Research

Dynamics of cytosolic and mitochondrial translation

Coordinated gene expression from the nuclear and mitochondrial genomes is pivotal for cellular homeostasis. Consequently, dysregulated protein synthesis in either compartment is linked to human diseases. Our major goal is to understand the dynamics and regulation of cytosolic and mitochondrial protein synthesis, at the molecular level. To achieve this, we are integrating quantitative biochemical, single-molecule fluorescence spectroscopy and high-resolution structural approaches (e.g. cryo-EM) using purified components, along with functional assays in vitro and in cells. The quantitative models established in our studies will provide insights into how protein synthesis goes awry in human diseases and guide the identification of novel therapeutic targets.