NG Naydenov, S Lechuga, EH Huang, and AI Ivanov; Myosin Motors: Novel Regulators and Therapeutic Targets in Colorectal Cancer. Cancers (Basel). Feb 2021, 13(4).
S K Sarvestani, S Signs, B Hu, Y Yeu, H Feng, Y Ni, D R Hill, R C Fisher, S Ferrandon, J Stiene, M Cruise, T H Hwang, X Shen, J R Spence, and E H Huang; Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity. Nature Communications. Jan 2021, 12(262).
R K DeHaan, S K Sarvestani, and E H Huang; Organoid Models of Colorectal Pathology: Do They Hold the Key to Personalized Medicine? A Systematic Review. Diseases of the Colon and Rectum. Nov 2020, 63(11).
S K Sarvestani, R K DeHaan, P G Miller, S Bose, X Shen, M L Shuler, and E H Huang; A Tissue Engineering Approach to Metastatic Colon Cancer. iScience. Oct 2020, 23(11).
EA Cermeño, MJ O'Melia, WM Han, A Veith, G Barber, EH Huang, SN Thomas, and AJ García;Hydrodynamic shear-based purification of cancer cells with enhanced tumorigenic potential. Integr Biol (Camb). Feb 2020, 12(1).
Y Liao, J Zhao, K Bulek, F Tang, X Chen, G Cai, S Jia, PL Fox, EH Huang, TT Pizzarro, MF Kalady, MW Jackson, S Bao, GC Sen, GR Stark, CJ Chang, and X Li; Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis. Nature Communications. Feb 2020, 11(1).
R C Fisher, K Bellamkonda, L A Molina, S Xiang, D Liska, S K Sarvestani, S Chakrabarti, A Berg, M L Jorgensen, D Hatala, S Chen, A Aiello, H D Appelman, E W Scott, and E H Huang; Disrupting Inflammation-Associated CXCL8-CXCR1 Signaling Inhibits Tumorigenicity Initiated by Sporadic- and Colitis-Colon Cancer Stem Cells. Neoplasia. Mar 2019, 21(3).
S Shawki, J Ashburn, SA Signs, and EH Huang;Colon Cancer: Inflammation Associated Cancer. Surg ONcol Clin N Am. Apr 2018, 27(2).
S J Sarvestani, S A Signs, V Lefebvre, S Mack, Y Ni, A Morton, E R Chan, X Li, P Fox, A Ting, M F Kaladay, M Cruise, J Ashburn, J Stiene, W Lai, D Liska, S Xiang, and E H Huang; Cancer-predicting transcriptomic and epigenetic signatures revealed for ulcerative colitis in patient-derived epithelial organoids. Oncotarget. 2018, 9.
S A Signs, R C fisher, U Tran, S Chakrabarti, S K Sarvestani, S Xiang, D Liska, V Roche, W Lai, H R Gittleman, O Wessely, and E H Huang; Stromal miR-20a controls paracrine CXCL8 secretion in colitis and colon cancer. Oncotarget, Feb 2018, 9 (16).
JS Do, S Kim, K Keslar, E Jang, EH Huang, RL Fairchild, TT Pizarro, and B Min; γδ T cells coexpressing gut homing α4β7 and αE integrins define a novel subset promoting intestinal inflammation. Journal of Immunology. Jan 2018, 198(2).
HJ Chen, Z Wei, J Sun, A Bhattacharya, DJ Savage, R serda, Y Mackeyev, SA Curley, P Bu, L Wang, S Chen, L Cohen-Gould, EH Huang, X Shen, SM Lipkin, NG Copeland, NA Jenkins, and NL Shuler; A recellularized human colon model identifies cancer driver genes. Nautre Biotechnology. Aug 2016, 34(8).
