Featured Publications
Cryo-EM structures of Myomaker reveal a molecular basis for myoblast fusion.
Long T, Zhang Y, Donnelly L, Li H, Pien YC, Liu N, Olson EN, Li X, 2023 Sep Nat Struct Mol BiolMolecular basis of Wnt biogenesis, secretion, and Wnt7-specific signaling.
Qi X, Hu Q, Elghobashi-Meinhardt N, Long T, Chen H, Li X, 2023 Oct CellStructural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate.
Chen H, Ahmed S, Zhao H, Elghobashi-Meinhardt N, Dai Y, Kim JH, McDonald JG, Li X, Lee CH, 2023 May CellStructure and mechanism of human cystine exporter cystinosin.
Guo X, Schmiege P, Assafa TE, Wang R, Xu Y, Donnelly L, Fine M, Ni X, Jiang J, Millhauser G, Feng L, Li X, 2022 Sep CellMechanisms and inhibition of Porcupine-mediated Wnt acylation.
Liu Y, Qi X, Donnelly L, Elghobashi-Meinhardt N, Long T, Zhou RW, Sun Y, Wang B, Li X, 2022 Jul NatureRegulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain.
Chen H, Qi X, Faulkner RA, Schumacher MM, Donnelly LM, DeBose-Boyd RA, Li X, 2022 Jul Nat Commun 1 13 4273Molecular basis of cholesterol efflux via ABCG subfamily transporters.
Sun Y, Wang J, Long T, Qi X, Donnelly L, Elghobashi-Meinhardt N, Esparza L, Cohen JC, Xie XS, Hobbs HH, Li X, 2021 Aug Proc Natl Acad Sci U S A 34 118
Wang R, Wang J, Hassan A, Lee CH, Xie XS, Li X,
2021 03
Nat Commun
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12
1782
Long T, Sun Y, Hassan A, Qi X, Li X,
2020 May
Nature
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339-343
Long T, Qi X, Hassan A, Liang Q, De Brabander JK, Li X,
2020 Jan
Nat Commun
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11
152
Wang R, Long T, Hassan A, Wang J, Sun Y, Xie XS, Li X,
2020 Aug
Nat Commun
1
11
3921
Cryo-EM structure of oxysterol-bound human Smoothened coupled to a heterotrimeric Gi.
Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X, 2019 Jun NatureStructures of human Patched and its complex with native palmitoylated sonic hedgehog.
Qi X, Schmiege P, Coutavas E, Wang J, Li X 2018 Jul NatureTwo Patched molecules engage distinct sites on Hedgehog yielding a signaling-competent complex.
Qi X, Schmiege P, Coutavas E, Li X 2018 Aug ScienceHuman TRPML1 channel structures in open and closed conformations.
Schmiege P, Fine M, Blobel G, Li X 2017 Oct Nature 7676 550 366-370
Li X, Tian Y, Li X, Barger SR,
2023 Oct
Trends Biochem Sci
10
48
829-831
GPR35 and mediators from platelets and mast cells in neutrophil migration and inflammation.
De Giovanni M, Chen H, Li X, Cyster JG, 2023 Mar Immunol Rev
Chen H, Qin Y, Chou M, Cyster JG, Li X,
2023 Apr
Elife
12
Molecular basis of mEAK7-mediated human V-ATPase regulation.
Wang R, Qin Y, Xie XS, Li X, 2022 Jun Nat Commun 1 13 3272
Chen H, Chen K, Huang W, Staudt LM, Cyster JG, Li X,
2022 Apr
Sci Adv
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8
eabn0067
Structural enzymology of cholesterol biosynthesis and storage.
Long T, Debler EW, Li X, 2022 Apr Curr Opin Struct Biol 74 102369Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response.
Chen H, Huang W, Li X, 2022 Apr StructureCholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states
Sun Y and Li X 2022 1 238-245Molecular structures of human ACAT2 disclose mechanism for selective inhibition.
