Publications

  1. Wang X, He Q, Zhou C, Xu Y, Liu D, Fujiwara N, Kubota N, Click A, Henderson P, Vancil J, Marquez CA, Gunasekaran G, Schwartz ME, Tabrizian P, Sarpel U, Fiel MI, Diao Y, Sun B, Hoshida Y, Liang S, Zhong Z. Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development. Immunity. 2023 Jan 10;56(1):58-77.e11. doi: 10.1016/j.immuni.2022.11.013. Epub 2022 Dec 14. PubMed PMID: 36521495; PubMed Central PMCID: PMC9839616.
  2. Fujiwara N, Kubota N, Crouchet E, Koneru B, Marquez CA, Jajoriya AK, Panda G, Qian T, Zhu S, Goossens N, Wang X, Liang S, Zhong Z, Lewis S, Taouli B, Schwartz ME, Fiel MI, Singal AG, Marrero JA, Fobar AJ, Parikh ND, Raman I, Li QZ, Taguri M, Ono A, Aikata H, Nakahara T, Nakagawa H, Matsushita Y, Tateishi R, Koike K, Kobayashi M, Higashi T, Nakagawa S, Yamashita YI, Beppu T, Baba H, Kumada H, Chayama K, Baumert TF, Hoshida Y. Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease. Sci Transl Med. 2022 Jun 22;14(650):eabo4474. doi: 10.1126/scitranslmed.abo4474. Epub 2022 Jun 22. PubMed PMID: 35731891; PubMed Central PMCID: PMC9236162.
  3. Baglieri J, Zhang C, Liang S, Liu X, Nishio T, Rosenthal SB, Dhar D, Su H, Cong M, Jia J, Hosseini M, Karin M, Kisseleva T, Brenner DA. Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice. Am J Pathol. 2021 Sep;191(9):1564-1579. doi: 10.1016/j.ajpath.2021.05.019. Epub 2021 Jun 11. PubMed PMID: 34119473; PubMed Central PMCID: PMC8406794.
  4. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 May;72(5):946-959. doi: 10.1016/j.jhep.2019.12.016. Epub 2019 Dec 31. PubMed PMID: 31899206; PubMed Central PMCID: PMC7167339.
  5. Zhong F, Liang S, Zhong Z. Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression. Trends Immunol. 2019 Dec;40(12):1120-1133. doi: 10.1016/j.it.2019.10.008. Epub 2019 Nov 16. Review. PubMed PMID: 31744765.
  6. Huo S, Zhang J, Liang S, Wu F, Zuo Y, Cui D, Zhang Y, Zhong Z, Zhong F. Membrane-bound and soluble porcine CD83 functions antithetically in T cell activation and dendritic cell differentiation in vitro. Dev Comp Immunol. 2019 Oct;99:103398. doi: 10.1016/j.dci.2019.103398. Epub 2019 May 20. PubMed PMID: 31121186.
  7. Nishio T, Hu R, Koyama Y, Liang S, Rosenthal SB, Yamamoto G, Karin D, Baglieri J, Ma HY, Xu J, Liu X, Dhar D, Iwaisako K, Taura K, Brenner DA, Kisseleva T. Activated hepatic stellate cells and portal fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice. J Hepatol. 2019 Sep;71(3):573-585. doi: 10.1016/j.jhep.2019.04.012. Epub 2019 May 7. PubMed PMID: 31071368.
  8. Liang S, Zhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E. Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria. J Biol Chem. 2019 Aug 16;294(33):12359-12369. doi: 10.1074/jbc.RA119.007409. Epub 2019 Jun 24. PubMed PMID: 31235522; PubMed Central PMCID: PMC6699832.
