The Bartelt Lab is focused on understanding the epigenetic basis of cerebellar neurodegenerative disorders to develop holistic gene therapies. Using single-cell and spatial sequencing approaches, we profile healthy and diseased states to identify gene regulatory mechanisms in disease and utilize functional genomic tools to advance therapeutic approaches. 

Neuron-cancer interactions that promote tumor growth and disrupt neural circuits. 

Understanding brain circuits in disease and cognition to develop restorative neuromodulation. 

The Liu Lab studies the seasonal clock and its roles in human health. We use a new seasonal primate model, the mouse lemur, and an interdisciplinary approach of molecular biology, genetics, omics, machine learning, and computational modeling. We also apply the mouse lemur primate model to study pathophysiology that is poorly represented in mice, with a focus on neurodegeneration, immunology, and metabolism.

We leverage our knowledge of fundamental neuroscience to create wearable bidirectional brain-machine interfaces for the restoration and assistance of upper limb sensation and movement in people with paralysis.

We use neuroimaging, neuromodulation, and behavioral experimentation to elucidate the brain circuits and mechanisms that support language and cognition, and to understand how these circuits differ in neurodevelopmental conditions such as autism. We are particularly interested in the role of cerebro-cerebellar circuits in language and cognition across development and disorders.

The work of the Chemical Advanced Neuroimaging Lab is focused on developing state-of-the-art proton MRS and MRSI methods and leveraging these tools to answer key clinical questions and improve the quality of neurologic care.

The Calvier Lab's research focuses on endothelial modulation as a therapeutic approach to inflammatory diseases.

Dr. Zhu has investigated disease mechanisms and attempted to develop novel therapeutic strategies for tumor suppressor gene (TSG), syndrome-associated tumors in the nervous system, and neuropsychiatric disorders.

The Ishii Laboratory is interested in understanding the bidirectional relationship between brain function and systemic metabolism with an emphasis on metabolic deficits in Alzheimer’s disease and how it differs from normal aging. Our laboratory focuses on generating hypotheses derived from open questions in clinical neurology and neuroendocrinology, testing these hypotheses using molecular genetics and neuroscience techniques in the laboratory, and whenever possible verifying these findings in clinically relevant human research studies.