Publications

Sexually Dimorphic Association of Circulating Plasminogen Activator Inhibitor-1 Levels and Body Mass Index with Cerebrospinal Fluid Biomarkers of Alzheimer's Pathology in Preclinical Alzheimer's Disease.

Eruysal E, Ravdin L, Zhang C, Kamel H, Iadecola C, Ishii M, 2023 J Alzheimers Dis 3 91 1073-1083

Amyloid-Beta Modulates Low-Threshold Activated Voltage-Gated L-Type Calcium Channels of Arcuate Neuropeptide Y Neurons Leading to Calcium Dysregulation and Hypothalamic Dysfunction.

Ishii M, Hiller AJ, Pham L, McGuire MJ, Iadecola C, Wang G, 2019 Oct J Neurosci 44 39 8816-8825

Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology.

Ishii M, Iadecola C, 2015 Nov Cell Metab 5 22 761-76

Transgenic mice overexpressing amyloid precursor protein exhibit early metabolic deficits and a pathologically low leptin state associated with hypothalamic dysfunction in arcuate neuropeptide y neurons.

Ishii M, Wang G, Racchumi G, Dyke JP, Iadecola C 2014 Jul J. Neurosci. 27 34 9096-106

Comparing the effects of four common drug classes on the progression of mild cognitive impairment to dementia using electronic health records.

Xu J, Wang F, Zang C, Zhang H, Niotis K, Liberman AL, Stonnington CM, Ishii M, Adekkanattu P, Luo Y, Mao C, Rasmussen LV, Xu Z, Brandt P, Pacheco JA, Peng Y, Jiang G, Isaacson R, Pathak J, 2023 May Sci Rep 1 13 8102

Midlife dyslipidaemia as a modifiable risk factor for later-life dementia.

Ishii M, 2021 Aug Lancet Healthy Longev 8 2 e453-e454

Risk factor for Alzheimer's disease breaks the blood-brain barrier.

Ishii M, Iadecola C, 2020 May Nature 7806 581 31-32

A Novel Neurovascular Liaison Governing the Blood-Brain Barrier.

Ishii M, Iadecola C, 2020 Jul Neuron 2 107 205-207

Apolipoprotein B as a New Link Between Cholesterol and Alzheimer Disease.

Ishii M, 2019 Jul JAMA Neurol 7 76 751-753

McLeod syndrome: Five new pedigrees with novel mutations.

Weaver J, Sarva H, Barone D, Bobker S, Bushara K, Hiller A, Ishii M, Jankovic J, Lakhani S, Niotis K, Scharre DW, Tuite P, Stutz A, Westhoff CM, Walker RH, 2019 Jul Parkinsonism Relat Disord 64 293-299

Plasma lipocalin-2 levels in the preclinical stage of Alzheimer's disease.

Eruysal E, Ravdin L, Kamel H, Iadecola C, Ishii M, 2019 Dec Alzheimers Dement (Amst) 11 646-653

Retinol Binding Protein 4 Levels Are Not Altered in Preclinical Alzheimer's Disease and Not Associated with Cognitive Decline or Incident Dementia.

Ishii M, Kamel H, Iadecola C, 2019 J Alzheimers Dis 1 67 257-263

Disorders of Body Weight, Sleep and Circadian Rhythm as Manifestations of Hypothalamic Dysfunction in Alzheimer's Disease.

Hiller AJ, Ishii M, 2018 Front Cell Neurosci 12 471

Endocrine Emergencies With Neurologic Manifestations.

Ishii M, 2017 Jun Continuum (Minneap Minn) 3, Neurology of Systemic Disease 23 778-801

Adipocyte-derived factors in age-related dementia and their contribution to vascular and Alzheimer pathology.

Ishii M, Iadecola C, 2016 May Biochim Biophys Acta 5 1862 966-74

Leptin Dysfunction and Alzheimer's Disease: Evidence from Cellular, Animal, and Human Studies.

McGuire MJ, Ishii M, 2016 Mar Cell Mol Neurobiol 2 36 203-17

Ishii M, Lavi E, Kamel H, Gupta A, Iadecola C, Navi BB 2014 Apr Neurohospitalist 2 4 86-9

Critical role of neuropeptides b/w receptor 1 signaling in social behavior and fear memory.

Nagata-Kuroiwa R, Furutani N, Hara J, Hondo M, Ishii M, Abe T, Mieda M, Tsujino N, Motoike T, Yanagawa Y, Kuwaki T, Yamamoto M, Yanagisawa M, Sakurai T 2011 PLoS ONE 2 6 e16972

Fasting-induced hypothermia and reduced energy production in mice lacking acetyl-CoA synthetase 2.

Sakakibara I, Fujino T, Ishii M, Tanaka T, Shimosawa T, Miura S, Zhang W, Tokutake Y, Yamamoto J, Awano M, Iwasaki S, Motoike T, Okamura M, Inagaki T, Kita K, Ezaki O, Naito M, Kuwaki T, Chohnan S, Yamamoto TT, Hammer RE, Kodama T, Yanagisawa M, Sakai J 2009 Feb Cell Metab. 2 9 191-202

Effect of neuropeptide B on feeding behavior is influenced by endogenous corticotropin-releasing factor activities.

Aikawa S, Ishii M, Yanagisawa M, Sakakibara Y, Sakurai T 2008 Nov Regul. Pept. 1-3 151 147-52

The NPB/NPW neuropeptide system and its role in regulating energy homeostasis, pain, and emotion.

Hondo M, Ishii M, Sakurai T, 2008 Results Probl Cell Differ 46 239-56

Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain.

Kitamura Y, Tanaka H, Motoike T, Ishii M, Williams SC, Yanagisawa M, Sakurai T 2006 Jun Brain Res. 1 1093 123-34

Targeted disruption of GPR7, the endogenous receptor for neuropeptides B and W, leads to metabolic defects and adult-onset obesity.

Ishii M, Fei H, Friedman JM, 2003 Sep Proc Natl Acad Sci U S A 18 100 10540-5

Mechanism-based inhibition of the melatonin rhythm enzyme: pharmacologic exploitation of active site functional plasticity.

Khalil EM, De Angelis J, Ishii M, Cole PA, 1999 Oct Proc Natl Acad Sci U S A 22 96 12418-23

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior.

Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M 1998 Feb Cell 4 92 573-85