Publications

Reelin Regulates Developmental Desynchronization Transition of Neocortical Network Activity.

Safety of Anti-Reelin Therapeutic Approaches for Chronic Inflammatory Diseases.

Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.

Reelin differentially shapes dendrite morphology of medial entorhinal cortical ocean and island cells.

Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency.

Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.

Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease.

Apoer2/Lrp8: the undercover cop of synaptic homeostasis.

The Role of X Chromosome in Alzheimer's Disease Genetics.

Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia.

Regulation of the hippocampal translatome by Apoer2-ICD release.

Apoer2-ICD-dependent regulation of hippocampal ribosome mRNA loading.

Reelin through the years: From brain development to inflammation.

Circulating Reelin promotes inflammation and modulates disease activity in acute and long COVID-19 cases.

The "6B" strategy: Build Back a Better Blood-Brain Barrier.

Correction: Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.

Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmonary Hypertension.

Reelin changes hippocampal learning in aging and Alzheimer's disease.

A key requirement for synaptic Reelin signaling in ketamine-mediated behavioral and synaptic action.

Wnt5a Promotes Lysosomal Cholesterol Egress and Protects Against Atherosclerosis.

Apolipoprotein E receptor 2 deficiency decreases endothelial adhesion of monocytes and protects against autoimmune encephalomyelitis.

Reelin restricts dendritic growth of interneurons in the neocortex.

Protein Phosphatase 2A Activation via ApoER2 in Trophoblasts Drives Preeclampsia in a Mouse Model of the Antiphospholipid Syndrome.

CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity.

Endothelial LRP1 protects against neurodegeneration by blocking cyclophilin A.

Serum amyloid A delivers retinol to intestinal myeloid cells to promote adaptive immunity.

Sodium-hydrogen exchanger 6 (NHE6) deficiency leads to hearing loss, via reduced endosomal signalling through the BDNF/Trk pathway.

Reelin signaling modulates GABAB receptor function in the neocortex.

Biolistic transfection and expression analysis of acute cortical slices.

Lymphoangiocrine signals promote cardiac growth and repair.

Sodium Phenylbutyrate-Taurursodiol for ALS.

Selective Inactivation of Reelin in Inhibitory Interneurons Leads to Subtle Changes in the Dentate Gyrus But Leaves Cortical Layering and Behavior Unaffected.

Kinetic Tuning of HDAC Inhibitors Affords Potent Inducers of Progranulin Expression.

LRP1 Deficiency in Vascular SMC Leads To Pulmonary Arterial Hypertension That Is Reversed By PPAR? Activation.

NGP 555, a ?-secretase modulator, shows a beneficial shift in the ratio of amyloid biomarkers in human cerebrospinal fluid at safe doses.

Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.

Reversal of ApoE4 induced recycling block as a novel prevention approach for Alzheimer's disease.

Low density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression.

Intracellular lipid metabolism impairs ? cell compensation during diet-induced obesity.

Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation.

Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.

Author Correction: Loss of the adaptor protein ShcA in endothelial cells protects against monocyte macrophage adhesion, LDL-oxydation, and atherosclerotic lesion formation.

How We Can Rebuild Trust in Science-And Why We Must.

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-?42 by LRP1-dependent apolipoprotein E isoform-specific mechanism.

Lrp4/Wise regulates palatal rugae development through Turing-type reaction-diffusion mechanisms.

Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF-RANKL signaling.

Building a better blood-brain barrier.

LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis.

A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease.

News on the molecular regulation and function of hepatic low-density lipoprotein receptor and LDLR-related protein 1.

The ApoE receptors Vldlr and Apoer2 in Central Nervous System Function and Disease.

Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.

ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease.

NGP 555, a ?-Secretase Modulator, Lowers the Amyloid Biomarker, A?42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents.

Imaging Subcellular Dynamics with Fast and Light-Efficient Volumetrically Parallelized Microscopy.

Functional Roles of the Interaction of APP and Lipoprotein Receptors.

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice.

Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member.

Ephrin Bs and canonical Reelin signalling.

Genome-wide RNAi screen reveals ALK1 mediates LDL uptake and transcytosis in endothelial cells.

FE65 and FE65L1 share common synaptic functions and genetically interact with the APP family in neuromuscular junction formation.

Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis.

Physiologic Reelin does not play a strong role in protection against acute stroke.

Convergent signaling pathways controlled by LRP1 cytoplasmic and extracellular domains limit cellular cholesterol accumulation.

Splicing therapeutics for Alzheimer's disease.

Reelin: Neurodevelopmental Architect and Homeostatic Regulator of Excitatory Synapses.

Prosaposin is a regulator of progranulin levels and oligomerization.

High-Fat Diet Changes Hippocampal Apolipoprotein E (ApoE) in a Genotype- and Carbohydrate-Dependent Manner in Mice.

Loss of Reelin protects against atherosclerosis by reducing leukocyte-endothelial cell adhesion and lesion macrophage accumulation.

ApoE Receptor 2 mediates trophoblast dysfunction and pregnancy complications induced by antiphospholipid antibodies in mice.

FE65 and FE65L1 amyloid precursor protein-binding protein compound null mice display adult-onset cataract and muscle weakness.

Agrin mediates chondrocyte homeostasis and requires both LRP4 and a-dystroglycan to enhance cartilage formation in vitro and in vivo.

Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.

Reelin protects against amyloid ? toxicity in vivo.

Genetic variants of ApoE and ApoER2 differentially modulate endothelial function.

Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice.

Activity-dependent FUS dysregulation disrupts synaptic homeostasis.

Standardizing scavenger receptor nomenclature.

An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.

The lipoprotein receptor LRP1 modulates sphingosine-1-phosphate signaling and is essential for vascular development.

Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.

More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration.

Is Apolipoprotein E Required for Cognitive Function in Humans?: Implications for Alzheimer Drug Development.

LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins.

Generation and characterization of an Nse-CreERT2 transgenic line suitable for inducible gene manipulation in cerebellar granule cells.

Differential splicing and glycosylation of Apoer2 alters synaptic plasticity and fear learning.

Constitutive and ligand-induced EGFR signalling triggers distinct and mutually exclusive downstream signalling networks.

Reelin mobilizes a VAMP7-dependent synaptic vesicle pool and selectively augments spontaneous neurotransmission.

Involvement of the Apoer2 and Lrp1 receptors in mediating the pathological effects of ApoE4 in vivo.

Progranulin Does Not Bind Tumor Necrosis Factor (TNF) Receptors and Is Not a Direct Regulator of TNF-Dependent Signaling or Bioactivity in Immune or Neuronal Cells.

Characterization and Distribution of Reelin-Positive Interneuron Subtypes in the Rat Barrel Cortex.

LDL receptor-related protein 1 (LRP1) modulates N-methyl-D-aspartate (NMDA) receptor-dependent intracellular signaling and NMDA-induced regulation of postsynaptic protein complexes.

Secreted progranulin is a homodimer and is not a component of high-density lipoproteins (HDL).

Reelin induces EphB activation.

The pro-neurotrophin receptor sortilin is a major neuronal apolipoprotein E receptor for catabolism of amyloid-? peptide in the brain.

Human apolipoprotein E isoforms differentially affect bone mass and turnover in vivo.

Role of the postnatal radial glial scaffold for the development of the dentate gyrus as revealed by reelin signaling mutant mice.

APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.

Progranulin: a proteolytically processed protein at the crossroads of inflammation and neurodegeneration.

Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin a5?1.

Apolipoprotein e and apolipoprotein e receptors: normal biology and roles in Alzheimer disease.

TDP-43 aggregation in neurodegeneration: are stress granules the key?

TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration.

Extracting ?-amyloid from Alzheimer's disease.

The nuclear hormone receptor PPAR? counteracts vascular calcification by inhibiting Wnt5a signalling in vascular smooth muscle cells.

Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates.

ApoER2 function in the establishment and maintenance of retinal synaptic connectivity.

Differential signaling by adaptor molecules LRP1 and ShcA regulates adipogenesis by the insulin-like growth factor-1 receptor.

Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia.

Apolipoprotein E induces antiinflammatory phenotype in macrophages.

TDP-43 is directed to stress granules by sorbitol, a novel physiological osmotic and oxidative stressor.

LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE--carrying lipoproteins.

Identification of neuronal RNA targets of TDP-43-containing ribonucleoprotein complexes.

Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via ?2GPI and apoER2.

Signaling through LRP1: Protection from atherosclerosis and beyond.

Wnt signaling in the murine diastema.

Lipoprotein receptor LRP1 regulates leptin signaling and energy homeostasis in the adult central nervous system.

Identification of alternatively spliced Dab1 and Fyn isoforms in pig.

Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion.

Origin, maturation, and astroglial transformation of secondary radial glial cells in the developing dentate gyrus.

Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation.

Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.

LRP4 mutations alter Wnt/beta-catenin signaling and cause limb and kidney malformations in Cenani-Lenz syndrome.

Emerging topics in Reelin function.

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling.

A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition.

Proteomic analysis of GLUT4 storage vesicles reveals LRP1 to be an important vesicle component and target of insulin signaling.

TDP-43 is a developmentally regulated protein essential for early embryonic development.

Lrp4: A novel modulator of extracellular signaling in craniofacial organogenesis.

Lrp4 regulates initiation of ureteric budding and is crucial for kidney formation--a mouse model for Cenani-Lenz syndrome.

Ectodomains of the LDL receptor-related proteins LRP1b and LRP4 have anchorage independent functions in vivo.

Reelin signaling antagonizes beta-amyloid at the synapse.

Mutations in VLDLR as a cause for autosomal recessive cerebellar ataxia with mental retardation (dysequilibrium syndrome).

Smooth muscle LDL receptor-related protein-1 inactivation reduces vascular reactivity and promotes injury-induced neointima formation.

Apolipoprotein E receptors in the nervous system.

LRP1 controls intracellular cholesterol storage and fatty acid synthesis through modulation of Wnt signaling.

Differential functions of the Apoer2 intracellular domain in selenium uptake and cell signaling.

Expanding functions of lipoprotein receptors.

Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo.

LRP1 controls cPLA2 phosphorylation, ABCA1 expression and cellular cholesterol export.

LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation.

Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis.

Contribution of the Reelin signaling pathways to nociceptive processing.

Lrp4 modulates extracellular integration of cell signaling pathways in development.

The Reelin receptors Apoer2 and Vldlr coordinate the patterning of Purkinje cell topography in the developing mouse cerebellum.

Gamma-secretase limits the inflammatory response through the processing of LRP1.

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.

Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice.

Disruption of LDL but not VLDL clearance in autosomal recessive hypercholesterolemia.

Overview: the long and winding road to understanding Alzheimer's disease.

LRP1 functions as an atheroprotective integrator of TGFbeta and PDFG signals in the vascular wall: implications for Marfan syndrome.

The Pafah1b complex interacts with the reelin receptor VLDLR.

Activation of ERK signaling upon alternative protease nexin-1 internalization mediated by syndecan-1.

Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease.

Reelin, lipoprotein receptors and synaptic plasticity.

Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration.

Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.

Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity.

Regulation of the small GTPase Rheb by amino acids.

ApoE receptor 2 controls neuronal survival in the adult brain.

Macrophage low-density lipoprotein receptor-related protein deficiency enhances atherosclerosis in ApoE/LDLR double knockout mice.

The switch on the RAPper's necklace...

Suppression of aging in mice by the hormone Klotho.

Reelin modulates NMDA receptor activity in cortical neurons.

Molecular mechanisms of lipoprotein receptor signalling.

Abnormal development of the apical ectodermal ridge and polysyndactyly in Megf7-deficient mice.

Low density lipoprotein receptor-related protein 1 (LRP1) controls endocytosis and c-CBL-mediated ubiquitination of the platelet-derived growth factor receptor beta (PDGFR beta).

Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction.

Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers.

Loss of Apaf-1 leads to partial rescue of the HAND2-null phenotype.

The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticity.

The modular adaptor protein autosomal recessive hypercholesterolemia (ARH) promotes low density lipoprotein receptor clustering into clathrin-coated pits.

Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2.

Mutations and addiction to EGFR: the Achilles 'heal' of lung cancers?

Neuronal LRP1 functionally associates with postsynaptic proteins and is required for normal motor function in mice.

Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol.

Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1.

Endocytosis of hepatic lipase and lipoprotein lipase into rat liver hepatocytes in vivo is mediated by the low density lipoprotein receptor-related protein.

