Our research aims to obtain a comprehensive picture of how genomic stability and chromatin dynamics affect neuronal functions, including learning behaviors, and to apply this knowledge to combat neurological disorders.
We are interested in understanding the deregulation of epigenetic and transcriptional pathways in human disease and in finding small molecules with therapeutic potential to normalize these gene expression patterns.
The McKnight Lab at UT Southwestern Medical Center studies a broad spectrum of biological phenomena by use of a combination of biochemical, genetic, biophysical, bioinformatic and molecular biological approaches.
The Mendell laboratory investigates fundamental aspects of post-transcriptional gene regulation, noncoding RNA regulation and function, and the roles of these pathways in normal physiology, cancer, and other diseases.
The main focus of the Minna Lab is translational (“bench to bedside”) cancer research aimed at developing new ways to diagnose, prevent, and treat lung cancer based on a detailed understanding of the molecular pathogenesis of lung cancer.
Our laboratory seeks to understand the molecular mechanisms of targeted therapy resistance in various cancers, to identify novel biomarkers, and to develop therapeutic approaches to prevent or overcome resistance.
Mukhopadhyay Lab research aims to understand how the primary cilium regulates downstream pathways to ultimately drive morphogenesis in different tissues. We undertake a multi-pronged approach including proteomics, cell biology, biochemistry, reverse genetics, and generation of innovative mouse models to study regulation of signaling pathways by cilia in in cellular and organismal contexts.