Yu (Gang) Lab

The mission of Yu Lab is to make fundamental discoveries about biological processes in health and disease.

With a particular focus on the molecular and cellular basis of neurodegeneration. Yu Lab is interested in the molecular and cellular basis of Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and related neurodegenerative disorders. Using both in vitro and in vivo approaches, the lab focuses on taking apart and putting together several disease-associated molecular machines, particularly the gamma-secretase complex. It is hoped that by doing so the underlying biological principles of these molecular machines and their relevance to disease pathogenesis will be understood.

Meet the Team

Gang G. Yu, Ph.D

Gang G. Yu, Ph.D

Principal Investigator

Associate Professor

Gang G. Yu, PhD, earned his Ph.D. in Biochemistry and Molecular Biology (1992-1996) from the University of Calgary, Canada. He served as a Postdoctoral Fellow (1996-2001) in the Center for Research into Neurodegenerative Diseases at the University of Toronto, Canada. Dr. Yu joined UT Southwestern in October 2001.

Lab Members

Daniel Dries, Ph.D.

Postdoctoral Fellow

University of California, San Diego

Yu-Hong Han, Ph.D.

Postdoctoral Fellow

University of Biochemistry and Cell Biology, CAS

Chantelle Spehton

Postdoctoral Fellow

University of Saskatchewan, Canada

Yun Wang, Ph.D.

Postdoctoral Fellow

State University of New York, Stoney Brook

Basar Cenik

Ph.D. Student


Colleen Dewey

Ph.D. Student


Paul Mayer

Ph.D. Students

Biological Chemistry

Shannon Good


BSc, Baylor University

Featured Publications

Dries DR and Yu G (2008). Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer’s disease.” Curr. Alz. Res. 5, 124-138.

Sephton C and Yu G (2008). Abeta predictor of Alzheimer’s disease symptoms. Archives of Neurology, 65, 875-876.

Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I (2006). Presenilins Form ER Ca(2 ) Leak Channels, a Function Disrupted by Familial Alzheimer's Disease-Linked Mutations. Cell 126, 981-993.1.

Shah S and Yu G (2006). SorLA: Sorting Out APP. Mol. Interv. 6, 74-76.

Shah S, Lee S, Tabuchi K, Hao Y, Yu C, LaPlant Q, Ball H, Dann C, Sudhof T, and Yu G (2005). Nicastrin Functions As A Gamma-Secretase-Substrate Receptor. Cell 122, 435-447.

Lee SF, Shah S, Yu C, Wigley WC, Li H, Lim M, Pedersen K, Han W, Thomas P, Lundkvist J, Hao YH, and Yu G (2004). A Conserved GXXXG Motif in APH-1 Is Critical for Assembly and Activity of the Gamma-Secretase Complex. J. Biol. Chem. 279, 4144-4152.

Luo W, Wang H, Li H, Kim B, Shah S, Lee HJ, Thinakaran G, Kim TW, Yu G, Xu H (2003). PEN-2 and APH-1 Coordinately Regulate Proteolytic Processing of Presenilin 1. J. Biol. Chem. 278, 7850-7854.

Rozmahel R, Mount HT, Chen F, Nguyen V, Huang J, Erdebil S, Liauw J, Yu G, Hasegawa H, Gu Y, Song YQ, Schmidt SD, Nixon RA, Mathews PM, Bergeron C, Fraser P, Westaway D, St. George-Hyslop P (2002). Alleles at the Nicastrin locus modify presenilin 1-deficiency phenotype. Proc Natl Acad Sci U S A. 99, 14452-144527.

Yang D, Tandon A, Chen F, Yu G, Yu H, Arawaka S, Hasegawa H, Duthie M, Schmidt S, Nixon R, Ramabhadran T, Mathews P, Gandy S, Mount H, St George-Hyslop P, Fraser P (2002). Mature glycosylation and trafficking of nicastrin modulate its binding to presenilins. J. Biol. Chem. 277, 28135-28142.

Lee S, Shah S, Li H, Yu C, Han W, Yu G (2002). Mammalian APH-1 Interacts with Presenilin and Nicastrin and Is Required for Intramembrane Proteolysis of Amyloid-beta Precursor Protein and Notch. J. Biol. Chem. 277, 45013-45019.

Contact Us

Get in touch with the Yu Lab

Phone: 214-648-5157
Fax: 214-648-1801


6000 Harry Hines Blvd.
Dallas, TX 75235

Join Our Lab

Yu Lab pledges to build a workplace culture that includes people of all shapes and sizes.

Yu Lab strives to facilitate the growth and success of the next generation of scientists, and welcome students, postdocs, and staff from all backgrounds and perspectives to join our lab.