Functions of lipoprotein receptors in neurons.

Cancer. A bull's eye for targeted lung cancer therapy.

The central fragment of Reelin, generated by proteolytic processing in vivo, is critical to its function during cortical plate development.

Reelin and cyclin-dependent kinase 5-dependent signals cooperate in regulating neuronal migration and synaptic transmission.

Receptor clustering is involved in Reelin signaling.

Apolipoprotein E receptors are required for reelin-induced proteasomal degradation of the neuronal adaptor protein Disabled-1.

Lipoprotein receptors in the vascular wall.

Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.

Phosphatidylinositol 3-kinase interacts with the adaptor protein Dab1 in response to Reelin signaling and is required for normal cortical lamination.

Reelin signaling directly affects radial glia morphology and biochemical maturation.

Interaction of reelin signaling and Lis1 in brain development.

LRP: a bright beacon at the blood-brain barrier.

Malformation of the radial glial scaffold in the dentate gyrus of reeler mice, scrambler mice, and ApoER2/VLDLR-deficient mice.

Insulin-secreting beta-cell dysfunction induced by human lipoproteins.

Elevated plasma factor VIII in a mouse model of low-density lipoprotein receptor-related protein deficiency.

Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes.

LDL receptor-related proteins in neurodevelopment.

Essential role of the apolipoprotein E receptor-2 in sperm development.

Reelin activates SRC family tyrosine kinases in neurons.

Genetic modulation of tau phosphorylation in the mouse.

Conditional expression of mutant M-line titins results in cardiomyopathy with altered sarcomere structure.

Coaxing the LDL receptor family into the fold.

Mouse models as tools for dissecting disorders of lipoprotein metabolism.

Normal sorting but defective endocytosis of the low density lipoprotein receptor in mice with autosomal recessive hypercholesterolemia.

LRP: role in vascular wall integrity and protection from atherosclerosis.

Integration of endocytosis and signal transduction by lipoprotein receptors.

Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning.

Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain.

Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure.

Platelet-derived growth factor mediates tyrosine phosphorylation of the cytoplasmic domain of the low Density lipoprotein receptor-related protein in caveolae.

Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice.

Reelin-mediated signaling locally regulates protein kinase B/Akt and glycogen synthase kinase 3beta.

Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice.

Lipoprotein receptors in the nervous system.

LRP: a multifunctional scavenger and signaling receptor.

The LDL receptor gene family: (un)expected signal transducers in the brain.

Deconstructing the LDL receptor--a rhapsody in pieces.

The LDL receptor gene family: signaling functions during development.

Iron status markers in 224 indigenous Greenlanders: influence of age, residence and traditional foods.

Apaf-1 deficiency and neural tube closure defects are found in fog mice.

Lipoprotein receptors: beacons to neurons?

Embryonic neuronal death due to neurotrophin and neurotransmitter deprivation occurs independent of Apaf-1.

Apolipoprotein E receptors: linking brain development and Alzheimer's disease.

Plasmodium sporozoites invade cells with targeted deletions in the LDL receptor related protein.

Adult Apaf-1-deficient mice exhibit male infertility.

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2.

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.

Cellular signalling by lipoprotein receptors.

Lipoprotein receptors: new roles for ancient proteins.

Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation.

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.

39-kDa receptor-associated protein (RAP) facilitates secretion and ligand binding of extracellular region of very-low-density-lipoprotein receptor: implications for a distinct pathway from low-density-lipoprotein receptor.

Gene targets and approaches for raising HDL.

An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.

The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development.

An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins.

Lipoprotein clearance mechanisms in LDL receptor-deficient "Apo-B48-only" and "Apo-B100-only" mice.

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants.

Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.

Cellular uptake of saposin (SAP) precursor and lysosomal delivery by the low density lipoprotein receptor-related protein (LRP).

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

Absence of P-selectin delays fatty streak formation in mice.

Avian and murine LR8B and human apolipoprotein E receptor 2: differentially spliced products from corresponding genes.

C1 inhibitor-C1s complexes are internalized and degraded by the low density lipoprotein receptor-related protein.

LDL-receptor structure. Calcium cages, acid baths and recycling receptors.

