Publications

Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.

Deja S, Fletcher JA, Kim CW, Kucejova B, Fu X, Mizerska M, Villegas M, Pudelko-Malik N, Browder N, Inigo-Vollmer M, Menezes CJ, Mishra P, Berglund ED, Browning JD, Thyfault JP, Young JD, Horton JD, Burgess SC, 2024 Mar Cell Metab

Persistent fasting lipogenesis links impaired ketogenesis with citrate synthesis in humans with nonalcoholic fatty liver.

Fu X, Fletcher JA, Deja S, Inigo-Vollmer M, Burgess SC, Browning JD, 2023 May J Clin Invest 9 133

Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.

Rome FI, Shobert GL, Voigt WC, Stagg DB, Puchalska P, Burgess SC, Crawford PA, Hughey CC, 2023 Jan Am J Physiol Endocrinol Metab 1 324 E9-E23

Impaired ketogenesis and increased acetyl-CoA oxidation promote hyperglycemia in human fatty liver.

Fletcher JA, Deja S, Satapati S, Fu X, Burgess SC, Browning JD, 2019 Apr JCI Insight 5

Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.

Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC, 2019 Apr Cell Metab.

Targeted Determination of Tissue Energy Status by LC-MS/MS.

Fu X, Deja S, Kucejova B, Duarte JAG, McDonald JG, Burgess SC, 2019 Apr Anal. Chem.

The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity.

Rauckhorst AJ, Gray LR, Sheldon RD, Fu X, Pewa AD, Feddersen CR, Dupuy AJ, Gibson-Corley KN, Cox JE, Burgess SC, Taylor EB 2017 Nov Mol Metab 11 6 1468-1479

Aerobic capacity mediates susceptibility for the transition from steatosis to steatohepatitis.

Morris EM, McCoin CS, Allen JA, Gastecki ML, Koch LG, Britton SL, Fletcher JA, Fu X, Ding WX, Burgess SC, Rector RS, Thyfault JP 2017 May J. Physiol. (Lond.)

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity.

Kucejova B, Duarte J, Satapati S, Fu X, Ilkayeva O, Newgard CB, Brugarolas J, Burgess SC 2016 Jun Cell Rep

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.

McCommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzien RF, Burgess SC, Finck BN 2015 Sep Cell Metab.

Limitations of detection of anaplerosis and pyruvate cycling from metabolism of [1-(13)C] acetate.

Burgess SC, Merritt ME, Jones JG, Browning JD, Sherry AD, Malloy CR 2015 Feb Nat. Med. 2 21 108-9

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston K, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC 2015 Dec J. Clin. Invest. 12 125 4447-4462

A HFD suppresses de novo lipogenesis and desaturation, but not elongation and triglyceride synthesis in mice.

Duarte JA, Carvalho F, Pearson M, Horton JD, Browning JD, Jones JG, Burgess SC 2014 Sep J. Lipid Res.

PEPCK-M expression in mouse liver potentiates, not replaces, PEPCK-C mediated gluconeogenesis.

Méndez-Lucas A, Duarte JA, Sunny NE, Satapati S, He T, Fu X, Bermúdez J, Burgess SC, Perales JC 2013 Mar J. Hepatol.

Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice.

Potthoff MJ, Potts A, He T, Duarte JA, Taussig R, Mangelsdorf DJ, Kliewer SA, Burgess SC 2013 Feb Am. J. Physiol. Gastrointest. Liver Physiol. 4 304 G371-80

The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men.

Browning JD, Baxter J, Satapati S, Burgess SC 2012 Mar J. Lipid Res. 3 53 577-86

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.

Satapati S, Sunny NE, Kucejova B, Fu X, He TT, Méndez-Lucas A, Shelton JM, Perales JC, Browning JD, Burgess SC 2012 Jun J. Lipid Res. 6 53 1080-92

Flux through hepatic pyruvate carboxylase and phosphoenolpyruvate carboxykinase detected by hyperpolarized 13C magnetic resonance.

Merritt ME, Harrison C, Sherry AD, Malloy CR, Burgess SC 2011 Nov Proc. Natl. Acad. Sci. U.S.A. 47 108 19084-9

Short-term weight loss and hepatic triglyceride reduction: evidence of a metabolic advantage with dietary carbohydrate restriction.

