Optimizing AAV vector delivery to the nervous system


The Bailey Lab focuses on developing gene therapies for neurological disorders. We work on monogenetic pediatric disorders, including SLC13A5 epileptic encephalopathy, multiple sulfatase deficiency, Charcot Marie Tooth disease type 4J, giant axonal neuropathy, and ECHS1 deficiency.

We are also developing approaches that bring the adeno-associated virus to bear on more complex, non-inherited neurodegenerative diseases.

Principal Investigator

Rachel Bailey, Ph.D.

Rachel Bailey, Ph.D.

Dr. Rachel Bailey has a broad background in studying protein aggregation in neurodegenerative disorders, modeling neurological diseases in rodents, developing gene therapies to treat those disorders, and identifying biomarkers for human testing.

She joined the UT Southwestern faculty in 2018 as an Assistant Professor in Pediatric Neurology with a secondary appointment in the Center for Alzheimer’s and Neurodegenerative Diseases. She was recruited to help build a gene therapy program that translates gene-based treatments for neurological disorders into human testing.

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