Our laboratory is interested in improving treatment for patients with glioblastoma (GBM) and other cancers. We work on understanding signal transduction pathways involved in the pathogenesis of cancer. Recent work has focused on investigating mechanisms of resistance to targeted treatment in GBM and lung cancer. We are also interested in mechanisms regulating invasion in GBM.
Our lab specializes in developing advanced algorithms for medical image analysis and pioneering artificial intelligence (AI) models tailored for medical research. These innovative tools are essential in improving diagnostic accuracy and assessing surgical outcomes with greater precision. We leverage a comprehensive approach, integrating both radiological and non-radiological imaging techniques to deliver thorough and accurate analyses.
We employ a variety of methods including evolutionary analysis, genomics, and molecular biology to study the biology of infection.
The Harbour Lab uses genomic technologies and genetically engineered human cells and mouse models to develop biomarkers and elucidate mechanisms of tumor evolution and metastasis in uveal melanoma and retinoblastoma.
Our focus is on gaining a greater understanding of how bacteria on the skin surface affect skin health and diseases.
The Hattori lab studies how neural circuits integrate sensorimotor information, memory, and internal state to guide behavior.
The goal of our research lab is to identify the early steps in the pathogenesis of AMD, and to investigate the novel methods to treat and even to prevent its development.
Heart-Brain Connection Program
The Hendrixson Lab is largely focused on exploring the biology of polarly-flagellated bacterial pathogens….and junk food, donuts, and cake.
The primary goal of Henkemeyer laboratory is to understand the biochemical signals that regulate cell-cell interactions during embryonic development.
Henne lab is interested in how cells spatially organize their metabolism to adapt to a constantly changing environment.
The Henning lab develops novel ultra-high field MRI and metabolic MRI methodology for human application and translates it to neuroscientific, physiological and clinical trials in brain, spine, heart and muscle disorders.
The goal of the Herz Lab is to identify the underlying biochemical principles of human diseases & disorders in order to design novel therapies to prevent, delay, or cure them.
We do difficult experiments at the frontier of cell physiology, often with our own methods and always with our own hands.
We strive to decipher mechanisms of structural, functional, and electrical remodeling in heart disease with an eye toward therapeutic intervention.
Our lab focuses on investigating the brain circuits implicated in treatment resistant depression with the ultimate goal of developing novel therapies for this devastating disease.
Our research program focuses on understanding how dysregulation of lipid uptake and trafficking contributes to human diseases.
We explore questions on genomes using a systems biology approach: developing and employing integrative approaches at the interface of gene regulation, epigenetics, single-cell genomics, and bioinformatics.
We are broadly interested in understanding how resident intestinal bacteria influence the biology of humans and other mammalian hosts.
A major focus of the Horton lab is to determine how these transcriptional regulators contribute to the development of steatosis in various disease processes such as diabetes, obesity, and beta-oxidation defects. A second area of investigation centers on determining the function of PCSK9, a protein that is involved in determining plasma LDL cholesterol levels through its ability to post-transcriptionally regulate the expression of the LDL receptor in liver.
We are multidisciplinary team of clinicians and scientists, focusing on liver cancer risk-predictive molecular biomarkers specific to clinical contexts (ex. geographic region, liver disease etiology, and patient race/ethnicity) individual risk-stratified personalized cancer screening.
In diseases like cancer, signaling pathways can be corrupted by mutations that cause the cells to grow and spread uncontrollably. Our lab is interested in understanding how these defective pathways reprogram cellular metabolism to drive cancer growth.
Jer-Tsong Hsieh Lab research interests focus on key molecular mechanisms leading to urologic cancer progression, development of precision medicine of cancer therapy assisted with non-invasive molecular imaging.
Ming-Chang Hu Lab strives to offer novel insight into the cellular and molecular mechanisms of AKI progression to CKD and cardiovascular diseases (vascular calcification and uremic cardiomyopathy) development in CKD, and set up a solid basis for preclinical and clinical study in the future.
