Search Labs

We are interested in taking bioinformatics and data integration approaches to gain insights into cancer metabolism, inborn errors of metabolism, and lung neoplasm.

How do cells sense metabolites to drive their growth and proliferation?  We seek to study metabolites not only as nutrients but as cellular instruction signals that dictate cell biology. 

The Callaway Lab studies how disruptions to lung development can predispose to long-term pathology.

The Calvier Lab's research focuses on endothelial modulation as a therapeutic approach to inflammatory diseases.

The Camacho Lab focuses on understanding key genetic events that lead to cancer in an effort to identify novel targets that will help improve existing therapies

The CDR Collaborative studies last mile delivery problems across the cancer control continuum to develop and implement solutions.

We study bacterial RNA polymerase function and regulation.

We conduct state-of-the-art clinical trials in the field of cardiovascular diseases, offering patients access to advanced clinical therapies that would otherwise not be available.

The global focus of the Cardiovascular Physiology Autonomic Function Laboratory is to examine the adaptive capacity of the circulation.

• We study the effects of exercise training, bed rest deconditioning, spaceflight, high altitude, aging, and the effects of cardiovascular diseases, such as heart failure.
• By using sophisticated tools to assess cardiovascular structure and function, our research team brings "Olympic" and "space age" science to the solution of common clinical problems such as fainting, hypertension, or patients with shortness of breath. 
• We focus on measuring how the cardio-respiratory system distributes oxygen from the environment to the muscles.
• Our facility is one of the few labs in the world that can measure the limitations to exercise capacity at every step along the "oxygen cascade" - including the lungs, heart and muscles.
• We use invasive and non-invasive tools to assess cardiovascular structure and function, as well as circulatory control mechanisms.

The work of Deborah Carlson, Ph.D., focuses on characterizing the inflammasome mediating the inflammatory response in the heart following thermal injury and thermal injury complicated with sepsis. 

Kidney disease has reached epidemic proportions in the U.S. The Carroll Lab performs basic and translational research focused on kidney development, maintenance and regeneration. 

Castrillion Lab's work is aimed at understanding why endometrial or uterine cancers arise and spread, with an eye on prevention, earlier and more accurate diagnosis, improved treatments, and better overall patient outcomes.

Interrogating the genome to better understand the mechanisms causing autism spectrum disorder and other neurodevelopmental disorders and inform innovative therapies

Dr. Chalak’s lab focuses on improving neonatal neurologic care and outcomes for vulnerable babies through the NeuroNICU clinical program, Neonatal Neurology Fellowship, and NIH research program.

The work of the CHemical Advanced Neuroimaging lab is focused on developing state-of-the-art proton MRS and MRSI methods and leveraging these tools to answer key clinical questions and improve the quality of neurologic care.

Our lab is creating better experimental models that reveal how cancer cells metastasize and evade our immune system. We use these models to develop new drugs that engage our immune system to kill cancer cells.

We are interested in building small organic molecules and studying their functions in biological systems. Our lab started in 2004 using state-of-the-art tools to address challenging issues in the field of natural product synthesis. 

Elizabeth Chen Lab focuses research on cell-cell fusion, drosophila myoblast fusion, invasive membrane protrusions, actin binding and bundling proteins, and mechanoresponsive proteins.

Welcome to the Reproductive Genomics Laboratory (RGL) at UT Southwestern Medical Center where we innovate at the intersection of genomics, bioengineering, and data science to answer fundamental questions in reproductive biology.

Chen lab studies how dysregulation of RNA synthesis and degradation drives childhood cancers with the ultimate goal of identifying new therapeutic vulnerabilities to exploit in treating them.

Our current research is focused on biochemical and structural studies of how membrane molecules signal to the actin cytoskeleton through a large, five-protein complex named the WAVE Regulatory Complex (WRC). 

Chen Lab is broadly interested in mechanisms of signal transduction, namely how a cell communicates with its surroundings and within itself.