Publications

Myc family proteins: Molecular drivers of tumorigenesis and resistance in neuroendocrine tumors

Hylton-McComas HM, Cordes A, Floros KV, Faber A, Drapkin BJ, Miles WO 2025 Jul Biochimica et Biophysica Acta - Reviews on Cancer 1880

KSR1 Mediates Small Cell Lung Carcinoma Tumor Initiation and Cisplatin Resistance

Chatterjee D, Svoboda RA, Huisman DH, Drapkin BJ, Vieira HM, Rao C, Askew JW, Fisher KW, Lewis RE 2025 Jun Molecular Cancer Research 23 553-566

Intrinsic electrical activity drives small-cell lung cancer progression

Peinado P, Stazi M, Ballabio C, Margineanu MB, Li Z, Colón CI, Hsieh MS, Pal Choudhuri S, Stastny V, Hamilton S, Le Marois A, Collingridge J, Conrad L, Chen Y, Ng SR, Magendantz M, Bhutkar A, Chen JS, Sahai E, Drapkin BJ, Jacks T, Vander Heiden MG, Kopanitsa MV, Robinson HP, Li L 2025 Mar Nature 639 765-775

Atypical Small Cell Lung Cancer: A New Malignancy Characterized by Chromothripsis, Carcinoid Tumors, and Wild-type RB1 and TP53

Nadeem U, Drapkin BJ 2025 Jan Cancer discovery 15 8-10

Concerning Safety and Efficacy of Concurrent and Consolidative Durvalumab With Thoracic Radiation Therapy in PDL1-Unselected Stage III Non-Small Cell Lung Cancer: Brief Report

Zhang Y, Iyengar P, Montalvo S, Westover KD, Rashdan S, Donthireddy K, Kim J, Dowell JE, Drapkin B, Bhalla S, Chukwuma C, Nadeem U, Ahn C, Timmerman RD, Gerber DE 2025 Jan International Journal of Radiation Oncology Biology Physics 121 68-74

A telomere-targeting drug depletes cancer initiating cells and promotes anti-tumor immunity in small cell lung cancer

Eglenen-Polat B, Kowash RR, Huang HC, Siteni S, Zhu M, Chen K, Bender ME, Mender I, Stastny V, Drapkin BJ, Raj P, Minna JD, Xu L, Shay JW, Akbay EA 2024 Dec Nature communications 15

Jumonji histone demethylases are therapeutic targets in small cell lung cancer

Nguyen A, Nuñez CG, Tran TA, Girard L, Peyton M, Catalan R, Guerena C, Avila K, Drapkin BJ, Chandra R, Minna JD, Martinez ED 2024 Sep Oncogene 43 2885-2899

Concerning safety and efficacy of concurrent and consolidative durvalumab with thoracic radiotherapy in PDL1-unselected stage III non-small cell lung cancer: brief report

Zhang Y, Iyengar P, Montalvo SK, Westover KD, Rashdan S, Donthireddy KR, Kim J, Dowell JE, Drapkin BJ, Bhalla S, Chukwuma C, Nadeem U, Ahn C, Timmerman R, Gerber DE 2024 Aug International Journal of Radiation Oncology Biology Physics S0360-3016 03177-8

Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

Duplaquet L, So K, Ying AW, Pal Choudhuri S, Li X, Xu GD, Li Y, Qiu X, Li R, Singh S, Wu XS, Hamilton S, Chien VD, Liu Q, Qi J, Somerville TD, Heiling HM, Mazzola E, Lee Y, Zoller T, Vakoc CR, Doench JG, Forrester WC, Abrams T, Long HW, Niederst MJ, Drapkin BJ, Kadoch C, Oser MG 2024 Aug Cancer Cell 42 1352-1369.e13

Acquired Cross-Resistance in Small Cell Lung Cancer due to Extrachromosomal DNA Amplification of MYC Paralogs

Pal Choudhuri S, Girard L, Lim JY, Wise JF, Freitas B, Yang D, Wong E, Hamilton S, Chien VD, Kim YJ, Gilbreath C, Zhong J, Phat S, Myers DT, Christensen CL, Mazloom-Farsibaf H, Stanzione M, Wong KK, Hung YP, Farago AF, Meador CB, Dyson NJ, Lawrence MS, Wu S, Drapkin BJ 2024 May Cancer discovery 14 804-827

Proteomics: A new dimension to decode small cell lung cancer

Chen H, Drapkin BJ, Minna JD 2024 Jan Cell 187 14-16

Induced degradation of lineage-specific oncoproteins drives the therapeutic vulnerability of small cell lung cancer to PARP inhibitors

Kim C, Wang XD, Liu Z, Hao J, Wang S, Li P, Zi Z, Ding Q, Jang S, Kim J, Luo Y, Huffman KE, Choudhuri SP, del Rio S, Cai L, Liang H, Drapkin BJ, Minna JD, Yu Y 2024 Jan Science Advances 10

Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies

Megyesfalvi Z, Heeke S, Drapkin BJ, Solta A, Kovacs I, Boettiger K, Horvath L, Ernhofer B, Fillinger J, Renyi-Vamos F, Aigner C, Schelch K, Lang C, Marko-Varga G, Gay CM, Byers LA, Morris BB, Heymach JV, Van Loo P, Hirsch FR, Dome B 2023 Sep Cancer Cell 41 1535-1540

Chromatin-bound RB targets promoters, enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

Sanidas I, Lee H, Rumde PH, Boulay G, Morris R, Golczer G, Stanzione M, Hajizadeh S, Zhong J, Ryan MB, Corcoran RB, Drapkin BJ, Rivera MN, Dyson NJ, Lawrence MS 2022 Sep Molecular cell 82 3333-3349.e9

Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer

Stanzione M, Zhong J, Wong E, LaSalle TJ, Wise JF, Simoneau A, Myers DT, Phat S, Sade-Feldman M, Lawrence MS, Kyle Hadden M, Zou L, Farago AF, Dyson NJ, Drapkin BJ 2022 May Science Advances 8

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer

Cejas P, Xie Y, Font-Tello A, Lim K, Syamala S, Qiu X, Tewari AK, Shah N, Nguyen HM, Patel RA, Brown L, Coleman I, Hackeng WM, Brosens L, Dreijerink KM, Ellis L, Alaiwi SA, Seo JH, Baca S, Beltran H, Khani F, Pomerantz M, Dall’Agnese A, Crowdis J, Van Allen EM, Bellmunt J, Morrisey C, Nelson PS, DeCaprio J, Farago A, Dyson N, Drapkin B, Liu XS, Freedman M, Haffner MC, Corey E, Brown M, Long HW 2021 Dec Nature communications 12

Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer

Cai L, Liu H, Huang F, Fujimoto J, Girard L, Chen J, Li Y, Zhang YA, Deb D, Stastny V, Pozo K, Kuo CS, Jia G, Yang C, Zou W, Alomar A, Huffman K, Papari-Zareei M, Yang L, Drapkin B, Akbay EA, Shames DS, Wistuba II, Wang T, Johnson JE, Xiao G, DeBerardinis RJ, Minna JD, Xie Y, Gazdar AF 2021 Dec Communications Biology 4

Single-cell imaging of T cell immunotherapy responses in vivo

Yan C, Yang Q, Zhang S, Millar DG, Alpert EJ, Do D, Veloso A, Brunson DC, Drapkin BJ, Stanzione M, Scarfò I, Moore JC, Iyer S, Qin Q, Wei Y, McCarthy KM, Rawls JF, Dyson NJ, Cobbold M, Maus MV, Langenau DM 2021 Aug Journal of Experimental Medicine 218

A rational targeted therapy for platinum-resistant small-cell lung cancer

Drapkin BJ, Minna JD 2021 Apr Cancer Cell 39 453-456

Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer

Huang F, Huffman KE, Wang Z, Wang X, Li K, Cai F, Yang C, Cai L, Shih TS, Zacharias LG, Chung A, Yang Q, Chalishazar MD, Ireland AS, Stewart CA, Cargill K, Girard L, Liu Y, Ni M, Xu J, Wu X, Zhu H, Drapkin B, Byers LA, Oliver TG, Gazdar AF, Minna JD, DeBerardinis RJ 2021 Jan Journal of Clinical Investigation 131

Lineage Switching: How lung cancer cells change identity

Von Itzstein MS, Drapkin BJ, Minna JD 2021 eLife 10

Advances in small-cell lung cancer (SCLC) translational research

Drapkin BJ, Rudin CM 2021 Cold Spring Harbor Perspectives in Medicine 11

Studying Lineage Plasticity One Cell at a Time

Drapkin BJ, Minna JD 2020 Aug Cancer Cell 38 150-152

SETD1A protects from senescence through regulation of the mitotic gene expression program

Tajima K, Matsuda S, Yae T, Drapkin BJ, Morris R, Boukhali M, Niederhoffer K, Comaills V, Dubash T, Nieman L, Guo H, Magnus NK, Dyson N, Shioda T, Haas W, Haber DA, Maheswaran S 2019 Dec Nature communications 10

Identification of DHODH as a therapeutic target in small cell lung cancer

Li L, Ng SR, Colón CI, Drapkin BJ, Hsu PP, Li Z, Nabel CS, Lewis CA, Romero R, Mercer KL, Bhutkar A, Phat S, Myers DT, Muzumdar MD, Westcott PM, Beytagh MC, Farago AF, Heiden MG, Dyson NJ, Jacks T 2019 Nov Science translational medicine 11

