Representative Publications from the Zhong Lab

The following are publications representative of the topics that the Zhong Lab studies.  For a more comprehensive list of publications for each lab member, use the menu to the left to make your selection.

Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria.
Liang SZhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E, J Biol  Chem. 2019 Aug 16;294(33):12359-12369.

Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression.
Zhong F, Liang SZhong Z#Trends Immunol. 2019 Dec;40(12):1120-1133. 

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.
Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T#, Brenner DA# Gastroenterology 2018 Nov

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.
Zhong Z*Liang S*, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M Nature 2018 Aug 560 7717 198-203

Limiting inflammation-the negative regulation of NF-κB and the NLRP3 inflammasome.
Afonina IS*, Zhong Z*, Karin M, Beyaert R Nat. Immunol. 2017 Jul 18 8 861-869

Papilloma-pseudovirus eradicates intestinal tumours and triples the lifespan of ApcMin/+ mice.
Zhong Z*, Zhai Y*, Bu P, Shah S, Qiao L Nat Commun 2017 8 Apr 11 15004.

Autophagy, Inflammation, and Immunity: A Troika Governing Cancer and Its Treatment.
Zhong Z*, Sanchez-Lopez E*, Karin M Cell 2016 Jul 166 2 288-298

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.
Zhong Z*, Umemura A*, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M Cell 2016 Feb 164 5 896-910

TRPM2 links oxidative stress to NLRP3 inflammasome activation.
Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala FS, Qiao L Nat Commun 2013 4 1611

*Co-first author
#Co-corresponding author