The Vongpatanasin lab studies neural control of blood pressure and the influence of nutrition and various hormones on the autonomic control of blood pressure in humans. Our laboratory has performed autonomic studies in both normal healthy subjects and patients with hypertension or autonomic dysfunction.
Studies in mice demonstrated that dietary phosphate (Pi) loading that mimic the level of US adult consumption leads to reduced spontaneous locomotor activity, exercise capacity, and reduced resting metabolic rate when in normal mice by impairing skeletal muscle mitochondrial function and fat oxidation. However, relevance of this findings in humans remains unknown.
The aim of this study is to determine if lowering blood pressure using FDA approved medication (antihypertensive drugs) alters brain pulsatility and reduces brain amyloid beta protein accumulation in older adults. Amyloid beta protein is high in the brain of older adults with Alzheimer's disease. Hypertension may increase accumulation of amyloid-beta protein in the brain and affect memory and thinking ability in older adults. However, it is inconclusive whether lowering blood pressure reduces brain amyloid-beta protein and improves brain function.
The investigators hypothesize that treating high blood pressure alters brain pulsatility, which in turn reduces accumulation of amyloid-beta protein in the brain and improves brain structure and function.
The PCOT study is a multi-site randomized trial of patients 70 years or older with high BP. The main goal of the study Preventing Cognitive Decline by Reducing BP Target Trial (PCOT) is to conduct a large pragmatic clinical trial (PCT) to test the hypothesis that patients who receive care with a combination of clinical decision support (CDS) and team-based care delivered in primary care practices will have better blood pressure control and a lower incidence of mild cognitive impairment and dementia than patients receiving usual medical care. Patients will be recruited from UT Southwestern Medical Center and Parkland Health & Hospital System.
Wanpen Vongpatanasin, M.D.
Professor, Department of Internal Medicine
Director, UTSW Hypertension Section and Hypertension Fellowship Program
Attending Physician, internal medicine and cardiology, Parkland Memorial Hospital and Zale Lipshy Pavilion — William P. Clements Jr. University Hospital
Dapagliflozin Attenuates Sympathetic and Pressor Responses to Stress in Young Prehypertensive Spontaneously Hypertensive Rats.Kim HK, Ishizawa R, Fukazawa A, Wang Z, Bezan Petric U, Chang Hu M, Smith SA, Mizuno M, Vongpatanasin W, 2022 Jun Hypertension 101161HYPERTENSIONAHA12219177
Renal Nerve Activity and Arterial Depressor Responses Induced by Neuromodulation of the Deep Peroneal Nerve in Spontaneously Hypertensive Rats.Gonzalez-Gonzalez MA, Romero K, Beitter J, Lloyd D, Lam DV, Hernandez-Reynoso AG, Kanneganti A, Kim HK, Bjune CK, Smith S, Vongpatanasin W, Romero-Ortega MI, 2022 Front Neurosci 16 726467
Medication Adherence and Blood Pressure Control: A Scientific Statement From the American Heart Association.Choudhry NK, Kronish IM, Vongpatanasin W, Ferdinand KC, Pavlik VN, Egan BM, Schoenthaler A, Houston Miller N, Hyman DJ, 2021 Oct Hypertension HYP0000000000000203
Evidence of reduced efferent renal sympathetic innervation after chemical renal denervation in humans.Hearon CM, Howden EJ, Fu Q, Yoo JK, Dias KA, Roberts-Reeves MA, Samels M, Sarma S, Nesbitt S, Vongpatanasin W, Goldstein DS, Addo T, Levine BD, 2021 03 Am J Hypertens
Superiority of Out-of-Office Blood Pressure for Predicting Hypertensive Heart Disease in Non-Hispanic Black Adults.Rader F, Franklin SS, Mirocha J, Vongpatanasin W, Haley RW, Victor RG, 2019 Sep Hypertension HYPERTENSIONAHA11913542
High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice.Peri-Okonny PA, Baskin KK, Iwamoto G, Mitchell JH, Smith SA, Kim HK, Szweda LI, Bassel-Duby R, Fujikawa T, Castorena CM, Richardson J, Shelton JM, Ayers C, Berry JD, Malladi VS, Hu MC, Moe OW, Scherer PE, Vongpatanasin W 2019 Jan Circulation
Usefulness of Blood Pressure Variability Indices Derived From 24-Hour Ambulatory Blood Pressure Monitoring in Detecting Autonomic Failure.Lodhi HA, Peri-Okonny PA, Schesing K, Phelps K, Ngo C, Evans H, Arbique D, Price AL, Vernino S, Phillips L, Mitchell JH, Smith SA, Yano Y, Das SR, Wang T, Vongpatanasin W, 2019 Apr J Am Heart Assoc 7 8 e010161
Hemodynamic and Mechanical Properties of the Proximal Aorta in Young and Middle-Aged Adults With Isolated Systolic Hypertension: The Dallas Heart Study.Yano Y, Neeland IJ, Ayers C, Peshock R, Berry JD, Lloyd-Jones DM, Greenland P, Mitchell GF, Vongpatanasin W 2017 May Hypertension
High Dietary Phosphate Intake Induces Hypertension and Augments Exercise Pressor Reflex Function in Rats.Mizuno M, Mitchell JH, Crawford S, Huang CL, Maalouf NM, Hu MC, Moe OW, Smith SA, Vongpatanasin W 2016 May Am. J. Physiol. Regul. Integr. Comp. Physiol. ajpregu.00124.2016
Department of Internal Medicine, Division of Cardiology
5323 Harry Hines Blvd.
Dallas, Texas 75309-8586