuits hippocampus entorhinal cortex prefrontal cortex
    Neuroscience

    Kittler Lab

    The ultimate goal of the Kittler Lab's research is to develop novel therapeutic approaches that target transcription factors, which play important roles in common solid tumors (brain, breast, lung and prostate cancer) and could therefore have translational potential.

    • Ralf Kittler, Ph.D.
    Cancer Biology

    Kober Lab

    We are investigating how protein degradation is controlled in cells and how protein degradation contributes to lipid homeostasis.

    • Daniel Kober, Ph.D.
    Protein degradation. Lipid Metabolism. Membrane protein biochemistry and structural biology.
    Biological Chemistry Molecular Biophysics

    Koh Lab

    We are broadly interested in understanding how resident intestinal microorganisms (particularly bacteria and fungi and collectively referred to as the gut microbiome) influence the health of human cancer and stem cell transplant patients.

    • Dr. Andrew Y. Koh, MD

    Kohler Lab

    The Kohler research group is committed to developing and implementing new tools optimized for the study of glycosylated molecules.

    • Jennifer Kohler, Ph.D.
    Glycobiology
    Organic Chemistry Biological Chemistry

    Konopka Lab

    We are taking a comparative genomics approach to identify genes that have been modified in the human brain.

    • Genevieve Konopka Ph.D.

    Kovacs Lab

    Our research focuses on two main areas: hyperpolarized 13C, 15N, 89Y and 107, 109Ag compounds, and conventional lanthanide-based T1 shortening and paraCEST imaging agents.

    • Zoltan Kovacs, Ph.D.
    Biomedical Engineering

    Krämer Lab

    The goal of the Krämer laboratory is to understand the molecular mechanisms that regulate responses to diverse cellular stresses.

    • Helmut Krämer, Ph.D.
    Retinal cell biology
    Genetics, Development and Disease Neuroscience

    Kraus Lab

    The Kraus Lab is interested in the basic mechanisms of nuclear signaling and gene regulation by small molecules and how these signaling pathways relate to human physiology and disease states.

    • W. Lee Kraus, Ph.D.
    Gene regulation
    Genetics, Development and Disease

    Lai (Helen) Lab

    We are interested in understanding how animals process both external and internal sensory information to interact appropriately with their environment.

    • Helen Lai, Ph.D.

    Le Lab

    Welcome to the Le Laboratory in the Department of Dermatology and Simmons Comprehensive Cancer Center. One aim of our lab is to help train the next generation of scientists and physicians.

    • Lu Q. Le, M.D., Ph.D.
    Neurofibromatosis Dermatology cancer biology stem cells Hair Development Epithelial stem cells Skin stem cells Hair stem cells
    Cancer Biology Genetics, Development and Disease

    Lee (Jeon) Lab

    Our research is aimed at innovating and translating computational technology to advance biomedical research and medical diagnoses/treatments.

    • Jeon Lee, Ph.D.

    Lehrman Lab

    The Lehrman lab uses biochemical approaches to study the functions of sugars and sugar-polymers coupled to proteins and lipids, and as free molecules. Our work involves broken-cell systems, living cultured cells, and animals. This area of research, known as Glycobiology, is an emerging field that encompasses most aspects of biology and medicine.

    • Mark Lehrman, Ph.D.
    Biological Chemistry Cell and Molecular Biology

    Levi Lab

    Our mission is to improve the lives of people living with skin and musculoskeletal diseases through rigorous science and compassion.

    • Benjamin Levi, M.D.

    Li (Bo) Lab

    We are interested in understanding the process of co-evolution of tumor and immune cells during cancer development, which can be tracked from clonal expansion events, together with components of the tumor microenvironment and infiltrating immune repertoire.

    • Bo Li, PhD

    Li (Guo-Min) Lab

    We are broadly interested in cellular mechanisms maintaining genome stability and their impact on human diseases, including cancer and neurodegenerative disorders.

    • Guo-Min Li, Ph.D.
    DNA mismatch repair
    Cancer Biology

    Li (Nan) Lab

    The N-LAB's mission is to develop novel neuroimaging and neuroengineering methods to integrate molecular and system neuroscience and solve brain science problems.

    • Nan Li, Ph.D.

    Li (Wen-hong) Lab

    The overarching goal of Wen-hong Li Lab is to investigate mechanisms responsible for maintaining islet cell function and to devise new strategies for enhancing beta cell fitness and robustness to prevent or treat diabetes.

    • Wen-hong Li
    Diabetes Islet biology chemical biology drug delivery molecular imaging
    Biological Chemistry Biomedical Engineering

    Li (Xiaochun) Lab

    Our lab focuses on membrane proteins in cholesterol biogenesis, transport, and signaling using multiple approaches from protein engineering, to x-ray crystallography and cryo-EM.

    • Xiaochun Li, Ph.D.
    Cell and Molecular Biology Molecular Biophysics

    Ligorio Lab

    Our mission is to understand the most fundamental questions in cancer biology, such as tumor initiation, progession, and response to therapy, through state-of-the-art experimentation, fruitful collaborations and, above all, out-of-the box thinking to develop novel, safe(r) and more effective therapies to win the fight against cancer!

    • Matteo Ligorio, MD, PhD

    Lin (Milo) Lab

    The Lin lab develops theoretical models and uses computational tools to find the performance limits of complex biological systems. 

    • Milo M. Lin, Ph.D.
    Biomedical Engineering Molecular Biophysics

    Lin (Weichun) Lab

    The goal of Lin (Weichun) Lab's research is to understand how neurons establish synaptic connections during development, and how these connections are maintained throughout adulthood. Toward this goal, we are currently focusing on the following two areas of research.

    • Weichun Lin, Ph.D.
    Neuroscience

    Liou Lab

    The Liou Lab seeks to understand the principles underlying communication between organelles within mammalian cells.

    • Jen Liou, Ph.D.
    Cellular Physiology
    Cell and Molecular Biology

    Liszczak Lab

    Glen Liszczak  laboratory is exploring cellular signaling mechanisms that regulate transcription and preserve genome stability.

    • Glen Liszczak, Ph.D.
    Biological Chemistry

    Liu (Chen) Lab

    The Liu lab investigates genetic and environmental factors leading towards obesity and metabolic syndrome in children and adolescents.

    • Chen Liu, Ph.D.

    Liu (Xin) Lab

    Xin Liu Lab is interested in understanding the regulation of transcription and chromatin dynamics underlying many fundamental biological processes including differentiation, development, and oncogenesis.

    • Xin Liu, Ph.D.
    Chromatin
    Molecular Biophysics

    Liu (Yi) Lab

    The Liu Lab is interested in the functions and mechanism of codon usage biases, circadian clocks, and non-coding RNA

    • Yi Liu, Ph.D.
    Genetics, Development and Disease

    Liu (Zhi-Ping) Lab

    The major interest of my lab is to understand the transcriptional regulatory mechanisms involved in human diseases with a focus on cardiovascular diseases and cancer. 

    • Zhi-Ping Liu, Ph.D.
    Epigenetics
    Genetics, Development and Disease

    Lu (Lenette) Lab

    For decades, the field of tuberculosis (TB) immunology has focused on T cell mediated protection, yet Mycobacterium tuberculosis (Mtb) still impacts one in four individuals worldwide today.

    • Lenette Lu M.D., Ph.D.
    antibody functions
    Immunology

    Lum Lab

    The lab of Lawrence Lum, Ph.D., studies cellular signaling processes important in adult stem cell renewal and cancer.

    • Lawrence Lum, Ph.D.

    Luo (Weibo) Lab

    The Luo lab studies oxygen homeostasis in human cancers with a focus on hypoxia-inducible factors. 

    • Weibo Luo, Ph.D.
    Hypoxia
    Biological Chemistry Cancer Biology

    Lux Lab

    The research interests of the Lux Lab lie in the development of novel nanomedicine platforms to diagnose and treat disease in vivo noninvasively.