Remnant lipoproteins inhibit malaria sporozoite invasion of hepatocytes.

The low density lipoprotein receptor-related protein can function independently from heparan sulfate proteoglycans in tissue factor pathway inhibitor endocytosis.

Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: evidence suggesting multiple cholesterol esterification enzymes in mammals.

Sustained somatic gene inactivation by viral transfer of Cre recombinase.

Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts.

Disruption of cholesterol 7alpha-hydroxylase gene in mice. II. Bile acid deficiency is overcome by induction of oxysterol 7alpha-hydroxylase.

Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.

The low-density-lipoprotein receptor-related protein (LRP) is processed by furin in vivo and in vitro.

The major subunit of the asialoglycoprotein receptor is expressed on the hepatocellular surface in mice lacking the minor receptor subunit.

Defective forebrain development in mice lacking gp330/megalin.

Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo.

Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor.

Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo.

Animal models for disorders of hepatic lipoprotein metabolism.

Essential functions of synapsins I and II in synaptic vesicle regulation.

Differential recognition of alpha 1-antitrypsin-elastase and alpha 1-antichymotrypsin-cathepsin G complexes by the low density lipoprotein receptor-related protein.

Sporulation protein SpoIVFB from Bacillus subtilis enhances processing of the sigma factor precursor Pro-sigma K in the absence of other sporulation gene products.

Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the mouse.

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

Two receptor systems are involved in the plasma clearance of tissue-type plasminogen activator (t-PA) in vivo.

Lipoprotein and receptor interactions in vivo.

Functions of the LDL receptor gene family.

Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit.

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

Effect of the 39-kDa receptor-associated protein on the hepatic uptake and endocytosis of chylomicron remnants and low density lipoproteins in the rat.

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.

Genetic deficiency in low density lipoprotein receptor-related protein confers cellular resistance to Pseudomonas exotoxin A. Evidence that this protein is required for uptake and degradation of multiple ligands.

Molecular dissection of ligand binding sites on the low density lipoprotein receptor-related protein.

Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist.

Low density lipoprotein receptor-related protein is necessary for the internalization of both tissue-type plasminogen activator-inhibitor complexes and free tissue-type plasminogen activator.

Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).

Short-term synaptic plasticity is altered in mice lacking synapsin I.

Insulin stimulates receptor-mediated uptake of apoE-enriched lipoproteins and activated alpha 2-macroglobulin in adipocytes.

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice.

The LDL Receptor-related Protein-Portrait of a Multifunctional Receptor

LDL receptor-related protein internalizes and degrades uPA-PAI-1 complexes and is essential for embryo implantation.

Putative apolipoprotein receptor gene (LRP, A2MR) is not rearranged in either myxoid liposarcoma or lipomas with translocations in 12q13-14.

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

The low density lipoprotein receptor-related protein: double agent or decoy?

Structure and biosynthesis of the signal-sequence receptor.

Opposing effects of apolipoproteins E and C on lipoprotein binding to low density lipoprotein receptor-related protein.

Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.

Apolipoprotein C-I modulates the interaction of apolipoprotein E with beta-migrating very low density lipoproteins (beta-VLDL) and inhibits binding of beta-VLDL to low density lipoprotein receptor-related protein.

The 68 kDa protein of signal recognition particle contains a glycine-rich region also found in certain RNA-binding proteins.

Low density lipoprotein receptor-related protein mediates endocytosis of monoclonal antibodies in cultured cells and rabbit liver.

The signal sequence receptor has a second subunit and is part of a translocation complex in the endoplasmic reticulum as probed by bifunctional reagents.

The LDL-receptor-related protein, LRP, is an apolipoprotein E-binding protein.

The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14.

Structure of the low-density lipoprotein receptor-related protein (LRP) promoter.

Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains.

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

The primary structure of the 70 kDa subunit of bovine soluble guanylate cyclase.

cDNA cloning of granzyme C, a granule-associated serine protease of cytolytic T lymphocytes.

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

Topological mapping of complement component C9 by recombinant DNA techniques suggests a novel mechanism for its insertion into target membranes.

Efficient construction of cDNA libraries in plasmid expression vectors using an adaptor strategy.

Regulation of cyclic GMP formation by soluble guanylate cyclase: stimulation by NO-containing compounds.