Browning JD, Baker JA, Rogers T, Davis J, Satapati S, Burgess SC 2011 May Am. J. Clin. Nutr. 5 93 1048-52

Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease.

Sunny NE, Parks EJ, Browning JD, Burgess SC 2011 Dec Cell Metab. 6 14 804-10

Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.

Sunny NE, Satapati S, Fu X, He T, Mehdibeigi R, Spring-Robinson C, Duarte J, Potthoff MJ, Browning JD, Burgess SC 2010 Jun Am. J. Physiol. Endocrinol. Metab. 6 298 E1226-35

FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response.

Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, Mohammadi M, Finck BN, Mangelsdorf DJ, Kliewer SA, Burgess SC 2009 Jun Proc. Natl. Acad. Sci. U.S.A. 26 106 10853-8

Alterations in hepatic glucose and energy metabolism as a result of calorie and carbohydrate restriction.

Browning JD, Weis B, Davis J, Satapati S, Merritt M, Malloy CR, Burgess SC 2008 Nov Hepatology 5 48 1487-96

Cytosolic phosphoenolpyruvate carboxykinase does not solely control the rate of hepatic gluconeogenesis in the intact mouse liver.

Burgess SC, He T, Yan Z, Lindner J, Sherry AD, Malloy CR, Browning JD, Magnuson MA 2007 Apr Cell Metab. 4 5 313-20

Effects of insulin and cytosolic redox state on glucose production pathways in the isolated perfused mouse liver measured by integrated 2H and 13C NMR.

Hausler N, Browning J, Merritt M, Storey C, Milde A, Jeffrey FM, Sherry AD, Malloy CR, Burgess SC 2006 Mar Biochem. J. Pt 2 394 465-73

A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride content. Hepatology

Browning JD, Davis J, Saboorian MH, and Burgess SC 2006 44 487-488

Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation

Pengxiang She, Shawn C. Burgess, Masakazu Shiota, Paul Flakoll, E Patrick Donahue, Craig R Malloy, A Dean Sherry, and Mark A Magnuson 2003 52 1649-1654

Reciprocal Regulation of Cardiac β-Oxidation and Pyruvate Dehydrogenase by Insulin.

Elnwasany A, Ewida HA, Menendez-Montes I, Mizerska M, Fu X, Kim CW, Horton JD, Burgess SC, Rothermel BA, Szweda PA, Szweda LI, 2024 May J Biol Chem 107412

Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization.

Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS, Kim DS, Sun X, An YA, Field BC, Lee C, Matsuo EI, Mizerska M, Sanjana I, Fujiwara N, Kusminski CM, Gordillo R, Gautron L, Marciano DK, Hu MC, Burgess SC, Susztak K, Moe OW, Scherer PE, 2023 Oct Nat Commun 1 14 6531

Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice.

Yiew NKH, Deja S, Ferguson D, Cho K, Jarasvaraparn C, Jacome-Sosa M, Lutkewitte AJ, Mukherjee S, Fu X, Singer JM, Patti GJ, Burgess SC, Finck BN, 2023 Nov iScience 11 26 108196

Fatty Acid Desaturation Gets a NAD+ Reputation.

Lutkewitte AJ, Burgess SC, Finck BN, 2019 Apr Cell Metab. 4 29 790-792

A Novel Inhibitor of Pyruvate Dehydrogenase Kinase Stimulates Myocardial Carbohydrate Oxidation in Diet-Induced Obesity.

Wu CY, Satapati S, Gui W, Wynn RM, Sharma G, Lou M, Qi X, Burgess SC, Malloy C, Khemtong C, Sherry AD, Chuang D, Merritt ME 2018 May J. Biol. Chem.

Roux-en-Y Gastric Bypass Compared to Equivalent Diet Restriction: Mechanistic Insights into Diabetes Remission.

Pop LM, Mari A, Zhao TJ, Mitchell L, Burgess S, Li X, Adams-Huet B, Lingvay I 2018 Mar Diabetes Obes Metab

Cytosolic Phosphoenolpyruvate Carboxykinase as a Cataplerotic Pathway in the Small Intestine.

Potts A, Uchida A, Deja S, Berglund ED, Kucejova B, Duarte JAG, Fu X, Browning JD, Magnuson MA, Burgess SC 2018 Apr Am. J. Physiol. Gastrointest. Liver Physiol.

The NQO1 bioactivatable drug, ?-Lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism.