    • Jacques Lux, Ph.D.
    Ultrasound
    Organic Chemistry Biomedical Engineering

    Ly Lab

    The Ly Laboratory studies how cell cycle defects and mitotic errors shape the complex mutational landscape of human cancer genomes.

    • Peter Ly, Ph.D.
    Genomic Instability Chromosome Biology Cell Cycle
    Cancer Biology Genetics, Development and Disease

    Madabhushi Lab

    Our research aims to obtain a comprehensive picture of how genomic stability and chromatin dynamics affect neuronal functions, including learning behaviors, and to apply this knowledge to combat neurological disorders.

    • Ram Madabhushi, Ph.D.
    Chromatin dynamics
    Neuroscience

    Maddipati Lab

    Using novel multi-omics approaches and model systems to treat pancreatic cancer

    • Ravi Maddipati, MD

    Madhuranthakam Lab

    Research in our laboratory is focused on the development and evaluation of various novel magnetic resonance imaging (MRI) techniques to improve diagnosis and therapy response assessment.

    • Ananth Madhuranthakam, Ph.D.
    Medical Imaging
    Biomedical Engineering

    Mahendroo Research Lab

    We study the molecular events that drive this process in a term pregnancy and how perturbation of these processes contribute to premature birth.

    • Mala Mahendroo, PhD

    MAIA Lab

    Medical Artificial Intelligence and Automation

    • Steve Jiang, Ph.D.
    Artificial intelligence
    Biomedical Engineering

    Malladi Lab

    We study how disseminated cancer cells survive and give rise to overt metastatic lesions.

    • Srinivas Malladi, Ph.D.
    Metastasis metabolism Breast Cancer Kidney Cancer Tumor microenvironment Dormancy Metastatic Latency Epigenetic reprogramming
    Cancer Biology

    Malloy Lab

    Malloy Lab has all the tools necessary for students at all levels to lean about metabolic imaging of physiology and disease and I am excited to participate.

    • Craig Malloy, M.D.
    Biomedical Engineering Molecular Biophysics

    Malter Lab

    Malter Lab focuses on exploring and characterizing intracellular signaling pathways in the immune and nervous systems and identifying how defects/abnormalities can lead to disease.

    • James Malter, M.D.
    alzheimer's disease signaling
    Cell and Molecular Biology Immunology

    Mangelsdorf/Kliewer Lab

    The Mangelsdorf/Kliewer Lab studies two signal transduction pathways that offer new therapeutic potential for treating diseases such as diabetes, obesity, cancer, and parasitism.

    • David Mangelsdorf
    • Steven Kliewer
    Endocrinology
    Cell and Molecular Biology Cell and Molecular Biology

    Mani Lab

    The overall focus of the Ram Mani Lab is to study the molecular genetic and epigenetic events associated with cancer development.

    • Ram Mani, Ph.D.
    Cancer Biology Genetics, Development and Disease

    Marciano Lab

    The Marciano laboratory investigates fundamental aspects of kidney development and regeneration, in both health and disease.

    • Denise Marciano, M.D., Ph.D.
    developmental biology tubule formation

    Martinez Lab

    We are interested in understanding the deregulation of epigenetic and transcriptional pathways in human disease and in finding small molecules with therapeutic potential to normalize these gene expression patterns. 

    • Elisabeth Martinez, Ph.D.
    cancer epigenetics Jumonji enzymes small molecule inhibitors chemical genomics gene expression disorders Cardiac Disease infectious disease malaria histone modifications
    Cancer Biology

    Mason Lab

    The overarching goal of Mason Lab's research is the development of prognostic imaging signatures defining biomarkers of disease progression and response to therapy.

    • Ralph P. Mason, Ph.D.
    cancer imaging
    Biomedical Engineering Cancer Biology

    McAdams Lab

    McAdams Lab at UT Southwestern focuses on functional neuro-imaging studies to examine the connection between biological, psychological, and social aspects of eating disorders.

    • Carrie J. McAdams, M.D., Ph.D.

    McBrayer Lab

    Our goal is to identify the metabolic mechanisms that push cells to become cancerous and find new ways to inhibit them.

    • Sam McBrayer

    McFadden Lab

    The McFadden lab uses genetically engineered mice and human cancer cells to identify new genes and small molecules that regulate cancer cell growth.

    • David McFadden, M.D., Ph.D.
    Cancer
    Biological Chemistry Genetics, Development and Disease

    McKnight Lab

    The McKnight Lab at UT Southwestern Medical Center studies a broad spectrum of biological phenomena by use of a combination of biochemical, genetic, biophysical, bioinformatic and molecular biological approaches.

    • Steven McKnight, Ph.D.
    Biological Chemistry

    Meeks Lab

    The Meeks Lab studies olfactory neural circuits that are involved in establishing and modifying mammalian social behaviors.

    • Julian Meeks, Ph.D.

    Mendell Lab

    The Mendell laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.

    • Josh Mendell, M.D., Ph.D.
    Cancer Biology Genetics, Development and Disease

    Mendelson Lab

    Research in the Mendelson lab focuses on molecular mechanisms involved in developmental and hormonal regulation of key genes and signaling pathways in perinatal biology and female reproduction.

    • Carole Mendelson, Ph.D.
    pregnancy parturition placenta
    Cell and Molecular Biology

    Meng (Xiaosong) Lab

    The mission in the Meng Lab is to develop a better understanding of how fundamental alterations to cell polarity contribute towards development of invasive disease in kidney cancer.

    • Xiaosong Meng, M.D., Ph.D.

    Michaely Lab

    Michaely Lab focuses on the function of the proteins that control plasma membrane function. We have on-going projects investigating ARH/LDLR endocytosis and caveolae signal transduction. 

    • Peter Michaely, Ph.D.
    Biological Chemistry

    Minassian Lab

    Minassian Lab has been involved in the identification and co-discovery of the causative gene mutations in over 20 different childhood neurological diseases. 

    • Berge Minassian, M.D.
    Genetics, Development and Disease Neuroscience

    Minna Lab

    The main focus of the Minna Lab is translational (“bench to bedside”) cancer research aimed at developing new ways to diagnose, prevent, and treat lung cancer based on a detailed understanding of the molecular pathogenesis of lung cancer.

    • John D. Minna, M.D.
    Cancer Biology Cell and Molecular Biology

    Mirpuri Lab

    Mirpuri Lab is focused on neonatal innate immunity and the role of maternal diet (mHFD), dietary metabolites and innate lymphoid cells in offspring outcomes.

    • Julie Mirpuri, M.D.

    Mishra Lab

    Our research focuses on how mitochondria are embedded in normal cellular function.

    • Prashant Mishra, MD, Ph.D.

    Mizuno Lab

    Dr. Mizuno's laboratory studies autonomic control of the cardiovascular system, particularly the underlying alterations in circulatory control in type 1 or type 2 diabetes and Alzheimer’s disease.

    • Masaki Mizuno, Ph.D.
    autonomic control of the cardiovascular system

    Montillo Lab

    We develop the theory and application of deep learning to improve diagnoses, prognoses and therapy decision making.

    • Albert Montillo, Ph.D.

    Mootha Lab

    Mootha Lab uses human genetics and genomics to understand the molecular basis of Fuchs' endothelial corneal dystrophy and develop novel therapeutic strategies.

    • V. Vinod Mootha, M.D.
    Fuchs' endothelial corneal dystrophy
    Genetics, Development and Disease

    Moreland Lab

    The Moreland and Potera Labs utilize basic science approaches, in vivo models, and clinical studies to investigate cellular functions of the innate immune system.

    • Jessica Moreland, M.D.
    Neutrophil Inflammation
    Molecular Microbiology

    Morrison Lab

    Our goal is to better understand the mechanisms that maintain adult tissues and how cancer cells hijack these mechanisms to enable the formation of tumors.

    • Sean J. Morrison, Ph.D.