  9. Zhang J, Fan J, Li Y, Liang S, Huo S, Wang X, Zuo Y, Cui D, Li W, Zhong Z, Zhong F. Porcine Parvovirus Infection Causes Pig Placenta Tissue Damage Involving Nonstructural Protein 1 (NS1)-Induced Intrinsic ROS/Mitochondria-Mediated Apoptosis. Viruses. 2019 Apr 25;11(4). doi: 10.3390/v11040389. PubMed PMID: 31027293; PubMed Central PMCID: PMC6520726.
  10. Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA. NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice. Gastroenterology. 2019 Mar;156(4):1156-1172.e6. doi: 10.1053/j.gastro.2018.11.019. Epub 2018 Nov 13. PubMed PMID: 30445007; PubMed Central PMCID: PMC6409207.
  11. Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M. New mitochondrial DNA synthesis enables NLRP3 inflammasome activation. Nature. 2018 Aug;560(7717):198-203. doi: 10.1038/s41586-018-0372-z. Epub 2018 Jul 25. PubMed PMID: 30046112; PubMed Central PMCID: PMC6329306.
  12. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA. The role of human cytochrome P450 2E1 in liver inflammation and fibrosis. Hepatol Commun. 2017 Dec;1(10):1043-1057. doi: 10.1002/hep4.1115. eCollection 2017 Dec. PubMed PMID: 29404441; PubMed Central PMCID: PMC5721400.
  13. Yang L, Miura K, Zhang B, Matsushita H, Yang YM, Liang S, Song J, Roh YS, Seki E. TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice. Cell Mol Gastroenterol Hepatol. 2017 May;3(3):469-483. doi: 10.1016/j.jcmgh.2016.12.004. eCollection 2017 May. PubMed PMID: 28462384; PubMed Central PMCID: PMC5403956.
  14. Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner DA, Kisseleva T. Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis. J Clin Invest. 2017 Apr 3;127(4):1254-1270. doi: 10.1172/JCI88845. Epub 2017 Mar 13. PubMed PMID: 28287406; PubMed Central PMCID: PMC5373891.
  15. Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057. PubMed PMID: 26919428; PubMed Central PMCID: PMC4769378.
  16. Li W, Chang Y, Liang S, Zhong Z, Li X, Wen J, Zhang Y, Zhang J, Wang L, Lin H, Cao X, Huang H, Zhong F. NLRP3 inflammasome activation contributes to Listeria monocytogenes-induced animal pregnancy failure. BMC Vet Res. 2016 Feb 24;12:36. doi: 10.1186/s12917-016-0655-2. PubMed PMID: 26911557; PubMed Central PMCID: PMC4765044.
  17. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner DA, Kisseleva T. Promising Therapy Candidates for Liver Fibrosis. Front Physiol. 2016;7:47. doi: 10.3389/fphys.2016.00047. eCollection 2016. Review. PubMed PMID: 26909046; PubMed Central PMCID: PMC4754444.
  18. Liang S, Kisseleva T, Brenner DA. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Front Physiol. 2016;7:17. doi: 10.3389/fphys.2016.00017. eCollection 2016. Review. PubMed PMID: 26869935; PubMed Central PMCID: PMC4735448.
  19. Zhang Y, Liang S, Li X, Wang L, Zhang J, Xu J, Huo S, Cao X, Zhong Z, Zhong F. Mutual enhancement of IL-2 and IL-7 on DNA vaccine immunogenicity mainly involves regulations on their receptor expression and receptor-expressing lymphocyte generation. Vaccine. 2015 Jul 9;33(30):3480-7. doi: 10.1016/j.vaccine.2015.05.068. Epub 2015 Jun 9. PubMed PMID: 26055295.
  20. Sobol A, Galluzzo P, Liang S, Rambo B, Skucha S, Weber MJ, Alani S, Bocchetta M. Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells. J Cell Physiol. 2015 May;230(5):1064-74. doi: 10.1002/jcp.24835. PubMed PMID: 25283437; PubMed Central PMCID: PMC4445069.