Silvers MA, Deja S, Singh N, Egnatchik RA, Sudderth J, Luo X, Beg MS, Burgess SC, DeBerardinis RJ, Boothman DA, Merritt ME 2017 Sep J. Biol. Chem.

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

Kim CW, Addy C, Kusunoki J, Anderson NN, Deja S, Fu X, Burgess SC, Li C, Ruddy M, Chakravarthy M, Previs S, Milstein S, Fitzgerald K, Kelley DE, Horton JD 2017 Sep Cell Metab. 3 26 576

FGF19, FGF21, and an FGFR1/?-Klotho-Activating Antibody Act on the Nervous System to Regulate Body Weight and Glycemia.

Lan T, Morgan DA, Rahmouni K, Sonoda J, Fu X, Burgess SC, Holland WL, Kliewer SA, Mangelsdorf DJ 2017 Oct Cell Metab.

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

Kim CW, Addy C, Kusunoki J, Anderson NN, Deja S, Fu X, Burgess SC, Li C, Ruddy M, Chakravarthy M, Previs S, Milstein S, Fitzgerald K, Kelley DE, Horton JD 2017 Aug Cell Metab. 2 26 394-406.e6

A Comprehensive Analysis of Myocardial Substrate Preference Emphasizes the Need For a Synchronized Fluxomic/Metabolomic Research Design.

Ragavan M, Kirpich A, Fu X, Burgess SC, McIntyre LM, Merritt ME 2017 Apr Am. J. Physiol. Heart Circ. Physiol. ajpheart.00016.2017

Aerobic capacity and hepatic mitochondrial lipid oxidation alters susceptibility for chronic high fat diet induced hepatic steatosis.

Morris EM, Meers GM, Koch LG, Britton SL, Fletcher JA, Shankar K, Fu X, Burgess SC, Ibdah JA, Rector RS, Thyfault JP 2016 Sep Am. J. Physiol. Endocrinol. Metab. ajpendo.00178.2016

A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism.

Amoasii L, Holland W, Sanchez-Ortiz E, Baskin KK, Pearson M, Burgess SC, Nelson BR, Bassel-Duby R, Olson EN 2016 Feb Genes Dev. 4 30 434-46

Mitochondrial metabolism mediates oxidative stress and inflammation in fatty liver.

Satapati S, Kucejova B, Duarte JA, Fletcher JA, Reynolds L, Sunny NE, He T, Nair LA, Livingston KA, Fu X, Merritt ME, Sherry AD, Malloy CR, Shelton JM, Lambert J, Parks EJ, Corbin I, Magnuson MA, Browning JD, Burgess SC 2016 Apr J. Clin. Invest. 4 126 1605

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis.

Gray LR, Sultana MR, Rauckhorst AJ, Oonthonpan L, Tompkins SC, Sharma A, Fu X, Miao R, Pewa AD, Brown KS, Lane EE, Dohlman A, Zepeda-Orozco D, Xie J, Rutter J, Norris AW, Cox JE, Burgess SC, Potthoff MJ, Taylor EB 2015 Sep Cell Metab.

Production of hyperpolarized (13)CO2 from [1-(13)C]pyruvate in perfused liver does reflect total anaplerosis but is not a reliable biomarker of glucose production.

Moreno KX, Moore CL, Burgess SC, Sherry AD, Malloy CR, Merritt ME 2015 Oct Metabolomics 5 11 1144-1156

A roadmap for interpreting (13)C metabolite labeling patterns from cells.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM 2015 Feb Curr. Opin. Biotechnol. 34C 189-201

Real-Time Detection of Hepatic Gluconeogenic and Glycogenolytic States Using Hyperpolarized [2-13C]Dihydroxyacetone.

Moreno KX, Satapati S, DeBerardinis RJ, Burgess SC, Malloy CR, Merritt ME 2014 Oct J. Biol. Chem.

Propionate stimulates pyruvate oxidation in the presence of acetate.

Purmal C, Kucejova B, Sherry AD, Burgess SC, Malloy CR, Merritt ME 2014 Oct Am. J. Physiol. Heart Circ. Physiol. 8 307 H1134-41

MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver.

Baskin KK, Grueter CE, Kusminski CM, Holland WL, Bookout AL, Satapati S, Kong YM, Burgess SC, Malloy CR, Scherer PE, Newgard CB, Bassel-Duby R, Olson EN 2014 Nov EMBO Mol Med

Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion.

