Jialiang (Shirley) Wang Lab

Wang Lab focuses on how genetic factor and transcription regulation function in skeletal disease and bone cancer

Projects in the Wang Lab utilize an interdisciplinary approach that spans genetics, multi-omics, in vivo and in vitro models to study bone development and to understand how skeletal disease and bone cancer can alter or hijack the process.

Smiling woman with auburn shoulder-length hair, wearing blue glasses.

Meet the PI

Dr. Shirley (Jialiang) Wang is an Assistant Professor in the Charles Y.C. and Jane Pak Center for Mineral Metabolism and Clinical Research (CMMCR), the Department of Physiology and the Department of Internal Medicine at UT Southwestern Medical Center. Dr. Wang have always been deeply interested in how genetic factors regulate development and how genetic abnormalities cause human disease. During her graduate studies, the major focus of her thesis was to study the function of the transcription factor PITX1 and its regulatory elements in limb development and human limb disorders. Dr. Wang did her postdoctoral research at Massachusetts General Hospital and Harvard Medical School (supported by the NIH/NIDDK NRSA T32 training grant), where she investigated the underlying mechanisms of the transcription factor SP7/Osterix in regulating osteocyte formation and osteoporosis. She is a recipient of the NIH/NIAMS Pathway to Independence Awards (K99/R00) to further utilize genetic models and multi-omics approaches to the study of bone development and human skeletal disease. In 2024, Dr. Wang joined the CMMCR as an Assistant Professor.

Dr. Wang was awarded the American Society for Bone and Mineral Research (ASBMR) John Haddad Young Investigator and the ASBMR Harold M. Frost Young Investigator. She is the board member of Advances in Mineral Metabolism (AIMM) and the committee of ASBMR Early-Stage Investigator.

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