Featured Publications
Glutathione limits RUNX2 oxidation and degradation to regulate bone formation.
Hu G, Yu Y, Sharma D, Pruett-Miller SM, Ren Y, Zhang GF, Karner CM, 2023 Jul JCI Insight
Shen L, Yu Y, Zhou Y, Pruett-Miller SM, Zhang GF, Karner CM,
2022 Mar
Elife
11
SLC1A5 provides glutamine and asparagine necessary for bone development in mice.
Sharma D, Yu Y, Shen L, Zhang GF, Karner CM, 2021 Oct Elife 10Biphasic regulation of glutamine consumption by WNT during osteoblast differentiation.
Shen L, Sharma D, Yu Y, Long F, Karner CM, 2021 Jan J Cell Sci 1 134The Amino Acid Sensor Eif2ak4/GCN2 Is Required for Proliferation of Osteoblast Progenitors in Mice.
Hu G, Yu Y, Tang YJ, Wu C, Long F, Karner CM, 2020 May J Bone Miner ResGlutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells.
Yu Y, Newman H, Shen L, Sharma D, Hu G, Mirando AJ, Zhang H, Knudsen E, Zhang GF, Hilton MJ, Karner CM, 2019 04 Cell Metab 4 29 966-978.e4Increased glutamine catabolism mediates bone anabolism in response to WNT signaling.
Karner CM, Esen E, Okunade AL, Patterson BW, Long F, 2015 Feb J Clin Invest 2 125 551-62Distinct roles of glutamine metabolism in benign and malignant cartilage tumors with IDH mutations.
Zhang H, Puviindran V, Nadesan P, Ding X, Shen L, Tang YJ, Tsushima H, Yahara Y, Ban GI, Zhang GF, Karner CM, Alman B, 2022 Feb J Bone Miner Res
Long JT, Leinroth A, Liao Y, Ren Y, Mirando AJ, Nguyen T, Guo W, Sharma D, Rouse D, Wu C, Cheah KSE, Karner CM, Hilton MJ,
2022 Feb
Elife
11
Shen L, Hu G, Karner CM,
2022 Feb
Curr Osteoporos Rep
Evaluation of Amino Acid Consumption in Cultured Bone Cells and Isolated Bone Shafts.
Shen L, Karner CM, 2022 04 J Vis Exp 182
Liu Z, Hussien AA, Wang Y, Heckmann T, Gonzalez R, Karner CM, Snedeker JG, Gray RS,
2021 Jul
Elife
10
Obesity alters the collagen organization and mechanical properties of murine cartilage.
Collins AT, Hu G, Newman H, Reinsvold MH, Goldsmith MR, Twomey-Kozak JN, Leddy HA, Sharma D, Shen L, DeFrate LE, Karner CM, 2021 Jan Sci Rep 1 11 1626HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly.
Sharma D, Mirando AJ, Leinroth A, Long JT, Karner CM, Hilton MJ, 2021 Dec PLoS Genet 12 17 e1009982
Johnston RA, Vullioud P, Thorley J, Kirveslahti H, Shen L, Mukherjee S, Karner CM, Clutton-Brock T, Tung J,
2021 Apr
Elife
10
Guo W, Spiller KV, Tang J, Karner CM, Hilton MJ, Wu C,
2021 Apr
Stem Cell Res
53
102317
Radiolabeled Amino Acid Uptake Assays in Primary Bone Cells and Bone Explants.
Shen L, Karner CM, 2021 Methods Mol Biol 2230 449-456
Sharma D, Hilton MJ, Karner CM,
2021
Methods Mol Biol
2230
367-376
Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity.
Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K, 2019 09 Sci Adv 9 5 eaax8352Molecular determinants of WNT9b responsiveness in nephron progenitor cells.
Dickinson KK, Hammond LC, Karner CM, Hastie ND, Carroll TJ, Goodyer P, 2019 PLoS One 4 14 e0215139
Karner CM, Long F,
2018 10
Bone
115
2-7
Cao C, Ren Y, Barnett AS, Mirando AJ, Rouse D, Mun SH, Park-Min KH, McNulty AL, Guilak F, Karner CM, Hilton MJ, Pitt GS,
2017 11
JCI Insight
22
2
Myc cooperates with ?-catenin to drive gene expression in nephron progenitor cells.
