The Elmquist laboratory uses mouse genetics to identify circuits in the nervous system that regulate energy balance and glucose homeostasis. We have developed unique mouse models allowing neuron-specific manipulation of genes regulating these processes.
Our laboratory is focused on the molecular control of lipid metabolism, particularly in the intestinal tract. We employ a variety of disciplines including molecular and cell biology, mouse models and organoid technologies.
The Gospocic group studies how epigenetic pathways and gene expression regulate brain plasticity in the context of social behavior and aging by working with a unique ant species Harpegnathos saltator. We take a multidisciplinary approach and combine functional genomics, biochemistry, and behavioral assays in H. saltator, as well as the conventional Drosophila and mouse models to expedite genetic screening and provide evolutionary context to identified epigenetic pathways.
Specialty Areas: epigenetics, chromatin biology, gene regulation, social behavior, aging, neurodegeneration
Jan’s Lab is interested in understanding the dynamics of protein-RNA complexes during ribosome biogenesis. We are particularly focused on the roles of ATPases in coordinating ribosomal RNA processing and remodeling events, as well as the importance of these enzymes in signaling between the ribosome biogenesis pathway and the cell cycle machinery.
