Featured Publications

TREM2-expressing macrophages in liver diseases.

Wang X, Qiu Z, Zhong Z, Liang S, 2025 May Trends Endocrinol Metab

Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development.

Wang X, He Q, Zhou C, Xu Y, Liu D, Fujiwara N, Kubota N, Click A, Henderson P, Vancil J, Marquez CA, Gunasekaran G, Schwartz ME, Tabrizian P, Sarpel U, Fiel MI, Diao Y, Sun B, Hoshida Y, Liang S, Zhong Z, 2022 Dec Immunity

Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria.

Liang S, Zhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E, 2019 Jun J. Biol. Chem.

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice.

Liang S, Ma HY, Zhong Z, Dhar D, Liu X, Xu J, Koyama Y, Nishio T, Karin D, Karin G, Mccubbin R, Zhang C, Hu R, Yang G, Chen L, Ganguly S, Lan T, Karin M, Kisseleva T, Brenner DA 2018 Nov Gastroenterology

New mitochondrial DNA synthesis enables NLRP3 inflammasome activation.

Zhong Z, Liang S, Sanchez-Lopez E, He F, Shalapour S, Lin XJ, Wong J, Ding S, Seki E, Schnabl B, Hevener AL, Greenberg HB, Kisseleva T, Karin M 2018 Aug Nature 7717 560 198-203

The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts.

Liang S, Kisseleva T, Brenner DA 2016 Front Physiol 7 17

Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease.

Fujiwara N, Kubota N, Crouchet E, Koneru B, Marquez CA, Jajoriya AK, Panda G, Qian T, Zhu S, Goossens N, Wang X, Liang S, Zhong Z, Lewis S, Taouli B, Schwartz ME, Fiel MI, Singal AG, Marrero JA, Fobar AJ, Parikh ND, Raman I, Li QZ, Taguri M, Ono A, Aikata H, Nakahara T, Nakagawa H, Matsushita Y, Tateishi R, Koike K, Kobayashi M, Higashi T, Nakagawa S, Yamashita YI, Beppu T, Baba H, Kumada H, Chayama K, Baumert TF, Hoshida Y, 2022 Jun Sci Transl Med 650 14 eabo4474

Non-degradable collagen increases liver fibrosis but not hepatocellular carcinoma in mice.

Baglieri J, Zhang C, Liang S, Liu X, Nishio T, Rosenthal SB, Dhar D, Su H, Cong M, Jia J, Hosseini M, Karin M, Kisseleva T, Brenner DA, 2021 Jun Am J Pathol

Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression.

Zhong F, Liang S, Zhong Z, 2019 Nov Trends Immunol.

Activated Hepatic Stellate Cells and Portal Fibroblasts contribute to cholestatic liver fibrosis in MDR2 knockout mice.

Nishio T, Hu R, Koyama Y, Liang S, Rosenthal SB, Yamamoto G, Karin D, Baglieri J, Ma HY, Xu J, Liu X, Dhar D, Iwaisako K, Taura K, Brenner DA, Kisseleva T, 2019 May J. Hepatol.

IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease.

Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T, 2019 Dec J. Hepatol.

TRIF Differentially Regulates Hepatic Steatosis and Inflammation/Fibrosis in Mice.

Yang L, Miura K, Zhang B, Matsushita H, Yang YM, Liang S, Song J, Roh YS, Seki E 2017 May Cell Mol Gastroenterol Hepatol 3 3 469-483

Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis.

Koyama Y, Wang P, Liang S, Iwaisako K, Liu X, Xu J, Zhang M, Sun M, Cong M, Karin D, Taura K, Benner C, Heinz S, Bera T, Brenner DA, Kisseleva T 2017 Mar J. Clin. Invest.

The role of human cytochrome P450 2E1 in liver inflammation and fibrosis.

Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R, Quehenberger O, Davidson NO, Dennis EA, Kisseleva T, Brenner DA 2017 12 Hepatol Commun 10 1 1043-1057

NF-?B Restricts Inflammasome Activation via Elimination of Damaged Mitochondria.

Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M 2016 Feb Cell 5 164 896-910

Promising Therapy Candidates for Liver Fibrosis.

Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH, Brenner DA, Kisseleva T 2016 Front Physiol 7 47

Amyloid precursor protein (APP) affects global protein synthesis in dividing human cells.

Sobol A, Galluzzo P, Liang S, Rambo B, Skucha S, Weber MJ, Alani S, Bocchetta M 2015 May J. Cell. Physiol. 5 230 1064-74

Novel fate-tracing strategies show that hepatic stellate cells mediate fibrosis in vivo.

Liang S, Zhong Z, Seki E 2014 Jun Gastroenterology 7 146 1823-5

TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis.

Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E 2014 Jul J. Clin. Invest.

Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-?B and JNK in hepatocytes.

Zhang B, Roh YS, Liang S, Liu C, Naiki M, Masuda K, Seki E 2014 PLoS ONE 12 9 e114071

TRPM2 links oxidative stress to NLRP3 inflammasome activation.

Zhong Z, Zhai Y, Liang S, Mori Y, Han R, Sutterwala FS, Qiao L 2013 Nat Commun 4 1611

Multimodality Approaches to Treat Hypoxic Non-Small Cell Lung Cancer (NSCLC) Microenvironment.

Liang S, Galluzzo P, Sobol A, Skucha S, Rambo B, Bocchetta M 2012 Feb Genes Cancer 2 3 141-51

Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway.

Eliasz S, Liang S, Chen Y, De Marco MA, Machek O, Skucha S, Miele L, Bocchetta M 2010 Apr Oncogene 17 29 2488-98