Vigueira PA, McCommis KS, Schweitzer GG, Remedi MS, Chambers KT, Fu X, McDonald WG, Cole SL, Colca JR, Kletzien RF, Burgess SC, Finck BN 2014 Jun Cell Rep 6 7 2042-53

Metabolomics, Stable Isotopes, and A-?+ Ketosis-Prone Diabetes.

Ramos-Roman MA, Burgess SC, Browning JD 2013 Mar Diabetes 3 62 682-4

Weight-Independent Effects of Roux-en-Y Gastric Bypass on Glucose Homeostasis via Melanocortin-4 Receptors in Mice and Humans.

Zechner JF, Mirshahi UL, Satapati S, Berglund ED, Rossi J, Scott MM, Still CD, Gerhard GS, Burgess SC, Mirshahi T, Aguirre V 2013 Mar Gastroenterology 3 144 580-590.e7

A Noncanonical, GSK3-Independent Pathway Controls Postprandial Hepatic Glycogen Deposition.

Wan M, Leavens KF, Hunter RW, Koren S, von Wilamowitz-Moellendorff A, Lu M, Satapati S, Chu Q, Sakamoto K, Burgess SC, Birnbaum MJ 2013 Jul Cell Metab. 1 18 99-105

Metabolic manifestations of insulin deficiency do not occur without glucagon action.

Lee Y, Berglund ED, Wang MY, Fu X, Yu X, Charron MJ, Burgess SC, Unger RH 2012 Sep Proc. Natl. Acad. Sci. U.S.A. 37 109 14972-6

Use of (2)H(2)O for estimating rates of gluconeogenesis: determination and correction of error due to transaldolase exchange.

Browning JD, Burgess SC 2012 Dec Am. J. Physiol. Endocrinol. Metab. 11 303 E1304-12

Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding.

Chambers KT, Chen Z, Crawford PA, Fu X, Burgess SC, Lai L, Leone TC, Kelly DP, Finck BN 2012 PLoS ONE 12 7 e52645

Noninvasive MRI of ?-cell function using a Zn2+-responsive contrast agent.

Lubag AJ, De Leon-Rodriguez LM, Burgess SC, Sherry AD 2011 Nov Proc. Natl. Acad. Sci. U.S.A. 45 108 18400-5

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death.

Kucejova B, Sunny NE, Nguyen AD, Hallac R, Fu X, Peña-Llopis S, Mason RP, Deberardinis RJ, Xie XJ, Debose-Boyd R, Kodibagkar VD, Burgess SC, Brugarolas J 2011 May Oncogene 18 30 2147-60

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1a pathway.

Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA 2011 Jun Cell Metab. 6 13 729-38

The impact of obesity, sex, and diet on hepatic glucose production in cats.

Kley S, Hoenig M, Glushka J, Jin ES, Burgess SC, Waldron M, Jordan ET, Prestegard JH, Ferguson DC, Wu S, Olson DE 2009 Apr Am. J. Physiol. Regul. Integr. Comp. Physiol. 4 296 R936-43

Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets.

Ronnebaum SM, Jensen MV, Hohmeier HE, Burgess SC, Zhou YP, Qian S, MacNeil D, Howard A, Thornberry N, Ilkayeva O, Lu D, Sherry AD, Newgard CB 2008 Oct J. Biol. Chem. 43 283 28909-17

Complicating factors in the application of the "average method" for determining the contribution of gluconeogenesis.

Burgess SC, Chandramouli V, Browning JD, Schumann WC, Previs SF 2008 Jun J. Appl. Physiol. 6 104 1852-3; author reply 1854-5

Carbohydrate-response element-binding protein deletion alters substrate utilization producing an energy-deficient liver.

Burgess SC, Iizuka K, Jeoung NH, Harris RA, Kashiwaya Y, Veech RL, Kitazume T, Uyeda K 2008 Jan J. Biol. Chem. 3 283 1670-8

Evidence that processes other than gluconeogenesis may influence the ratio of deuterium on the fifth and third carbons of glucose: implications for the use of 2H2O to measure gluconeogenesis in humans.

Bock G, Schumann WC, Basu R, Burgess SC, Yan Z, Chandramouli V, Rizza RA, Landau BR 2008 Jan Diabetes 1 57 50-5

Metabolic cycling in control of glucose-stimulated insulin secretion.

