Targeted Therapy for Cancer
We focus on the discovery of targeted therapies for major drivers of cancer using protein chemistry, enzymology, structural biology, informatics and cell biology. Some of our favorite targets are RAS and kinase proteins.
Drugging RAS
Drug hunters struggled for decades to target RAS. We were among the first to develop irreversible KRAS G12C inhibitors.
Find out moreRAS Structure
RAS mutations are found in many malignant tumors, but not all RAS mutations work alike. We study how mutations impact RAS protein dynamics.
Find out moreDrugging Kinases
Protein kinase inhibitors are a major class of targeted therapies, especially for cancer. We are working to expand the arsenal of kinase inhibitors.
Find out more
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