The mission of the Najafov Lab is to understand the role of cell death in physiology and disease. Our research is focused on necroptosis and how it can be targeted to develop novel strategies for treating cancer.
The mission of Napierala Lab is to contribute to the development of therapies and a cure for Friedreich’s ataxia (FRDA) by elucidating molecular mechanisms causing the disease, developing novel cellular and animal models of FRDA, identifying disease biomarkers and testing novel therapeutic approaches.
The focus of the Neuromuscular Center is the diagnosis and treatment of muscle diseases known as metabolic myopathies, including inherited disorders of muscle fat, carbohydrate, and mitochondrial muscle metabolism.
We study bacterial colonization of the intestinal tract, to understand how both benign and pathological bacteria affect their environment. Our long-term goal is to treat intestinal diseases by genetically engineering bacteria in vivo.
Research conducted by the Nomellini Lab utilizes animal models as well as human samples to examine the interaction between the innate and adaptive immune responses that occur after injury or infection, and the heterogeneity of the immune responses that occur in each individual. Led by Vanessa Nomellini, M.D., Ph.D., our lab ultimately aims to develop personalized immune therapies to reverse the immunosuppression that can occur in ICU survivors.
Vanessa Nomellini, M.D., Ph.D.
immunotherapyinjury repairgeneral surgeryemergency s burntraumacritical care surgeryICU
The long-term goals of the Nwariaku Laboratory are to understand the cellular mechanisms that regulate endothelial dysfunction during inflammatory and neoplastic conditions with a hope to use this knowledge in designing novel therapeutic agents.