Featured Publications
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.
Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ. July 2009 41(7) 793-799
Carroll TJ, Park JS, Hayashi S, Majumdar A, McMahon AP.
August 2005
9 (2)
283-92
Deletion of Lats1/2 in adult kidney epithelia leads to renal cell carcinoma.
Carter P, Schnell U, Chaney C, Tong B, Pan X, Ye J, Mernaugh G, Cotton JL, Margulis V, Mao J, Zent R, Evers BM, Kapur P, Carroll TJ, 2021 Jun J Clin Invest 11 131
England AR, Chaney CP, Das A, Patel M, Malewska A, Armendariz D, Hon GC, Strand DW, Drake KA, Carroll TJ,
2020 Aug
Development
15
147
Drake KA, Chaney CP, Das A, Roy P, Kwartler CS, Rakheja D, Carroll TJ,
2020 07
Development
21
147
Lkb1 deficiency confers glutamine dependency in polycystic kidney disease.
Flowers EM, Sudderth J, Zacharias L, Mernaugh G, Zent R, DeBerardinis RJ, Carroll TJ 2018 Feb Nat Commun 1 9 814Disparate levels of beta-catenin activity determine nephron progenitor cell fate.
Ramalingam H, Fessler AR, Das A, Valerius MT, Basta J, Robbins L, Brown AC, Oxburgh L, McMahon AP, Rauchman M, Carroll TJ 2018 Apr Dev. Biol.Myc cooperates with beta-catenin to drive gene expression in the nephron progenitor cells.
Pan X, Karner CM, Carroll TJ 2017 Oct Development
Oxburgh L, Carroll TJ
2016 May
Curr. Opin. Nephrol. Hypertens.
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation.
Das A, Tanigawa S, Karner CM, Xin M, Lum L, Chen C, Olson EN, Perantoni AO, Carroll TJ 2013 Sep Nat. Cell Biol. 9 15 1035-44Defining the Signals that Constitute the Nephron Progenitor Niche.
Carroll TJ, Das A 2013 Apr J. Am. Soc. Nephrol.
Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ
2011 Apr
Development
7
138
1247-57
Marose TD, Merkel CE, McMahon AP, Carroll TJ.
February 2008
314(1)
112-26
Kobayashi A, Valerius MT, Mugford JW, Carroll TJ, Self M, Oliver G, McMahon AP.
August 2008
3(2)
169-81
Vascular deficiencies in renal organoids and ex vivo kidney organogenesis.
Ryan AR, England AR, Chaney CP, Cowdin MA, Hiltabidle M, Daniel E, Gupta AK, Oxburgh L, Carroll TJ, Cleaver O, 2021 May Dev Biol 477 98-116
Chen Z, Li S, Mo J, Hawley E, Wang Y, He Y, Brosseau JP, Shipman T, Clapp DW, Carroll TJ, Le LQ,
2020 Oct
JCI Insight
20
5
Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids.
Kumar Gupta A, Sarkar P, Wertheim JA, Pan X, Carroll TJ, Oxburgh L, 2020 May Commun Biol 1 3 231
Hunter RW, Liu Y, Manjunath H, Acharya A, Jones BT, Zhang H, Chen B, Ramalingam H, Hammer RE, Xie Y, Richardson JA, Rakheja D, Carroll TJ, Mendell JT
2018 Jun
Genes Dev.
Wu LMN, Deng Y, Wang J, Zhao C, Wang J, Rao R, Xu L, Zhou W, Choi K, Rizvi TA, Remke M, Rubin JB, Johnson RL, Carroll TJ, Stemmer-Rachamimov AO, Wu J, Zheng Y, Xin M, Ratner N, Lu QR
2018 Feb
Cancer Cell
2
33
292-308.e7
Spatiotemporal heterogeneity and patterning of developing renal blood vessels.
