Publications

Physiological Effects of Soat1 Inactivation on Homeostasis of the Mouse Ocular Surface.

Wilkerson A, Yuksel S, Acharya R, Butovich IA, 2024 Jul Invest Ophthalmol Vis Sci 8 65 2

Primary cilia control cellular patterning of Meibomian glands during morphogenesis but not lipid composition.

Portal C, Lin Y, Rastogi V, Peterson C, Yiu SC, Foster JW, Wilkerson A, Butovich IA, Iomini C, 2023 Mar Commun Biol 1 6 282

Probing dietary triacylglycerol metabolism and meibogenesis in mice: A stable isotope-labeled tracer LC-MS/MS study.

Butovich I, Yuksel S, Wilkerson A, 2023 Feb J Biol Chem 103046

Dysregulation of Lipid Metabolism in Aging Meibomian Glands and Its Molecular Markers.

Butovich IA, Wilkerson A, Yuksel S, 2023 Aug Int J Mol Sci 17 24

Sdr16c5 and Sdr16c6 control a dormant pathway at a bifurcation point between meibogenesis and sebogenesis.

Butovich IA, Wilkerson A, Goggans KR, Belyaeva OV, Kedishvili NY, Yuksel S, 2023 Apr J Biol Chem 104725

Dynamic Changes in the Gene Expression Patterns and Lipid Profiles in the Developing and Maturing Meibomian Glands.

Butovich IA, Wilkerson A, 2022 Jul Int J Mol Sci 14 23

Effects of Aging on Human Meibum.

Butovich IA, Suzuki T, 2021 Sep Invest Ophthalmol Vis Sci 12 62 23

Physiological effects of inactivation and the roles of Elovl3/ELOVL3 in maintaining ocular homeostasis.

Wilkerson A, Bhat N, Quoc Hai Pham H, Yuksel S, Butovich I, 2021 Feb FASEB J 2 35 e21327

Differential effects of dietary cholesterol and triglycerides on the lipid homeostasis in Meibomian glands.

Butovich IA, Wilkerson A, Yuksel S, 2021 Apr J Steroid Biochem Mol Biol 211 105894

Delineating a novel metabolic high triglycerides-low waxes syndrome that affects lipid homeostasis in meibomian and sebaceous glands.

Butovich IA, Suzuki T, 2020 Oct Exp Eye Res 199 108189

Comparative Transcriptomic and Lipidomic Analyses of Human Male and Female Meibomian Glands Reveal Common Signature Genes of Meibogenesis.

Butovich IA, Bhat N, Wojtowicz JC, 2019 Sep Int J Mol Sci 18 20

Effects of sex (or lack thereof) on meibogenesis in mice (Mus musculus): Comparative evaluation of lipidomes and transcriptomes of male and female tarsal plates.

Butovich IA, McMahon A, Wojtowicz JC, Bhat N, Wilkerson A, 2019 Mar Ocul Surf

On the pivotal role of Elovl3/ELOVL3 in meibogenesis and ocular physiology of mice.

Butovich IA, Wilkerson A, Bhat N, McMahon A, Yuksel S, 2019 Jun FASEB J. fj201900725R

Meibomian glands, meibum, and meibogenesis.

Butovich IA 2017 Jun Exp. Eye Res.

Dissecting lipid metabolism in meibomian glands of humans and mice: An integrative study reveals a network of metabolic reactions not duplicated in other tissues.

Butovich IA, McMahon A, Wojtowicz JC, Lin F, Mancini R, Itani K 2016 Mar Biochim. Biophys. Acta

Comparative Characterization of Human Meibomian Glands, Free Sebaceous Glands, and Hair-Associated Sebaceous Glands Based on Biomarkers, Analysis of Secretion Composition, and Gland Morphology.

Liu Y, Butovich IA, Garreis F, Zahn I, Scholz M, Gaffling S, Jabari S, Dietrich J, Paulsen F, 2024 Mar Int J Mol Sci 6 25

Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis.

Yuksel S, Aredo B, Zegeye Y, Zhao CX, Tang M, Li X, Hulleman JD, Gautron L, Ludwig S, Moresco EMY, Butovich IA, Beutler BA, Ufret-Vincenty RL, 2023 May Commun Biol 1 6 533

Comparative Biophysical Study of Meibomian Lipids of Wild Type and Soat1-Null Mice: Implications to Meibomian Gland Dysfunction and Dry Eye Disease.

