Elucidating Tau Fibril Formation using Correlative Cryo-CLEM in situ

S Shahmoradian, J Monistrol, HT Tran, V Perez, J Jiou, J Vaquer-Alicea, ...
Journal of Biological Chemistry 300 (3)

Docking for molecules that bind in a symmetric stack to Alzheimer’s disease tau fibrils with SymDOCK

MS Smith, P Kunach, IS Knight, R Kormos, JG Pepe, I Glenn, JJ Irwin, ...
Biophysical Journal 123 (3), 298a

Docking for molecules that bind in a symmetric stack with SymDOCK

MS Smith, IS Knight, RC Kormos, JG Pepe, P Kunach, MI Diamond, ...
Journal of Chemical Information and Modeling 64 (2), 425-434

Cryo-EM structure of Alzheimer’s disease tau filaments with PET ligand MK-6240

P Kunach, J Vaquer-Alicea, MS Smith, R Hopewell, J Monistrol, L Moquin, ...

Cryo-EM structure determination of sub nanomolar affinity PET ligand, MK-6240, bound to Alzheimer’s Disease Paired Helical Filament

P Kunach, J Vaquer-Alicea, J Monistrol, J Therriault, C Tissot, R Hopewell, ...
Alzheimer's Association International Conference

A compartmentalized neuronal cell-culture platform compatible with cryo-fixation by high-pressure freezing for ultrastructural imaging

HT Tran, MS Lucas, T Ishikawa, SH Shahmoradian, C Padeste
Frontiers in neuroscience 15, 726763

Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates

JG Galaz-Montoya, SH Shahmoradian, K Shen, J Frydman, W Chiu
Communications Biology 4 (1), 849

Micrometer-resolution reconstruction and analysis of whole mouse brain vasculature by synchrotron-based phase-contrast tomographic microscopy

A Miettinen, AG Zippo, A Patera, A Bonnin, SH Shahmoradian, ...
bioRxiv, 2021.03. 16.435616

Topological Insights into Mutant Huntingtin Exon 1 and PolyQ Aggregates by Cryo-Electron Tomography

JG Galaz-Montoya, SH Shahmoradian, K Shen, J Frydman, W Chiu
bioRxiv, 2020.12. 08.417048

Alterations in sub-axonal architecture between normal aging and Parkinson’s diseased human brains using label-free cryogenic X-ray nanotomography

HT Tran, EHR Tsai, AJ Lewis, T Moors, J Bol, I Rostami, A Diaz, AJ Jonker, ...
Frontiers in neuroscience 14, 570019

A lathe system for micrometre-sized cylindrical sample preparation at room and cryogenic temperatures

M Holler, J Ihli, EHR Tsai, F Nudelman, M Verezhak, WD van de Berg, ...
Journal of synchrotron radiation 27 (2), 472-476

Imaging of post-mortem human brain tissue using electron and X-ray microscopy

AJ Lewis, C Genoud, M Pont, WDJ Van de Berg, S Frank, H Stahlberg, ...
Current opinion in structural biology 58, 138-148

Breakthroughs in medicine and bioimaging with up-conversion nanoparticles

I Rostami, AH Rezvani, Z Hu, SH Shahmoradian
International Journal of Nanomedicine

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

SH Shahmoradian, AJ Lewis, C Genoud, J Hench, TE Moors, PP Navarro, ...
Nature Neuroscience 22 (7), 1099-1109

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles

PP Navarro, C Genoud, D Castaño-Díez, A Graff-Meyer, AJ Lewis, ...
Scientific reports 8 (1), 18046

OMNY PIN—A versatile sample holder for tomographic measurements at room and cryogenic temperatures

M Holler, J Raabe, R Wepf, SH Shahmoradian, A Diaz, B Sarafimov, ...
Review of Scientific Instruments 88 (11)

Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography

SH Shahmoradian, EHR Tsai, A Diaz, M Guizar-Sicairos, J Raabe, ...
Scientific Reports 7 (doi:10.1038/s41598-017-05587-4)

Control of the structural landscape and neuronal proteotoxicity of mutant Huntingtin by domains flanking the polyQ tract.

K Shen, B Calamini, J Fauerbach, B Ma, SH Shahmoradian, LIL Serrano, ...
eLife 5,

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington’s disease

X Zhao, XQ Chen, E Han, Y Hu, P Paik, Z Ding, J Overman, AL Lau, ...

Preparation of Primary Neurons for Visualizing Neurites in a Frozen-hydrated State Using Cryo-Electron Tomography

SH Shahmoradian, MR Galiano, C Wu, S Chen, MN Rasband, ...
Journal of Visualized Experiments

TRiC’s tricks inhibit huntingtin aggregation

SH Shahmoradian, JG Galaz-Montoya, MF Schmid, Y Cong, B Ma, ...
Elife 2, e00710

Structural Characterizations of Aggregating Proteins Relevant to Neurodegenerative Diseases

SH Shahmoradian
Baylor College of Medicine. Department of Molecular Physiology and Biophysics.

Supramolecular non-amyloid intermediates in the early stages of α-synuclein aggregation

JA Fauerbach, DA Yushchenko, SH Shahmoradian, W Chiu, TM Jovin, ...
Biophysical journal 102 (5), 1127-1136

Patterning of multiple layered projections to the auditory midbrain prior to experience

RL Fathke, ML Gabriele
Hearing research 249 (1-2), 36-43

Early segregation of layered projections from the lateral superior olivary nucleus to the central nucleus of the inferior colliculus in the neonatal cat

ML Gabriele, SH Shahmoradian, CC French, CK Henkel, JG McHaffie
Brain research 1173, 66-77

Banded ephrin-B3 expression patterns in the neonatal rat inferior colliculus

SH Shahmoradian, RL James, NS Simpson, ML Gabriele
Soc for Neurosci Abstr 35, 942.2