Daniel E, Azizoglu DB, Ryan AR, Walji TA, Chaney CP, Sutton GI, Carroll TJ, Marciano DK, Cleaver O 2018 Apr AngiogenesisHemodynamic Forces Sculpt Developing Heart Valves through a KLF2-WNT9B Paracrine Signaling Axis.
Goddard LM, Duchemin AL, Ramalingan H, Wu B, Chen M, Bamezai S, Yang J, Li L, Morley MP, Wang T, Scherrer-Crosbie M, Frank DB, Engleka KA, Jameson SC, Morrisey EE, Carroll TJ, Zhou B, Vermot J, Kahn ML 2017 Oct Dev. CellTalin regulates integrin ?1 dependent and independent cell functions in ureteric bud development.
Mathew S, Palamuttam RJ, Mernaugh G, Ramalingam H, Lu Z, Zhang MZ, Ishibe S, Critchley DR, Fässler R, Pozzi A, Sanders CR, Carroll TJ, Zent R 2017 Oct DevelopmentMYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma.
Bailey ST, Smith AM, Kardos J, Wobker SE, Wilson HL, Krishnan B, Saito R, Lee HJ, Zhang J, Eaton SC, Williams LA, Manocha U, Peters DJ, Pan X, Carroll TJ, Felsher DW, Walter V, Zhang Q, Parker JS, Yeh JJ, Moffitt RA, Leung JY, Kim WY 2017 Jun Nat Commun 8 15770
Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA
2017 Jan
J. Am. Soc. Nephrol.
Cdc42 regulates epithelial cell polarity and cytoskeletal function in kidney tubule development.
Elias BC, Das A, Parekh DV, Mernaugh G, Adams R, Yang Z, Brakebusch C, Pozzi A, Marciano DK, Carroll TJ, Zent R 2015 Oct J. Cell. Sci.A Cre-inducible fluorescent reporter for observing apical membrane dynamics.
Pan X, Schnell U, Karner CM, Small EV, Carroll TJ 2015 Mar Genesis
Caprioli A, Villasenor A, Wylie LA, Braitsch C, Marty-Santos L, Barry D, Karner CM, Fu S, Meadows SM, Carroll TJ, Cleaver O
2015 Aug
Dev. Biol.
Wang X, Moon J, Dodge ME, Pan X, Zhang L, Hanson JM, Tuladhar R, Ma Z, Shi H, Williams NS, Amatruda JF, Carroll TJ, Lum L, Chen C
2013 Mar
J. Med. Chem.
6
56
2700-4
Generation and characterization of KsprtTA and KsptTA transgenic mice.
Pan X, Small EV, Igarashi P, Carroll TJ 2013 Feb Genesis
Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L
2012 Jun
J. Biol. Chem.
27
287
23246-54
Carroll TJ, Yu J
2012
Curr. Top. Dev. Biol.
101
185-212
The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development.
Peng Y, Clark C, Luong R, Tu WH, Lee J, Johnson DT, Das A, Carroll TJ, Sun Z 2011 Nov J. Biol. Chem. 46 286 40331-42
Carroll TJ
2011 Jul
Organogenesis
3
7
163-4
Carroll TJ, Das A
2011 Jul
Organogenesis
3
7
180-90
Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.
Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R 2010 Oct Development 19 137 3233-43Macrophage Wnt7b is critical for kidney repair and regeneration.
Lin SL, Li B, Rao S, Yeo EJ, Hudson TE, Nowlin BT, Pei H, Chen L, Zheng JJ, Carroll TJ, Pollard JW, McMahon AP, Lang RA, Duffield JS 2010 Mar Proc. Natl. Acad. Sci. U.S.A. 9 107 4194-9Tankyrase is necessary for canonical Wnt signaling during kidney development.
Karner CM, Merkel CE, Dodge M, Ma Z, Lu J, Chen C, Lum L, Carroll TJ 2010 Jul Dev. Dyn. 7 239 2014-23
Karner CM, Dietrich MF, Johnson EB, Kappesser N, Tennert C, Percin F, Wollnik B, Carroll TJ, Herz J
2010
PLoS ONE
4
5
e10418
Yu J, Carroll TJ, Rajagopal J, Kobayashi A, Ren Q, McMahon AP
2009 Jan
Development
1
136
161-71
Aberrant planar cell polarity induced by urinary tract obstruction.