  21. Zhang B, Roh YS, Liang S, Liu C, Naiki M, Masuda K, Seki E. Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes. PLoS One. 2014;9(12):e114071. doi: 10.1371/journal.pone.0114071. eCollection 2014. PubMed PMID: 25470242; PubMed Central PMCID: PMC4254918.
  22. Lin H, Liang S, Zhong Z, Wen J, Li W, Wang L, Xu J, Zhong F, Li X. Soluble CD83 inhibits human monocyte differentiation into dendritic cells in vitro. Cell Immunol. 2014 Nov-Dec;292(1-2):25-31. doi: 10.1016/j.cellimm.2014.08.003. Epub 2014 Sep 6. PubMed PMID: 25243645.
  23. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. J Clin Invest. 2014 Aug;124(8):3566-78. doi: 10.1172/JCI74068. Epub 2014 Jul 1. PubMed PMID: 24983318; PubMed Central PMCID: PMC4109552.
  24. Liang S, Zhong Z, Seki E. Novel fate-tracing strategies show that hepatic stellate cells mediate fibrosis in vivo. Gastroenterology. 2014 Jun;146(7):1823-5. doi: 10.1053/j.gastro.2014.04.010. Epub 2014 Apr 21. PubMed PMID: 24768331; PubMed Central PMCID: PMC4743044.
  25. Li W, Han D, Liang S, Zhong Z, Li X, Wen J, Lin H, Wang L, Li X, Zhong X, Zhong F. Molecular mechanism for the effects of E. coli heat-labile enterotoxin on mouse embryo survival. Reprod Toxicol. 2014 Jun;45:31-8. doi: 10.1016/j.reprotox.2014.01.005. Epub 2014 Jan 17. PubMed PMID: 24440567.
  26. Wen J, Pan S, Liang S, Zhong Z, He Y, Lin H, Li W, Wang L, Li X, Zhong F. Soluble form of canine transferrin receptor inhibits canine parvovirus infection in vitro and in vivo. Biomed Res Int. 2013;2013:172479. doi: 10.1155/2013/172479. Epub 2013 Sep 8. PubMed PMID: 24089666; PubMed Central PMCID: PMC3780538.
  27. Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala FS, Qiao L. TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun. 2013;4:1611. doi: 10.1038/ncomms2608. PubMed PMID: 23511475; PubMed Central PMCID: PMC3605705.
  28. Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala F, Qiao L. TRPM2 links oxidative stress to the NLRP3 inflammasome activation (P1268). J Immunol. 2013;190. PubMed PMID: 25221348; PubMed Central PMCID: PMC4160441.
  29. Liang S, Galluzzo P, Sobol A, Skucha S, Rambo B, Bocchetta M. Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) Microenvironment. Genes Cancer. 2012 Feb;3(2):141-51. doi: 10.1177/1947601912457025. PubMed PMID: 23050046; PubMed Central PMCID: PMC3463922.
  30. Eliasz S, Liang S, Chen Y, De Marco MA, Machek O, Skucha S, Miele L, Bocchetta M. Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene. 2010 Apr 29;29(17):2488-98. doi: 10.1038/onc.2010.7. Epub 2010 Feb 15. PubMed PMID: 20154720; PubMed Central PMCID: PMC2861728.
  31. Li X, Zhong Z, Liang S, Wang X, Zhong F. Effect of cryopreservation on IL-4, IFNgamma and IL-6 production of porcine peripheral blood lymphocytes. Cryobiology. 2009 Dec;59(3):322-6. doi: 10.1016/j.cryobiol.2009.09.004. Epub 2009 Sep 18. PubMed PMID: 19766617.
  32. Zhong F, Zhong ZY, Liang S, Li XJ. High expression level of soluble SARS spike protein mediated by adenovirus in HEK293 cells. World J Gastroenterol. 2006 Mar 7;12(9):1452-7. doi: 10.3748/wjg.v12.i9.1452. PubMed PMID: 16552820; PubMed Central PMCID: PMC4124329.