Jensen MV, Joseph JW, Ronnebaum SM, Burgess SC, Sherry AD, Newgard CB 2008 Dec Am. J. Physiol. Endocrinol. Metab. 6 295 E1287-97

Partial resistance to peroxisome proliferator-activated receptor-alpha agonists in ZDF rats is associated with defective hepatic mitochondrial metabolism.

Satapati S, He T, Inagaki T, Potthoff M, Merritt ME, Esser V, Mangelsdorf DJ, Kliewer SA, Browning JD, Burgess SC 2008 Aug Diabetes 8 57 2012-21

Normal flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion.

Joseph JW, Odegaard ML, Ronnebaum SM, Burgess SC, Muehlbauer J, Sherry AD, Newgard CB 2007 Oct J. Biol. Chem. 43 282 31592-600

Abnormalities of glucose homeostasis and the hypothalamic-pituitary-adrenal axis in mice lacking hexose-6-phosphate dehydrogenase.

Rogoff D, Ryder JW, Black K, Yan Z, Burgess SC, McMillan DR, White PC 2007 Oct Endocrinology 10 148 5072-80

Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.

Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA 2007 Jun Cell Metab. 6 5 415-25

Regulation of the Fasting Response by PPARa-Mediated Induction of Fibroblast Growth Factor 21

Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammad M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA 2007 IN PRESS

A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion.

Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB, Jensen MV 2006 Oct J. Biol. Chem. 41 281 30593-602

Hepatic UDP-glucose 13C isotopomers from [U-13C]glucose: a simple analysis by 13C NMR of urinary menthol glucuronide.

Mendes AC, Caldeira MM, Silva C, Burgess SC, Merritt ME, Gomes F, Barosa C, Delgado TC, Franco F, Monteiro P, Providencia L, Jones JG 2006 Nov Magn Reson Med 5 56 1121-5

The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism.

Chevalier S, Burgess SC, Malloy CR, Gougeon R, Marliss EB, Morais JA 2006 Mar Diabetes 3 55 675-81

Storage and oxidation of long-chain fatty acids in the C57/BL6 mouse heart as measured by NMR spectroscopy.

Stowe KA, Burgess SC, Merritt M, Sherry AD, Malloy CR 2006 Jul FEBS Lett. 17 580 4282-7

Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice.

Burgess SC, Leone TC, Wende AR, Croce MA, Chen Z, Sherry AD, Malloy CR, Finck BN 2006 Jul J. Biol. Chem. 28 281 19000-8

A low-carbohydrate diet rapidly and dramatically reduces intrahepatic triglyceride content.

Browning JD, Davis J, Saboorian MH, Burgess SC 2006 Aug Hepatology 2 44 487-8

Adiabatic JHSQC for 13C isotopomer analysis.

Merritt ME, Burgess SC, Spitzer TD 2006 Apr Magn Reson Chem 4 44 463-6

Effects of Insulin and Cytosolic Redox State on Glucose Production Pathways in the Isolated Perfused Mouse Liver by Integrated 2H and 13C NMR

Natasha Hausler, Matthew Merritt, Charles Storey, Angela Milde, A. Dean Sherry Craig R. Malloy and SC Burgess 2006 395 663

Lung preservation solution substrate composition affects rat lung oxidative metabolism during hypothermic storage.

Peltz M, Hamilton TT, He TT, Adams GA, Koshy S, Burgess SC, Chao RY, Jessen ME, Meyer DM 2005 Oct Respir Physiol Neurobiol 3 148 275-83

Perfusion preservation maintains myocardial ATP levels and reduces apoptosis in an ex vivo rat heart transplantation model.

Peltz M, He TT, Adams GA, Koshy S, Burgess SC, Chao RY, Meyer DM, Jessen ME 2005 Oct Surgery 4 138 795-805

Comparison of [3,4-13C2]glucose to [6,6-2H2]glucose as a tracer for glucose turnover by nuclear magnetic resonance.

Jin ES, Jones JG, Burgess SC, Merritt ME, Sherry AD, Malloy CR 2005 Jun Magn Reson Med 6 53 1479-83

Effect of murine strain on metabolic pathways of glucose production after brief or prolonged fasting.

