Yue Lab

Our Mission

The Yue lab studies molecular and cellular mechanisms underlying musculoskeletal regeneration and tumorigenesis, and develops novel immunotherapeutics to treat patients.

Meet the PI

Tao Yue, Ph.D.

Tao Yue, Ph.D.

Dr. Yue obtained his Ph.D at the Center of Developmental Biology, University of Texas Southwestern Medical Center (UTSW) in 2011. From 2011 to 2020, he worked as a postdoctoral fellow in the lab of Nobel Laureate Dr. Bruce Beutler at the Center for the Genetics of Host Defense on identification and characterization of genes implicated in the innate and adaptive immune responses. Now he is a tenure-track assistant professor in Center for Organogenesis Research and Trauma, Simmons Comprehensive Cancer Center, Departments of Surgery and Immunology, at UTSW.


Tao Yue is an Assistant Professor in the Department of Surgery, at the Center for Organogenesis, Regeneration, and Trauma, with a joint appointment in the Department of Immunology. Dr. Yue hails from China, where earned his Bachelor of Science degree in Biology from South China Normal University. He subsequently pursued graduate studies at Sun Yat-sen University before successfully completing his Doctorate in Genetics and Development at the University of Texas Southwestern Medical Center.

Following the completion of his Ph.D., Dr. Yue engaged in postdoctoral research under the esteemed guidance of Nobel Laureate Dr. Bruce Beutler at the Center for the Genetics of Host Defense. During this time, he focused on the identification and characterization of genes implicated in innate and adaptive immune responses.

In 2022, Dr. Yue was recruited to the University of Texas Southwestern Medical Center, where he established a laboratory dedicated to investigating immune regulation in the context of musculoskeletal regeneration after injuries and tumorigenesis. Additionally, his research endeavors encompass the development of innovative immunotherapeutic approaches aimed at enhancing tissue regeneration and eradicating tumors.

Meet Our Team

Ji Hae (Lauren) Choi

Ji Hae (Lauren) Choi


The primary focus of the Yue laboratory revolves around the examination of immune regulation in musculoskeletal regeneration following injuries and tumorigenesis. To achieve this objective, we employ state-of-the-art next-generation multidisciplinary methodologies, such as multi-omics, functional screening, protein engineering, and the utilization of clinically relevant mouse models of injuries and cancers. Additionally, we utilize cellular and molecular immunology approaches. Our primary goal is to elucidate the fundamental molecular and cellular mechanisms involved in these crucial biological processes. Through our research, we aim to develop future immunotherapeutic strategies that exhibit enhanced efficacy and reduced toxicity. These strategies would facilitate the faithful repair of tissue damage and more effectively eradicate tumors.

Epigenetic Regulation

We are focusing on studying the epigenetic regulation in wound healing and tissue regeneration to identify critical epigenetic modifiers implicated in these processes and investigate their molecular and cellular mechanisms to develop potential therapies. We are using cutting-edge next generation multidisciplinary approaches, including multi-omics, functional screening, and clinically relevant mouse models of musculoskeletal injuries, as well as cellular and molecular immunology approaches to uncover drug-able epigenetic regulators during tissue repair.

regeneration project

Osteosarcoma Sarcoma

Another research area in the lab focuses on sarcoma, particularly osteosarcoma (OS). OS is the most common bone sarcoma in children and adolescents. We are interested in understanding the role of epigenetic regulation of the immunosuppressive tumor microenvironment during OS progression and lung metastasis and developing novel immunotherapeutic intervention with improved efficacy and reduced toxicity.

cancer project