Yao Lab

The long-term goal of Yao Laboratory is to identify molecular and cellular mechanisms that determine the efficacy of vaccines and immunotherapies against infectious diseases and cancers. There are two major directions in the Yao Lab.

1. Long-term T cell immunity is critical in combating chronic viral infection and cancer. We have found that transcription factors TOX and BACH2 are critical for the formation of stem-like CD8 T cells and the development of long-term immunity. We will dissect the molecule targets of TOX and BACH2 that mediate their function in T cells.
2. Immunotherapy has revolutionized the treatment of patients with renal cell carcinoma (RCC). However, only a minority of patients with RCC achieved complete responses after immunotherapies. In the Yao Lab, we aim to understand the T-cell intrinsic and extrinsic mechanisms that determine their antitumor responses induced by immunotherapies. Using mouse RCC models and patient samples, we will identify and validate prognostic biomarkers for immunotherapies against RCC. In addition, we will use gene-editing technologies to uncover and validate novel pathways that can be targeted to enhance antitumor T-cell responses during cancer immunotherapies.