Zeng Lab is interested in understanding at the molecular level key questions lying at the interface between biochemistry, cell biology, metabolic and neural physiology, including the bidirectional communication between autonomic neurons and adipocytes, the molecular basis of the phenotypic plasticity, or the lack of, in brown, beige and white adipocytes, and roles of uncharacterized enzymatic pathways in adipose thermogenesis.
The lab's long-term goal is to illuminate the function of immune surface molecules and to open up a new research field at the interface of cancer, immunology, and stem cell research. Zhang Lab also actively develops novel therapies for cancer treatment.
Zhang (Chun-Li) Lab research focuses on cellular plasticity in the adult nervous system and modeling human neurodegenerative diseases. We use cell culture and genetically modified mice as model systems. Molecular, cellular, electrophysiological, and behavioral methods are employed.
Chun-Li Zhang, Ph.D.
in vivo reprogrammingneurogenesisglial cellsastrocytesNG2 gliachun-li zhangutswutsouthwestern
The central theme of our research program in our laboratory is to explore the co-evolution between tumor cells and the tumor microenvironment (TME) during the development of therapeutic resistance and metastatic relapse.
Our lab combines normative theories and biologically plausible neural circuit models to study the principles of neural information processing, in order to answer how perception, cognition, and behavior emerge from neural circuits.
Our aim is to develop computational methods to unveil the hidden biological circuitries behind the data, from understanding sequence-based regulations to the evolution of genomes and their impact to diseases.
Our lab is interested in understanding the relationship between injury, regeneration, and cancer. We are focused on identifying the genes and mechanisms that regulate regenerative capacity in the liver and understanding how these contribute to hepatocellular carcinoma development.
The Zia Research Group focuses on clinical and translational hematology research to improve the understanding of pediatric thrombotic and hemostatic disorders with the long-term goal of improving the lives of affected children and young adults with these disorders.
We investigate the neuro-hormonal basis for complex eating behaviors and blood glucose control, with the ultimate goal of designing new methods to prevent and treat extremes of body weight, blood glucose, and associated disorders of mood and metabolism.