Wu Lab

The wild and fascinating world

Virus Infections, Host Metabolism, and Tumorigenesis

Our mission is to study these complex interactions in upper aerodigestive tract, using a combination of multiple model systems including primary cultured human nasal and oral epithelial cells, mouse models, and nasal mucosal biopsy specimens from clinical patients, coupled with state-of-the-art omics.

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Our Research

Our research is driven by a desire to understand

  1. how respiratory viruses subvert the nasal and oral epithelia for cellular entry, replication, and egress

  2. how metabolic disorders interfere with the antiviral immunity during viral infections

  3. how virus infections induce tumorigenesis in upper aerodigestive tract

 
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Meet the Team

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Chien-Ting Wu, Ph.D.

 

Department of Microbiology
Assistant Professor
chien-ting.wu@utsouthwestern.edu

 
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Hsin-Yi Chen, Ph.D.

 

Department of Microbiology
Research Scientist
 

 

Featured Publications

Wu CT*, Lidsky PV*, Xiao Y*, Cheng R*, Lee IT, Nakayama T, Jiang S, He W, E TR, Rojas-Hernandez LS, Ye C, Chiem K, Shon J, Martinez-Sobrido L, Bertozzi CR, Nolan GP, Milla C, Nayak JV, Andino R, Jackson PK. SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. Cell. (In revision)

Nakayama T*, Lee IT*, Jiang S*, Matter MS*, Yan CH*, Overdevest JB*, Wu CT*, Goltsev Y, Shih KC, Liao CK, Zhu B, Lidsky PV, Xiao Y, Zarabanda D, Yang A, Easwaran M, Schürch CM, Chu P, Chen H, Stalder AK, Mcllwain DR, Borchard NA, Gall PA, Dholakia SS, Xu L, Tai CJ, Yeh TH, Duran JM, Mertz KD, Patel ZM, Haslbauer JD, Jackson PK, Menter T, Andino R, Canoll PD, Deconde AS, Hwang PH, Tzankov A, Nolan GP, Nayak JV. Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers. Cell Rep Med. 2021 Oct 19;2(10):100421.

Wu CT, Hilgendorf KI, Bevacqua RJ, Hang Y, Demeter J, Kim SK, Jackson PK. Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Genes Dev. 2021 Sep 1;35(17-18):1243-1255.

Wu CT*, Lidsky PV*, Xiao Y*, Lee IT*, Cheng R*, Nakayama T*, Jiang S*, Demeter J, Bevacqua RJ, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK. SARS-CoV-2 infects human pancreatic beta cells and elicits beta cell impairment. Cell Metab. 2021 Aug 3;33(8):1565-1576.e5.

Lee IT*, Nakayama T*, Wu CT*, Goltsev Y*, Jiang S*, Gall PA, Liao CK, Shih LC, Schurch CM, McIlwain DR, Chu P, Borchard NA, Zarabanda D, Dholakia SS, Yang A, Kim D, Chen H, Kanie T, Lin CD, Tsai MH, Phillips KM, Kim R, Overdevest JB, Tyler MA, Yan CH, Lin CF, Lin YT, Bau DT, Tsay GJ, Patel ZM, Tsou YA, Tzankov A, Matter MS, Tai C J, Yeh TH, Hwang PH, Nolan GP, Nayak JV, Jackson PK. ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs. Nat Commun. 2020 Oct 28;11(1):5453.

(* Denotes First Author Status)

Contact Us

Email address: chien-ting.wu@utsouthwestern.edu
Office Number: 214-648-4836
Lab Number: 214-648-4841

Mailing Address
NL4. 108A, 5323 Harry Hines Blvd. Dallas, TX 75390

Physical Address
NL4. 110A, 6000 Harry Hines Blvd. Dallas, TX 75390