Our Mission
The Yue lab studies molecular and cellular mechanisms underlying musculoskeletal regeneration and tumorigenesis, and develops novel immunotherapeutics to treat patients.
Meet the PI
Tao Yue, Ph.D.
Dr. Yue obtained his Ph.D at the Center of Developmental Biology, University of Texas Southwestern Medical Center (UTSW) in 2011. From 2011 to 2020, he worked as a postdoctoral fellow in the lab of Nobel Laureate Dr. Bruce Beutler at the Center for the Genetics of Host Defense on identification and characterization of genes implicated in the innate and adaptive immune responses. Now he is a tenure-track assistant professor in Center for Organogenesis Research and Trauma, Simmons Comprehensive Cancer Center, Departments of Surgery and Immunology, at UTSW.
Biography
Tao Yue is an Assistant Professor in the Department of Surgery, at the Center for Organogenesis, Regeneration, and Trauma, with a joint appointment in the Department of Immunology. Dr. Yue hails from China, where earned his Bachelor of Science degree in Biology from South China Normal University. He subsequently pursued graduate studies at Sun Yat-sen University before successfully completing his Doctorate in Genetics and Development at the University of Texas Southwestern Medical Center.
Following the completion of his Ph.D., Dr. Yue engaged in postdoctoral research under the esteemed guidance of Nobel Laureate Dr. Bruce Beutler at the Center for the Genetics of Host Defense. During this time, he focused on the identification and characterization of genes implicated in innate and adaptive immune responses.
In 2022, Dr. Yue was recruited to the University of Texas Southwestern Medical Center, where he established a laboratory dedicated to investigating immune regulation in the context of musculoskeletal regeneration after injuries and tumorigenesis. Additionally, his research endeavors encompass the development of innovative immunotherapeutic approaches aimed at enhancing tissue regeneration and eradicating tumors.
Meet Our Team
Ji Hae (Lauren) Choi
Research
The primary focus of the Yue laboratory revolves around the examination of immune regulation in musculoskeletal regeneration following injuries and tumorigenesis. To achieve this objective, we employ state-of-the-art next-generation multidisciplinary methodologies, such as multi-omics, functional screening, protein engineering, and the utilization of clinically relevant mouse models of injuries and cancers. Additionally, we utilize cellular and molecular immunology approaches. Our primary goal is to elucidate the fundamental molecular and cellular mechanisms involved in these crucial biological processes. Through our research, we aim to develop future immunotherapeutic strategies that exhibit enhanced efficacy and reduced toxicity. These strategies would facilitate the faithful repair of tissue damage and more effectively eradicate tumors.
Epigenetic Regulation
We are focusing on studying the epigenetic regulation in wound healing and tissue regeneration to identify critical epigenetic modifiers implicated in these processes and investigate their molecular and cellular mechanisms to develop potential therapies. We are using cutting-edge next generation multidisciplinary approaches, including multi-omics, functional screening, and clinically relevant mouse models of musculoskeletal injuries, as well as cellular and molecular immunology approaches to uncover drug-able epigenetic regulators during tissue repair.
Osteosarcoma Sarcoma
Another research area in the lab focuses on sarcoma, particularly osteosarcoma (OS). OS is the most common bone sarcoma in children and adolescents. We are interested in understanding the role of epigenetic regulation of the immunosuppressive tumor microenvironment during OS progression and lung metastasis and developing novel immunotherapeutic intervention with improved efficacy and reduced toxicity.
SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity.
Yue T, Zhan X, Zhang D, Jain R, Wang KW, Choi JH, Misawa T, Su L, Quan J, Hildebrand S, Xu D, Li X, Turer E, Sun L, Moresco EMY, Beutler B, 2021 05 Science 6543 372Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40.
Zhang D, Yue T, Choi JH, Nair-Gill E, Zhong X, Wang KW, Zhan X, Li X, Choi M, Tang M, Quan J, Hildebrand S, Moresco EMY, Beutler B, 2019 Aug Nat. Immunol.