I Kryczek, L Wang, K Wu, W Li, E Zhao, T Cui, S Wei, Y Liu, Y Wang, L Vatan, W Szeliga, JK Greenson, J Roliński, W Zgodzinski, EH Huang, K Tao, G Wang, and W Zou;Inflammatory regulatory T cells in the microenvironments of ulcerative colitis and colon carcinoma. Oncoimmunology. Aug 2016, 5(8).
S Chen, RC Fisher, SA Signs, LA Molina, AK Shenoy, MC Lopez, HV Baker, JM Koomen, Y Chen, H Gittleman, J Barnholtz-Sloan, A Berg, HD Appelman, and EH Huang;Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis. Oncotarget. Jun 2016, 8(31).
E R Fearon, E H Huang; CDX2: Linking Cell and Patient Fates in Colon Cancer. Cell Stem Cell, Feb 2016, 18(2).
A Iqbal, A Raza, EH Huang, L Goldstein, SJ Hughes, and SA Tan;Cost Effectiveness of a Novel Attempt to Reduce Readmission after Ileostomy Creation. JSLS. Jan-Mar 2017, 21(1).
N Nagarsheth, D Peng, I Kryczek, K Wu, W Li, E Zhao, L Zhao, S Wei, T Frankel, L Vatan, W Szeliga, Y Dou, S Owens, V Marquez, K Tao, EH Huang, G Wang, and W Zou;PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer. Cancer Research. Jan 2016, 76(2).
J Zhao, K Bulek, MF Gulen, JA Zepp, G Karagkounis, BN Martin, H Zhou, M Yu, X Liu, EH Huang, PL Fox, MF Kaladay, SD Markowitz, and X Li;Human Colon Tumors Express a Dominant-Negative Form of SIGIRR That Promotes Inflammation and Colitis-Associated Colon Cancer in Mice. Gastroenterology. Dec 2015, 149(7).
D Sun, Y Lin, J Hong, H Chen, N Nagarsheth, D Peng, S Wei, EH Huang, J Fang,, I Kryczek, and W Zou; Th22 cells control colon tumorigenesis through STAT3 and Polycomb Repression complex 2 signaling. Oncoimmunology. Aug 2016, 5(8).
MR Carstens RC Fisher, AP Acharya, EA Butterworth, E Scott, EH Huang, and BG Keselowsky; Drug-eluting microarrays to identify effective chemotherapeutic combinations targeting patient-derived cancer stem cells. Proc Natl Acad Sci U S A. Jul 2015, 112(28).
EH Huang and S Wexner; SSAT/ASCRS Joint Symposium: controversies in surgery for ulcerative colitis. J Gastrointest Surg. Jul 2014, 18(7).
I Kryczek, Y Lin, N Nagarsheth, D Peng, L Zhao, E Zhao, L Vatan, W Szeliga, Y Dou, S Owens, W Zgodzinski, M Majewski, G Wallner, J Fang, EH Huang, and W Zou;IL-22+CD4+ T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity. May 2015, 40(5).
S Chen and EH Huang; The colon cancer stem cell microenvironment holds keys to future cancer therapy. J Gastrointest Surg. May 2014, 18(5).
A Shenoy, E Butterworth, and EH Huang;ALDH as a marker for enriching tumorigenic human colonic stem cells. Methods Mol Biol. 2012, 916.
N Tennyson, WM Mendenhall, CG Morris, EH Huang, and RA Zlotecki;Transanal Excision with Radiation Therapy for Rectal Adenocarcinoma. Clinical Medicine and Research. Nov 2012, 10(4).
A K Shenoy, R C Fisher, E A Butterworth, L Pi, L Chang, H D Appelman, M Chang, E W Scott, and E H Huang; Transition from Colitis to Cancer: High Wnt Activity Sustains the Tumor-Initiating Potential of Colon Cancer Stem Cell Precursors. Cancer Research, Oct 2012; 72(19).
D Zheng, H Chen, MY Bartee, J Williams, JA Davids, EH Huang, J Moreb, and A Lucas;Virus-derived anti-inflammatory proteins: potential therapeutics for cancer. Trends Mol Med. Jun 2012, 18(6).