Xu X, Wilkerson A, Li G, Butovich IA, Zuo YY, 2023 Aug Invest Ophthalmol Vis Sci 11 64 20

Novel Lipids of the Rabbit Harderian Gland Improve Tear Stability in an Animal Model of Dry Eye Disease.

Butovich IA, Yuksel S, Leonard B, Gadek T, Polans AS, Albert DM, 2021 Sep J Ocul Pharmacol Ther

Depletion of Cholesteryl Esters Causes Meibomian Gland Dysfunction-Like Symptoms in a Soat1-Null Mouse Model.

Butovich IA, Wilkerson A, Yuksel S, 2021 Feb Int J Mol Sci 4 22

Comprehensive profiling of Asian and Caucasian meibomian gland secretions reveals similar lipidomic signatures regardless of ethnicity.

Butovich IA, Suzuki T, Wojtowicz J, Bhat N, Yuksel S, 2020 09 Sci Rep 1 10 14510

Cyclic Change of Fatty Acid Composition in Meibum During the Menstrual Cycle.

Suzuki T, Fujiwara S, Kinoshita S, Butovich IA, 2019 Apr Invest. Ophthalmol. Vis. Sci. 5 60 1724-1733

A role for ELOVL4 in the mouse meibomian gland and sebocyte cell biology.

McMahon A, Lu H, Butovich IA 2014 Mar Invest. Ophthalmol. Vis. Sci.

Time-dependent degenerative transformations in the lipidome of chalazia.

Wojtowicz JC, Butovich IA, McMahon A, Hogan RN, Itani KM, Mancini R, Molai M, Linsenbardt E 2014 Aug Exp. Eye Res. 127C 261-269

Biophysical and morphological evaluation of human normal and dry eye meibum using hot stage polarized light microscopy.

Butovich IA, Lu H, McMahon A, Ketelson H, Senchyna M, Meadows D, Campbell E, Molai M, Linsenbardt E 2013 Nov Invest. Ophthalmol. Vis. Sci.

Tear film lipids.

Butovich IA 2013 Jun Exp. Eye Res.

The Spectrophotometric Sulfo-Phospho-Vanillin Assessment of Total Lipids in Human Meibomian Gland Secretions.

McMahon A, Lu H, Butovich IA 2013 Jan Lipids

Differential scanning calorimetric evaluation of human meibomian gland secretions and model lipid mixtures: Transition temperatures and cooperativity of melting.

Lu H, Wojtowicz JC, Butovich IA 2013 Apr Chem. Phys. Lipids

Disruption and destabilization of meibomian lipid films caused by increasing amounts of ceramides and cholesterol.

Arciniega JC, Uchiyama E, Butovich IA 2013 Invest. Ophthalmol. Vis. Sci. 2 54 1352-60

Toward an animal model of the human tear film: biochemical comparison of the mouse, canine, rabbit, and human meibomian lipidomes.

Butovich IA, Lu H, McMahon A, Eule JC 2012 Oct Invest. Ophthalmol. Vis. Sci. 11 53 6881-96

Evaluation and quantitation of intact wax esters of human meibum by gas-liquid chromatography-ion trap mass spectrometry.

Butovich IA, Arciniega JC, Lu H, Molai M 2012 Jun Invest. Ophthalmol. Vis. Sci. 7 53 3766-81

The international workshop on meibomian gland dysfunction: report of the subcommittee on tear film lipids and lipid-protein interactions in health and disease.

Green-Church KB, Butovich I, Willcox M, Borchman D, Paulsen F, Barabino S, Glasgow BJ 2011 Mar Invest. Ophthalmol. Vis. Sci. 4 52 1979-93

Pilot, prospective, randomized, double-masked, placebo-controlled clinical trial of an omega-3 supplement for dry eye.

Wojtowicz JC, Butovich I, Uchiyama E, Aronowicz J, Agee S, McCulley JP 2011 Mar Cornea 3 30 308-14

Effects of free fatty acids on meibomian lipid films.

Arciniega JC, Nadji EJ, Butovich IA 2011 Jun

Epidermal expression of an Elovl4 transgene rescues neonatal lethality of homozygous Stargardt disease-3 mice.

McMahon A, Butovich IA, Kedzierski W 2011 Jun J. Lipid Res. 6 52 1128-38

Lipidomics of human Meibomian gland secretions: Chemistry, biophysics, and physiological role of Meibomian lipids.

Butovich IA 2011 Jul Prog. Lipid Res. 3 50 278-301

On the presence of (O-acyl)-omega-hydroxy fatty acids and of their esters in human meibomian gland secretions.