Burgess SC, Jeffrey FM, Storey C, Milde A, Hausler N, Merritt ME, Mulder H, Holm C, Sherry AD, Malloy CR 2005 Jul Am. J. Physiol. Endocrinol. Metab. 1 289 E53-61

Differing mechanisms of hepatic glucose overproduction in triiodothyronine-treated rats vs. Zucker diabetic fatty rats by NMR analysis of plasma glucose.

Jin ES, Burgess SC, Merritt ME, Sherry AD, Malloy CR 2005 Apr Am. J. Physiol. Endocrinol. Metab. 4 288 E654-62

Impaired tricarboxylic acid cycle activity in mouse livers lacking cytosolic phosphoenolpyruvate carboxykinase.

Burgess SC, Hausler N, Merritt M, Jeffrey FM, Storey C, Milde A, Koshy S, Lindner J, Magnuson MA, Malloy CR, Sherry AD 2004 Nov J. Biol. Chem. 47 279 48941-9

Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue.

Boucher A, Lu D, Burgess SC, Telemaque-Potts S, Jensen MV, Mulder H, Wang MY, Unger RH, Sherry AD, Newgard CB 2004 Jun J. Biol. Chem. 26 279 27263-71

Glucose production, gluconeogenesis, and hepatic tricarboxylic acid cycle fluxes measured by nuclear magnetic resonance analysis of a single glucose derivative.

Jin ES, Jones JG, Merritt M, Burgess SC, Malloy CR, Sherry AD 2004 Apr Anal. Biochem. 2 327 149-55

Glucose production pathways by 2H and 13C NMR in patients with HIV-associated lipoatrophy.

Weis BC, Margolis D, Burgess SC, Merritt ME, Wise H, Sherry AD, Malloy CR 2004 Apr Magn Reson Med 4 51 649-54

Sources of plasma glucose by automated Bayesian analysis of 2H NMR spectra.

Merritt M, Bretthorst GL, Burgess SC, Sherry AD, Malloy CR 2003 Oct Magn Reson Med 4 50 659-63

Analysis of gluconeogenic pathways in vivo by distribution of 2H in plasma glucose: comparison of nuclear magnetic resonance and mass spectrometry.

Burgess SC, Nuss M, Chandramouli V, Hardin DS, Rice M, Landau BR, Malloy CR, Sherry AD 2003 Jul Anal. Biochem. 2 318 321-4

Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation.

She P, Burgess SC, Shiota M, Flakoll P, Donahue EP, Malloy CR, Sherry AD, Magnuson MA 2003 Jul Diabetes 7 52 1649-54

Noninvasive evaluation of liver metabolism by 2H and 13C NMR isotopomer analysis of human urine.

Burgess SC, Weis B, Jones JG, Smith E, Merritt ME, Margolis D, Dean Sherry A, Malloy CR 2003 Jan Anal. Biochem. 2 312 228-34

Increased hepatic fructose 2,6-bisphosphate after an oral glucose load does not affect gluconeogenesis.

Jin ES, Uyeda K, Kawaguchi T, Burgess SC, Malloy CR, Sherry AD 2003 Aug J. Biol. Chem. 31 278 28427-33

Comparison of 2H2O Measured Gluconeogenesis Determined by Both NMR and MS

Shawn C Burgess, Merrill Nuss, Bernard R Landau, A Dean Sherry and Craig R Malloy 2003 318 321-324

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS).

Lu D, Mulder H, Zhao P, Burgess SC, Jensen MV, Kamzolova S, Newgard CB, Sherry AD 2002 Mar Proc. Natl. Acad. Sci. U.S.A. 5 99 2708-13

13C NMR Isotopomer Analysis Reveals a Connection Between Pyruvate Cycling and Glucose-Stimulated Insulin Secretion (GSIS)

Danhong Lu, Hindrik Mulder, Piyu Zhao, Shawn C Burgess, Mette V Jensen, Svetlana Kamzolova, Christopher B Newgard and A Dean Sherry 2002 99 2708-2713

NMR indirect detection of glutamate to measure citric acid cycle flux in the isolated perfused mouse heart.

Burgess SC, Babcock EE, Jeffrey FM, Sherry AD, Malloy CR 2001 Sep FEBS Lett. 1 505 163-7

13C isotopomer analysis of glutamate by J-resolved heteronuclear single quantum coherence spectroscopy.

Burgess SC, Carvalho RA, Merritt ME, Jones JG, Malloy CR, Sherry AD 2001 Feb Anal. Biochem. 2 289 187-95