Yue T, Tian A, Jiang J
2012 Feb
Dev. Cell
2
22
255-67
A critical role for dorsal progenitors in cortical myelination.
Yue T, Xian K, Hurlock E, Xin M, Kernie SG, Parada LF, Lu QR 2006 Jan J. Neurosci. 4 26 1275-80Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice.
Xin M, Yue T, Ma Z, Wu FF, Gow A, Lu QR 2005 Feb J. Neurosci. 6 25 1354-65
Wang X, Liu L, Yue T, Sun Z, Bae J, Tseng KF, Zhang A, Qiao J, Fu YX,
2023 Jul
Signal Transduct Target Ther
1
8
268
Sulfatides are endogenous ligands for the TLR4-MD-2 complex.
Su L, Athamna M, Wang Y, Wang J, Freudenberg M, Yue T, Wang J, Moresco EMY, He H, Zor T, Beutler B, 2021 07 Proc Natl Acad Sci U S A 30 118
Xu D, Lyon S, Bu CH, Hildebrand S, Choi JH, Zhong X, Liu A, Turer EE, Zhang Z, Russell J, Ludwig S, Mahrt E, Nair-Gill E, Shi H, Wang Y, Zhang D, Yue T, Wang KW, SoRelle JA, Su L, Misawa T, McAlpine W, Sun L, Wang J, Zhan X, Choi M, Farokhnia R, Sakla A, Schneider S, Coco H, Coolbaugh G, Hayse B, Mazal S, Medler D, Nguyen B, Rodriguez E, Wadley A, Tang M, Li X, Anderton P, Keller K, Press A, Scott L, Quan J, Cooper S, Collie T, Qin B, Cardin J, Simpson R, Tadesse M, Sun Q, Wise CA, Rios JJ, Moresco EMY, Beutler B,
2021 07
Proc Natl Acad Sci U S A
28
118
Dominant atopy risk mutations identified by mouse forward genetic analysis.
SoRelle JA, Chen Z, Wang J, Yue T, Choi JH, Wang KW, Zhong X, Hildebrand S, Russell J, Scott L, Xu D, Zhan X, Bu CH, Wang T, Choi M, Tang M, Ludwig S, Zhan X, Li X, Moresco EMY, Beutler B, 2021 04 Allergy 4 76 1095-1108Mutual inhibition between Prkd2 and Bcl6 controls T follicular helper cell differentiation.
Misawa T, SoRelle JA, Choi JH, Yue T, Wang KW, McAlpine W, Wang J, Liu A, Tabeta K, Turer EE, Evers B, Nair-Gill E, Poddar S, Su L, Ou F, Yu L, Russell J, Ludwig S, Zhan X, Hildebrand S, Li X, Tang M, Murray AR, Moresco EMY, Beutler B, 2020 Jan Sci Immunol 43 5
Wang KW, Zhan X, McAlpine W, Zhang Z, Choi JH, Shi H, Misawa T, Yue T, Zhang D, Wang Y, Ludwig S, Russell J, Tang M, Li X, Murray AR, Moresco EMY, Turer EE, Beutler B,
2019 May
Proc. Natl. Acad. Sci. U.S.A.
Cho YS, Li S, Wang X, Zhu J, Zhuo S, Han Y, Yue T, Yang Y, Jiang J,
2019 Dec
Genes Dev.
Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway.
Ma G, Li S, Han Y, Li S, Yue T, Wang B, Jiang J 2016 Nov Dev. Cell 4 39 438-451Overlapping functions of the MAP4K family kinases Hppy and Msn in Hippo signaling.
Li S, Cho YS, Yue T, Ip YT, Jiang J 2015 Cell Discov 1 15038Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways.
Ren F, Wang B, Yue T, Yun EY, Ip YT, Jiang J 2010 Dec Proc. Natl. Acad. Sci. U.S.A. 49 107 21064-9
Nuki G,
1980 Jul
Rep Rheum Dis
73
1p.