Publications

Featured Publications

ZMYND8 protects breast cancer stem cells against oxidative stress and ferroptosis through activation of NRF2.

Luo M, Bao L, Xue Y, Zhu M, Kumar A, Xing C, Wang JE, Wang Y, Luo W, 2024 Jan J Clin Invest 6 134

SAP30 promotes breast tumor progression by bridging the transcriptional corepressor SIN3 complex and MLL1.

Bao L, Kumar A, Zhu M, Peng Y, Xing C, Wang JE, Wang Y, Luo W, 2023 Sep J Clin Invest 17 133

Targeting BCAT1 combined with a-ketoglutarate triggers metabolic synthetic lethality in glioblastoma.

Zhang B, Peng H, Zhou M, Bao L, Wang C, Cai F, Zhang H, Wang JE, Niu Y, Chen Y, Wang Y, Hatanpaa K, Copland JA, DeBerardinis RJ, Wang Y, Luo W, 2022 May Cancer Res

ZMYND8 is a master regulator of 27-hydroxycholesterol that promotes tumorigenicity of breast cancer stem cells.

Luo M, Bao L, Chen Y, Xue Y, Wang Y, Zhang B, Wang C, Corley CD, McDonald JG, Kumar A, Xing C, Fang Y, Nelson ER, Wang JE, Wang Y, Luo W, 2022 07 Sci Adv 28 8 eabn5295

ZMYND8 expression in breast cancer cells blocks T-lymphocyte surveillance to promote tumor growth.

Wang Y, Luo M, Chen Y, Wang Y, Zhang B, Ren Z, Bao L, Wang Y, Wang JE, Fu YX, Luo W, Wang Y, 2020 Nov Cancer Res

HIF-2-induced long non-coding RNA RAB11B-AS1 promotes hypoxia-mediated angiogenesis and breast cancer metastasis.

Niu Y, Bao L, Chen Y, Wang C, Luo M, Zhang B, Zhou M, Wang JE, Fang YV, Kumar A, Xing C, Wang Y, Luo W, 2020 Jan Cancer Res.

Methylation of hypoxia-inducible factor (HIF)-1a by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration.

Bao L, Chen Y, Lai HT, Wu SY, Wang JE, Hatanpaa KJ, Raisanen JM, Fontenot M, Lega B, Chiang CM, Semenza GL, Wang Y, Luo W 2018 May Nucleic Acids Res.

ZMYND8 acetylation mediates HIF-dependent breast cancer progression and metastasis.

Chen Y, Zhang B, Bao L, Jin L, Yang M, Peng Y, Kumar A, Wang JE, Wang C, Zou X, Xing C, Wang Y, Luo W 2018 Apr J. Clin. Invest.

Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1.

Luo W, Hu H, Chang R, Zhong J, Knabel M, O'Meally R, Cole RN, Pandey A, Semenza GL 2011 May Cell 5 145 732-44

KDM6B promotes PARthanatos via suppression of O6-methylguanine DNA methyltransferase repair and sustained checkpoint response.

Yang M, Wang C, Zhou M, Bao L, Wang Y, Kumar A, Xing C, Luo W, Wang Y, 2022 Jun Nucleic Acids Res 11 50 6313-6331

MIF is a 3' flap nuclease that facilitates DNA replication and promotes tumor growth.

Wang Y, Chen Y, Wang C, Yang M, Wang Y, Bao L, Wang JE, Kim B, Chan KY, Xu W, Capota E, Ortega J, Nijhawan D, Li GM, Luo W, Wang Y, 2021 05 Nat Commun 1 12 2954

Multifaceted role of branched-chain amino acid metabolism in cancer.

Peng H, Wang Y, Luo W, 2020 Oct Oncogene 44 39 6747-6756

CHD4 promotes breast cancer progression as a coactivator of hypoxia-inducible factors.

Wang Y, Chen Y, Bao L, Zhang B, Wang JE, Kumar A, Xing C, Wang Y, Luo W, 2020 Jul Cancer Res.

Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma.

Zhang B, Chen Y, Shi X, Zhou M, Bao L, Hatanpaa KJ, Patel T, DeBerardinis RJ, Wang Y, Luo W, 2020 Feb Cell. Mol. Life Sci.

PARP-1 and its associated nucleases in DNA damage response.

Wang Y, Luo W, Wang Y, 2019 Jul DNA Repair (Amst.) 102651

Hypoxia Mediates Tumor Malignancy and Therapy Resistance.

Luo W, Wang Y, 2019 Adv. Exp. Med. Biol. 1136 1-18

Epigenetic regulators: multifunctional proteins modulating hypoxia-inducible factor-a protein stability and activity.

Luo W, Wang Y 2017 Oct Cell. Mol. Life Sci.

The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B 2013 Aug Immunity 2 39 272-85

Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression.

Luo W, Chang R, Zhong J, Pandey A, Semenza GL 2012 Dec Proc. Natl. Acad. Sci. U.S.A. 49 109 E3367-76

Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.

Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV, Pardoll DM, Pan F 2011 Sep Cell 5 146

Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.

Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza GL 2010 Feb J. Biol. Chem. 6 285 3651-63