Shaul / Mineo Lab

The overall goal of our laboratory is to discover the processes in endothelial cells that govern cardiovascular and metabolic health and disease.

Striving to have transformative impact on our understanding of conditions that threaten the well-being of millions, we focus our attention on molecules associated with the endothelial cell plasma membrane and how they dictate the responses of the endothelium to extracellular cues. Our mission is to identify novel targets for new preventative and treatment strategies against cardiovascular disease and type 2 diabetes. 

Our Research

aortic root lipid staining

Endothelial Underpinnings of Atherosclerosis

We are investigating the initiating mechanisms by which hypercholesterolemia changes the microenvironment in the artery wall to drive atherogenesis.

fluorescent tagged insulin

Endothelial Mechanisms Contributing to Type 2 Diabetes Development

Springboarding from our discovery that endothelial processes underlie how obesity causes insulin resistance, we are attacking type 2 diabetes pathogenesis from an entirely new angle.

Endothelial cell monolayer

Endothelial Basis of Cardiovascular and Metabolic Disease

Our studies in endothelial cell biology aim to identify novel therapeutic targets in the battle against cardiovascular disease and type 2 diabetes.

mouse stroke

Endothelial Basis for Thrombotic Disorders

We are interrogating how events in endothelial cells convert risk factors into clinical thrombotic events, including those underlying myocardial infarction and stroke.

Meet the Principal Investigators

Phil Shaul

Phil Shaul, M.D.

Associates First Capital Distinguished Chair in Pediatrics
Vice Chair for Research, Department of Pediatrics
Director, Center for Pulmonary and Vascular Biology

Professor, Department of Pediatrics

Chieko Mineo, Ph.D.

Chieko Mineo, Ph.D.

Professor, Center for Pulmonary and Vascular Biology, Department of Pediatrics, Department of Cell Biology

Get Involved

Meet the Team

Get to know our Principal Investigator and team of researchers.

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Join Our Lab

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