    Mu (Ping) Lab

    Our laboratory seeks to understand the mechanisms of antiandrogen resistance in prostrate cancer, to identify novel biomarkers, and to develop therapeutic approaches to prevent or overcome resistance.

    • Ping Mu, Ph.D.
    Cancer Biology Genetics, Development and Disease

    Mukhopadhyay Lab

    Mukhopadhyay Lab research aims to understand how the primary cilium regulates downstream pathways to ultimately drive morphogenesis in different tissues. We undertake a multi-pronged approach including proteomics, cell biology, biochemistry, reverse genetics, and generation of innovative mouse models to study regulation of signaling pathways by cilia in in cellular and organismal contexts.

    • Saikat Mukhopadhyay, M.D., Ph.D.
    Developmental signaling
    Cancer Biology Genetics, Development and Disease

    Munshi Lab

    The Munshi Lab is a dedicated group of scientists seeking to identify the molecular drivers of normal cardiac rhythm and disease-associated dysrhythmias.

    • Nikhil Munshi

    Najafov Lab

    The mission of the Najafov Lab is to understand the role of cell death in physiology and disease. Our research is focused on necroptosis and how it can be targeted to develop novel strategies for treating cancer.

    • Ayaz Najafov, PhD

    Nam (Yunsun) Lab

    The Nam lab asks how the shape of an RNA regulates its function. We study the biochemical and structural mechanisms in RNA-mediated gene regulation pathways important for normal and disease states.

    • Yunsun Nam

    Napierala Lab

    The mission of Napierala Lab is to contribute to the development of therapies and a cure for Friedreich’s ataxia (FRDA) by elucidating molecular mechanisms causing the disease, developing novel cellular and animal models of FRDA, identifying disease biomarkers and testing novel therapeutic approaches.

    • Marek Napierala, Ph.D.
    Neuroscience

    Neuromuscular Diseases Laboratory

    The focus of the Neuromuscular Center is the diagnosis and treatment of muscle diseases known as metabolic myopathies, including inherited disorders of muscle fat, carbohydrate, and mitochondrial muscle metabolism.

    • Ronald G. Haller, M.D.
    • Salman Bhai, M.D.

    Neurorepair Lab

    The Neurorepair Lab focuses on the investigation of mechanisms of injury and recovery following damage to the central nervous system (CNS), primarily following stroke and perinatal hypoxia. 

    • Mark P. Goldberg, M.D.

    Nicastro Lab

    The Nicastro Lab studies 3D ultra-structures and cell biological functions of macro-molecular complexes inside cells.

    • Daniela Nicastro
    Structural Cellbiology
    Cell and Molecular Biology Molecular Biophysics

    Nijhawan Lab

    The ultimate goal of the Nijhawan lab aims is to discover first in class drugs for the treatment of cancer. 

    • Deepak Nijhawan M.D., Ph.D.
    Drug Discovery
    Biological Chemistry

    Nitschke Lab

    Our lab works with murine disease models and employs BiochemistryMolecular and Cell Biology to investigate brain glycogen metabolism and related neurodegenerative diseases.

    • Felix Nitschke, Ph.D.
    Glycogen metabolism
    Biological Chemistry Neuroscience

    Norgard Lab

    The Norgard Laboratory is engaged in three areas of infectious disease research: syphilis, Lyme disease, and tularemia.

    • Michael Norgard, Ph.D.
    Bacterial pathogenesis
    Molecular Microbiology

    Nwariaku Lab

    The long-term goals of the Nwariaku Laboratory are to understand the cellular mechanisms that regulate endothelial dysfunction during inflammatory and neoplastic conditions with a hope to use this knowledge in designing novel therapeutic agents. 

    • Ohwofiemu Nwariaku, M.D.

    O'Donnell Lab

    O'Donnell Lab investigates mechanisms of tumor initiation, progression, and metastasis using molecular and biochemical studies and animal models.

    • Kathryn O'Donnell, Ph.D.
    Cancer Biology Genetics, Development and Disease

    Obata Lab

    The focus of the Obata Lab is to study how environmental signals (e.g., microbiota, diet, day/night cycles) shape intestinal neural circuits and immune cell networks. A variety of experimental techniques are used, including state-of-the-art imaging technologies, viral tracing of gut innervation, in vivo and ex vivo physiological assays, gnotobiotic systems and multi-omics technologies. The Obata lab is also interested in elucidating the molecular mechanisms of inter-organ communication, including the Gut-Brain axis.

     

    • Yuki Obata, Ph.D.

    Oh Lab

    The Oh lab is committed to elucidating how GPCRs work in regulating metabolism and identifying new avenues for developing therapeutics to treat metabolic syndromes such as type 2 diabetes, insulin resistance.

    • Dayoung Oh, Ph.D.
    G protein-coupled receptor type 2 diabetes obesity metabolic syndrome
    Cell and Molecular Biology

    Olson Lab

    Olson Lab studies muscle cells as a model for understanding how stem cells adopt specific fates and how programs of cell differentiation and morphogenesis are controlled during development.

    • Eric N. Olson, Ph.D.
    Genetics, Development and Disease

    Orchard Lab

    Orchard Lab at UT Southwestern Medical Center

    • Robert C. Orchard II, PhD
    Immunology Molecular Microbiology

    Orth Lab

    The Orth lab is interested in elucidation the activity of virulence factors from pathogenic bacteria so that we can gain novel molecular insight into eukaryotic signaling systems.

    • Kim Orth, Ph.D.
    Signal Transduction and Pathogenesis
    Biological Chemistry Molecular Microbiology

    Osborne Lab

    The Osborne Lab focuses on how regulation of miRNA and mRNA controls the branching of developing cells, and how disregulation of these pathways contributes to aggressive tumor behavior.

    • Jihan Osborne, Ph.D.
    Cell and Molecular Biology

    Otwinowski Lab

    The main research focus of the Otwinowski lab is on developing computational and statistical
    methods and protocols for macromolecular structure determination using X-ray crystallography.

    • Zbyszek Otwinowski

    Oz Lab

    Oz Lab combines imaging, interventional radiology, radiotracers (novel and known), and animal models to study physiology and disease pathophysiology. 

    • Orhan K. Öz, M.D., Ph.D.
    Biomedical Engineering

    Pan Lab

    The Pan laboratory uses Drosophila and mice as model systems to investigate size-control mechanisms in normal development and their pathological roles in cancer.

    • Duojia (DJ) Pan, Ph.D.
    Genetics, Development and Disease

    Parikh Lab

    The Parikih lab focuses on mechanisms underlying acute kidney injury and sepsis.

    • Samir Parikh, M.D.
    Acute kidney injury sepsis mitochondrial maintenance
    Cell and Molecular Biology

    Park Lab

    Welcome to the PARK Lab.

    Our lab focuses on:

    1. Development of novel noninvasive imaging methods for in vivo metabolism and function
    2. Identification of characteristics in metabolic diseases
    3. Clinical translations of the metabolic imaging methods
    • Jae Mo Park, Ph.D.
    glioblastoma brain Liver cardiac skeletal muscle metabolism
    Biomedical Engineering

    Parker Lab

    We study how cells duplicate their genomic material and how this process goes awry in disease.

    • Matthew Parker

    Parkland Outcomes after Prematurity Study (POPS)

    The Parkland Outcomes after Prematurity Study research group focuses on the short- and long-term effects of preterm birth, to improve lifelong health outcomes for current and future patients.

    • Kara Goss, M.D.
    • Charles Rosenfeld, M.D.
    • Luc Brion, M.D.
    Prematurity late outcomes parkland nicu database neonatal care
    Integrative Molecular and Biomedical Sciences

    Pascual Lab

    In the Pascual Lab, we study the genetic and molecular basis of neurological and neuromuscular diseases of infancy and childhood.

