Statistical methodology development
Dr. Wang's research interests primarily involve the development of statistical methodologies for the design and analysis of clinical trials, as well as the evaluation of correlated data and repeated measurements. Her specific focus has been on power analysis, experimental design, and sample size determination for longitudinal studies using Frequentist and Bayesian approaches. Dr. Wang has also developed the methodologies that are very flexible and can accommodate various pragmatic issues such as longitudinal and clustered outcomes, random variability in cluster size, unbalanced randomization, complicated correlation structures, missing data, and small sample sizes. Those methodologies have achieved great performances across a broad spectrum of design configurations and made innovative contributions to clinical studies.
Another area of Dr. Wang's research interest is the collaboration with clinicians, investigators, and multidisciplinary research teams on a wide range of biomedical and clinical studies. Through these collaborations, Dr. Wang has provided statistical expertise and guidance to support the design, implementation, and analysis of research studies. Her contributions have led to many peer-reviewed publications and have helped to ensure that research findings are sound and reliable. Dr. Wang is dedicated to advancing the use of rigorous statistical methods in clinical research to improve the quality of evidence and ultimately enhance patient health.
The Wang lab applies single-molecule fluorescence biophysical, quantitative biochemical, structural, and genetics approaches to unravel the intricate relationships between structure, dynamics and function in complex dynamic biological systems. Our primary goal is to understand the dynamic mechanisms of cytosolic and mitochondrial protein synthesis and how they are dysregulated in human diseases.
Our research revolves around using state-of-the-art bioinformatics and biostatistics approaches to study the implications of tumor immunology for tumorigenesis, metastasis, prognosis, and treatment response in a variety of cancers.
Dr. Waugh is a physician-scientist whose research focuses on the structural brain abnormalities that lead to dystonia, a movement disorder that leads muscles to twist and contort into painful positions.
The Wert laboratory studies the post-mitotic neuronal cells of the retina, particularly the photoreceptor cells. Our goal is to discover and understand the mechanisms underlying retinal degenerative disease, and to provide novel therapeutics for these complex degenerative disorders using gene therapy and genome engineering technologies, human stem cell transplantations, and metabolic rescue.
We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.
Scientists in the Center for Pediatric Bone Biology and Translational Research work to discover the underlying causes of poorly understood musculoskeletal disorders in children, and to understand the fundamental steps that lead to disease.
In our laboratory, we utilize molecular and cellular approaches to decipher mechanisms of extracellular matrix remodeling of the female reproductive tract in both physiologic states (e.g., during pregnancy, parturition, and the puerperium) and pathologic conditions (pelvic organ prolapse, urinary incontinence, and injury of the external anal sphincter).