INTERNAL MEDICINE RESEARCH

Miguel Vazquez Lab

Research Interests

Chronic kidney disease is associated with increased morbidity and mortality. Diabetes and hypertension are the most common causes of chronic kidney disease. Our team at UT Southwestern is conducting the study Improving Chronic Disease Management with Pieces (IDC-Pieces) in patients with coexistent chronic kidney disease, diabetes, and hypertension. This is a large multicenter pragmatic clinical trial supported by the Healthcare Systems Collaboratory of the National Institutes of Health. Our study is a collaboration with colleagues from the Parkland Center for Clinical Innovations and four large healthcare systems (Parkland Health and Hospital Systems, Texas Health Resources, VA of North Texas Health Care System, and ProHealth of Connecticut). ICD Pieces will test if a collaborative model of care incorporating a novel technology platform and practice facilitators will improve outcomes for patients with chronic kidney disease, diabetes, and hypertension.

Publications

Preventing cognitive decline by reducing BP target (PCOT): A randomized, pragmatic, multi-health systems clinical trial.

Giacona JM, Bates BM, Sundaram V, Brinker S, Moss E, Paspula R, Kassa S, Zhang R, Ahn C, Zhang S, Basit M, Burkhalter L, Cullum CM, Carlew A, Kelley BJ, Plassman BL, Vazquez M, Vongpatanasin W, 2024 Jan Contemp Clin Trials 138 107443

Pragmatic Trial of Hospitalization Rate in Chronic Kidney Disease.

Vazquez MA, Oliver G, Amarasingham R, Sundaram V, Chan K, Ahn C, Zhang S, Bickel P, Parikh SM, Wells B, Miller RT, Hedayati S, Hastings J, Jaiyeola A, Nguyen TM, Moran B, Santini N, Barker B, Velasco F, Myers L, Meehan TP, Fox C, Toto RD, 2024 Apr N Engl J Med 13 390 1196-1206

Preventing cognitive decline by reducing BP target (PCOT): A randomized, pragmatic, multi-health systems clinical trial

John M. Giacona, Brooke M. Bates, Venkatraghavan Sundaram. Stephanie Brinker, Elizabeth Moss, Raja Paspula, Sentayehu Kassa, Rong Zhang, Chul Ahn, Song Zhang, Mujeeb Basit, Lorrie Bulkhalter, Munro Cullum, Anne Carlew, Brendan J. Kelley, Brenda L. Plassman, Miguel Vazquez, Wanpen Vongpatanasin 2024 Contemporary Clinical Trials 138

Cancer Treatment in CKD: Time to Move Beyond Renalism.

Berger JR, Vazquez MA, 2023 Sep Kidney360 9 4 e1193-e1195

Arteriovenous Fistula Maturation, Functional Patency, and Intervention Rates.

Huber TS, Berceli SA, Scali ST, Neal D, Anderson EM, Allon M, Cheung AK, Dember LM, Himmelfarb J, Roy-Chaudhury P, Vazquez MA, Alpers CE, Robbin ML, Imrey PB, Beck GJ, Farber AM, Kaufman JS, Kraiss LW, Vongpatanasin W, Kusek JW, Feldman HI, 2021 Sep JAMA Surg

Rationale and design of the Kidney Precision Medicine Project.

de Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O'Toole JF, Palevsky PM, Parikh CR, Poggio ED, Rosas SE, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA, Waikar SS, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J, 2021 Mar Kidney Int 3 99 498-510

Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studies.

Tuzzio L, Meyers CM, Dember LM, Grudzen CR, Melnick ER, Staman KL, Huang SS, Richards J, DeBar L, Vazquez MA, Green BB, Coronado GD, Jarvik JG, Braciszewski J, Ho PM, Wells BL, James K, Toto R, D'Onofrio G, Volandes A, Kuklinski MR, Catalano RF, Sterling SA, Morse EF, Curtis L, Larson EB, 2021 Jun Healthc (Amst) 8 Suppl 1 100432

Systematic Review and Meta-Analysis of Native Kidney Biopsy Complications.

Poggio ED, McClelland RL, Blank KN, Hansen S, Bansal S, Bomback AS, Canetta PA, Khairallah P, Kiryluk K, Lecker SH, McMahon GM, Palevsky PM, Parikh S, Rosas SE, Tuttle K, Vazquez MA, Vijayan A, Rovin BH, 2020 Oct Clin J Am Soc Nephrol

Dialysis for Undocumented Immigrants: Challenges and Solutions.

Berger JR, Quinones H, Vazquez MA, 2020 Jun Kidney360 6 1 549-552

Dialysis for Undocumented Immigrants: Challenges and Solutions

Berger J, Quinones H, and Vazquez MA. 2020 Kidney 360 1 6 549-552

Addressing guideline and policy changes during pragmatic clinical trials.