    • Juan M Pascual, M.D., Ph.D.
    Neuroscience

    Pawlowski Lab

    Dr. Pawlowski's laboratory studies how mutant genes affect the structure of the Organ of Corti, and searches for treatments against otitis media and infection of cochlear implants.

    • Karen Pawlowski, Ph.D.

    Pediatric Cardiac MR Imaging Lab

    Our lab focuses on the use of cardiac magnetic resonance imaging (CMR) in pediatric and congenital heart disease.

    • Mohammad Tarique Hussain, M.D., Ph.D.
    Biomedical Engineering

    Pedrosa Lab

    The mission of the Pedrosa Lab is to develop and implement new imaging methods that facilitate better morphologic and pathophysiologic characterization of diseases in the body for improved patient outcomes

    • Ivan Pedrosa, M.D., Ph.D.,
    Biomedical Engineering

    Petroll Lab

    Petroll Lab applies engineering approaches and design principles to the investigation of fundamental clinical and biological problems in ophthalmology, while providing training to graduate students, medical students, and post-docs. 

    • W. Matthew Petroll, Ph.D.
    Corneal wound healing cell mechanics
    Biomedical Engineering

    Pfeiffer (Brad) Lab

    The Pfeiffer Lab is interested in how the brain forms neural representations of experience, how those representations are consolidated into long-term memory, and how those representations can be later recalled to inform behavior.

    • Brad Pfeiffer, Ph.D.

    Pfeiffer (Julie) Lab

    Our lab uses tractable model viruses to learn about niche-specific factors that influence viral infection and evolution.

    • Julie Pfeiffer, Ph.D.
    Molecular Microbiology

    Phillips Lab

    We are developing inhibitors of pyrimidine biosynthesis and polyamine biosynthesis to treat malaria and African sleeping sickness. We study polyamine and nucleotide metabolism in African trypanosomes to learn about novel metabolism and regulation.

    • Meg Phillips, Ph.D.
    Drug Discovery
    Biological Chemistry Molecular Biophysics

    Poojary Lab

    The goal of our research is to identify key immune checkpoints of gastrointestinal disorders that could be targeted for therapeutic intervention and drug development.

    • Venuprasad K. Poojary, Ph.D.
    glioblastoma brain Liver cardiac skeletal muscle metabolism
    Immunology

    Pool Lab

    The Pool Lab studies neural circuits that provide a sense of purpose and direction to animal behavior and develops targeted gene therapies to re-engineer their function.

    • Allan-Hermann Pool, PhD

    Pouratian Lab

    Pouratian Lab's primary mission is to explore basic human neuroscientific principles as well as identify brain mapping biomarkers of disease that can drive innovative approaches to restore function to patients with neurological and psychiatric diseases.

    • Nader Pouratian, M.D., Ph.D.
    Human neuroscience
    Neuroscience

    PROSPR METRICS

    The METRICS PROSPR II Research Center studies the multilevel factors that hamper or facilitate the cervical cancer screening process and reduce disparities in vulnerable populations.

    • Jasmin Tiro, Ph.D.
    • Jennifer Haas, M.D., MSPH
    • Aruna Kamineni, Ph.D., MPH
    • Sarah Kobrin, Ph.D.

    Psychoneuroendocrine Research Program

    The Psychoneuroendocrine Research Program (PNE) at UT Southwestern Medical Center focuses on two different areas of research: substance abuse, particularly dual diagnoses (e.g., depression or bipolar disorder); and the effects of corticosteroids (e.g., prednisone) on mood and memory.

    • E. Sherwood Brown, M.D., Ph.D.
    Clinical Psychology

    Psychosocial Research/Depression Clinic

    Dr. Robin Jarrett’s Psychosocial Research and Depression Clinic aims to understand how psychosocial factors influence health in mood and related disorders.

    • Robin B. Jarrett, Ph.D.
    Clinical Psychology

    Qin Lab

    Qin Lab focuses on the development of novel synthetic transformations and strategies that will allow access to bioactive, complex natural products and efficient synthesis of pharmaceuticals and their derivatives.

    • Tian Qin, Ph.D.
    Chemical synthesis Bioactive natural products Cross Couplings Bioisosteres
    Organic Chemistry

    Radhakrishnan Lab

    We are interested in how membrane cholesterol controls diverse cellular signaling pathways to ensure lipid homeostasis, enable cell growth, and protect against infections. 

    • Arun Radhakrishnan, Ph.D.
    Cholesterol
    Biological Chemistry Molecular Biophysics

    Raj Lab

    Our mission is to decrease suffering and death from metastatic cancers

    • Ganesh V. Raj, M.D., Ph.D.
    Cancer Biology

    Rajaram Lab

    We are driven by the belief that the spatial organization of tissue provides a powerful  window into cell-cell interactions, a crucial component of disease progression and response.

    • Satwik Rajaram

    Raksha Jain Lab

    The Jain Lab is broadly interested in sex disparities in research on women's health, as well as the impact of sex hormones on airway diseases and immune response.

    • Raksha Jain, M.D., M.S.C.I.
    Adult Cystic Fibrosis Biology of sex differences gender disparities in health Pseudomonas aeruginosa
    Molecular Microbiology

    Ready Lab

    The Ready Lab is engaged in the discovery and synthesis of biologically active small molecules

    • Joseph Ready, Ph.D.
    Organic Chemistry
    Organic Chemistry

    Reddy Lab

    The Reddy Lab focuses on restoring effective antigen presentation to enhance anti-tumor immunity in breast cancers.

    • Sangetha Reddy, M.D.
    Breast Cancer immunotherapy cancer immunology Translational Research Antigen presentation
    Cancer Biology Immunology

    Reese (Michael) Lab

    Our lab is broadly focused on the cellular signaling that drives the interactions between the intracellular parasite Toxoplasma gondii and its varied hosts.

    • Michael Reese

    Reese (Tiffany) Lab

    In our lab, we investigate the interactions between these multiple pathogens and the immune system.

    • Tiffany A. Reese, Ph.D.

    Reinecker Lab

    The Reinecker laboratory unravels and targets molecular mechanisms of key human genetic variants that cause chronic inflammatory diseases and cancer by creating novel genetic mouse and human organotypic model systems.

    • Hans-Christian Reinecker, M.D.
    mucosal immunity chronic inflammatory disease Inflammatory bowel disease

    Repa Lab

    We are interested in the molecular mechanisms by which nuclear hormone receptors regulate lipid and carbohydrate metabolism in the liver, intestine, pancreatic islet, and central nervous system.

    • Joyce Repa, Ph.D.

    Reynolds (Kimberly) Lab

    We use statistical analysis of genome sequences drawn from thousands of organisms to distill out general patterns describing the organization of cellular systems and individual proteins.

    • Kimberly Reynolds

    Rice Lab

    The Rice Lab uses structure, biochemistry, reconstitution, microscopy, computer modeling, and more to study the molecular mechanisms that generate and regulate microtubule dynamics.

    • Luke Rice

    Rizo-Rey Lab

    We investigate the mechanism of neurotransmitter release using a variety of biophysical approaches, including NMR spectroscopy, X-ray crystallography, cryo-EM, molecular dynamics simulations and liposome fusion assays.

    • Jose Rizo-Rey

    Roberts Lab

    Roberts Lab focuses on understanding the cellular and circuit mechanisms for behavioral learning, learning from social experiences and from example.

    • Todd Roberts, Ph.D.
    Neuroscience

    Rohatgi Lab

    The Rohatgi lab focuses on the role of reverse cholesterol transport in atheroprotection.

    • Anand Rohatgi, M.D.
    Preventative cardiology ASCVD

    Rosen Lab

    The Rosen Lab seeks to understand the formation, regulation and functions of enigmatic, cellular compartments termed biomolecular condensates.

    • Dr. Michael Rosen
    biomolecular condensates
    Molecular Biophysics

    Rosenberg Lab

    The significance of our research is to show effective anti-Aβ42 antibody production in large animals and safety of DNA Aβ42 immunotherapy in these models to proceed with vaccination in patients at risk for Alzheimer’s disease.