Butovich IA 2011 Jan Invest. Ophthalmol. Vis. Sci. 1 52 639-41

Comparative HPLC-MS analysis of canine and human meibomian lipidomes: many similarities, a few differences.

Butovich IA, Borowiak AM, Eule JC 2011 Sci Rep 1 24

Fatty acid composition of cholesteryl esters of human meibomian gland secretions.

Butovich IA 2010 Oct Steroids 10 75 726-33

Meibomian lipid films and the impact of temperature.

Butovich IA, Arciniega JC, Wojtowicz JC 2010 Nov Invest. Ophthalmol. Vis. Sci. 11 51 5508-18

On the presence and role of polar lipids in meibum.

Butovich IA 2010 Dec Invest. Ophthalmol. Vis. Sci. 12 51 6908-10; author reply 6910-1

The Meibomian puzzle: combining pieces together.

Butovich IA 2009 Nov Prog Retin Eye Res 6 28 483-98

Cholesteryl esters as a depot for very long chain fatty acids in human meibum.

Butovich IA 2009 Mar J. Lipid Res. 3 50 501-13

Historical brief on composition of human meibum lipids.

Wojtowicz JC, Butovich IA, McCulley JP 2009 Jul Ocul Surf 3 7 145-53

Adsorption of human tear lipocalin to human meibomian lipid films.

Millar TJ, Mudgil P, Butovich IA, Palaniappan CK 2009 Jan Invest. Ophthalmol. Vis. Sci. 1 50 140-51

Human tear film and meibum. Very long chain wax esters and (O-acyl)-omega-hydroxy fatty acids of meibum.

Butovich IA, Wojtowicz JC, Molai M 2009 Dec J. Lipid Res. 12 50 2471-85

Lipidomic analysis of human meibum using HPLC-MSn.

Butovich IA 2009 Methods Mol. Biol. 579 221-46

On the lipid composition of human meibum and tears: comparative analysis of nonpolar lipids.

Butovich IA 2008 Sep Invest. Ophthalmol. Vis. Sci. 9 49 3779-89

Impact on ocular surface evaporation of an artificial tear solution containing hydroxypropyl guar.

Uchiyama E, Di Pascuale MA, Butovich IA, McCulley JP 2008 Nov Eye Contact Lens 6 34 331-4

Understanding and analyzing meibomian lipids--a review.

Butovich IA, Millar TJ, Ham BM 2008 May Curr. Eye Res. 5 33 405-20

Inhibition of lipoxygenases and cyclooxygenases by linoleyl hydroxamic acid: comparative in vitro studies.

Butovich IA, Lukyanova SM 2008 Jun J. Lipid Res. 6 49 1284-94

Lipids of human meibum: mass-spectrometric analysis and structural elucidation.

Butovich IA, Uchiyama E, McCulley JP 2007 Oct J. Lipid Res. 10 48 2220-35

Pattern of vital staining and its correlation with aqueous tear deficiency and meibomian gland dropout.

Uchiyama E, Aronowicz JD, Butovich IA, McCulley JP 2007 Jul Eye Contact Lens 4 33 177-9

Increased evaporative rates in laboratory testing conditions simulating airplane cabin relative humidity: an important factor for dry eye syndrome.

Uchiyama E, Aronowicz JD, Butovich IA, McCulley JP 2007 Jul Eye Contact Lens 4 33 174-6

Liquid chromatography-mass spectrometric analysis of lipids present in human meibomian gland secretions.

Butovich IA, Uchiyama E, Di Pascuale MA, McCulley JP 2007 Aug Lipids 8 42 765-76

Retinal pathology and skin barrier defect in mice carrying a Stargardt disease-3 mutation in elongase of very long chain fatty acids-4.

McMahon A, Butovich IA, Mata NL, Klein M, Ritter R, Richardson J, Birch DG, Edwards AO, Kedzierski W 2007 Mol. Vis. 13 258-72

Dihydroxydocosahexaenoic acids of the neuroprotectin D family: synthesis, structure, and inhibition of human 5-lipoxygenase.

Butovich IA, Lukyanova SM, Bachmann C 2006 Nov J. Lipid Res. 11 47 2462-74

Correlations in a change in aqueous tear evaporation with a change in relative humidity and the impact.

McCulley JP, Aronowicz JD, Uchiyama E, Shine WE, Butovich IA 2006 Apr Am. J. Ophthalmol. 4 141 758-60

A one-step method of 10,17-dihydro(pero)xydocosahexa-4Z,7Z,11E,13Z,15E,19Z-enoic acid synthesis by soybean lipoxygenase.

