The Psychoneuroendocrine Research Program (PNE) at UT Southwestern Medical Center focuses on two different areas of research: substance abuse, particularly dual diagnoses (e.g., depression or bipolar disorder); and the effects of corticosteroids (e.g., prednisone) on mood and memory. The PNE Program has been conducting research in mood, memory, and substance abuse since 1998 and is under the direction of E. Sherwood Brown, MD, PhD, MBA, Professor of Psychiatry here at UT Southwestern Medical Center.