    • Roger Rosenberg, M.D.
    Immunology Neuroscience

    Rothermel Lab

    Research in the Rothermel Laboratory focuses on deciphering the molecular mechanisms that control cardiac structure and function during normal development and in response to pathological stress.

    • Beverly A. Rothermel, Ph.D.
    Cardiology Circadian rhythms Down syndrome
    Cell and Molecular Biology

    Sabari Lab

    We study how biomolecular condensates organize gene regulation.

    • Ben Sabari

    Sadek Lab

    A major focus of our lab is to identify mechanisms of cardiomyocyte cell cycle regulation, and discover ways to reawaken regenerative pathways in the adult mammalian heart. We are also developing several structural, molecular, and physiological tools to interrogate the mechanistic underpinnings of various forms of cardiomyopathy.

    • Hesham A Sadek, M.D., Ph.D.
    Heart Regeneration
    Genetics, Development and Disease

    Saelices Lab

    Saelices Lab employs crystallography and cryo-EM to study amyloid deposition and design anti-amyloid tools.

    • Lorena Saelices, Ph.D.
    Amyloid diseases
    Molecular Biophysics Neuroscience

    Sandstrom Lab

    The Sandstrom Lab works to identify the fundamental molecular mechanisms through which the immune system can recognize pathogens and stress. 

    • Andrew Sandstrom
    Inflammasome NLRP1 Host-Pathogen Innate Immunology Innate Immunity Cell Death Inflammation
    Immunology

    Satterthwaite Lab

    Satterthwaite Lab studies the signals that control B lymphocyte development, activation, and differentiation into antibody-secreting plasma cells, both normally and in autoimmune diseases such as lupus. We hope that by defining these events, we can reveal new approaches to modulate antibody responses therapeutically.

    • Anne Satterthwaite, Ph.D.
    B cells autoimmunity
    Immunology

    Saunders Lab

    The Saunders Lab aims to advance our understanding of the bacterial domain of life using high throughput genetics to map the molecular interactions that underly cellular physiology.

    • Scott H. Saunders, Ph.D.

    Scherer Lab

    The main focus in our laboratory is the identification and physiological characterization of adipocyte-specific gene products and the elucidation of pathways that are an integral part of the complex set of reactions that drive adipogenesis.

    • Philipp Scherer Ph.D.

    Schizophrenia/Tamminga Research

    The lab investigates the nature and treatment of cognitive deficits commonly seen in schizophrenia and related disorders.

    • Carol A. Tamminga, M.D.
    Psychosis
    Clinical Psychology Neuroscience

    Schmid Lab

    We study clathrin-mediated endocytosis (CME), the major and best understood endocytic pathway.  

    • Marcel Mettlen, Ph.D.
    Cell and Molecular Biology

    Schoggins Lab

    The Schoggins Lab studies innate immunity at the virus-host interface. We are interested in mechanisms of cellular antiviral defense and the role these responses play during viral disease.

    • John W. Schoggins
    Antiviral immunity
    Immunology Molecular Microbiology

    Schroeder Lab

    What are the causes and consequences of cytoskeletal diversification?

    • Courtney Schroeder

    Seemann Lab

    The Seemann Lab studies the molecular mechanisms governing the function and inheritance of the mammalian Golgi apparatus.

    • Joachim Seemann, Ph.D.
    Cancer Biology Cell and Molecular Biology

    Shabel Lab

    We aim to characterize the ways in which reward systems vary from individual to individual and understand how this variation determines propensity for depression and addiction-like behavior.

    • Steve Shabel, Ph.D.
    Neuroscience of Motivated Behavior
    Neuroscience

    Shah (Meena) Lab

    Nutrition and exercise intervention to reduce cardiovascular risk factors; weight loss and maintenance in bariatric surgery patients; role of nutrition and exercise in cardiovascular risk factors; influence of the eating environment on energy intake.

    • Meena Shah, Ph.D.

    Shahmoradian Lab

    The Shahmoradian lab focuses on some of the smallest levels of biological function, to see how disease-causing proteins behave in their crowded native intracellular setting.

    • Sarah Shamoradian, Ph.D.
    tau protein alzheimer's disease protein aggregation structural biology
    Molecular Biophysics

    Shakkottai Lab

    Our lab researches Cerebellar Dysfunction, Brainstem Dysfunction, High-Throughput Screen, and Human Studies.

    • Vikram Shakkottai, M.D., Ph.D.
    Molecular Biophysics Neuroscience

    Shaul / Mineo Lab

    The overall goal of our laboratory is to discover the processes in endothelial cells that govern cardiovascular and metabolic health and disease. 

    • Phil Shaul, M.D.
    • Chieko Mineo, Ph.D.
    Endothelial Cell Biology
    Genetics, Development and Disease Genetics, Development and Disease

    Shay Lab

    Shay Lab is interested in the relationships between aging and cancer and have focused on the role of the telomeres and telomerase in these processes.

    • Jerry Shay, Ph.D.
    aging & cancer
    Cancer Biology Genetics, Development and Disease

    Shiloh Lab

    The ultimate aim of the Shiloh Lab is to contribute to the development of vaccines and treatments for Mycobacterium tuberculosis (Mtb).

    • Michael Shiloh, M.D., Ph.D.
    Tuberculosis Microbial pathogenesis
    Immunology Molecular Microbiology

    Sieber Lab

    Our primary goal in Sieber Lab is to understand the dynamic changes in metabolic programs that support developmental and disease progression. 

    • Matt Sieber, Ph.D.
    Genetics, Development and Disease

    Siegwart Lab

    We aim to globally understand how the physical and chemical properties of materials affect interactions with biological systems in the context of improving therapies.

    • Daniel Siegwart

    Sinnett Lab

    The Sinnett Lab develops and assesses gene therapies for rare neurodevelopmental disorders.

    • Sarah Sinnett, Ph.D.

    Skapek Lab

    Our laboratory work examines the interface between cancer and developmental biology.

    • Stephen Skapek, M.D.
    Cancer Biology Genetics, Development and Disease

    Smith (Myles) Lab

    Smith Lab strives to develop enabling tools for organic synthesis, allowing bioactive molecules of great complexity to be prepared in a concise and sustainable fashion.

    • Myles Smith, Ph.D.
    Organic Chemistry
    Organic Chemistry Biological Chemistry

    SoRelle Lab

    Our lab aim is to discover and translate findings into diagnostic and therapeutic solutions for patients with allergy.

    • Jeffrey SoRelle, M.D.
    Immunology

    Sorrell Lab

    The Sorrell laboratory utilizes integrative approaches that include metabolomics, transcriptomics, organoid cultures, live microcopy, and animal models, to investigate fundamental pathways that control the uptake of nutrients and the biosynthesis of macromolecules in proliferative cells.

    • Maralice Conacci-Sorrell, Ph.D.
    Cancer Biology Cell and Molecular Biology

    Sreelatha Lab

    Our laboratory is interested in investigating the molecular mechanisms of selenoproteins in health and disease.

    • Anju Sreelatha, Ph.D.
    Selenoprotein O
    Biological Chemistry Cell and Molecular Biology

    Story Lab

    The Story Lab has a robust research portfolio that includes radiation-induced carcinogenesis associated with the unique environment of space, molecular markers of carcinogenic risk after radiation, intrinsic radiosensitivity, modulation of drug and radiation response by pentaazamacrocyclic ring compounds with dismutase activity, high-dose per fraction radiotherapy, charged particle radiotherapy, the mechanism(s) of action of Tumor Treating Fields, and the enhancement of cancer therapy through radiation and drug combination used concomitantly with Tumor Treating Fields.

    • Michael Story, Ph.D.
    radiation biology
    Cancer Biology

    Stowe Lab

    The Stowe Lab conducts both bench and clinical research with the goal of deepening the understanding of the etiology of stroke as well as finding better therapies for those who have suffered a stroke.

