Publications

Featured Publications

In Vivo PET Imaging of Preynaptic Density Reveals Stress-Associated Synaptic Deficits Related to Behavioral and Molecular Alterations in Rats.

Asch RH, Hernandez Martin N, Garcia-Milian R, Fowles K, DiLeone RJ, Cai Z, Liston CM, Esterlis I, 2025 Sep Biol Psychiatry Cogn Neurosci Neuroimaging

Neural Signatures of Bipolar Disorder and Psychotropic Medication Effects: A Multimodal PET-MRI Study.

Asch RH, Fan S, Cool R, Boster S, DellaGioia N, Naganawa M, Nabulsi N, Lacadie C, Pietrzak RH, Esterlis I, 2025 Nov Biol Psychiatry

Challenges and rewards of in vivo synaptic density imaging, and its application to the study of depression.

Asch RH, Abdallah CG, Carson RE, Esterlis I, 2024 Nov Neuropsychopharmacology 1 50 153-163

The metabotropic glutamate receptor 5 as a biomarker for psychiatric disorders.

Asch RH, Hillmer AT, Baldassarri SR, Esterlis I, 2023 Int Rev Neurobiol 168 265-310

An In Vivo Examination of the Relationship Between Metabotropic Glutamate 5 Receptor and Suicide Attempts in People With Borderline Personality Disorder.

Davis MT, Asch RH, Weiss ER, Wagner A, Fineberg SK, Nabulsi N, Matuskey D, Carson RE, Esterlis I, 2025 Mar Biol Psychiatry Cogn Neurosci Neuroimaging 3 10 324-332

Exploring the influence of synaptic density and anxiety on pain perception: evidence from a [11C]UCB-J positron emission tomography imaging study.

Moisieienko K, Asch RH, Davis MT, Pietrzak RH, Esterlis I, 2025 Jul Int J Neuropsychopharmacol 7 28

Venous blood sampling for less invasive in vivo quantification of synaptic density with constant infusion of [18F]SynVesT-1 and PET.

Asch RH, Naganawa M, Moisieienko K, Weed M, Kapinos M, Zheng MQ, Hillmer AT, Carson RE, Pietrzak RH, Esterlis I, 2025 Feb EJNMMI Res 1 15 8

In vivo evidence for metabotropic glutamate receptor 5 dysregulation in chronic pain.

Davis MT, Weiss ER, DellaGioia N, Boster S, Asch RH, Moisieienko K, Esterlis I, 2025 Dec Neuropsychopharmacology

Evaluation of radio-thin-layer chromatography as an alternative to radio-HPLC for [18F]SynVesT-1 metabolism analysis in rats.

Balayeva T, Asch RH, Tan PW, Mennie W, Tong J, Chen B, Zhuang Z, Zheng C, Zheng M, Toyonaga T, Cai Z, 2025 Nucl Med Biol 146-147 109029

Deficits in prefrontal metabotropic glutamate receptor 5 are associated with functional alterations during emotional processing in bipolar disorder.

Asch RH, Worhunsky PD, Davis MT, Holmes SE, Cool R, Boster S, Carson RE, Blumberg HP, Esterlis I, 2024 Sep J Affect Disord 361 415-424

Metabotropic Glutamate Receptor 5 as a Potential Biomarker of the Intersection of Trauma and Cannabis Use.

Weiss ER, Davis MT, Asch RH, D'Souza DC, Cool R, Esterlis I, 2024 Oct Int J Neuropsychopharmacol 10 27

First-in-Human Study of 18F-SynVesT-2: An SV2A PET Imaging Probe with Fast Brain Kinetics and High Specific Binding.

Drake LR, Wu Y, Naganawa M, Asch R, Zheng C, Najafzadeh S, Pracitto R, Lindemann M, Li S, Ropchan J, Labaree D, Emery PR, Dias M, Henry S, Nabulsi N, Matuskey D, Hillmer AT, Gallezot JD, Carson RE, Cai Z, Huang Y, 2024 Feb J Nucl Med 3 65 462-9

Preliminary Study of White Matter Abnormalities and Associations With the Metabotropic Glutamate Receptor 5 to Distinguish Bipolar and Major Depressive Disorders.

Fan S, Asch RH, Davis MT, DellaGioia N, Cool R, Blumberg HP, Esterlis I, 2024 Chronic Stress (Thousand Oaks) 8 24705470231225320

Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder.

Holmes SE, Asch RH, Davis MT, DellaGioia N, Pashankar N, Gallezot JD, Nabulsi N, Matuskey D, Sanacora G, Carson RE, Blumberg HP, Esterlis I, 2023 Jun Biol Psychiatry 12 93 1099-1107

Examining sex differences in responses to footshock stress and the role of the metabotropic glutamate receptor 5: an [18F]FPEB and positron emission tomography study in rats.

