D'Orso Lab studies gene regulatory networks in normal and disease states as well as in the context of host-pathogen interactions.
Our research program aims to elucidate the basic principles that govern gene regulatory programs in normal and disease states. Specifically, we are exploring new mechanisms of transcriptional elongation control, factor-chromatin interaction, non-coding RNA functions, signaling regulation, viral latency, and cancer drivers, and discovering targets that can be chemically manipulated.
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