    • Ann Stowe, Ph.D.

    Strand Lab

    The main goals of the Strand Lab are to create accurate cellular atlases of the human and mouse lower urinary tract, characterize the molecular and cellular alterations in human lower urinary tract disease, and build appropriate models of the human disease in novel mouse models.

    • Douglas Strand, Ph.D.
    Benign prostatic hyperplasia
    Cancer Biology Genetics, Development and Disease

    Stroud Lab

    We investigate epigenome regulation of nervous system development and homeostasis. We are particularly interested in understanding how disruption of these mechanisms lead to neurological disorders.

     

    • Hume Stroud

    Structural Biology Lab

    The UTSW Structural Biology Laboratory (SBL) was formed to add macromolecular crystallography to the scientific toolkit available to the general researcher.

    • Diana R. Tomchick, Ph.D.
    Biological Chemistry Molecular Biophysics

    Sumer Lab

    Sumber Lab conducts translational research that seeks to uncover the mysteries of cancer and develop powerful methods for its detection and cure.

    • Baran Sumer, M.D.
    Cell Metabolism Immunology Surgical Imaging
    Biomedical Engineering

    Sun (Lu) Lab

    The Sun Lab studies the most numerous cells in the brain, called “glial cells”.

    • Lu Sun, Ph.D.
    neuron-glia interaction oligodendrocytes myelination neuroscience neurological disorders multiple sclerosis neonatal white matter injury
    Genetics, Development and Disease Neuroscience

    Sun (Xiankai) Lab

    The Sun Lab is focused on developing novel imaging probes for noninvasive assessment of specific biomarkers implicated in disease initiation, progression, or regression, and exploring the translational roles of imaging probes and/or methodologies in clinical medicine practice with the ultimate goal to improve the outcome of patient care.

    • Xiankai Sun, Ph.D.
    Biomedical Engineering

    Syeda Lab

    Our lab's focus is to develop novel tools aimed at understanding ion channel physiology and molecular mechanism in an isolated membrane environment.

    • Dr. Ruhma Syeda
    Piezo1 Ion channels Mechanotransduction Mechanically activated ion channels Lipid bilayers Single channels Electrophysiology
    Molecular Biophysics Neuroscience

    Tagliabracci Lab

    The Tagliabracci Lab studies the phosphorylation of extracellular proteins by a novel family of secreted kinases. This kinase family is so different from canonical kinases that it was not included as a branch on the human kinome tree.

    • Vincent "Vinnie" Tagliabracci, Ph.D.
    Pseudokinases
    Cell and Molecular Biology Genetics, Development and Disease

    Takahashi Lab

    The Takahashi Lab is interested in understanding the genetic and molecular basis of circadian rhythms as well as other complex behaviors.

    • Joseph Takahashi, Ph.D.
    Neuroscience

    Tambar Lab

    The Tambar Group develops new strategies and concepts in synthetic chemistry to address challenging problems in chemistry and biology.

    • Uttam K. Tambar
    Organic Chemistry
    Organic Chemistry Biological Chemistry

    Terada Lab

    The Terada Lab is focused on several areas of cellular signaling which control basic mechanical and cell fate decision programs. 

    • Lance Terada, M.D.
    Lung cancer
    Cell and Molecular Biology

    Terman Lab

    Research in my laboratory focuses on better understanding the molecules and mechanisms that assemble axonal connections with a goal of utilizing this knowledge to encourage axons to reestablish their connections after trauma or disease.

    • Jonathan Terman, Ph.D.
    Neuroscience

    Texas Computational Memory Lab

    Texas Computational Memory Lab research focuses on analyzing the neural activity that gives rise to successful memories and facilitates memory retrieval. 

    • Bradley Lega
    memory encoding retrieval
    Neuroscience

    Toprak Lab

    We investigate genetic and molecular basis of phenotypic diversity observed in nature by using a range of methodologies such as whole genome sequencing, fluidics, long-term evolution experiments, and large-scale combinatorial mutagenesis. 

    • Erdal Toprak, Ph.D.

    Trivedi Lab

    The Center for Depression Research and Clinical Care (CDRC) is nationally recognized for its cutting edge research in unipolar and bipolar depression. The research conducted within the center brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.

    • Madhukar H. Trivedi, M.D.
    Clinical Psychology

    TRUST Lab

    Translational Research in UltraSound Theranostics (TRUST) Lab at UT Southwestern

    • Robert Mattrey, M.D.
    Biomedical Engineering

    Tsai Lab

    Tsai Lab studies the cellular and molecular mechanisms of synapse and neural circuit development.

    • Peter Tsai M.D. Ph.D
    Autism neurodevelopmental disorders cerebellum
    Neuroscience

    Tu Lab

    The Tu Lab is investigating how a variety of cellular processes and decisions are coordinated with metabolic state, and how the dysregulation of these mechanisms might be linked to disease and aging.

    • Benjamin P. Tu

    Turer Lab

    The Turer Lab is interested in finding genes with novel functions in intestinal immune homeostasis. Our projects generally involve a mix of experimental approaches examining both the intestinal epithelium as well as hematopoietic causes of intestinal inflammation.

    • Emre Erol Turer, M.D., Ph.D.

    Tzen Lab

    spinal cord injury, wound, pressure ulcer

    • Yi-Ting Tzen

    Ufret-Vincenty Lab

    The long-term goal of the Ufret-Vincenty Lab is to develop new therapeutic strategies for age-related macular degeneration (AMD).

    • Rafael L. Ufret-Vincenty, M.D.

    Unger Lab

    In addition to glucagon and t1dm, the Unger lab studied the interrelationships between obesity and type 2 diabetes (t2dm) and metabolic syndrome.

    • Roger Unger

    van Oers Lab

    Children with in-born errors of immunity are prone to life-threatening viral, bacterial, and fungal infections. We study the causes of their immune system problems, combining clinical insights and mouse models genocopying the various mutations. This work includes a profiling of immune responses to infections (e.g., COVID-19) in normal healthy individuals and patients.

    • Nicolai S.C. van Oers, Ph.D.
    Thymus functions
    Immunology Molecular Microbiology

    Vega Lab

    Dr. Vega and co-workers have discovered three other causes of high LDL. First, she found that some patients have abnormal LDL particles that cannot be removed from circulation because the abnormal LDL does not recognize the receptors. 

    • Gloria Lena Vega, Ph.D.
    Biological Chemistry

    Vernino Lab

    Vernino Lab focuses on the mechanisms of autoimmune disorders of the nervous system. We use a variety of techniques including animal physiology, cellular electrophysiology, histology, and immunology. 

    • Steven Vernino, M.D., Ph.D.
    Autoimmune neurology

    Vinogradov Lab

    The main focus of the Vinogradov Lab is developing MRI methods that are based on the intrinsic biochemical processes and physical properties of the tissue: chemical exchange rearrangements, molecular networks, and relaxation.

    • Elena Vinogradov, Ph.D.
    Biomedical Engineering

    Vitetta Lab

    Our research efforts are currently focused in four areas of cancer research.

    • Ellen S. Vitetta, Ph.D.
    Immunology

    Volk Lab

    The Volk Lab's research focuses on the hippocampus as they research how the brain balances dynamic learning and persistent memory.

    • Lenora Volk, Ph.D.
    Memory Learning hippocampus KIBRA synaptic plasticity AMPA receptor neurodevelopmental disorder
    Neuroscience

    Vongpatanasin Lab

    Dr. Vongpatanasin studies neural control of blood pressure and the influence of various hormones and antihypertensive agents on autonomic control of blood pressure in humans. 

    • Wanpen Vongpatanasin, M.D.
    antihypertensive agents

    Wai Lab

    The research of Wai Lab focuses on female pelvic floor disorders and understanding the functional anatomy of the lower urinary tract and anal sphincter.

    • Clifford Wai, M.D.

