Chen X, Huang H. Tumor cell-intrinsic epigenetic SETpoint of cancer-associated fibroblasts. Cancer Cell. 2024 May 13;42(5):744-746.
Zhu Z, Lou G, Teng X, Wang H, Luo Y, Shi W, Yihunie K, Hao S, DeGolier K, Liao C, Huang H, Zhang Q, Fry T, Wang T, Yao C, Wu T. FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells. Nat Immunol. 2024 Jan;25(1):117-128.
Shah AM, Guo L, Jaichander P, Morales MG, Chen K, Huang H, Hernandez KC, Xu L, Bassel-Duby R, Olson EN, Liu N. TWIST2 Mediated Chromatin Remodeling Promotes Fusion-Negative Rhabdomyosarcoma. Sci Adv. 2023 Apr 28;9(17):eade8184. PMID: 37115930
Huang H*, Wang Z, Zhang Y, Pradhan RN, Ganguly D, Chandra R, Murimwa G, Wright S, Gu X, Maddipati R, Müller S, Turley SJ, Brekken RA. Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer. Cancer Cell. 2022 Jun 13;40(6):656-673.e7. PMID: 35523176 (*Lead Corresponding Author, Highlighted in Cancer Cell. 2022 Jun 13;40(6):595-597; Cancer Discov. 2022 Jul 6;12(7):1609.)
Kim K, Huang H, He L, Parida P, Marquez-Palencia M, Carrillo D, Miyata J, Stevens C, Kapur P, Brugarolas J, Brekken RA, Malladi S. Cell competition shapes metastatic latency and relapse. Cancer Discov. 2022 Sep 13:CD-22-0236. PMID: 36098678
Dixit A, Sarver AL, Zettervall J, Huang H, Zheng K, Brekken RA, Provenzano P. Targeting TNF-α producing macrophages activate antitumor immunity in pancreatic cancer through IL33 signaling. JCI Insight. 2022 Oct 18;e153242. PMID: 36256464
Zhang Y, Huang H, Coleman M, Ziemys A, Gopal P, Kazmi S, Brekken RA. VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment. JCI Insight. 2021 Oct 21;e150735. PMID: 34673569
Huang H, Brekken RA. Location matters: Profiling diffuse type gastric cancer at the single cell level. Clin Cancer Res. 2021 Sep 23;clincanres.2935.2021. PMID: 34556549
Deng J, Kang Y, Cheng C, Li X, Dai B, Katz MH, Men T, Kim MP, Koay E, Huang H, Brekken RA, Fleming JB. DDR1-induced Neutrophil Extracellular Traps Drive Pancreatic Cancer Metastasis. JCI Insight. 2021 Jul 8;146133. PMID: 34237033
Huang H, Brekken RA. Beyond Stiffness: Collagen Signaling in Pancreatic Cancer and Pancreas Regeneration. Am J Pathol. 2020 May 22;S0002-9440(20)30245-5. PMID: 32450151
Huang H, Brekken RA. Recent Advances in Understanding Cancer-Associated Fibroblasts in Pancreatic Cancer. Am J Physiol Cell Physiol. 2020 May 20. Online ahead of print. PMID: 32432930
Huang H, Zhang Y, Gallegos V, Sorrelle N, Zaid MM, Toombs J, Du W, Wright S, Hagopian M, Wang Z, Hosein AN, Sathe AA, Xing C, Koay EJ, Driscoll KE, Brekken RA. Targeting TGFβR2-mutant Tumors Exposes Vulnerabilities to Stromal TGFβ Blockade in Pancreatic Cancer. EMBO Mol Med. 2019 Nov 7;11(11):e10515. PMID: 31609088 PMCID: PMC6835203 (Comment in EMBO Mol Med. 2019 Nov 7;11(11):e11414.)
Hosein AN, Huang H, Wang Z, Parmar K, Du W, Huang J, Maitra A, Olson E, Verma U, Brekken RA. Cellular Heterogeneity During Mouse Pancreatic Ductal Adenocarcinoma Progression at Single-Cell Resolution. JCI Insight. 2019 Jul 23;5(16):e129212. PMID: 31335328 PMCID: PMC6777805
Zhu D*, Huang H*, Pinkas DM, Luo J, Ganguly D, Fox AE, Arner E, Xiang Q, Tu ZC, Bullock AN, Brekken RA, Ding K, Lu X. 2-Amino-2,3-dihydro-1 H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy. J Med Chem. 2019 Aug 22;62(16):7431-7444. PMID: 31310125 PMCID: PMC6985936 (*Co-first Author)
Huang H, Wright S, Zhang J, Brekken RA. Getting a Grip on Adhesion: Cadherin Switching and Collagen Signaling. Biochim Biophys Acta Mol Cell Res. 2019 Nov;1866(11):118472. PMID: 30954569
Huang H, Brekken RA. The Next Wave of Stroma-Targeting Therapy in Pancreatic Cancer. Cancer Res. 2019 Jan 15;79(2):328-330. PMID: 30647067
Du W*, Huang H*, Sorrelle N, Brekken RA. Sitravatinib Potentiates Immune Checkpoint Blockade in Refractory Cancer Models. JCI Insight. 2018 Nov 2;3(21):e124184. PMID: 30385724 PMCID: PMC6238734 (*Co-first Author)
Aguilera KY*, Huang H*, Du W, Hagopian MM, Wang Z, Hinz S, Hwang TH, Wang H, Fleming JB, Castrillon DH, Ren X, Ding K, Brekken RA. Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma. Mol Cancer Ther. 2017 Nov;16(11):2473-2485. PMID: 28864681 PMCID: PMC5669827 (*Co-first Author)
Huang H, Du W, Brekken RA. Extracellular Matrix Induction of Intracellular Reactive Oxygen Species. Antioxid Redox Signal. 2017 Oct 20;27(12):774-784. PMID: 28791881
Huang H, Svoboda RA, Lazenby AJ, Saowapa J, Chaika N, Ding K, Wheelock MJ, Johnson KR. Up-regulation of N-cadherin by Collagen I-activated Discoidin Domain Receptor 1 in Pancreatic Cancer Requires the Adaptor Molecule Shc1. J Biol Chem. 2016 Oct 28;291(44):23208-23223. PMID: 27605668 PMCID: PMC5087738