Li L, Zepeda-Orozco D, Patel V, Truong P, Karner CM, Carroll TJ, Lin F 2009 Dec Am. J. Physiol. Renal Physiol. 6 297 F1526-33Canonical Wnt signaling regulates organ-specific assembly and differentiation of CNS vasculature.
Stenman JM, Rajagopal J, Carroll TJ, Ishibashi M, McMahon J, McMahon AP 2008 Nov Science 5905 322 1247-50
Rajagopal J, Carroll TJ, Guseh JS, Bores SA, Blank LJ, Anderson WJ, Yu J, Zhou Q, McMahon AP, Melton DA
2008 May
Development
9
135
1625-34
Molecular regulation of kidney development: is the answer blowing in the Wnt?
Merkel CE, Karner CM, Carroll TJ 2007 Nov Pediatr. Nephrol. 11 22 1825-38Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation.
Tu X, Joeng KS, Nakayama KI, Nakayama K, Rajagopal J, Carroll TJ, McMahon AP, Long F 2007 Jan Dev. Cell 1 12 113-27Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3.
Ma Z, Gong Y, Patel V, Karner CM, Fischer E, Hiesberger T, Carroll TJ, Pontoglio M, Igarashi P 2007 Dec Proc. Natl. Acad. Sci. U.S.A. 51 104 20386-91
Juriloff DM, Harris MJ, McMahon AP, Carroll TJ, Lidral AC
2006 Aug
Birth Defects Res. Part A Clin. Mol. Teratol.
8
76
574-9
Apical-basal polarity, Wnt signaling and vertebrate organogenesis.
Karner C, Wharton KA, Carroll TJ 2006 Apr Semin. Cell Dev. Biol. 2 17 214-22
Karner C, Wharton KA, Carroll TJ
2006 Apr
Semin. Cell Dev. Biol.
2
17
194-203
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature.
Lobov IB, Rao S, Carroll TJ, Vallance JE, Ito M, Ondr JK, Kurup S, Glass DA, Patel MS, Shu W, Morrisey EE, McMahon AP, Karsenty G, Lang RA 2005 Sep Nature 7057 437 417-21Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder.
Batourina E, Tsai S, Lambert S, Sprenkle P, Viana R, Dutta S, Hensle T, Wang F, Niederreither K, McMahon AP, Carroll TJ, Mendelsohn CL 2005 Oct Nat. Genet. 10 37 1082-9
Kobayashi A, Kwan KM, Carroll TJ, McMahon AP, Mendelsohn CL, Behringer RR
2005 Jun
Development
12
132
2809-23
Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction.
Basson MA, Akbulut S, Watson-Johnson J, Simon R, Carroll TJ, Shakya R, Gross I, Martin GR, Lufkin T, McMahon AP, Wilson PD, Costantini FD, Mason IJ, Licht JD 2005 Feb Dev. Cell 2 8 229-39
Yu, J., Carroll, T.J., and McMahon, A.P.
2002
129
5301-12
Synergism between Pax-8 and lim-1 in embryonic kidney development.
Carroll TJ, Vize PD 1999 Oct Dev. Biol. 1 214 46-59Dynamic patterns of gene expression in the developing pronephros of Xenopus laevis.
Carroll TJ, Wallingford JB, Vize PD 1999 Dev. Genet. 3-4 24 199-207Synergism between Pax-8 and Lim-1 in embryonic kidney development
Carroll, T. J. and Vize, P 1999 214(1) 46-59
Wallingford JB, Carroll TJ, Vize PD
1998 Oct
Dev. Biol.
1
202
103-12
Carroll TJ, Vize PD
1996 Jun
Dev. Dyn.
2
206
131-8