The Tagliabracci Lab studies the phosphorylation of extracellular proteins by a novel family of secreted kinases. This kinase family is so different from canonical kinases that it was not included as a branch on the human kinome tree.
Vincent "Vinnie" Tagliabracci, Ph.D.
Pseudokinases
Cell and Molecular BiologyGenetics, Development and Disease
Under the guidance of director Dr. Daolin Tang, the research group focuses on basic, translational and clinical application research on damage-associated molecular patterns (DAMPs) signaling pathways. Inflammation is a fundamental response to infection and injury in all multicellular organisms. The danger hypothesis states that endogenous molecules (protein and non-protein) released during cell death or tissue damage can trigger inflammation in the absence of infection, collectively referred to as DAMPs. We are particularly interested in elucidating the molecular mechanisms underlying stress-induced cellular defense and cell death signaling in normal and cancer cells, and how release of DAMPs modulates immune responses in disease.
Daolin Tang, M.D., Ph.D.
molecular diagnosticsBacterial pathogenesisTumor microenvironmentpancreatic cancerCell Death
The Tatara Laboratory applies engineering technologies to study and treat infectious diseases. We are particularly engaged in device-related infection, orthopedic immunology, and pathogen virulence on biomaterial surfaces.
Research in my laboratory focuses on better understanding the molecules and mechanisms that assemble axonal connections with a goal of utilizing this knowledge to encourage axons to reestablish their connections after trauma or disease.
In our lab, we focus on the mechanisms of cerebrovascular reactivity, exploring how blood vessels in the brain respond to changes in carbon dioxide, blood pressure, and other stimuli.
This information will appear on the lab listing page.The Tong lab studies the cellular and molecular mechanisms of cardiovascular diseases associated with systemic metabolic disorders, particularly heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF), with an eye toward translating these findings into innovative solutions to clinical problems.
Dan Tong, M.D., Ph.D.
Heart Failure with Preserved Ejection FractionAtrial FibrillationClonal Hematopoiesis
Cell and Molecular BiologyGenetics, Development and Disease
We investigate genetic and molecular basis of phenotypic diversity observed in nature by using a range of methodologies such as whole genome sequencing, fluidics, long-term evolution experiments, and large-scale combinatorial mutagenesis.
My research interests include prevention of progression of renal diseases, diagnoses, and management of lipid disorders in renal disease, hypertensive nephrosclerosis, the role of angiotensin II converting enzyme inhibitors, and angiotensin II receptor blockers in renal disease.
The Center for Depression Research and Clinical Care (CDRC) is nationally recognized for its cutting-edge research in unipolar and bipolar depression. The research conducted within the center brings better understanding of the causes of depression, identifies effective new treatments, and improves existing ones.
The Tu Lab is investigating how a variety of cellular processes and decisions are coordinated with metabolic state, and how the dysregulation of these mechanisms might be linked to disease and aging.
The Turer Lab is interested in finding genes with novel functions in intestinal immune homeostasis. Our projects generally involve a mix of experimental approaches examining both the intestinal epithelium as well as hematopoietic causes of intestinal inflammation.