Evan Nair-Gill Lab

Center for the Genetics of Host Defense

The Nair-Gill Lab dissects the cellular infrastructure that dictates immune cell survival and fate decisions.

The adaptive immune system retains a vast array of lymphocytes to defend against infectious diseases and cancer. These cells must persist for long periods in a quiescent state until activation, after which they demonstrate incredible functional plasticity leading to diverse fates. Our lab takes a multidisciplinary approach to define mechanisms that control lymphocyte quiescence and fate decisions. We use these insights to discover how quiescence and fate are corrupted in diseases of immune hyperactivation and immunosuppression.

Meet the PI

Evan Nair-Gill, M.D., Ph.D.

Evan Nair-Gill, M.D., Ph.D.

Dr. Evan Nair-Gill grew up in Madison, Wisconsin. He received his B.S. in biological chemistry from the University of Chicago and earned his M.D. and Ph.D. degrees from the University of California, Los Angeles. He completed his Ph.D. thesis in Dr. Owen Witte’s lab where he studied immune cell metabolism to develop imaging probes of immune function. Evan moved to Dallas in 2013 to complete internal medicine residency and rheumatology fellowship at UT Southwestern. During fellowship, he worked in Dr. Bruce Beutler’s lab where he investigated the cellular mechanisms that control lymphocyte quiescence.

The Nair-Gill lab was established within the Center for the Genetics of Host Defense in 2021 with support from the Rheumatology Research Foundation, the National Institute for Allergy and Infectious Diseases, and the UT Southwestern Disease Oriented Clinical Scholar Award.

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