White Lab

Perrin C. White, M.D., Principal Investigator

Dr. White has studied the molecular basis of several genetic diseases of steroid hormone synthesis and metabolism over the years. Some of these diseases affect growth, sexual differentiation or the ability to conserve salt in the blood, whereas others cause high blood pressure. Most recently, he has branched into study of a very large cell-surface molecule that his laboratory discovered serendipitously. It is important for development of the nervous system; mutations in this protein cause seizures, as well as, deafness and progressive blindness (Usher syndrome).

D. Randy McMillian, Ph.D., Assistant Professor

Dr. McMillan's interests involve the role of G protein-coupled receptors (GPCR) in development. He and Dr. White have cloned the gene that codes for the largest known GPCR, the Very Large G protein coupled Receptor 1 (VLGR1). Presently, he is involved in characterizing the function of VLGR1 to determine its role in development of the mammalian central nervous system.

Daniela C. Rogoff, M.D., Ph.D., Postdoctoral Researcher

Dr. Rogoff was trained in Buenos Aires, Argentina. During her residency she became interested in adrenal disorders and focused her research on this subject. She began working in Dr. White's laboratory in September 2005. Her current project involves the study of the effect of specific cofactors in glucocorticoid action.