    Wakeland Lab

    The Wakeland Lab utilizes state-of-the-art genomic strategies to investigate the diversity of the human and mouse immune systems. 

    • Edward Wakeland, Ph.D.
    Immunology

    Wang (Boyuan) Lab

    The Wang Lab uses chemical biology tools to study the molecular mechanisms underlying interesting bacterial behaviors.

    • Boyuan Wang, Ph.D.
    Biological Chemistry

    Wang (Fei) Lab

    The broad research interest of Fei Wang lab is in dissecting molecular mechanisms of essential membrane-associated cellular events in eukaryotic cell development.

    • Fei Wang, Ph.D.
    meiosis autophagy
    Biological Chemistry Cell and Molecular Biology

    Wang (Jerry) Lab

    We apply advanced MRI technologies to study many different diseases.

    • Zhiyue Jerry Wang, Ph.D.

    Wang (Jijia) Lab

    Dr. Wang's primary research interest includes the statistical methodology development for the design and analysis of clinical trials, as well as the evaluation of repeated measurements and correlated data. 

    • Jijia Wang, Ph.D.

    Wang (Richard) Lab

    Our research focuses on how the conserved signaling pathways that underlie normal skin development are altered during the development of non-melanoma skin cancers and inflammatory skin disease.

    • Richard Wang, M.D., Ph.D.
    Skin cancer
    Biological Chemistry Cancer Biology

    Wang (Tao) Lab

    Our research revolves around using state-of-the-art bioinformatics and biostatistics approaches to study the implications of tumor immunology for tumorigenesis, metastasis, prognosis, and treatment response in a variety of cancers.

    • Tao Wang

    Wang (Weiwei) Lab

    We study ion channel clusters. To study such clusters without the complications arising from the complex cellular environment, components from cells are purified and studied in isolation.

    • Weiwei Wang, Ph.D.
    Molecular Biophysics

    Wang (Yingfei) Lab

    The Wang Lab studies neurodegeneration and cell death induced by brain injury, mitochondrial dysfunction, and/or genome instability.

    • Yingfei Wang
    Cell Death Neurodegeneration
    Genetics, Development and Disease Neuroscience

    Waugh Lab

    Dr. Waugh is a physician-scientist whose research focuses on the structural brain abnormalities that lead to dystonia, a movement disorder that leads muscles to twist and contort into painful positions.

    • Jeff Waugh M.D., Ph.D.
    Dystonia
    Neuroscience

    Weaver Lab

    The over-arching theme of the Weaver Lab is to deeply understand how proteolytic factors mediate diverse physiological functions.

    • Benjamin Weaver

    Welch Lab

    The Welch Lab has a primary interest in developing materials and medical devices for use in treatment of congenital heart disease.

    • Tre Welch, Ph.D.
    Biomedical Engineering

    Wert Lab

    The Wert laboratory studies the post-mitotic neuronal cells of the retina, particularly the photoreceptor cells. Our goal is to discover and understand the mechanisms underlying retinal degenerative disease, and to provide novel therapeutics for these complex degenerative disorders using gene therapy and genome engineering technologies, human stem cell transplantations, and metabolic rescue.

    • Katherine J. Wert, Ph.D.
    Retinal degenerative disease Photoreceptor degeneration
    Genetics, Development and Disease Neuroscience

    Westover Lab

    Our laboratory was established in 2012 in the Department of Biochemistry at UT Southwestern Medical Center. The Biochemistry Department features exceptional depth of expertise in both biology and chemistry. 

    • Ken Westover, M.D., Ph.D.
    Targeted cancer therapy
    Biological Chemistry Cancer Biology

    Wetzel Lab

    Wetzel Lab targets critical steps in the parasite’s life cycle in order to develop therapeutics for Leishmaniasis.

    • Dawn Wetzel, M.D., Ph.D.
    Cell and Molecular Biology Molecular Microbiology

    White Lab

    White, Perrin Lab - Labs - Research

    • Perrin White

    Whitehurst Lab

    The Whitehurst Lab uses RNAi-based functional genomics to identify gene products that support viability and/or modulate chemotherapeutic sensitivity in tumor cells. 

    • Angelique Whitehurst, Ph.D.
    Cancer Biology Cell and Molecular Biology

    Williams Lab

    We are interested in understanding at a cellular level the neural control of energy balance and glucose metabolism, and elucidating how these events may participate in human disease.

    • Kevin W. Williams

    Wilson (Kathleen) Lab

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    • Kathleen Wilson

    Wise Lab

    Scientists in the Center for Pediatric Bone Biology and Translational Research work to discover the underlying causes of poorly understood musculoskeletal disorders in children, and to understand the fundamental steps that lead to disease.

    • Carol A. Wise
    • Jonathan Rios

    Wolf Lab

    Wolf Lab's research focuses on the roles of urinary proteins Uromodulin and Mucin-1 in health and disease.

    • Matthias Wolf, M.D.
    Cell and Molecular Biology

    Woodruff Lab

    We use live-cell microscopy, nano-rheology, and synthetic biology to understand oocyte ageing, embryogenesis, and cancer onset.

    • Jeff Woodruff, Ph.D.
    Protein Phase Separation
    Cell and Molecular Biology Molecular Biophysics

    Word Lab

    In our laboratory, we utilize molecular and cellular approaches to decipher mechanisms of extracellular matrix remodeling of the female reproductive tract in both physiologic states (e.g., during pregnancy, parturition, and the puerperium) and pathologic conditions (pelvic organ prolapse, urinary incontinence, and injury of the external anal sphincter).

    • R. Ann Word, M.D.

    Wu (Jiang) Lab

    We are interested in the function of chromatin regulation of signaling pathways important for neural development, brain tumor growth and autism pathogenesis. 

    • Jiang Wu, Ph.D.
    Genetics, Development and Disease Neuroscience

    Wu (Jun) Lab

    The Wu Laboratory mainly focuses on using stem cell models to gain novel insights in mammalian development and develop regenerative medical applications.

    • Jun Wu, Ph.D.
    stem cell interspecies chimeras blastocyst complementation stem cell embryo models
    Cell and Molecular Biology Genetics, Development and Disease

    Wu (Sihan) Lab

    The long-term goal of our lab is to understand the functions of ecDNA and how ecDNA is maintained in cancer. 

    • Sihan Wu

    Wu (Tuoqi) Lab

    The Wu Lab focuses on understanding the molecular pathways that govern T cell differentiation and function during infection and cancer.

    • Tuoqi Wu Ph.D.
    T cell exhaustion T cell stemness chronic viral infection cancer immunotherapy aging single-cell multi-omics
    Cancer Biology Immunology

    Xiao Lab

    I am interested in developing computational models and algorithms for big data to predict patients' outcomes, which can help clinicians to tailor treatment plans for individual patients.

    • Guanghua Xiao

    Xie (Xiao-Song) Lab

    The focus of our current research is the biochemistry and molecular characterization of ABCG5/ABCG8 transporter, aiming at understanding the mechanism by which this transport system operates to translocate cholesterol cross membranes.

    • Xiao-Song Xie, Ph.D.

    Xie (Yang) Lab

    Our team is interested in developing computational models to predict patient outcomes, which will allow clinicians to tailor treatment plans for individual patients.

    • Yang Xie

    Xing Lab

    Welcome to the Xing Lab in the Eugene McDermott Center for Human Growth and Development!

    • Chao Xing, Ph.D.
    bioinformatics statistical genomics statistical genetics genetics biostatistics human disease
    Biomedical Engineering Genetics, Development and Disease

    Xu (Che) Lab

    Dr. Xu’s primary research interests include tissue engineering of the vocal fold, anatomy and physiology of voice production, and laryngeal biomechanics. 

    • Che Xu, Ph.D.

    Xu (Jian) Lab

    Our goal is to better understand the gene regulatory processes that control stem cell development and cancers.