Butovich IA 2006 Apr J. Lipid Res. 4 47 854-63

Impact of evaporation on aqueous tear loss.

McCulley JP, Uchiyama E, Aronowicz JD, Butovich IA 2006 Trans Am Ophthalmol Soc 104 121-8

On the structure and synthesis of neuroprotectin D1, a novel anti-inflammatory compound of the docosahexaenoic acid family.

Butovich IA 2005 Nov J. Lipid Res. 11 46 2311-4

Novel oxylipins formed from docosahexaenoic acid by potato lipoxygenase--10(S)-hydroxydocosahexaenoic acid and 10,20-dihydroxydocosahexaenoic acid.

Butovich IA, Hamberg M, Rådmark O 2005 Mar Lipids 3 40 249-57

Inhibition of potato lipoxygenase by linoleyl hydroxamic acid: kinetic and EPR spectral evidence for a two-step reaction.

Butovich IA, Reddy CC 2002 Aug Biochem. J. Pt 3 365 865-71

The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives.

Sánchez C, Butovich IA, Braña AF, Rohr J, Méndez C, Salas JA 2002 Apr Chem. Biol. 4 9 519-31

[Characteristics of the aggregative state of the substrate in the reaction of 5-lipoxygenase oxidation of linoleic acid].

Butovich IA, Kharchenko OV, Paboka IuN, Kazachkov MG 2001 Mar-Apr Ukr. Biokhim. Zh. 2 73 39-43

Enzyme-catalyzed and enzyme-triggered pathways in dioxygenation of 1-monolinoleoyl-rac-glycerol by potato tuber lipoxygenase.

Butovich IA, Reddy CC 2001 Apr Biochim. Biophys. Acta 2 1546 379-98

Oxidation of linoleyl alcohol by potato tuber lipoxygenase: kinetics and positional, stereo, and geometrical (cis, trans) specificity of the reaction.

Butovich IA, Luk'yanova SM, Reddy CC 2000 Jun Arch. Biochem. Biophys. 1 378 65-77

[The protective effect of omega-3 polyunsaturated fatty acids on the activity of the isolated rat heart during myocardial ischemia-reperfusion].

Kvochina LI, Tumanovs'ka LV, Marchenko HI, Moibenko OO, Butovych IA, Kharchenko OV. 2000 Fiziol Zh. 46 2 98-108

[Kinetic mechanisms of linoleic acid oxidation by 5-lipoxygenase from Solanum tuberosum L].

Kharchenko OV, Kulinichenko HI, Butovych IA 1999 Jul-Aug Ukr. Biokhim. Zh. 4 71 40-4

[Role of phospholipids in the regulation of activity of porcine leukocyte 12-lipoxygenase].

Butovich IA, Kharchenko OV 1999 Jan-Feb Ukr. Biokhim. Zh. 1 71 38-43

[Inhibitory effect of linoleyl-hydroxamic acid on the oxidation of linoleic acid by 12-lipoxygenase from porcine leukocytes].

Kharchenko OV, Cernjuk VN, Butovich IA 1999 Jan-Feb Ukr. Biokhim. Zh. 1 71 33-7

Oxidation of linoleyl alcohol by potato tuber lipoxygenase: possible mechanism and the role of carboxylic group in substrate binding.

Butovich IA, Lukyanova SM, Reddy CC 1998 Aug Biochem. Biophys. Res. Commun. 2 249 344-9

[The effect of linoleyl hydroxamic acid on lipid peroxidation processes and on the enzymatic activity of the antioxidant system in rats under hypoxia].

Kukoba TV, Seredenko MM, Butovych IA, Moibenko OO. 1998 Fiziol Zh. 44 5-6 43-8

Fatty acids hydroxamic derivatives as inhibitors of 5-lipoxygenase.

Bondarenko LB, Oghiy SA, Butovich IA 1997 Adv. Exp. Med. Biol. 407 471-5

[Effect of lipoxygenase derivatives of linoleic acid on functional activity of neutrophils].

Brovkovich VM, Moibenko AA, Butovich IA, Brovkovich SD, Ogii SA 1996 May-Jun Ukr. Biokhim. Zh. 3 68 79-84

12(S)-hydroxyeicosatetraenoic acid and 13(S)-hydroxyoctadecadienoic acid regulation of protein kinase C-alpha in melanoma cells: role of receptor-mediated hydrolysis of inositol phospholipids.