Long T, Liu Y, Li X, 2021 Sep StructureStructural basis of acyl-CoA transport across the peroxisomal membrane by human ABCD1.
Wang R, Qin Y, Li X, 2021 Nov Cell ResAtomic insights into ML-SI3 mediated human TRPML1 inhibition.
Schmiege P, Fine M, Li X, 2021 Jun StructureInsights into the Irritating Mechanisms of TRPA1 Revealed by Cryo-EM.
Fine M, Li X, 2021 Jan Neuron 2 109 194-196Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Long T, Liu Y, Qin Y, DeBose-Boyd RA, Li X, 2021 Aug Sci Adv 34 7Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.
Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X, 2020 Sep Nat. Chem. Biol.Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling.
Qi X, Li X, 2020 May Trends Biochem. Sci. 5 45 397-410Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
Wang R, Qi X, Schmiege P, Coutavas E, Li X, 2020 Feb Sci Adv 7 6 eaaz1466Structure of human Dispatched-1 provides insights into Hedgehog ligand biogenesis.
Chen H, Liu Y, Li X, 2020 Aug Life Sci Alliance 8 3
Fine M, Li X, Dang S,
2019 Nov
Cell Calcium
86
102107
Structural basis for human sterol isomerase in cholesterol biosynthesis and multidrug recognition.
Long T, Hassan A, Thompson BM, McDonald JG, Wang J, Li X, 2019 Jun Nat Commun 1 10 2452The regulatory mechanism of mammalian TRPMLs revealed by cryo-EM.
Schmiege P, Fine M, Li X 2018 Mar FEBS J.Structural basis for PtdInsP2 mediated human TRPML1 regulation
Fine M, Schmiege P and Li X 2018 9 4192
Li X, Lu F, Trinh MN, Schmiege P, Seemann J, Wang J, Blobel G
2017 Aug
Proc. Natl. Acad. Sci. U.S.A.
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9116-9121
Li X, Wang J, Coutavas E, Shi H, Hao Q, Blobel G
2016 Jun
Proc. Natl. Acad. Sci. U.S.A.
Sun L, Li X, Shi Y
2016 Jan
Curr. Opin. Struct. Biol.
37
97-107
Triazoles inhibit cholesterol export from lysosomes by binding to NPC1.
Trinh MN, Lu F, Li X, Das A, Liang Q, De Brabander JK, Brown MS, Goldstein JL 2016 Dec Proc. Natl. Acad. Sci. U.S.A.
Li X, Saha P, Li J, Blobel G, Pfeffer SR
2016 Aug
Proc. Natl. Acad. Sci. U.S.A.
Crystal structure of a phosphorylation-coupled vitamin C transporter.
Luo P, Yu X, Wang W, Fan S, Li X, Wang J 2015 Feb Nat. Struct. Mol. Biol.Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum.
Li X, Roberti R, Blobel G 2014 Oct Nature
Condon SM, Mitsuuchi Y, Deng Y, Laporte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, Burns JM, Graham MA, McKinlay MA, Li X, Wang J, Shi Y, Feltham R, Bettjeman B, Cumming MH, Vince JE, Khan N, Silke J, Day CL, Chunduru SK
2014 Apr
J. Med. Chem.
Structure of a presenilin family intramembrane aspartate protease.
Li X, Dang S, Yan C, Gong X, Wang J, Shi Y 2013 Jan Nature 7430 493 56-61Structural mechanisms of DIAP1 auto-inhibition and DIAP1-mediated inhibition of drICE.
Li X, Wang J, Shi Y 2011 Aug Nat Commun 2 408
Li X, Wang B, Feng L, Kang H, Qi Y, Wang J, Shi Y
2009 Sep
Proc. Natl. Acad. Sci. U.S.A.
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14837-42
Gao X, Lu F, Zhou L, Dang S, Sun L, Li X, Wang J, Shi Y
2009 Jun
Science
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324
1565-8