Trivedi Lab

Our vision is a future free from the burden of depression.

The Center for Depression Research and Clinical Care (CDRC) is a nationally recognized center of excellence in the research and treatment of mood disorders, including depression and bipolar disorder.

Real People. Real Research.

Built on a quarter-century of research in mood disorders, the CDRC was established in 2015 to realize a future free from the burden of depression. Our team has led research into new treatments, including brain and blood tests, for depression and suicide. We have established evidence-based programs that transform our ability to prevent, diagnose, and treat depression. Critically, we have built networks and established research-driven programs that extend our reach to adolescents; addressing youth depression and suicide with mental health promotion and resilience training that encourages a conversation long overdue. We have witnessed the difference our efforts make for people with mental disorders and their families. Such results speak to the value of the work to which we have dedicated ourselves.

Meet the Director

Dr. Trivedi Professional Photo

Founding Director

For more than two decades, Dr. Madhukar Trivedi and his colleagues at UT Southwestern Medical Center have conducted cutting-edge research to improve the treatment of depression.

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BrainStorm: Decoding Depression

Depression is a massive public health issue. Thankfully, there are teams of scientists dedicated to researching mental health, suicide, and substance use disorders. On this podcast series, we decode the science of mood disorders through discussions with a leading expert in the field, Dr. Madhukar Trivedi.

We’re here to change the way we think and talk about depression, in an accessible, approachable way.

Quote from Madhukar Trivedi, M.D.

Depression should be seen like any other kind of chronic disease, like diabetes or hypertension. Therefore, we have to always be on the hunt for better treatments.
Madhukar Trivedi, M.D. Founding Director Center for Depression Research and Clinical Care

Recent News & Discoveries

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BrainStorm: Decoding Depression, Season 2, episode 9 release

Season 2’s final episode, hosted by Erin A. Harper, PhD, NCSP is all about resilience. Are you born with it? Can it be taught? Listen in as Dr. Madhukar Trivedi and special guests Tobi Fuller, PhD and Adrienne Mays, MEd take a deep dive into this topic.

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Unraveling the relationship between gut microbes and brain health

The role of the microbiome in intestinal and systemic health has garnered close attention among researchers for many years. Now evidence is mounting that this collection of microorganisms in the human gut can also impact a person’s neurological and emotional health, according to a recent perspective article in Science by neuroscientist Jane Foster, Ph.D., Professor of Psychiatry.

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CDRC faculty presents at Dallas Museum of Art

Dr. Russell Toll, Assistant Professor with the Center for Depression Research and Clinical Care at UT Southwestern, engaged the Dallas Museum of Art community for an exploration of the science within art and the art within science through the works of Matthew Wong on February 8th. Dr. Toll painted a picture of the need to utilize EEG imaging in prevention and TMS services for treatment of depression and other mental health concerns.

Medscape's InDiscussion Podcast Series

Season 2 release of Medscape's InDiscussion Podcast series on Major Depressive Disorder.

Dr. Madhukar Trivedi hosts another 6-part podcast series on topics related to Major Depressive Disorder (MDD) with thought leaders in the field of mental health and wellness. Season 2 begins a discussion with the CDRC's own, Dr. Manish Jha, about using the 'Primary Care First' model to screen and treat MDD.

Stay Engaged

Meet the Team

The CDRC has faculty members with expertise in neuroimaging, cognitive and behavioral phenotyping, biospecimens, biostatistics, genetics, adolescent behaviors, novel treatments and addiction.

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YAM Trainers Team

Explore Our Initiatives

To better understand the areas of greatest impact, we have identified and partnered with schools, community organizations, and healthcare systems on initiatives to improve the diagnosis and treatment of mood disorders and enhance suicide prevention efforts.

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Drs. Andy Keller and Madhukar Trivedi

Learn About Our Community

The CDRC is always striving to build bridges to better mental health and wellbeing for our community in Texas and beyond. Accomplishing this means addressing the particular needs and levels of community involvement that make success possible.

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Drs. Ayvaci and Chin Fatt presenting

Depression Research Clinic

Email address:
Phone Number: 214-648-4357

Mailing Address
1440 Empire Central
Level 3 Mood Disorders
Dallas, TX 75247-9119

Physical Address
1440 Empire Central
Level 3 Mood Disorders
Dallas, TX 75247-9119

Fort Worth Depression Research Clinic

Email address:
Phone Number: 817-262-2761

Physical Address
400 W. Magnolia Ave.
Fort Worth, TX 76104

Solving Depression, Saving Tomorrows

Be part of the great impact we're having on science and medical care across the globe.

Continued advancements come through tireless pursuit, and our Center's faculty and staff understand that the commitment we renew each day is built upon a foundation of scholarship and a network of like-minded organizations. By sharing our findings worldwide, we strive to improve patient care and further the research momentum of our fellow scientists. Made possible by public grants and philanthropic investments, these programs provide civic and health partners with resources and tools to better prevent, identify, and treat depression in individuals of all ages.