CM Wilke, L Wang, S Wei, I Kryczek, EH Huang, J Kao, Y Lin, J Fang, and W Zou;Endogenous interleukin-10 constrains Th17 cells in patients with inflammatory bowel disease. J Transl Med. De 2011, 9.
JB Wenger, N Santos, Y Liu, J Dallas, S Subbiah, S Hochwald, EH Huang, DT Dang, CJ Allegra, H Leusch, and LH Dang;Can we develop effective combination antiangiogenic therapy for patients with hepatocellular carcinoma?. Oncology Reviews. Sep 2011, 5(3).
ER Remily-Wood, RZ Liu, Y Xiang, Y Chen, CE Thomas, N Rajyaguru, LM Kaufman, JE Ochoa, L Hazlehurst, J Pinilla-Ibarz, J Lancet, G Zhang, E Haura, D Shibata, T Yeatman, KS Smalley, WS Dalton, E Scott, GC Bloom, SA Eschrich, and JM Koomen;A database of reaction monitoring mass spectrometry assays for elucidating therapeutic response in cancer. Proteomics Clin Appl. Aug 2011, 5(7-8).
MR Hughes and EH Huang;Molecular Basis of Hereditary Colorectal Cancer. Semin Colon Rectal Surg. Jun 2011, 22(2).
I Kryczek, K Wu, E Zhao, S Wei, L Vatan, W Szeliga, EH Huang, J Greenson, A Chang, J Roliński, P Radwan, J Fang, G Wang, and W Zou;IL-17+ Regulatory T Cells in the Microenvironments of Chronic Inflammation and Cancer. The Journal of Immunology. Apr 2011, 186(7).
EH Huang, LA Johnson, K Eaton, MJ Hynes, JE Carpentino, and PD Higgins;Atorvastatin Induces Apoptosis In Vitro and Slows Growth of Tumor Xenografts but Not Polyp Formation in Min Mice. Dig Dis Sci. Nov 2010, 55(11).
Y Chen, M Gruidl, E Remily-Wood, RZ Liu, S Eschrich, M Lloyd, A Nasir, MM Bui, EH Huang, D Shibata, T Yeatman, and JM Koomen;Quantification of β-Catenin Signaling Components in Colon Cancer Cell Lines, Tissue Sections, and Microdissected Tumor Cells using Reaction Monitoring Mass Spectrometry. J Proteom Res. Aug 2010, 9(8).
AC Offodile, E Balik, A Hoffman, V Moon, R Baxter, M Grieco, D Moradi, IY Kim, A Nasar, V Cekic, DL Feingold, TD Arnell, EH Huang, and RL Whelan;Does prior abdominal surgery influence conversion rates and outcomes of laparoscopic right colectomy in patients with neoplasia?. Dis Colon Rectum. Jun 2010, 17(2).
J E Carpentino, M J Hynes, H D Appelman, T Zheng, D A Steindler, E W Scott, and E H Huang; Aldehyde Dehydrogenase–Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer. Cancer Research, Oct 2009; 69(20).
I Kryczek, M Banerjee, P Cheng, L Vatan, W Szeliga, S Wei, EH Huang, E Finlayson, D Simeone, TH Welling, A Chang, G Coukos, R Liu, and W Zou; Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Blood. Aug 2009, 114(6).
I Kryczek, R Liu, G Wang, K Wu, X Shu, W Szeliga, L Vatan, E Finlayson, EH Huang, D Simeone, B Redman, TH Welling, A Chang, and W Zou;FOXP3 defines regulatory T cells in human tumor and autoimmune disease. Cancer Research. May 2009, 69(9).
EH Huang, MJ Hynes, T Zhang, C Ginestier, G Dontu, H Appelman, JZ Fields, MS Wicha, and BM Boman;Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis. Cancer Research. Apr 2009, 69(8).
EH Huang and MS Wicha;Colon cancer stem cells: implications for prevention and therapy. Trends Mol Med. Nov 2008, 14(11).
