About Our Research
The Florian-Rodriguez Lab investigates the cellular and molecular mechanisms of pelvic organ prolapse.
The Florian-Rodriguez Lab focuses on elucidating the pathophysiological mechanisms underlying pelvic organ prolapse (POP), with a specific emphasis on the role of cellular senescence and its effects on the vaginal extracellular matrix (ECM). Our research integrates animal models with translational approaches to examine how senescent cell populations contribute to ECM remodeling, tissue weakening, and loss of structural integrity in the pelvic floor.
By combining molecular biology, histological analysis, and biomechanical testing, we aim to define the cellular pathways that drive age-related and injury-induced changes in vaginal tissue. Through this work, we seek to identify novel biomarkers and therapeutic targets to inform the development of more effective, durable treatments for POP and related pelvic floor disorders.
Collaborators
Meet the PI
Dr. Maria Florian-Rodriguez
Dr. Maria Florian-Rodriguez is a physician-scientist whose research bridges the gap between bench and bedside in the field of urogynecology. Her work focuses on the molecular and cellular mechanisms underlying pelvic floor disorders, with particular interest in tissue regeneration, cellular senescence, fibrosis, and the impact of injury and repair pathways on surgical outcomes. Through translational studies, she aims to develop novel strategies for preventing and treating pelvic organ prolapse. Her research is driven by a deep commitment to improving long-term outcomes for women through science-informed care.
Publications
Bastawros D, Rabon H, Noor N, Florian-Rodriguez ME, Hobson D, Tarr ME,
2020 Jun
Female Pelvic Med Reconstr Surg
Petrikovets A, Weber Lebrun EE, Carlos DM, Perlman B, Florian-Rodriguez ME, Bochenska K, Eto CU, Lespinasse P, Mahajan ST, El-Nashar S, Crisp CC, Sheyn D,
2020 Jul
Female Pelvic Med Reconstr Surg
7
26
452-457
Vaginal Hysterectomy Suturing Skills Training Model and Curriculum.
Balgobin S, Owens DM, Florian-Rodriguez ME, Wai CY, McCord EH, Hamid CA, 2019 Sep Obstet Gynecol 3 134 553-558Rectal prolapse and urinary retention: A case report of an "anal cystocele".
Florian-Rodriguez ME, Mehta K, Khatri G, Schaffer JI 2019 Jan Case Rep Womens Health 21 e00100
Maldonado PA, Jackson LA, Florian-Rodriguez ME, Wai CY
2019 Jan
Female Pelvic Med Reconstr Surg
Effect of Protease Inhibitors in Healing of the Vaginal Wall.
Florian-Rodriguez M, Chin K, Hamner J, Acevedo J, Keller P, Word RA, 2019 Aug Sci Rep 1 9 12354
Lavelle ES, Alam P, Meister M, Florian-Rodriguez M, Elmer-Lyon C, Kowalski J, Carter-Brooks C, Mazloomdoost D, Zyczynski H, Lowder J, Gutman R, Sutkin G,
2019 10
Obstet Gynecol
4
134
727-735
Maldonado PA, Norris KP, Florian-Rodriguez ME, Shah NM, Wai CY
2017 Dec
Female Pelvic Med Reconstr Surg
Florian-Rodriguez ME, Hamner JJ, Corton MM
2017 11
Am. J. Obstet. Gynecol.
5
217
607.e1-607.e4
Inferior gluteal and other nerves associated with sacrospinous ligament: a cadaver study.
Florian-Rodriguez ME, Hare A, Chin K, Phelan JN, Ripperda CM, Corton MM 2016 Nov Am. J. Obstet. Gynecol. 5 215 646.e1-646.e6Contact the PI
- Dr. Maria Florian-Rodriguez
- Florian-Rodriguez Lab
- 5323 Harry Hines, F2.304B, Dallas, TX, 75390
More to come...
Biorepository
Open Positions