Pan X, Karner CM, Carroll TJ, 2017 11 Development 22 144 4173-4182
Karner CM, Long F,
2017 05
Cell Mol Life Sci
9
74
1649-1657
Bmp Induces Osteoblast Differentiation through both Smad4 and mTORC1 Signaling.
Karner CM, Lee SY, Long F, 2017 02 Mol Cell Biol 4 37
Karner CM, Esen E, Chen J, Hsu FF, Turk J, Long F,
2016 Jun
J Biol Chem
25
291
13028-39
Lim J, Shi Y, Karner CM, Lee SY, Lee WC, He G, Long F,
2016 Jan
Development
2
143
339-47
Caprioli A, Villasenor A, Wylie LA, Braitsch C, Marty-Santos L, Barry D, Karner CM, Fu S, Meadows SM, Carroll TJ, Cleaver O,
2015 Oct
Dev Biol
2
406
222-34
A Cre-inducible fluorescent reporter for observing apical membrane dynamics.
Pan X, Schnell U, Karner CM, Small EV, Carroll TJ, 2015 Mar-Apr Genesis 3-4 53 285-93Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.
Karner CM, Long F, Solnica-Krezel L, Monk KR, Gray RS, 2015 Aug Hum Mol Genet 15 24 4365-73
Shi Y, Chen J, Karner CM, Long F,
2015 Apr
Proc Natl Acad Sci U S A
15
112
4678-83
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation.
Das A, Tanigawa S, Karner CM, Xin M, Lum L, Chen C, Olson EN, Perantoni AO, Carroll TJ, 2013 Sep Nat Cell Biol 9 15 1035-44
Esen E, Chen J, Karner CM, Okunade AL, Patterson BW, Long F,
2013 May
Cell Metab
5
17
745-55
Dodge ME, Moon J, Tuladhar R, Lu J, Jacob LS, Zhang LS, Shi H, Wang X, Moro E, Mongera A, Argenton F, Karner CM, Carroll TJ, Chen C, Amatruda JF, Lum L,
2012 Jun
J Biol Chem
27
287
23246-54
Lienkamp SS, Liu K, Karner CM, Carroll TJ, Ronneberger O, Wallingford JB, Walz G,
2012 Dec
Nat Genet
12
44
1382-7
Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.
Tu X, Chen J, Lim J, Karner CM, Lee SY, Heisig J, Wiese C, Surendran K, Kopan R, Gessler M, Long F, 2012 PLoS Genet 3 8 e1002577
Karner CM, Das A, Ma Z, Self M, Chen C, Lum L, Oliver G, Carroll TJ,
2011 Apr
Development
7
138
1247-57
Integrin-linked kinase regulates p38 MAPK-dependent cell cycle arrest in ureteric bud development.
Smeeton J, Zhang X, Bulus N, Mernaugh G, Lange A, Karner CM, Carroll TJ, Fässler R, Pozzi A, Rosenblum ND, Zent R, 2010 Oct Development 19 137 3233-43Tankyrase is necessary for canonical Wnt signaling during kidney development.
Karner CM, Merkel CE, Dodge M, Ma Z, Lu J, Chen C, Lum L, Carroll TJ, 2010 Jul Dev Dyn 7 239 2014-23
Karner CM, Dietrich MF, Johnson EB, Kappesser N, Tennert C, Percin F, Wollnik B, Carroll TJ, Herz J,
2010 Apr
PLoS One
4
5
e10418
Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis.
Karner CM, Chirumamilla R, Aoki S, Igarashi P, Wallingford JB, Carroll TJ, 2009 Jul Nat Genet 7 41 793-9Aberrant planar cell polarity induced by urinary tract obstruction.
Li L, Zepeda-Orozco D, Patel V, Truong P, Karner CM, Carroll TJ, Lin F, 2009 Dec Am J Physiol Renal Physiol 6 297 F1526-33Molecular regulation of kidney development: is the answer blowing in the Wnt?
Merkel CE, Karner CM, Carroll TJ, 2007 Nov Pediatr Nephrol 11 22 1825-38Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3.
Ma Z, Gong Y, Patel V, Karner CM, Fischer E, Hiesberger T, Carroll TJ, Pontoglio M, Igarashi P, 2007 Dec Proc Natl Acad Sci U S A 51 104 20386-91