Publications

Featured Publications

Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions.

Hansen JM, de Jong MF, Wu Q, Zhang LS, Heisler DB, Alto LT, Alto NM, 2021 Jun Cell 12 184 3178-3191.e18

Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol.

Abrams ME, Johnson KA, Perelman SS, Zhang LS, Endapally S, Mar KB, Thompson BM, McDonald JG, Schoggins JW, Radhakrishnan A, Alto NM, 2020 07 Nat Microbiol 7 5 929-942

A NIK-SIX signalling axis controls inflammation by targeted silencing of non-canonical NF-?B.

Liu Z, Mar KB, Hanners NW, Perelman SS, Kanchwala M, Xing C, Schoggins JW, Alto NM 2019 Mar Nature

Shigella flexneri suppresses NF-?B activation by inhibiting linear ubiquitin chain ligation.

de Jong MF, Liu Z, Chen D, Alto NM 2016 Nat Microbiol 7 1 16084

Myristoylome Profiling Reveals a Concerted Mechanism of ARF GTPase Deacylation by the Bacterial Protease IpaJ.

Burnaevskiy N, Peng T, Reddick LE, Hang HC, Alto NM 2015 Mar Mol. Cell

Proteolytic elimination of N-myristoyl modifications by the Shigella virulence factor IpaJ.

Burnaevskiy N, Fox TG, Plymire DA, Ertelt JM, Weigele BA, Selyunin AS, Way SS, Patrie SM, Alto NM 2013 Mar Nature

Identification of F-actin as the dynamic hub in a microbial-induced GTPase polarity circuit.

Orchard RC, Kittisopikul M, Altschuler SJ, Wu LF, Süel GM, Alto NM 2012 Feb Cell 4 148 803-15

The assembly of a GTPase-kinase signalling complex by a bacterial catalytic scaffold.

Selyunin AS, Sutton SE, Weigele BA, Reddick LE, Orchard RC, Bresson SM, Tomchick DR, Alto NM 2011 Jan Nature 7328 469 107-11

Accessible cholesterol is localized in bacterial plasma membrane protrusions.

Abrams ME, Johnson KA, Radhakrishnan A, Alto NM, 2020 Dec J Lipid Res 12 61 1538

A systematic exploration of the interactions between bacterial effector proteins and host cell membranes.

Weigele BA, Orchard RC, Jimenez A, Cox GW, Alto NM 2017 Sep Nat Commun 1 8 532

Cell-Based Screen Identifies Human Interferon-Stimulated Regulators of Listeria monocytogenes Infection.

Perelman SS, Abrams ME, Eitson JL, Chen D, Jimenez A, Mettlen M, Schoggins JW, Alto NM 2016 Dec PLoS Pathog. 12 12 e1006102

STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease.

Dobbs N, Burnaevskiy N, Chen D, Gonugunta VK, Alto NM, Yan N 2015 Aug Cell Host Microbe 2 18 157-68

Selective protection of an ARF1-GTP signaling axis by a bacterial scaffold induces bidirectional trafficking arrest.

Selyunin AS, Reddick LE, Weigele BA, Alto NM 2014 Mar Cell Rep 5 6 878-91

Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics.

Huang Z, Sutton SE, Wallenfang AJ, Orchard RC, Wu X, Feng Y, Chai J, Alto NM 2009 Aug Nat. Struct. Mol. Biol. 8 16 853-60