Asch RH, Pothula S, Toyonaga T, Fowles K, Groman SM, Garcia-Milian R, DiLeone RJ, Taylor JR, Esterlis I, 2023 Feb Neuropsychopharmacology 3 48 489-497

Evaluating infusion methods and simplified quantification of synaptic density in vivo with [11C]UCB-J and [18F]SynVesT-1 PET.

Asch RH, Naganawa M, Nabulsi N, Huan Y, Esterlis I, Carson RE, 2023 Dec J Cereb Blood Flow Metab 12 43 2120-2129

Examining mGlu5 Receptor Availability as a Predictor of Vulnerability to PTSD: An [18F]FPEB and PET Study in Male and Female Rats.

Asch RH, Fowles K, Pietrzak RH, Taylor JR, Esterlis I, 2023 Chronic Stress (Thousand Oaks) 7 24705470231215001

Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders.

Baldassarri SR, Asch RH, Hillmer AT, Pietrzak RH, DellaGioia N, Esterlis I, Davis MT, 2023 Chronic Stress (Thousand Oaks) 7 24705470231154842

Lower synaptic density is associated with psychiatric and cognitive alterations in obesity.

Asch RH, Holmes SE, Jastreboff AM, Potenza MN, Baldassarri SR, Carson RE, Pietrzak RH, Esterlis I, 2022 Jan Neuropsychopharmacology 2 47 543-552

Perinatal dietary omega-3 fatty acid deficiency reduces maternal nurturing behavior in rats: dissociation from elevated pro-inflammatory signaling.

Asch RH, Schurdak JD, McNamara RK, 2021 Sep Nutr Neurosci 9 24 735-746

Psychological Resilience to the Challenges of Physical Aging in Older U.S. Veterans: Results From the 2019-2020 National Health and Resilience in Veterans Study.

Asch RH, Kachadourian L, Southwick SM, Esterlis I, Pietrzak RH, 2021 Dec Am J Geriatr Psychiatry 12 29 1280-1285

Polygenic risk for traumatic loss-related PTSD in US military veterans: Protective effect of secure attachment style.

Asch RH, Esterlis I, Wendt FR, Kachadourian L, Southwick SM, Gelernter J, Polimanti R, Pietrzak RH, 2021 Dec World J Biol Psychiatry 10 22 792-799

The hidden burden of social anxiety disorder in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.

Byrne SP, Fogle BM, Asch R, Esterlis I, Harpaz-Rotem I, Tsai J, Pietrzak RH, 2021 Aug J Affect Disord 291 9-14

Predicting Post-Concussion Symptom Recovery in Adolescents Using a Novel Artificial Intelligence.

Fleck DE, Ernest N, Asch R, Adler CM, Cohen K, Yuan W, Kunkel B, Krikorian R, Wade SL, Babcock L, 2021 Apr J Neurotrauma 7 38 830-836

Risk and resilience factors associated with traumatic loss-related PTSD in U.S. military veterans: Results from the National Health and Resilience in Veterans Study.

Asch RH, Esterlis I, Southwick SM, Pietrzak RH, 2021 Apr Psychiatry Res 298 113775

Omega-3 fatty acid deficiency impairs frontostriatal recruitment following repeated amphetamine treatment in rats: A 7 Tesla in vivo phMRI study.

McNamara RK, Schurdak JD, Asch RH, Lindquist DM, 2019 Aug Nutr Neurosci 8 22 587-595

Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findings.

McNamara RK, Asch RH, Lindquist DM, Krikorian R, 2018 Sep Prostaglandins Leukot Essent Fatty Acids 136 23-34

Deficits in Docosahexaenoic Acid Accrual during Adolescence Reduce Rat Forebrain White Matter Microstructural Integrity: An in vivo Diffusion Tensor Imaging Study.

McNamara RK, Schurdak JD, Asch RH, Peters BD, Lindquist DM, 2018 Dev Neurosci 1 40 84-92

Governing roles for Trib3 pseudokinase during stress erythropoiesis.

Dev A, Asch R, Jachimowicz E, Rainville N, Johnson A, Greenfest-Allen E, Wojchowski DM, 2017 May Exp Hematol 49 48-55.e5

Glutamate homeostasis in the adult rat prefrontal cortex is altered by cortical docosahexaenoic acid accrual during adolescence: An in vivo1H MRS study.

McNamara RK, Asch RH, Schurdak JD, Lindquist DM, 2017 Dec Psychiatry Res Neuroimaging 270 39-45

Effects of dietary-induced alterations in rat brain docosahexaenoic acid accrual on phospholipid metabolism and mitochondrial bioenergetics: An in vivo31P MRS study.

Lindquist DM, Asch RH, Schurdak JD, McNamara RK, 2017 Dec J Psychiatr Res 95 143-146