Combination olaparib and temozolomide in relapsed small-cell lung cancer

Farago AF, Yeap BY, Stanzione M, Hung YP, Heist RS, Marcoux JP, Zhong J, Rangachari D, Barbie DA, Phat S, Myers DT, Morris R, Kem M, Dubash TD, Kennedy EA, Digumarthy SR, Sequist LV, Hata AN, Maheswaran S, Haber DA, Lawrence MS, Shaw AT, Mino-Kenudson M, Dyson NJ, Drapkin BJ 2019 Oct Cancer discovery 9 1372-1387

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish

Yan C, Brunson DC, Tang Q, Do D, Iftimia NA, Moore JC, Hayes MN, Welker AM, Garcia EG, Dubash TD, Hong X, Drapkin BJ, Myers DT, Phat S, Volorio A, Marvin DL, Ligorio M, Dershowitz L, McCarthy KM, Karabacak MN, Fletcher JA, Sgroi DC, Iafrate JA, Maheswaran S, Dyson NJ, Haber DA, Rawls JF, Langenau DM 2019 Jun Cell 177 1903-1914.e14

Unexpected Synergy Reveals New Therapeutic Strategy in SCLC

Drapkin BJ, Farago AF 2019 May Trends in Pharmacological Sciences 40 295-297

ATLANTIS: A Phase III study of lurbinectedin/doxorubicin versus topotecan or cyclophosphamide/doxorubicin/vincristine in patients with small-cell lung cancer who have failed one prior platinum-containing line

Farago AF, Drapkin BJ, Lopez-Vilarino De Ramos JA, Galmarini CM, Núñez R, Kahatt C, Paz-Ares L 2019 Jan Future Oncology 15 231-239

Clustered incidence of adult acute promyelocytic leukemia

Brunner AM, Kim PG, Sadrzadeh H, Drapkin BJ, Sprague KA, Sloan JM, Chai-Ho W, Bhargava P, Pozdnyakova O, Fathi AT 2018 Nov Leukemia Research 74 47-50

Genomic and functional fidelity of small cell lung cancer patient-derived xenografts

Drapkin BJ, George J, Christensen CL, Mino-Kenudson M, Dries R, Sundaresan T, Phat S, Myers DT, Zhong J, Igo P, Hazar-Rethinam MH, Licausi JA, Gomez-Caraballo M, Kem M, Jani KN, Azimi R, Abedpour N, Menon R, Lakis S, Heist RS, Büttner R, Haas S, Sequist LV, Shaw AT, Wong KK, Hata AN, Toner M, Maheswaran S, Haber DA, Peifer M, Dyson N, Thomas RK, Farago AF 2018 May Cancer discovery 8 600-615

Clonal Evolution And The Role Of Serial Liquid Biopsies In A Case Of Small-Cell Lung Cancer-Transformed EGFR mutant non-small-cell lung cancer

Mooradian MJ, Piotrowska Z, Drapkin BJ, Dias-Santagata D, Marcoux N, Arnaoutakis K, Nagy RJ, Lanman R, Iafrate AJ, Farago AF, Mino-Kenudson M, Hata AN, Sequist LV 2017 JCO Precision Oncology 2017 1-7

Plasma T790M result alters treatment options in a previously T790 wild-type EGFR-mutant lung cancer

Piotrowska Z, Drapkin B, Engelman JA, Nagy RJ, Lanman RB, Sequist LV 2016 Journal of Thoracic Oncology 11 e95-e97

Association between baseline body mass index and overall survival among patients over age 60 with acute myeloid leukemia

Brunner AM, Sadrzadeh H, Feng Y, Drapkin BJ, Ballen KK, Attar EC, Amrein PC, Mcafee SL, Chen YB, Neuberg DS, Fathi AT 2013 Aug American Journal of Hematology 88 642-646

Trends in all-cause mortality among patients with chronic myeloid leukemia: A surveillance, epidemiology, and end results database analysis

Brunner AM, Campigotto F, Sadrzadeh H, Drapkin BJ, Chen YB, Neuberg DS, Fathi AT 2013 Jul Cancer 119 2620-2629

Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin

Drapkin BJ, Lu Y, Procko AL, Timney BL, Cross FR 2009 Jan Molecular Systems Biology 5

Cyclin and cyclin-dependent kinase substrate requirements for preventing rereplication reveal the need for concomitant activation and inhibition

Ikui AE, Archambault V, Drapkin BJ, Campbell V, Cross FR 2007 Mar Genetics 175 1011-1022

Disruption of mechanisms that prevent rereplication triggers a DNA damage response

Archambault V, Ikui AE, Drapkin BJ, Cross FR 2005 Aug Molecular and cellular biology 25 6707-6721

Targeted proteomic study of the cyclin-Cdk module

Archambault V, Chang EJ, Drapkin BJ, Cross FR, Chait BT, Rout MP 2004 Jun Molecular cell 14 699-711