Publications

The Roles of DNA Topoisomerase II? in Transcription.

Madabhushi R 2018 Jun Int J Mol Sci 7 19

Emerging themes in neuronal activity-dependent gene expression.

Madabhushi R, Kim TK 2017 Dec Mol. Cell. Neurosci.

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes.

Madabhushi R, Gao F, Pfenning AR, Pan L, Yamakawa S, Seo J, Rueda R, Phan TX, Yamakawa H, Pao PC, Stott RT, Gjoneska E, Nott A, Cho S, Kellis M, Tsai LH 2015 Jun Cell 7 161 1592-605

DNA damage and its links to neurodegeneration.

Madabhushi R, Pan L, Tsai LH 2014 Jul Neuron 2 83 266-82

SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons.

Dobbin MM, Madabhushi R, Pan L, Chen Y, Kim D, Gao J, Ahanonu B, Pao PC, Qiu Y, Zhao Y, Tsai LH 2013 Aug Nat. Neurosci. 8 16 1008-15

RNAPII and DNA supercoiling regulate cohesin engagement in neurons.

Crewe M, Delint-Ramirez I, Halawa O, Heady L, Madabhushi R, 2026 Jun Nucleic Acids Res 11 54

The heat shock transcription factor, HSF1, stimulates the catalytic engagement of topoisomerase IIβ over topoisomerase IIα.

Konada L, Catley TE, Heady L, Crewe M, Delint-Ramirez I, Wiggins L, Fajardo Briseno S, Bhat MY, Segev A, Pyne ALB, Madabhushi R, 2026 Jun Mol Cell

DNA damage and its links to neuronal aging and degeneration.

Delint-Ramirez I, Madabhushi R, 2025 Jan Neuron 1 113 7-28

NPAS4 juggles neuronal activity-dependent transcription and DSB repair with NuA4.

Delint-Ramirez I, Madabhushi R, 2023 Apr Mol Cell 8 83 1208-1209

Calcineurin dephosphorylates topoisomerase II? and regulates the formation of neuronal-activity-induced DNA breaks.

Delint-Ramirez I, Konada L, Heady L, Rueda R, Jacome ASV, Marlin E, Marchioni C, Segev A, Kritskiy O, Yamakawa S, Reiter AH, Tsai LH, Madabhushi R, 2022 Oct Mol Cell 20 82 3794-3809.e8

Cortical neurons gradually attain a post-mitotic state.

Anda FC, Madabhushi R, Rei D, Meng J, Gräff J, Durak O, Meletis K, Richter M, Schwanke B, Mungenast A, Tsai LH 2016 Sep Cell Res. 9 26 1033-47

The Role of Epigenetic Mechanisms in the Regulation of Gene Expression in the Nervous System.

Cholewa-Waclaw J, Bird A, von Schimmelmann M, Schaefer A, Yu H, Song H, Madabhushi R, Tsai LH 2016 Nov J. Neurosci. 45 36 11427-11434

Alzheimer's disease: A protective factor for the ageing brain.

Tsai LH, Madabhushi R 2014 Mar Nature 7493 507 439-40

Activity-dependent p25 generation regulates synaptic plasticity and A?-induced cognitive impairment.

Seo J, Giusti-Rodríguez P, Zhou Y, Rudenko A, Cho S, Ota KT, Park C, Patzke H, Madabhushi R, Pan L, Mungenast AE, Guan JS, Delalle I, Tsai LH 2014 Apr Cell 2 157 486-98

Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex.

de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, Rei D, Soda T, Madabhushi R, Ginty DD, Kolodkin AL, Tsai LH 2012 Jun Nat. Neurosci. 7 15 1022-31