Search Labs

The Neuro-Oncology Translational Research Laboratory studies primary brain tumors from pure basic science through the continuum to clinical trials. 

Our goal is to employ cryo-EM to determine high resolution structures of important membrane protein complexes involved in cellular signaling, including cellular receptors and ion channels. We also combine structural approaches with functional studies to reveal the structure-function relationships of these membrane proteins.

The Bailey lab focuses on developing gene therapies for neurological disorders. We work on monogenetic pediatric disorders, including SLC13A5 epileptic encephalopathy, multiple sulfatase deficiency, Charcot Marie Tooth disease type 4J, giant axonal neuropathy and ECHS1 deficiency.

We study the role of chromatin regulation in cell fate decisions.

Our laboratory has characterized many of the transporters responsible for proximal tubule acidification and solute transport

The Beckham lab is a dynamic multidisciplinary laboratory that studies viral pathogenesis and neuroimmune responses.

Dr. Bedimo studies strategies for optimally managing drug-resistant HIV patients, analyzing metabolic abnormalities in HIV patients, and studying the effects of HCV co-infection. 

We combine classical genetics with modern technology to understand human physiology and search for breakthrough treatments for diseases.

The Bezerra Lab current studies investigate how developmental defects increase the susceptibility of the biliary epithelium to infectious and toxic insults.

The Bioinformatics Lab provides services to manage and analyze next-generation sequencing data.

This facility is the home to five high field solution NMR spectrometers ranging from 500 MHz to 800 MHz and a Solid State 600 MHz DNP system, primarily in support of studies of macromolecular structure, function and dynamics.

Our research is largely aimed at understanding how an organism detects mechanical force.

The Bowen Lab focuses on the development of hybrid positron emission tomography (PET) (e.g. PET-CT and PET-MR) tools to enable precision imaging for the care and study of oncology, neurology, and cardiology patients.

The Brekken laboratory, located in the Hamon Center for Therapeutic Oncology Research, studies tumor-host interactions with a particular emphasis on extracellular matrix (ECM) and angiogenesis.

Our laboratory discovered a family of transcription factors called sterol regulatory element-binding proteins (SREBPs) that control cholesterol and fatty acid synthesis. 

Dr. Brown's Psychoneuroendocrine Research Program (PNE) at UT Southwestern Medical Center focuses on two different areas of research: substance abuse, particularly dual diagnoses (e.g., depression or bipolar disorder); and the effects of corticosteroids (e.g., prednisone) on mood and memory.

• To understand how kidney cancer develops at the molecular level.
• To translate our findings into new treatments for kidney cancer patients.
• To train the next generation of physicians and scientists.

The Burgess lab uses Nuclear Magnetic Resonance spectroscopy and Mass Spectrometry in conjunction with stable isotope (non-radioactive) tracers to study how metabolic flux is altered by disease, pharmacology, or targeted genetic interventions.

Burstein Laboratory focuses on understanding the regulation of the inflammatory response at a molecular level, and elucidating how these events may participate in human disease.

The Busch Lab develops optical technologies for minimally and non-invasive bedside assessment of microvascular blood flow and oxygen saturation, allowing continuous assessment of aerobic metabolism. 

Buszczak laboratory seeks to gain new insights into mRNA translation, ribosome biogenesis and germ cell biology