Wang Lab

Meet the PI

Jinfan Wang

Jinfan Wang

Assistant Professor

Department of Biochemistry

Graduate Program: Biological Chemistry

Dynamics of cytosolic and mitochondrial translation

The Wang lab integrates single-molecule fluorescence microscopy with quantitative biochemical, structural, and genetics approaches to unravel the intricate relationships between structure, dynamics and function in complex dynamic biological systems. Our primary goal is to understand the dynamic mechanisms of cytosolic and mitochondrial protein synthesis and how they are dysregulated in human diseases.

Featured Publications

Rapid 40S scanning and its regulation by mRNA structure during eukaryotic translation initiation. Wang J, Shin BS, Alvarado C, Kim JR, Bohlen J, Dever TE, Puglisi JD, Cell 2022, Nov, 185, 4474-4487.e17.
Structural basis for the transition from translation initiation to elongation by an 80S-eIF5B complex.
Wang J, Wang J, Shin BS, Kim JR, Dever TE, Puglisi JD, Fernández IS, Nat Commun 2020, 11, 5003.
eIF5B gates the transition from translation initiation to elongation.
Wang J, Johnson AG, Lapointe CP, Choi J, Prabhakar A, Chen DH, Petrov AN, Puglisi JD, Nature 2019, 573, 605-608.

We are hiring at all levels! Join us to build a diverse, interdisciplinary research team!

Graduate students: email Jinfan to set up a time to chat about potential research projects.

Technicians/Postdocs/Scientists: email Jinfan with an updated CV and a brief cover letter introducing yourself (with a description of your research experience and future interests).