Publications

Featured Publications

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes.

Shahmoradian SH, Lewis AJ, Genoud C, Hench J, Moors TE, Navarro PP, Castaño-Díez D, Schweighauser G, Graff-Meyer A, Goldie KN, Sütterlin R, Huisman E, Ingrassia A, Gier Y, Rozemuller AJM, Wang J, Paepe A, Erny J, Staempfli A, Hoernschemeyer J, Großerüschkamp F, Niedieker D, El-Mashtoly SF, Quadri M, Van IJcken WFJ, Bonifati V, Gerwert K, Bohrmann B, Frank S, Britschgi M, Stahlberg H, Van de Berg WDJ, Lauer ME, Nat Neurosci 2019 07 22 7 1099-1109

Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography.

Shahmoradian SH, Tsai EHR, Diaz A, Guizar-Sicairos M, Raabe J, Spycher L, Britschgi M, Ruf A, Stahlberg H, Holler M, Sci Rep 2017 07 7 1 6291

TRiC's tricks inhibit huntingtin aggregation.

Shahmoradian SH, Galaz-Montoya JG, Schmid MF, Cong Y, Ma B, Spiess C, Frydman J, Ludtke SJ, Chiu W, Elife 2013 Jul 2 e00710

Supramolecular non-amyloid intermediates in the early stages of a-synuclein aggregation.

Fauerbach JA, Yushchenko DA, Shahmoradian SH, Chiu W, Jovin TM, Jares-Erijman EA, Biophys J 2012 Mar 102 5 1127-36

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates.

Galaz-Montoya JG, Shahmoradian SH, Shen K, Frydman J, Chiu W, Commun Biol 2021 07 4 1 849

A Compartmentalized Neuronal Cell-Culture Platform Compatible With Cryo-Fixation by High-Pressure Freezing for Ultrastructural Imaging.

Tran HT, Lucas MS, Ishikawa T, Shahmoradian SH, Padeste C, Front Neurosci 2021 15 726763

A lathe system for micrometre-sized cylindrical sample preparation at room and cryogenic temperatures.

Holler M, Ihli J, Tsai EHR, Nudelman F, Verezhak M, van de Berg WDJ, Shahmoradian SH, J Synchrotron Radiat 2020 Mar 27 Pt 2 472-476

Alterations in Sub-Axonal Architecture Between Normal Aging and Parkinson's Diseased Human Brains Using Label-Free Cryogenic X-ray Nanotomography.

Tran HT, Tsai EHR, Lewis AJ, Moors T, Bol JGJM, Rostami I, Diaz A, Jonker AJ, Guizar-Sicairos M, Raabe J, Stahlberg H, van de Berg WDJ, Holler M, Shahmoradian SH, Front Neurosci 2020 14 570019

Imaging of post-mortem human brain tissue using electron and X-ray microscopy.

Lewis AJ, Genoud C, Pont M, van de Berg WD, Frank S, Stahlberg H, Shahmoradian SH, Al-Amoudi A, Curr Opin Struct Biol 2019 10 58 138-148

Breakthroughs in medicine and bioimaging with up-conversion nanoparticles.

Rostami I, Rezvani Alanagh H, Hu Z, Shahmoradian SH, Int J Nanomedicine 2019 14 7759-7780

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles.

Navarro PP, Genoud C, Castaño-Díez D, Graff-Meyer A, Lewis AJ, de Gier Y, Lauer ME, Britschgi M, Bohrmann B, Frank S, Hench J, Schweighauser G, Rozemuller AJM, van de Berg WDJ, Stahlberg H, Shahmoradian SH, Sci Rep 2018 12 8 1 18046

OMNY PIN-A versatile sample holder for tomographic measurements at room and cryogenic temperatures.

Holler M, Raabe J, Wepf R, Shahmoradian SH, Diaz A, Sarafimov B, Lachat T, Walther H, Vitins M, Rev Sci Instrum 2017 Nov 88 11 113701

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.

Shen K, Calamini B, Fauerbach JA, Ma B, Shahmoradian SH, Serrano Lachapel IL, Chiu W, Lo DC, Frydman J, Elife 2016 10 5

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.

Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC, Proc Natl Acad Sci U S A 2016 09 113 38 E5655-64

Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography.

Shahmoradian SH, Galiano MR, Wu C, Chen S, Rasband MN, Mobley WC, Chiu W, J Vis Exp 2014 Feb 84 e50783

Early segregation of layered projections from the lateral superior olivary nucleus to the central nucleus of the inferior colliculus in the neonatal cat.

Gabriele ML, Shahmoradian SH, French CC, Henkel CK, McHaffie JG, Brain Res 2007 Oct 1173 66-77