Liu B, Khan WA, Hannun YA, Timar J, Taylor JD, Lundy S, Butovich I, Honn KV 1995 Sep Proc. Natl. Acad. Sci. U.S.A. 20 92 9323-7

[Effect of 13(S)-HPODE, a lipoxygenase product of linoleic acid, on calcium transport and Na,K-ATPase activity in the myocardial sarcolemma].

Cherednichenko GA, Moibenko AA, Butovich IA, Ogii SA 1995 Sep Biull Eksp Biol Med 9 120 255-8

[Effect of 1,25-dihydroxyvitamin D3 on 15-lipoxygenase activity].

Bondarenko LB, Kharchenko OV, Butovich IA 1995 May-Jun Vopr. Med. Khim. 3 41 29-31

On the interfacial phenomena in lipoxygenase catalysis.

Butovich IA, Kharchenko OV, Babenko VM 1995 Adv. Prostaglandin Thromboxane Leukot. Res. 23 159-61

[A hormonally-active form of vitamin D3--1,25-dihydroxyvitamin D3--an inhibitor of leukocyte lipoxygenase].

Bondarenko LB, Kharchenko OV, Butovich IA 1994 Sep-Oct Vopr. Med. Khim. 5 40 2-4

[The correction of disorders in arachidonic acid metabolism in coronary spasm of an immune origin].

Marchenko HI, Kotsiuruba VM, Butovych IA, Sorochyns'kyi AE, Zrazhevs'ka VK, Tumanovs'ka LV. 1994 May-Aug Fiziol Zh. 40 3-4 81-7

[The mechanisms of the changes in coronary vascular resistance in anaphylactic shock].

Moibenko AA, Grabovskii LA, Kotsiuruba VN, Bulakh VN, Tumanovskaia LV, Azarov VI, Butovich IA 1994 Feb Fiziol Zh Im I M Sechenova 2 80 77-82

12-lipoxygenases and 12(S)-HETE: role in cancer metastasis.

Honn KV, Tang DG, Gao X, Butovich IA, Liu B, Timar J, Hagmann W 1994 Dec Cancer Metastasis Rev. 3-4 13 365-96

The unusual action of (R,S)-2-hydroxy-2-trifluoromethyl-trans-n-octadec-4-enoic acid on 5-lipoxygenase from potato tubers.

Butovich IA, Soloshonok VA, Kukhar VP 1991 Jul Eur. J. Biochem. 1 199 153-5

[Amphiphilic aliphatic acids--activators of 5-lipoxygenase. The adsorption-micellar regulatory mechanism].

Butovich IA, Kukhar' VP 1991 Dokl. Akad. Nauk SSSR 6 316 1486-90

[Activation of 5-lipoxygenase by lipophilic n-alkyl-containing acids--an allosteric process].

Butovich IA, Soloshonok VA, Solodenko VA, Kukhar' VP 1990 Feb Bioorg. Khim. 2 16 270-1

[Potato 5-lipoxygenase. Kinetics of linoleic acid oxidation].

Butovich IA, Kukhar' VP 1989 Mar-Apr Ukr. Biokhim. Zh. 2 61 106-8

[Activity of lipoxygenase incorporated into reversed micelles of aerosol OT in octane].

Butovich IA, Mogilevich TV, Kukhar' VP 1989 Mar-Apr Ukr. Biokhim. Zh. 2 61 54-9

[Catalytic properties of extracellular phenol oxidases from the higher basidiomycete Pleurotus ostreatus (Fr.) Kumm].

Butovich IA, Semichaevskii VD 1986 Jul-Aug Ukr. Biokhim. Zh. 4 58 18-26

[Stability and catalytic properties of o-diphenol oxidase. 2. Oxidation of monophenols].

Butovich IA 1986 Jan-Feb Ukr. Biokhim. Zh. 1 58 16-21

[Stability and catalytic properties of o-diphenol oxidase. 1. Oxidation of o-diphenols].

Butovich IA 1986 Jan-Feb Ukr. Biokhim. Zh. 1 58 10-6

[Inactivation of o-diphenoloxidase in the pyrocatechol oxidation reaction].

Butovich IA, Tertykh VA 1984 Sep-Oct Ukr. Biokhim. Zh. 5 56 527-32

[A method for determining theo-diphenoloxidase activity in the pyrocatechol oxidation reaction].

Butovich IA, Tertykh VA 1984 Jul-Aug Ukr. Biokhim. Zh. 4 56 437-41