Search Labs

We study how biomolecular condensates organize gene regulation.

A major focus of our lab is to identify mechanisms of cardiomyocyte cell cycle regulation, and discover ways to reawaken regenerative pathways in the adult mammalian heart. We are also developing several structural, molecular, and physiological tools to interrogate the mechanistic underpinnings of various forms of cardiomyopathy.

Saelices Lab employs crystallography and cryo-EM to study amyloid deposition and design anti-amyloid tools.

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We seek to understand the processes that control the immune system and how they malfunction in autoimmune diseases of the brain, including multiple sclerosis (MS).

The Sandstrom Lab works to identify the fundamental molecular mechanisms through which the immune system can recognize pathogens and stress. 

Satterthwaite Lab studies the signals that control B lymphocyte development, activation, and differentiation into antibody-secreting plasma cells, both normally and in autoimmune diseases such as lupus. We hope that by defining these events, we can reveal new approaches to modulate antibody responses therapeutically.

The Saunders Lab aims to advance our understanding of the bacterial domain of life using high throughput genetics to map the molecular interactions that underly cellular physiology.

The Saxena lab's research interests include Icodextin in high peritoneal transporters; Kremezin study in patients with chronic kidney disease; SV40 in focal segmental glomerulosclerosis; molecular studies in lupus nephritis.

The main focus in our laboratory is the identification and physiological characterization of adipocyte-specific gene products and the elucidation of pathways that are an integral part of the complex set of reactions that drive adipogenesis.

The lab investigates the nature and treatment of cognitive deficits commonly seen in schizophrenia and related disorders.

We study clathrin-mediated endocytosis (CME), the major and best understood endocytic pathway.  

The Schoggins Lab studies innate immunity at the virus-host interface. We are interested in mechanisms of cellular antiviral defense and the role these responses play during viral disease.

What are the causes and consequences of cytoskeletal diversification?

The Seemann Lab studies the molecular mechanisms governing the function and inheritance of the mammalian Golgi apparatus.

We aim to characterize the ways in which reward systems vary from individual to individual and understand how this variation determines propensity for depression and addiction-like behavior.

Nutrition and exercise intervention to reduce cardiovascular risk factors; weight loss and maintenance in bariatric surgery patients; role of nutrition and exercise in cardiovascular risk factors; influence of the eating environment on energy intake.

The Shahmoradian lab focuses on deciphering the structure and native cellular context of brain disease-causing proteins using cryo-electron microscopy and tomography. 

Our lab researches Cerebellar Dysfunction, Brainstem Dysfunction, High-Throughput Screen, and Human Studies.

The Sharma lab is interested in investigating intermediary metabolism utilizing carbon-13 stable isotope tracers in conjunction with magnetic resonance spectroscopy (MRS), magnetic resonance imaging (MRI), and mass spectrometry (MS).

The overall goal of our laboratory is to discover the processes in endothelial cells that govern cardiovascular and metabolic health and disease. 

Shay Lab is interested in the relationships between aging and cancer and have focused on the role of the telomeres and telomerase in these processes.

The ultimate aim of the Shiloh Lab is to contribute to the development of vaccines and treatments for Mycobacterium tuberculosis (Mtb).

Our primary goal in Sieber Lab is to understand the dynamic changes in metabolic programs that support developmental and disease progression. 

We aim to globally understand how the physical and chemical properties of materials affect interactions with biological systems in the context of improving therapies.

The Sinnett Lab develops and assesses gene therapies for rare neurodevelopmental disorders.

Our work examines the interface between cancer and developmental biology

Smith Lab strives to develop enabling tools for organic synthesis, allowing bioactive molecules of great complexity to be prepared in a concise and sustainable fashion.

Our lab aim is to discover and translate findings into diagnostic and therapeutic solutions for patients with allergy.

The Sorrell laboratory utilizes integrative approaches that include metabolomics, transcriptomics, organoid cultures, live microcopy, and animal models, to investigate fundamental pathways that control the uptake of nutrients and the biosynthesis of macromolecules in proliferative cells.

Our laboratory is interested in investigating the molecular mechanisms of selenoproteins in health and disease.

The Story Lab has a robust research portfolio that includes radiation-induced carcinogenesis associated with the unique environment of space, molecular markers of carcinogenic risk after radiation, intrinsic radiosensitivity, modulation of drug and radiation response by pentaazamacrocyclic ring compounds with dismutase activity, high-dose per fraction radiotherapy, charged particle radiotherapy, the mechanism(s) of action of Tumor Treating Fields, and the enhancement of cancer therapy through radiation and drug combination used concomitantly with Tumor Treating Fields.

The Stowe Lab conducts both bench and clinical research with the goal of deepening the understanding of the etiology of stroke as well as finding better therapies for those who have suffered a stroke.

The main goals of the Strand Lab are to create accurate cellular atlases of the human and mouse lower urinary tract, characterize the molecular and cellular alterations in human lower urinary tract disease, and design new mouse models.

We investigate epigenome regulation of nervous system development and homeostasis. We are particularly interested in understanding how disruption of these mechanisms lead to neurological disorders.

The UTSW Structural Biology Laboratory (SBL) was formed to add macromolecular crystallography to the scientific toolkit available to the general researcher.

The vision of the lab is to further understand the pathogenesis of autoimmunity of the central nervous system through basic science and translational research.

Sumber Lab conducts translational research that seeks to uncover the mysteries of cancer and develop powerful methods for its detection and cure.

The Sun Lab studies the most numerous cells in the brain, called “glial cells”.

The Sun Lab is focused on developing novel imaging probes for noninvasive assessment of specific biomarkers implicated in disease initiation, progression, or regression, and exploring the translational roles of imaging probes and/or methodologies in clinical medicine practice with the ultimate goal to improve the outcome of patient care.

Our lab's focus is to develop novel tools aimed at understanding ion channel physiology and molecular mechanism in an isolated membrane environment.