    • Jian Xu

    Xu (Lin) Lab

    The lab focuses on developing bioinformatics algorithms and deep learning models to identify new disease genes and therapeutic targets for human diseases, as well as development and maintenance of data management system for genomic and clinical databases.

    • Lin Xu

    Xu (Wei) Lab

    Wei Xu Lab strives to achieve a mechanistic understanding of fundamental cognitive processes whose dysfunctions are implicated in neuropsychiatric disorders.

    • Wei Xu
    neural circuits Learning and memory neuroscience technology
    Neuroscience

    Xuelian Luo Lab

    The Luo lab studies the molecular mechanisms of intracellular signal transduction, focusing on the spindle checkpoint and the Hippo tumor-suppressor pathway.

    • Xuelian "Sue" Luo, Ph.D.
    Molecular Biophysics

    Xuewu Zhang Lab

    The Zhang lab studies intra- and inter-molecular interactions to understand how signaling proteins are regulated, using biochemistry, X-ray crystallography, cryo-EM and cell biology.

    • Xuewu Zhang, Ph.D.
    structural biology signaling transmembrane receptor axon guidance Innate Immunity
    Molecular Biophysics

    Yamamoto Lab

    Our lab focuses on the neural dynamics for successful memory access and retrieval during episodic working memory tasks to elucidate the neural circuit mechanism in the hippocampal-cortical network.

    • Jun Yamamoto, PhD
    Neuroscience

    Yamazaki Lab

    Since I began studying the biological rhythms of insects during graduate school, I have been fascinated with the accuracy of the circadian timing system and the phenomenal influence of the circadian clock on almost all biological activities. This fascination has fueled my interest in learning about circadian rhythms for more than a quarter of a century.

    • Shin Yamazaki, Ph.D.
    Neuroscience

    Yan Lab

    The Yan Lab studies molecular mechanisms of innate immunity in infection, autoimmune diseases, cancer immunology and neurodegenative diseases.

    • Nan Yan, Ph.D
    Innate Immunity
    Immunology Molecular Microbiology

    Yao Lab

    Yao Laboratory identifies molecular and cellular mechanisms that determine the efficacy of vaccines and immunotherapies against infectious diseases and cancers.

    • Chen Yao, Ph.D.

    Yin (Helen) Lab

    We study how the membrane lipid phosphatidylinositol 4,5 bisphosphate (PIP2) regulates the actin scaffold in proliferating and autophagic cells.

    • Helen Yin, Ph.D.
    Cell and Molecular Biology

    Young-Jai Lab

    We are interested in how metabolism regulates various behaviors. We use two invertebrate model systems of C. elegans and D. melanogaster, ultimately aiming to unveil conserved neuro-molecular mechanisms throughout animals including mammals.

    • Young-Jai You

    Yu (Gang) Lab

    Yu Lab is interested in the molecular and cellular basis of Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and related neurodegenerative disorders.

    • Gang G. Yu, Ph.D
    Cell and Molecular Biology Neuroscience

    Zaki Lab

    Zaki Lab's research focuses on the the study of gastrointestinal inflammation and cancer.

    • Hasan Zaki, Ph.D.
    Inflammation host-pathogen interaction Gut microbiome Inflammasome Innate Immunity Cancer Gastrointestinal disorders lipids Cell Signaling
    Cancer Biology Immunology

    Zang (Qun Sophia) Lab

    Zang Lab investigates the molecular mechanisms underlying the pathogenesis of sepsis. We use the heart as a model, since cardiac dysfunction is a vital component of multi-organ failure during sepsis.

    • Qun Sophia Zang, Ph.D.

    Zeng Lab

    Zeng Lab is interested in understanding at the molecular level key questions lying at the interface between biochemistry, cell biology, metabolic and neural physiology, including the bidirectional communication between autonomic neurons and adipocytes, the molecular basis of the phenotypic plasticity, or the lack of, in brown, beige and white adipocytes, and roles of uncharacterized enzymatic pathways in adipose thermogenesis.

    • Xing Zeng
    Adipocyte Lipid Droplet Lipid Metabolism Sympathetic Innervation
    Cell and Molecular Biology

    Zhan Lab

    Zhan Lab's mission is to advance medical genetics research through cutting-edge statistic models and computationally efficient software tools

    • Xiaowei Zhan
    microbiome antibiotic resistance genome wide association analysis deep learning spatial transcriptomics data science
    Biomedical Engineering

    Zhang (Chengcheng "Alec") Lab

    The lab's long-term goal is to illuminate the function of immune surface molecules and to open up a new research field at the interface of cancer, immunology, and stem cell research. Zhang Lab also actively develops novel therapies for cancer treatment.

    • Chengcheng (Alec) Zhang, Ph.D.
    cancer immunology
    Cancer Biology Immunology

    Zhang (Chun-Li) Lab

    Zhang (Chun-Li) Lab research focuses on cellular plasticity in the adult nervous system and modeling human neurodegenerative diseases. We use cell culture and genetically modified mice as model systems. Molecular, cellular, electrophysiological, and behavioral methods are employed.

    • Chun-Li Zhang, Ph.D.
    in vivo reprogramming neurogenesis glial cells astrocytes NG2 glia chun-li zhang utsw utsouthwestern
    Genetics, Development and Disease Neuroscience

    Zhang (Hong) Lab

    Enter a description of the lab. This information will appear on the lab listing page.

    • Hong Zhang

    Zhang (Qing) Lab

    Our lab currently studies hypoxia, prolyl hydroxylase, and VHL signaling in cancer, especially breast and renal cell carcinomas.

    • Qing Zhang, Ph.D.
    Breast Cancer Kidney Cancer Hypoxia VHL Post-translational modification Oxygen Sensing signaling
    Cancer Biology Genetics, Development and Disease

    Zhang (Siyuan) Lab

    The central theme of our research program in our laboratory is to explore the co-evolution between tumor cells and the tumor microenvironment (TME) during the development of therapeutic resistance and metastatic relapse.

    • Siyuan Zhang

    Zhang (Wenhao) Lab

    Our lab combines normative theories and biologically plausible neural circuit models to study the principles of neural information processing, in order to answer how perception, cognition, and behavior emerge from neural circuits. 

    • Wen-hao Zhang

    Zhang (Zhao) Lab

    In the Zhang Lab, we seek to understand the key molecular mechanisms to maintain energy balance in our body, with the long-term goal of creating novel therapeutic strategies.

    • Zhao Zhang, Ph.D.
    Metabolic disease
    Genetics, Development and Disease

    Zheng Lab

    Zheng Lab is dedicated to women’s health care, specializing in gynecologic pathology, particularly in oncologic and hormone related pathology within the GYN Pathology field.

    • Wenxin Zheng, M.D.

    Zhong Lab

    Zhong Lab studies studies inflammation, mitochondrial stress responses, tumor immunology and obesity-associated liver disorders.  

    • Zhenyu Zhong Ph.D.
    Cancer Biology Immunology

    Zhou Lab

    Our aim is to develop computational methods to unveil the hidden biological circuitries behind the data, from understanding sequence-based regulations to the evolution of genomes and their impact to diseases.

    • Jian Zhou

    Zhu (Hao) Lab

    Our lab is interested in understanding the relationship between injury, regeneration, and cancer. We are focused on identifying the genes and mechanisms that regulate regenerative capacity in the liver and understanding how these contribute to hepatocellular carcinoma development.

    • Hao Zhu

    Zia Research Group

    The Zia Research Group focuses on clinical and translational hematology research to improve the understanding of pediatric thrombotic and hemostatic disorders with the long-term goal of improving the lives of affected children and young adults with these disorders.

    • Ayesha Zia, M.D.

    Zigman Lab

    We investigate the neuro-hormonal basis for complex eating behaviors and blood glucose control, with the ultimate goal of designing new methods to prevent and treat extremes of body weight, blood glucose, and associated disorders of mood and metabolism.

    • Jeffrey Zigman