Curtis LH, Dember LM, Vazquez MA, Murray D, DeBar L, Staman KL, Septimus E, Mor V, Volandes A, Wells BL, Huang SS, Green BB, Coronado G, Meyers CM, Tuzzio L, Hernandez AF, Sugarman J, 2019 May Clin Trials 1740774519845682

Association of Scheduled vs Emergency-Only Dialysis With Health Outcomes and Costs in Undocumented Immigrants With End-stage Renal Disease.

Nguyen OK, Vazquez MA, Charles L, Berger JR, Quiñones H, Fuquay R, Sanders JM, Kapinos KA, Halm EA, Makam AN 2019 Feb JAMA Intern Med 2 179 175-183

Personalized medicine and Hispanic health: improving health outcomes and reducing health disparities - a National Heart, Lung, and Blood Institute workshop report.

Avilés-Santa ML, Heintzman J, Lindberg NM, Guerrero-Preston R, Ramos K, Abraído-Lanza AL, Bull J, Falcón A, McBurnie MA, Moy E, Papanicolaou G, Piña IL, Popovic J, Suglia SF, Vázquez MA 2017 BMC Proc Suppl 11 11 11

Acute Rejection Rates and Graft Outcomes According to Induction Regimen among Recipients of Kidneys from Deceased Donors Treated with Tacrolimus and Mycophenolate.

Tanriover B, Jaikaransingh V, MacConmara MP, Parekh JR, Levea SL, Ariyamuthu VK, Zhang S, Gao A, Ayvaci MU, Sandikci B, Rajora N, Ahmed V, Lu CY, Mohan S, Vazquez MA 2016 Jun Clin J Am Soc Nephrol

Pragmatic Clinical Trials in CKD: Opportunities and Challenges.

de Boer IH, Kovesdy CP, Navaneethan SD, Peralta CA, Tuot DS, Vazquez MA, Crews DC 2016 Jun J. Am. Soc. Nephrol.

Vascular Function at Baseline in the Hemodialysis Fistula Maturation Study.

Dember LM, Imrey PB, Duess MA, Hamburg NM, Larive B, Radeva M, Himmelfarb J, Kraiss LW, Kusek JW, Roy-Chaudhury P, Terry CM, Vazquez MA, Vongpatanasin W, Beck GJ, Vita JA 2016 J Am Heart Assoc 7 5

Oversight on the borderline: Quality improvement and pragmatic research.

Finkelstein JA, Brickman AL, Capron A, Ford DE, Gombosev A, Greene SM, Iafrate RP, Kolaczkowski L, Pallin SC, Pletcher MJ, Staman KL, Vazquez MA, Sugarman J 2015 Sep Clin Trials

Induction Therapies in Live Donor Kidney Transplantation on Tacrolimus and Mycophenolate With or Without Steroid Maintenance.

Tanriover B, Zhang S, MacConmara M, Gao A, Sandikci B, Ayvaci MU, Mete M, Tsapepas D, Rajora N, Mohan P, Lakhia R, Lu CY, Vazquez M 2015 Jun Clin J Am Soc Nephrol 6 10 1041-9

Effect of fish oil supplementation on graft patency and cardiovascular events among patients with new synthetic arteriovenous hemodialysis grafts: a randomized controlled trial.

Lok CE, Moist L, Hemmelgarn BR, Tonelli M, Vazquez MA, Dorval M, Oliver M, Donnelly S, Allon M, Stanley K 2012 May JAMA 17 307 1809-16

Effect of dipyridamole plus aspirin on hemodialysis graft patency.

Dixon BS, Beck GJ, Vazquez MA, Greenberg A, Delmez JA, Allon M, Dember LM, Himmelfarb J, Gassman JJ, Greene T, Radeva MK, Davidson IJ, Ikizler TA, Braden GL, Fenves AZ, Kaufman JS, Cotton JR, Martin KJ, McNeil JW, Rahman A, Lawson JH, Whiting JF, Hu B, Meyers CM, Kusek JW, Feldman HI 2009 May N. Engl. J. Med. 21 360 2191-201

Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial.

Dember LM, Beck GJ, Allon M, Delmez JA, Dixon BS, Greenberg A, Himmelfarb J, Vazquez MA, Gassman JJ, Greene T, Radeva MK, Braden GL, Ikizler TA, Rocco MV, Davidson IJ, Kaufman JS, Meyers CM, Kusek JW, Feldman HI 2008 May JAMA 18 299 2164-71

The evaluation of renal transplantation candidates: clinical practice guidelines.

Kasiske BL, Cangro CB, Hariharan S, Hricik DE, Kerman RH, Roth D, Rush DN, Vazquez MA, Weir MR 2001 Am. J. Transplant. 1 Suppl 2 3-95

Recommendations for the outpatient surveillance of renal transplant recipients. American Society of Transplantation.

Kasiske BL, Vazquez MA, Harmon WE, Brown RS, Danovitch GM, Gaston RS, Roth D, Scandling JD, Singer GG 2000 Oct J. Am. Soc. Nephrol. 11 Suppl 15 S1-86

Contact Vazquez Lab

Kidney Research
5323 Harry Hines Blvd.
Dallas, TX 75390
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Phone: 214-648-8884
Fax: 214-648-2071