BM Boman and EH Huang;Human colon cancer stem cells: a new paradigm in gastrointestinal oncology. J Clin Oncol. Jun 2008, 26(17).
CD Logsdon, MK Fuentes, EH Huang, and T Arumugam;RAGE and RAGE ligands in cancer. Curr Mol Med. Dec 2007, 7(8).
MK Fuentes, SS Nigavekar, T Arumugam, CD Logsdon, AM Schmidt, JC Park, and EH Huang;RAGE activation by S100P in colon cancer stimulates growth, migration, and cell signaling pathways. Dis Colon Rectum. Aug 2007, 50(8).
SP Desai, BF El-Rayes, E Ben-Josef, JK Greenson, JA Knol, EH Huang, KA Griffith, PA Phillip, CJ McGinn, MM Zalupski;A phase II study of preoperative capecitabine and radiation therapy in patients with rectal cancer. Am J Clin Oncol. Aug 2007, 30(4).
P Daleraba, S Dylla, I Park, R Liu, X Wang, R Cho, T Hoey, A Guerney, E H Huang, D M Simeone, A A Shelton, G Parmiani, C Castelli, and M F Clarke; Phenotypic characterization of human colorectal cancer stem cells. PNAS, Jun 2007: 104(24).
EH Huang, DG Heidt, CW Li, and DM Simeone;Cancer stem cells: a new paradigm for understanding tumor progression and therapeutic resistance. Surgery. Apr 2007, 141(4).
EH Huang, JC Park, H Appelman, AD Weinberg, M Banerjee, CD Logsdon, and AM Schmidt;Induction of inflammatory bowel disease accelerates adenoma formation in Min +/- mice. Surgery. Jun 2006, 139(6).
JJ Carter, DL Feingold, A Oh, I Kirman, Z Asi, Stapleton G, EH Huang, RL Fine, and RL Whelan; Perioperative immunomodulation with Flt3 kinase ligand or a whole tumor cell vaccine is associated with a reduction in lung metastasis formation after laparotomy in mice. Surg Innov. Mar 2006, 13(1).
JJ Carter, DL Feingold, P Wildbrett, A Oh, I Kirman, Z Asi, G Stapleton, EH Huang, RL Fine, and RL Whelan;Significant reduction of laparotomy-associated lung metastases and subcutaneous tumors after perioperative immunomodulation with flt3 ligand in mice. Surg Innov. Dec 2005, 12(4).
DL Feingold, T Addona, KA Forde, TD Arnell, JJ Carter, EH Huang, and RL Whelan;Safety and reliability of tattooing colorectal neoplasms prior to laparoscopic resection. J Gastrointest Surg. Jul-Aug 2004, 8(5).
I Kirman, EH Huang, and RL Whelan;B cell response to tumor antigens is associated with depletion of B progenitors in murine colocarcinoma. Surgery. Mar 2004, 135(3).
JJ Carter, DL Feingold, I Kirman, A Oh, P Wildbrett, Z Asi, R Fowler, EH Huang, and RL Whelan;Laparoscopic-assisted cecectomy is associated with decreased formation of postoperative pulmonary metastases compared with open cecectomy in a murine model. Surgery. Sep 2003, 134(3).
I Kirman, V Cekic, N Poltratskaia, Z Asi, M Bessler, EH Huang, KA Forde, and RL Whelan; Plasma from patients undergoing major open surgery stimulates in vitro tumor growth: Lower insulin-like growth factor binding protein 3 levels may, in part, account for this change. Surgery, Aug 2002, 132(2).
EH Huang and HL Kaufman; CEA-base vaccines. Expert Rev Vaccines. Jun 202, 1(1).
EH Huang, JJ Carter, RL Whelan, YH Liu, JO Resenberg, H Rotterdam, AM Schmidt, DM Stern, and KA Forde;Colonoscopy in mice. Surgical Endoscopy, Jan 2002;16(1).