2D/3D Cryo-Electron Microscopy In Cells and Tissues

Understanding the Macromolecular Context of Neurodegeneration

The Shahmoradian Lab focuses on deciphering the structures of brain disease-associated proteins and macromolecular assemblies within their native cellular environment. The resolved protein structures can then serve as a basis for the design of improved imaging and therapeutic molecules.

Our research extends from cells and animal models to human patient material. To capture the most natural state of these proteins and their environment, the lab primarily uses cryo-correlative light and electron microscopy (cryo-CLEM), in situ cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET).

The lab also develops and applies new technologies using materials science and chemistry approaches to push the boundaries of these techniques.


A researcher points to an image on a computer screen while another looks on. Using cryo-confocal microscopy to visualize fluorescently-labelled key proteins within a cell model of neurodegeneration.